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SPDR® S&P Biotech ETF (XBI)

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Upturn Advisory Summary
12/18/2025: XBI (4-star) is a STRONG-BUY. BUY since 136 days. Simulated Profits (42.48%). Updated daily EoD!
Analysis of Past Performance
Type ETF | Historic Profit 61.43% | Avg. Invested days 74 | Today’s Advisory Strong Buy |
Upturn Star Rating ![]() | Upturn Advisory Performance | ETF Returns Performance |
Key Highlights
Volume (30-day avg) - | Beta 0.8 | 52 Weeks Range 66.65 - 105.45 | Updated Date 06/30/2025 |
52 Weeks Range 66.65 - 105.45 | Updated Date 06/30/2025 |
Upturn AI SWOT
SPDR® S&P Biotech ETF
ETF Overview
Overview
The SPDRu00ae S&P Biotech ETF (XBI) seeks to track the S&P Biotechnology Select Industry Index. It provides exposure to a broad range of biotechnology companies, including those involved in drug discovery, development, and manufacturing. The ETF's investment strategy focuses on companies that are part of the biotechnology and pharmaceutical sectors.
Reputation and Reliability
State Street Global Advisors (SSGA) is a leading global asset manager and the sponsor of the SPDR ETFs. SSGA has a long-standing reputation for reliability and expertise in the exchange-traded fund market.
Management Expertise
SSGA employs experienced investment professionals and utilizes a passive management approach, aiming to replicate the performance of its underlying index.
Investment Objective
Goal
To provide investors with a diversified investment in the biotechnology sector.
Investment Approach and Strategy
Strategy: The ETF aims to track the S&P Biotechnology Select Industry Index, which is an equal-weighted index. This means that each constituent company has a similar weighting in the index, regardless of its market capitalization.
Composition The ETF primarily holds common stocks of companies operating in the biotechnology industry. These companies can range from small-cap to large-cap, with a focus on those engaged in the research, development, and commercialization of pharmaceuticals and medical treatments.
Market Position
Market Share: As of recent data, XBI holds a significant position within the biotechnology ETF sector, though specific market share figures fluctuate.
Total Net Assets (AUM): 8000000000
Competitors
Key Competitors
- iShares Biotechnology ETF (IBB)
- ARK Genomic Revolution ETF (ARKG)
Competitive Landscape
The biotechnology ETF market is competitive, with several large players offering similar exposure. XBI's equal-weighting strategy is a key differentiator from market-cap-weighted ETFs like IBB. ARKG offers a more actively managed, thematic approach. XBI's advantage lies in its broad diversification and equal weighting, which can provide exposure to smaller, potentially faster-growing companies. A disadvantage might be its susceptibility to significant price swings due to its equal-weighting methodology.
Financial Performance
Historical Performance: The ETF has exhibited strong performance in periods of biotech sector growth, but also experienced significant drawdowns during market corrections. Past performance is not indicative of future results.
Benchmark Comparison: XBI aims to track the S&P Biotechnology Select Industry Index and generally performs in line with its benchmark, with minor tracking differences due to expenses.
Expense Ratio: 0.0035
Liquidity
Average Trading Volume
The SPDRu00ae S&P Biotech ETF generally exhibits high average trading volume, indicating good liquidity for investors.
Bid-Ask Spread
The bid-ask spread for XBI is typically tight, reflecting its high trading volume and making it cost-effective to trade.
Market Dynamics
Market Environment Factors
The biotech sector is influenced by factors such as clinical trial success rates, regulatory approvals (e.g., FDA), patent expirations, government healthcare policy, and innovation in drug discovery. Economic conditions can also impact investor sentiment towards riskier, growth-oriented sectors like biotech.
Growth Trajectory
The biotech sector has shown a consistent long-term growth trajectory driven by advancements in science and an aging global population. XBI's strategy of providing broad exposure allows it to participate in this growth across various sub-segments of the industry.
Moat and Competitive Advantages
Competitive Edge
XBI's primary competitive advantage is its equal-weighting methodology, which ensures broad exposure to a diverse range of biotechnology companies, including smaller, emerging players that might be underrepresented in market-cap-weighted indices. This diversification can mitigate the impact of any single company's performance and offers investors access to the full spectrum of innovation within the biotech landscape.
Risk Analysis
Volatility
The SPDRu00ae S&P Biotech ETF is known for its high historical volatility, reflecting the inherent risks and speculative nature of the biotechnology sector.
Market Risk
Specific market risks include the potential for failed clinical trials, adverse regulatory decisions, intense competition, patent challenges, and shifts in healthcare policy. The biotech sector is also sensitive to broader market sentiment towards growth and innovation stocks.
Investor Profile
Ideal Investor Profile
The ideal investor for XBI is one with a high-risk tolerance, a long-term investment horizon, and a strong belief in the growth potential of the biotechnology sector. Investors should be comfortable with significant price fluctuations.
Market Risk
This ETF is best suited for investors seeking aggressive growth opportunities and who are willing to accept higher levels of risk and volatility. It is generally not recommended for risk-averse investors or those with very short-term investment goals.
Summary
The SPDRu00ae S&P Biotech ETF (XBI) offers diversified exposure to the biotechnology sector through an equal-weighted index. Its broad holdings and focus on innovation make it attractive for investors with a high-risk tolerance and long-term outlook. While it offers significant growth potential, it is also characterized by high volatility and sector-specific risks. XBI competes in a crowded ETF space, with its equal-weighting strategy as a key differentiator.
Similar ETFs
Sources and Disclaimers
Data Sources:
- State Street Global Advisors (SSGA) Website
- Financial Data Aggregators (e.g., Morningstar, ETF.com)
Disclaimers:
This JSON output is for informational purposes only and does not constitute financial advice. Data is subject to change and may not be exhaustive. Investors should conduct their own due diligence before making investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About SPDR® S&P Biotech ETF
Exchange NYSE ARCA | Headquaters - | ||
IPO Launch date - | CEO - | ||
Sector - | Industry - | Full time employees - | Website |
Full time employees - | Website | ||
In seeking to track the performance of the S&P Biotechnology Select Industry Index (the index), the fund employs a sampling strategy. It generally invests substantially all, but at least 80%, of its total assets in the securities comprising the index. The index represents the biotechnology segment of the S&P Total Market Index (S&P TMI).

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