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ProShares UltraShort Nasdaq Biotechnology (BIS)



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Upturn Advisory Summary
07/29/2025: BIS (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type ETF | Historic Profit -8.73% | Avg. Invested days 45 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | ETF Returns Performance ![]() |
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Key Highlights
Volume (30-day avg) - | Beta -1.09 | 52 Weeks Range 13.56 - 25.71 | Updated Date 06/29/2025 |
52 Weeks Range 13.56 - 25.71 | Updated Date 06/29/2025 |
Upturn AI SWOT
ProShares UltraShort Nasdaq Biotechnology
ETF Overview
Overview
ProShares UltraShort Nasdaq Biotechnology (BIS) seeks daily investment results, before fees and expenses, that correspond to two times the inverse (-2x) of the daily performance of the Nasdaq Biotechnology Index. It is designed for investors seeking to profit from a short-term decline in the biotechnology sector.
Reputation and Reliability
ProShares is a well-known provider of leveraged and inverse ETFs with a generally solid reputation for providing products that track their stated objectives closely on a daily basis.
Management Expertise
ProShares has a dedicated team with experience in managing complex ETF products, including leveraged and inverse strategies.
Investment Objective
Goal
To deliver two times the inverse of the daily performance of the Nasdaq Biotechnology Index.
Investment Approach and Strategy
Strategy: Inverse and leveraged, seeking to deliver -2x the daily return of the Nasdaq Biotechnology Index.
Composition Primarily holds financial instruments, such as swap agreements, to achieve its leveraged inverse objective. Does not directly hold the underlying stocks of the Nasdaq Biotechnology Index.
Market Position
Market Share: BIS holds a segment of the inverse/leveraged biotech ETF market; however, its specific market share fluctuates with AUM and competitive offerings.
Total Net Assets (AUM): 67860000
Competitors
Key Competitors
- Direxion Daily S&P Biotech Bear 3X Shares (LABD)
Competitive Landscape
The competitive landscape consists of other leveraged and inverse biotechnology ETFs. BIS competes with LABD primarily. BIS's advantage lies in its focused objective to track -2x daily performance, while LABD seeks -3x. However, the higher leverage of LABD may attract some investors.
Financial Performance
Historical Performance: Historical performance is directly tied to the performance of the Nasdaq Biotechnology Index. Given its inverse nature, BIS will generally increase in value when the index decreases.
Benchmark Comparison: The effectiveness of BIS is gauged by how closely it tracks -2x the daily performance of the Nasdaq Biotechnology Index.
Expense Ratio: 0.95
Liquidity
Average Trading Volume
BIS's average trading volume is moderate, providing sufficient liquidity for most traders but large orders can still move the price.
Bid-Ask Spread
The bid-ask spread is generally reasonable, allowing for relatively efficient trading.
Market Dynamics
Market Environment Factors
BIS is affected by factors impacting the biotechnology sector, including FDA approvals, clinical trial results, and overall market sentiment towards healthcare and innovation.
Growth Trajectory
BIS's growth trajectory is inversely correlated to the biotechnology sector's performance. Changes to strategy are uncommon, as the focus is on maintaining the target leverage ratio.
Moat and Competitive Advantages
Competitive Edge
BIS offers a specific leveraged inverse exposure to the biotechnology sector. Its competitive advantage lies in its simplicity and directness in tracking the specified index. The fund offers a straightforward approach for traders looking to bet against the biotech industry in the short term. The disadvantage lies in the daily reset of leverage which can result in erosion of value over time.
Risk Analysis
Volatility
BIS experiences high volatility due to its leveraged nature. The fund is designed to amplify returns, it also magnifies losses.
Market Risk
BIS is subject to market risk associated with the biotechnology sector, including regulatory risks, clinical trial failures, and pricing pressures.
Investor Profile
Ideal Investor Profile
BIS is best suited for sophisticated investors and active traders with a short-term outlook and a strong understanding of leveraged and inverse ETFs. It is not suitable for long-term investors.
Market Risk
Best for active traders seeking short-term exposure to the inverse performance of the biotechnology sector.
Summary
ProShares UltraShort Nasdaq Biotechnology (BIS) is a leveraged inverse ETF designed for experienced traders seeking short-term profits from a declining biotech sector. It delivers -2x the daily performance of the Nasdaq Biotechnology Index, making it a risky but potentially rewarding option for those with a bearish outlook. The fund's high expense ratio and daily reset add to the complexity, making it unsuitable for passive, long-term investors. Investors should carefully consider their risk tolerance and understand the intricacies of leveraged inverse ETFs before investing.
Peer Comparison
Sources and Disclaimers
Data Sources:
- ProShares website
- ETF.com
- FactSet
Disclaimers:
The information provided is for informational purposes only and does not constitute financial advice. Investors should conduct their own due diligence and consult with a financial advisor before making investment decisions. Leveraged and inverse ETFs are complex instruments and should be used with caution.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About ProShares UltraShort Nasdaq Biotechnology
Exchange NASDAQ | Headquaters - | ||
IPO Launch date - | CEO - | ||
Sector - | Industry - | Full time employees - | Website |
Full time employees - | Website |
The fund invests in financial instruments that ProShare Advisors believes, in combination, should produce daily returns consistent with the Daily Target. The index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies. Under normal circumstances, the fund will obtain inverse leveraged exposure to at least 80% of its total assets in components of the index or in instruments with similar economic characteristics. The fund is non-diversified.

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