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ProShares UltraShort Nasdaq Biotechnology (BIS)

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Upturn Advisory Summary
12/18/2025: BIS (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type ETF | Historic Profit -8.64% | Avg. Invested days 45 | Today’s Advisory PASS |
Upturn Star Rating ![]() | Upturn Advisory Performance | ETF Returns Performance |
Key Highlights
Volume (30-day avg) - | Beta -1.09 | 52 Weeks Range 13.56 - 25.71 | Updated Date 06/29/2025 |
52 Weeks Range 13.56 - 25.71 | Updated Date 06/29/2025 |
Upturn AI SWOT
ProShares UltraShort Nasdaq Biotechnology
ETF Overview
Overview
ProShares UltraShort Nasdaq Biotechnology (BIS) is an exchange-traded fund that seeks to deliver twice the inverse of the daily performance of the Nasdaq Biotechnology Index. This means it's designed for investors who want to profit from a decline in the biotechnology sector, or to hedge their existing long positions in that sector.
Reputation and Reliability
ProShares is a well-established issuer of alternative ETFs, known for its inverse and leveraged strategies. They have a significant track record in offering these specialized products.
Management Expertise
ProShares leverages experienced management teams with expertise in structured products, derivatives, and index replication to construct and manage its ETFs.
Investment Objective
Goal
To provide investors with twice the inverse of the daily performance of the Nasdaq Biotechnology Index.
Investment Approach and Strategy
Strategy: BIS aims to achieve its investment objective by using derivatives such as swap agreements and futures contracts. It does not directly hold the securities of the Nasdaq Biotechnology Index constituents.
Composition The ETF's holdings are primarily comprised of derivative instruments designed to mirror the inverse performance of the Nasdaq Biotechnology Index. These can include swap agreements, futures contracts, and other financial instruments.
Market Position
Market Share: Precise market share data for niche leveraged/inverse ETFs is challenging to pinpoint, but BIS operates within the specialized inverse biotech ETF segment.
Total Net Assets (AUM): 181.72 Million USD
Competitors
Key Competitors
- Direxion Daily S&P Biotech Bear 3X Shares (LABD)
- ProShares UltraShort Semiconductors (SMDD)
Competitive Landscape
The competitive landscape for inverse biotech ETFs includes other leveraged and inverse ETFs. ProShares' advantage lies in its established brand and focus on specific sector inversions. A disadvantage is that these ETFs are complex and can experience significant tracking error over longer periods due to compounding effects.
Financial Performance
Historical Performance: Due to its leveraged and inverse nature, the historical performance of BIS is highly variable and dependent on short-term market movements. Its performance over longer periods can significantly deviate from the stated objective due to the effects of daily rebalancing and compounding.
Benchmark Comparison: BIS is designed to move inversely to the Nasdaq Biotechnology Index, aiming for twice the inverse daily return. Over longer periods, its performance will likely diverge from -2x the index's return due to compounding effects.
Expense Ratio: 0.95%
Liquidity
Average Trading Volume
The ETF exhibits moderate average trading volume, suggesting reasonable liquidity for active traders.
Bid-Ask Spread
The bid-ask spread is typically tight, indicating relatively low transaction costs for most market participants.
Market Dynamics
Market Environment Factors
BIS is influenced by factors affecting the biotechnology sector, including drug trial results, regulatory approvals, patent expirations, M&A activity, and overall economic sentiment impacting healthcare and innovation investments. Federal Reserve policy and interest rate changes can also play a role.
Growth Trajectory
The growth trajectory for BIS is directly tied to anticipated downturns in the biotechnology sector. Its strategy is not one of long-term capital appreciation but rather short-term directional betting or hedging.
Moat and Competitive Advantages
Competitive Edge
BIS offers a direct, leveraged inverse exposure to the biotechnology sector, catering to sophisticated investors seeking to capitalize on short-term declines. Its advantage is its specialized focus and the potential for amplified gains during sector downturns. However, its complexity and the risk of significant tracking error over time are also key characteristics.
Risk Analysis
Volatility
BIS is characterized by extremely high volatility due to its 2x leveraged inverse strategy. Its daily price movements can be substantial, both upwards and downwards.
Market Risk
The primary market risk is that the biotechnology sector could experience sustained upward price movements, leading to substantial losses for BIS. Additionally, the compounding effect inherent in daily rebalancing means that over periods longer than one day, the ETF's performance will likely not be exactly twice the inverse of the index's performance.
Investor Profile
Ideal Investor Profile
BIS is suitable for experienced investors who understand the risks of leveraged and inverse ETFs. It is intended for short-term speculation or hedging strategies, not for buy-and-hold investors.
Market Risk
This ETF is best suited for active traders and short-term investors looking to bet against the biotechnology sector or hedge existing long positions.
Summary
ProShares UltraShort Nasdaq Biotechnology (BIS) is a highly specialized ETF designed for short-term inverse exposure to the biotech sector. It aims for twice the inverse daily return of the Nasdaq Biotechnology Index, utilizing derivatives. Its high volatility and compounding effects make it unsuitable for long-term investors, but it can be a tool for active traders seeking to profit from or hedge against sector declines.
Similar ETFs
Sources and Disclaimers
Data Sources:
- ProShares Website (ETF Fact Sheet)
- Financial Data Providers (e.g., Yahoo Finance, Morningstar)
Disclaimers:
This information is for educational purposes only and should not be considered investment advice. Leveraged and inverse ETFs are complex and carry a high risk of loss. Investors should consult with a financial advisor before making any investment decisions. Performance data is historical and not indicative of future results.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About ProShares UltraShort Nasdaq Biotechnology
Exchange NASDAQ | Headquaters - | ||
IPO Launch date - | CEO - | ||
Sector - | Industry - | Full time employees - | Website |
Full time employees - | Website | ||
The fund invests in financial instruments that ProShare Advisors believes, in combination, should produce daily returns consistent with the Daily Target. The index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies. Under normal circumstances, the fund will obtain inverse leveraged exposure to at least 80% of its total assets in components of the index or in instruments with similar economic characteristics. The fund is non-diversified.

Note: This website is maintained by Upturn Corporation, which is an investment adviser registered with the U.S. Securities and Exchange Commission. Such registration does not imply a certain level of skill or training. Investing in securities has risks. Past performance is no guarantee of future returns. No assurance is provided as to any particular investment return, and you may lose money using our services. You are strongly advised to consult appropriate counsel before making any investments in companies you learn about through our services. You should obtain appropriate legal, tax, investment, accounting, and other advice that takes into account your investment portfolio and overall financial situation. You are solely responsible for conducting due diligence on a potential investment. We do not affect trades for you. You will select your own broker through which to transact. Investments are not FDIC insured, they are not guaranteed, and they may lose value. Please see the Privacy Policy, Terms of Use, and Disclosure for more information.
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