
Cancel anytime
- Chart
- Upturn Summary
- Highlights
Upturn AI SWOT
- About
SPDR® S&P Biotech ETF (XBI)



- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- Pass (Skip investing)


(see disclosures)
- ALL
- YEAR
- MONTH
- WEEK
Upturn Advisory Summary
09/16/2025: XBI (2-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type ETF | Historic Profit 26.06% | Avg. Invested days 60 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | ETF Returns Performance ![]() |
![]() ![]() | ![]() ![]() |
Key Highlights
Volume (30-day avg) - | Beta 0.8 | 52 Weeks Range 66.65 - 105.45 | Updated Date 06/30/2025 |
52 Weeks Range 66.65 - 105.45 | Updated Date 06/30/2025 |
Upturn AI SWOT
SPDR® S&P Biotech ETF
ETF Overview
Overview
The SPDRu00ae S&P Biotech ETF (XBI) seeks to provide investment results that, before fees and expenses, correspond generally to the total return performance of the S&P Biotechnology Select Industry Index. It focuses on the biotechnology sector, allocating assets primarily to companies involved in the research, development, manufacturing, and marketing of biotechnology products.
Reputation and Reliability
State Street Global Advisors (SSGA) is a well-established and reputable ETF provider with a long track record of managing index-tracking funds.
Management Expertise
SSGA has extensive experience in managing index funds and employs a team of professionals with expertise in the ETF market.
Investment Objective
Goal
To provide investment results that, before fees and expenses, correspond generally to the total return performance of the S&P Biotechnology Select Industry Index.
Investment Approach and Strategy
Strategy: The ETF employs a replication strategy, attempting to hold all of the stocks in the S&P Biotechnology Select Industry Index in proportion to their weighting in the index.
Composition The ETF holds a portfolio of common stocks of U.S. biotechnology companies.
Market Position
Market Share: XBI holds a significant market share within the biotechnology ETF sector, reflecting its popularity among investors seeking exposure to this industry.
Total Net Assets (AUM): 7240000000
Competitors
Key Competitors
- iShares Biotechnology ETF (IBB)
- ARK Genomic Revolution ETF (ARKG)
- Invesco Dynamic Biotechnology & Genome ETF (PBE)
Competitive Landscape
The biotechnology ETF sector is competitive, with IBB holding a larger market share than XBI; ARKG focuses on genomic companies. XBI's equal-weight approach differentiates it from IBB's market-cap-weighted index, potentially offering better diversification. However, IBB's larger AUM and greater liquidity may be advantageous for some investors.
Financial Performance
Historical Performance: Past performance is not indicative of future results. Investors should consider performance over various time horizons.
Benchmark Comparison: The ETF's performance should be compared to the S&P Biotechnology Select Industry Index to assess its tracking efficiency.
Expense Ratio: 0.35
Liquidity
Average Trading Volume
XBI's average trading volume is high, indicating strong liquidity and ease of trading for investors.
Bid-Ask Spread
The bid-ask spread is typically tight, reflecting good liquidity and lower transaction costs for investors.
Market Dynamics
Market Environment Factors
Economic indicators, sector growth prospects, regulatory changes, and scientific breakthroughs in biotechnology significantly influence XBI's performance.
Growth Trajectory
XBI's growth trajectory depends on the overall performance of the biotechnology sector, which is driven by innovation, regulatory approvals, and market demand for new therapies; there have been no recent major changes to the fund's strategy or holdings.
Moat and Competitive Advantages
Competitive Edge
XBI's competitive edge lies in its equal-weighting methodology, which provides more balanced exposure to biotechnology companies, including smaller firms with high growth potential. This approach reduces the influence of larger, more established companies and potentially enhances diversification. Its low expense ratio compared to some active ETFs is an additional competitive advantage. The ETFu2019s pure play focus on biotech provides specific sector access.
Risk Analysis
Volatility
XBI is subject to high volatility due to the inherent risks of the biotechnology sector, including clinical trial failures, regulatory hurdles, and patent expirations.
Market Risk
Market risk is a primary concern due to XBI's concentration in the biotechnology sector, which is sensitive to economic cycles, interest rate changes, and investor sentiment; single stock risk is mitigated by holding all components of the index.
Investor Profile
Ideal Investor Profile
The ideal investor for XBI is someone who seeks exposure to the biotechnology sector, is comfortable with high volatility, and has a long-term investment horizon.
Market Risk
XBI is suitable for investors seeking long-term capital appreciation through exposure to the biotechnology sector, with a willingness to accept high volatility.
Summary
The SPDRu00ae S&P Biotech ETF (XBI) offers investors exposure to the biotechnology sector through an equal-weighted index-tracking approach. XBI's investment objective mirrors the performance of the S&P Biotechnology Select Industry Index, providing broad diversification and focused access to US biotech companies. The fundu2019s equal weighting mitigates concentration risk, allowing smaller companies greater influence. XBI's volatile and sector-specific nature makes it most suitable for long-term investors comfortable with potential market fluctuations and its relatively low expense ratio makes it favorable compared to other biotechnology related funds.
Peer Comparison
Sources and Disclaimers
Data Sources:
- State Street Global Advisors (SSGA) Website
- ETF.com
- Morningstar
- Bloomberg
Disclaimers:
The data and analysis provided are for informational purposes only and should not be considered investment advice. Investors should conduct their own research and consult with a qualified financial advisor before making any investment decisions. Past performance is not indicative of future results. Market share figures are estimates and may vary based on source.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About SPDR® S&P Biotech ETF
Exchange NYSE ARCA | Headquaters - | ||
IPO Launch date - | CEO - | ||
Sector - | Industry - | Full time employees - | Website |
Full time employees - | Website |
In seeking to track the performance of the S&P Biotechnology Select Industry Index (the index), the fund employs a sampling strategy. It generally invests substantially all, but at least 80%, of its total assets in the securities comprising the index. The index represents the biotechnology segment of the S&P Total Market Index (S&P TMI).

Note: This website is maintained by Upturn Corporation, which is an investment adviser registered with the U.S. Securities and Exchange Commission. Such registration does not imply a certain level of skill or training. Investing in securities has risks. Past performance is no guarantee of future returns. No assurance is provided as to any particular investment return, and you may lose money using our services. You are strongly advised to consult appropriate counsel before making any investments in companies you learn about through our services. You should obtain appropriate legal, tax, investment, accounting, and other advice that takes into account your investment portfolio and overall financial situation. You are solely responsible for conducting due diligence on a potential investment. We do not affect trades for you. You will select your own broker through which to transact. Investments are not FDIC insured, they are not guaranteed, and they may lose value. Please see the Privacy Policy, Terms of Use, and Disclosure for more information.