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ProShares UltraShort Nasdaq Biotechnology (BIS)

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Upturn Advisory Summary
11/04/2025: BIS (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type ETF | Historic Profit -8.64% | Avg. Invested days 45 | Today’s Advisory PASS |
Upturn Star Rating ![]() | Upturn Advisory Performance | ETF Returns Performance |
Key Highlights
Volume (30-day avg) - | Beta -1.09 | 52 Weeks Range 13.56 - 25.71 | Updated Date 06/29/2025 |
52 Weeks Range 13.56 - 25.71 | Updated Date 06/29/2025 |
Upturn AI SWOT
ProShares UltraShort Nasdaq Biotechnology
ETF Overview
Overview
ProShares UltraShort Nasdaq Biotechnology (BIS) seeks daily investment results, before fees and expenses, that correspond to two times the inverse (-2x) of the daily performance of the Nasdaq Biotechnology Index.
Reputation and Reliability
ProShares is a well-established issuer known for its leveraged and inverse ETFs. They have a long track record and are considered reliable within the ETF market.
Management Expertise
ProShares has a dedicated management team specializing in complex ETF products, including inverse and leveraged funds.
Investment Objective
Goal
Seeks daily investment results, before fees and expenses, that correspond to two times the inverse (-2x) of the daily performance of the Nasdaq Biotechnology Index.
Investment Approach and Strategy
Strategy: The ETF aims to deliver twice the inverse of the daily returns of the Nasdaq Biotechnology Index. It is not intended for long-term holding.
Composition The ETF uses a combination of financial instruments, including swaps, futures contracts, and other derivatives, to achieve its leveraged inverse exposure to the Nasdaq Biotechnology Index.
Market Position
Market Share: The market share of BIS within the inverse biotechnology ETF market is substantial but can fluctuate based on investor sentiment and trading volume.
Total Net Assets (AUM): 57580328
Competitors
Key Competitors
- LABD
- BIS
Competitive Landscape
The competitive landscape is relatively concentrated. BIS holds a large portion of the market share. The advantage is providing twice inverse exposure for the biotech index and the disadvantage is the daily reset leading to potential return erosion over longer periods, especially in volatile markets.
Financial Performance
Historical Performance: Historical performance can be highly volatile due to the leveraged and inverse nature of the ETF. Returns are significantly impacted by the daily performance of the Nasdaq Biotechnology Index.
Benchmark Comparison: The ETF is benchmarked against two times the inverse of the daily performance of the Nasdaq Biotechnology Index. Tracking error can occur due to fees, expenses, and the complexities of managing the derivatives portfolio.
Expense Ratio: 0.95
Liquidity
Average Trading Volume
The average trading volume of BIS is relatively high, suggesting good liquidity.
Bid-Ask Spread
The bid-ask spread for BIS is typically narrow, indicating lower trading costs.
Market Dynamics
Market Environment Factors
Economic indicators, biotechnology sector growth, FDA approvals, and market sentiment towards the healthcare industry all influence BIS's performance.
Growth Trajectory
Growth trends are highly dependent on short-term movements in the biotechnology sector. Changes in strategy are infrequent as the ETF's objective is clearly defined.
Moat and Competitive Advantages
Competitive Edge
BIS's competitive advantage lies in its specific focus on providing leveraged inverse exposure to the Nasdaq Biotechnology Index. It offers investors a tool to potentially profit from a decline in the biotechnology sector or hedge existing positions. The -2x leverage factor distinguishes it from unleveraged inverse ETFs. ProShares' reputation and expertise in managing complex ETFs also contribute to its edge.
Risk Analysis
Volatility
BIS exhibits high volatility due to its leveraged and inverse nature. Investors should expect significant price fluctuations.
Market Risk
Market risk is substantial as the ETF is directly linked to the performance of the Nasdaq Biotechnology Index. Sector-specific risks, such as regulatory changes and clinical trial failures, can significantly impact its performance.
Investor Profile
Ideal Investor Profile
The ideal investor is a sophisticated trader or investor with a high-risk tolerance, a short-term investment horizon, and a strong understanding of inverse and leveraged ETFs. They typically use it for hedging or tactical short-term trades.
Market Risk
BIS is best suited for active traders seeking short-term exposure to the biotechnology sector. It is not suitable for long-term investors or passive index followers due to the potential for significant value erosion over time.
Summary
ProShares UltraShort Nasdaq Biotechnology (BIS) offers -2x leveraged inverse exposure to the Nasdaq Biotechnology Index, making it a high-risk, high-reward investment vehicle. It is designed for sophisticated traders with a short-term outlook who seek to profit from declines in the biotechnology sector or hedge existing positions. Due to the daily reset feature and leverage, BIS is not suitable for long-term holding. Its performance is highly volatile and sensitive to market sentiment and sector-specific news.
Similar ETFs
Sources and Disclaimers
Data Sources:
- ProShares website
- ETF.com
- Morningstar
Disclaimers:
The information provided is for informational purposes only and should not be considered financial advice. Past performance is not indicative of future results. Investing in leveraged and inverse ETFs involves significant risks.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About ProShares UltraShort Nasdaq Biotechnology
Exchange NASDAQ | Headquaters - | ||
IPO Launch date - | CEO - | ||
Sector - | Industry - | Full time employees - | Website |
Full time employees - | Website | ||
The fund invests in financial instruments that ProShare Advisors believes, in combination, should produce daily returns consistent with the Daily Target. The index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies. Under normal circumstances, the fund will obtain inverse leveraged exposure to at least 80% of its total assets in components of the index or in instruments with similar economic characteristics. The fund is non-diversified.

Note: This website is maintained by Upturn Corporation, which is an investment adviser registered with the U.S. Securities and Exchange Commission. Such registration does not imply a certain level of skill or training. Investing in securities has risks. Past performance is no guarantee of future returns. No assurance is provided as to any particular investment return, and you may lose money using our services. You are strongly advised to consult appropriate counsel before making any investments in companies you learn about through our services. You should obtain appropriate legal, tax, investment, accounting, and other advice that takes into account your investment portfolio and overall financial situation. You are solely responsible for conducting due diligence on a potential investment. We do not affect trades for you. You will select your own broker through which to transact. Investments are not FDIC insured, they are not guaranteed, and they may lose value. Please see the Privacy Policy, Terms of Use, and Disclosure for more information.
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