BIS
BIS 1-star rating from Upturn Advisory

ProShares UltraShort Nasdaq Biotechnology (BIS)

ProShares UltraShort Nasdaq Biotechnology (BIS) 1-star rating from Upturn Advisory
$9.93
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Upturn Advisory Summary

12/18/2025: BIS (1-star) is currently NOT-A-BUY. Pass it for now.

Upturn Star Rating

Upturn 1 star rating for performance

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Analysis of Past Performance

Type ETF
Historic Profit -8.64%
Avg. Invested days 45
Today’s Advisory PASS
Upturn Star Rating upturn star rating icon
Upturn Advisory Performance Upturn Advisory Performance icon 2.0
ETF Returns Performance Upturn Returns Performance icon 1.0
Upturn Profits based on simulation icon Profits based on simulation
Upturn last close icon Last Close 12/18/2025

Key Highlights

Volume (30-day avg) -
Beta -1.09
52 Weeks Range 13.56 - 25.71
Updated Date 06/29/2025
52 Weeks Range 13.56 - 25.71
Updated Date 06/29/2025

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ProShares UltraShort Nasdaq Biotechnology

ProShares UltraShort Nasdaq Biotechnology(BIS) company logo displayed in Upturn AI summary

ETF Overview

overview logo Overview

ProShares UltraShort Nasdaq Biotechnology (BIS) is an exchange-traded fund that seeks to deliver twice the inverse of the daily performance of the Nasdaq Biotechnology Index. This means it's designed for investors who want to profit from a decline in the biotechnology sector, or to hedge their existing long positions in that sector.

Reputation and Reliability logo Reputation and Reliability

ProShares is a well-established issuer of alternative ETFs, known for its inverse and leveraged strategies. They have a significant track record in offering these specialized products.

Leadership icon representing strong management expertise and executive team Management Expertise

ProShares leverages experienced management teams with expertise in structured products, derivatives, and index replication to construct and manage its ETFs.

Investment Objective

Icon representing investment goals and financial objectives Goal

To provide investors with twice the inverse of the daily performance of the Nasdaq Biotechnology Index.

Investment Approach and Strategy

Strategy: BIS aims to achieve its investment objective by using derivatives such as swap agreements and futures contracts. It does not directly hold the securities of the Nasdaq Biotechnology Index constituents.

Composition The ETF's holdings are primarily comprised of derivative instruments designed to mirror the inverse performance of the Nasdaq Biotechnology Index. These can include swap agreements, futures contracts, and other financial instruments.

Market Position

Market Share: Precise market share data for niche leveraged/inverse ETFs is challenging to pinpoint, but BIS operates within the specialized inverse biotech ETF segment.

Total Net Assets (AUM): 181.72 Million USD

Competitors

Key Competitors logo Key Competitors

  • Direxion Daily S&P Biotech Bear 3X Shares (LABD)
  • ProShares UltraShort Semiconductors (SMDD)

Competitive Landscape

The competitive landscape for inverse biotech ETFs includes other leveraged and inverse ETFs. ProShares' advantage lies in its established brand and focus on specific sector inversions. A disadvantage is that these ETFs are complex and can experience significant tracking error over longer periods due to compounding effects.

Financial Performance

Historical Performance: Due to its leveraged and inverse nature, the historical performance of BIS is highly variable and dependent on short-term market movements. Its performance over longer periods can significantly deviate from the stated objective due to the effects of daily rebalancing and compounding.

Benchmark Comparison: BIS is designed to move inversely to the Nasdaq Biotechnology Index, aiming for twice the inverse daily return. Over longer periods, its performance will likely diverge from -2x the index's return due to compounding effects.

Expense Ratio: 0.95%

Liquidity

Average Trading Volume

The ETF exhibits moderate average trading volume, suggesting reasonable liquidity for active traders.

Bid-Ask Spread

The bid-ask spread is typically tight, indicating relatively low transaction costs for most market participants.

Market Dynamics

Market Environment Factors

BIS is influenced by factors affecting the biotechnology sector, including drug trial results, regulatory approvals, patent expirations, M&A activity, and overall economic sentiment impacting healthcare and innovation investments. Federal Reserve policy and interest rate changes can also play a role.

Growth Trajectory

The growth trajectory for BIS is directly tied to anticipated downturns in the biotechnology sector. Its strategy is not one of long-term capital appreciation but rather short-term directional betting or hedging.

Moat and Competitive Advantages

Competitive Edge

BIS offers a direct, leveraged inverse exposure to the biotechnology sector, catering to sophisticated investors seeking to capitalize on short-term declines. Its advantage is its specialized focus and the potential for amplified gains during sector downturns. However, its complexity and the risk of significant tracking error over time are also key characteristics.

Risk Analysis

Volatility

BIS is characterized by extremely high volatility due to its 2x leveraged inverse strategy. Its daily price movements can be substantial, both upwards and downwards.

Market Risk

The primary market risk is that the biotechnology sector could experience sustained upward price movements, leading to substantial losses for BIS. Additionally, the compounding effect inherent in daily rebalancing means that over periods longer than one day, the ETF's performance will likely not be exactly twice the inverse of the index's performance.

Investor Profile

Ideal Investor Profile

BIS is suitable for experienced investors who understand the risks of leveraged and inverse ETFs. It is intended for short-term speculation or hedging strategies, not for buy-and-hold investors.

Market Risk

This ETF is best suited for active traders and short-term investors looking to bet against the biotechnology sector or hedge existing long positions.

Summary

ProShares UltraShort Nasdaq Biotechnology (BIS) is a highly specialized ETF designed for short-term inverse exposure to the biotech sector. It aims for twice the inverse daily return of the Nasdaq Biotechnology Index, utilizing derivatives. Its high volatility and compounding effects make it unsuitable for long-term investors, but it can be a tool for active traders seeking to profit from or hedge against sector declines.

Similar ETFs

Sources and Disclaimers

Data Sources:

  • ProShares Website (ETF Fact Sheet)
  • Financial Data Providers (e.g., Yahoo Finance, Morningstar)

Disclaimers:

This information is for educational purposes only and should not be considered investment advice. Leveraged and inverse ETFs are complex and carry a high risk of loss. Investors should consult with a financial advisor before making any investment decisions. Performance data is historical and not indicative of future results.

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Information icon for Upturn AI Summarization data freshness disclaimer Summarized information shown could be a few years old and not current.

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About ProShares UltraShort Nasdaq Biotechnology

Exchange NASDAQ
Headquaters -
IPO Launch date -
CEO -
Sector -
Industry -
Full time employees -
Website
Full time employees -
Website

The fund invests in financial instruments that ProShare Advisors believes, in combination, should produce daily returns consistent with the Daily Target. The index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies. Under normal circumstances, the fund will obtain inverse leveraged exposure to at least 80% of its total assets in components of the index or in instruments with similar economic characteristics. The fund is non-diversified.