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ProShares UltraShort Nasdaq Biotechnology (BIS)



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Upturn Advisory Summary
09/15/2025: BIS (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type ETF | Historic Profit -8.73% | Avg. Invested days 45 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | ETF Returns Performance ![]() |
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Key Highlights
Volume (30-day avg) - | Beta -1.09 | 52 Weeks Range 13.56 - 25.71 | Updated Date 06/29/2025 |
52 Weeks Range 13.56 - 25.71 | Updated Date 06/29/2025 |
Upturn AI SWOT
ProShares UltraShort Nasdaq Biotechnology
ETF Overview
Overview
The ProShares UltraShort Nasdaq Biotechnology (BIS) is an exchange-traded fund (ETF) designed to provide twice the inverse (opposite) of the daily performance of the Nasdaq Biotechnology Index. It is a geared or leveraged inverse fund, primarily targeting sophisticated investors seeking to profit from short-term declines in the biotechnology sector. The fund uses derivatives to achieve its investment objective, aiming for a 2x inverse return on the index.
Reputation and Reliability
ProShares is a well-known issuer specializing in leveraged and inverse ETFs. They have a track record of providing such specialized investment products.
Management Expertise
ProShares has extensive experience in managing leveraged and inverse funds, with a dedicated team focused on this area.
Investment Objective
Goal
To seek daily investment results, before fees and expenses, that correspond to twice (2x) the inverse (opposite) of the daily performance of the Nasdaq Biotechnology Index.
Investment Approach and Strategy
Strategy: The ETF employs a leveraged inverse strategy, using derivatives like swaps and futures contracts to achieve its 2x inverse exposure to the Nasdaq Biotechnology Index.
Composition The ETF holds a portfolio of derivative instruments, primarily swaps, to generate the desired leveraged inverse exposure. It does not typically hold physical stocks.
Market Position
Market Share: BIS's market share is limited to the inverse leveraged biotechnology ETF sub-segment.
Total Net Assets (AUM): 76740000
Competitors
Key Competitors
- Direxion Daily S&P Biotech Bear 3X Shares (LABD)
Competitive Landscape
The competitive landscape is dominated by a few key players offering inverse and leveraged exposure to the biotechnology sector. BIS aims to provide 2x inverse exposure, while competitors offer different multiples of leverage. BIS offers a targeted approach for investors with specific short-term views on the biotechnology sector, but faces the risk of amplified losses if the index rises.
Financial Performance
Historical Performance: Historical performance is highly dependent on the Nasdaq Biotechnology Index performance; due to the daily reset and leverage, long-term performance can deviate significantly from -2x the index return.
Benchmark Comparison: The ETF aims to provide -2x the daily return of the Nasdaq Biotechnology Index; however, compounding effects can lead to deviations over longer periods.
Expense Ratio: 0.95
Liquidity
Average Trading Volume
The average trading volume is moderate, which is typical for leveraged and inverse ETFs.
Bid-Ask Spread
The bid-ask spread can vary, reflecting demand and volatility in the biotechnology sector; it is recommended to check current quotes before trading.
Market Dynamics
Market Environment Factors
The ETF's performance is highly sensitive to news and events affecting the biotechnology sector, including regulatory approvals, clinical trial results, and broader market sentiment.
Growth Trajectory
Growth depends on investor demand for inverse exposure to the biotechnology sector. It changes its holdings and strategy to provide daily -2x return.
Moat and Competitive Advantages
Competitive Edge
BIS's competitive advantage lies in its focused approach, offering -2x daily exposure. Its leverage allows sophisticated investors to amplify potential gains from correctly anticipating short-term declines in the biotechnology sector. It is a tactical tool for short term trading that requires continuous monitoring due to the daily reset feature. It is not designed for long-term investment.
Risk Analysis
Volatility
High volatility is inherent due to the leveraged nature of the fund and the inherent volatility of the biotechnology sector.
Market Risk
The ETF is exposed to significant market risk due to its leveraged inverse nature. Any positive movement in the Nasdaq Biotechnology Index can result in substantial losses.
Investor Profile
Ideal Investor Profile
The ideal investor is a sophisticated trader with a short-term negative outlook on the biotechnology sector. They should understand the risks associated with leveraged and inverse ETFs and have the ability to actively manage their positions.
Market Risk
BIS is best suited for active traders with a short-term investment horizon, not long-term investors or passive index followers.
Summary
ProShares UltraShort Nasdaq Biotechnology (BIS) is a leveraged inverse ETF designed for sophisticated investors seeking to profit from short-term declines in the biotechnology sector. It provides twice the inverse of the Nasdaq Biotechnology Index's daily performance. Due to the daily reset and leverage, its performance can deviate significantly from -2x the index return over longer periods. This ETF is most suitable for experienced traders with a short-term outlook and a deep understanding of the risks involved in leveraged and inverse products. This ETF should not be used for buy and hold investment purposes.
Peer Comparison
Sources and Disclaimers
Data Sources:
- ProShares website
- SEC filings
- ETF.com
- Yahoo Finance
Disclaimers:
The data provided is for informational purposes only and does not constitute financial advice. Past performance is not indicative of future results. Investing in ETFs involves risk, including the potential loss of principal. Leveraged and inverse ETFs are particularly risky and are not suitable for all investors.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About ProShares UltraShort Nasdaq Biotechnology
Exchange NASDAQ | Headquaters - | ||
IPO Launch date - | CEO - | ||
Sector - | Industry - | Full time employees - | Website |
Full time employees - | Website |
The fund invests in financial instruments that ProShare Advisors believes, in combination, should produce daily returns consistent with the Daily Target. The index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies. Under normal circumstances, the fund will obtain inverse leveraged exposure to at least 80% of its total assets in components of the index or in instruments with similar economic characteristics. The fund is non-diversified.

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