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SPDR® S&P Biotech ETF (XBI)

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Upturn Advisory Summary
12/03/2025: XBI (4-star) is a STRONG-BUY. BUY since 125 days. Simulated Profits (44.64%). Updated daily EoD!
Analysis of Past Performance
Type ETF | Historic Profit 63.88% | Avg. Invested days 71 | Today’s Advisory Strong Buy |
Upturn Star Rating ![]() | Upturn Advisory Performance | ETF Returns Performance |
Key Highlights
Volume (30-day avg) - | Beta 0.8 | 52 Weeks Range 66.65 - 105.45 | Updated Date 06/30/2025 |
52 Weeks Range 66.65 - 105.45 | Updated Date 06/30/2025 |
Upturn AI SWOT
SPDR® S&P Biotech ETF
ETF Overview
Overview
The SPDRu00ae S&P Biotech ETF (XBI) seeks to provide investment results that, before fees and expenses, correspond generally to the total return performance of the S&P Biotechnology Select Industry Index, a modified equal weighted index. It focuses on the US biotechnology sector and aims for capital appreciation through investments in a diversified portfolio of biotech companies.
Reputation and Reliability
State Street Global Advisors (SSGA) is a well-established and reputable ETF issuer with a long track record in the market.
Management Expertise
SSGA has extensive experience in managing index-tracking ETFs and possesses the necessary expertise to effectively manage XBI.
Investment Objective
Goal
The ETF aims to track the performance of the S&P Biotechnology Select Industry Index.
Investment Approach and Strategy
Strategy: The ETF employs a passive management strategy, attempting to replicate the composition and weighting of its underlying index.
Composition The ETF primarily holds stocks of US biotechnology companies, with holdings generally reflecting the index composition.
Market Position
Market Share: XBI has a notable market share within the biotech ETF sector.
Total Net Assets (AUM): 7230000000
Competitors
Key Competitors
- iShares Biotechnology ETF (IBB)
- ARK Genomic Revolution ETF (ARKG)
- VanEck Biotech ETF (BBH)
Competitive Landscape
The biotech ETF sector is competitive, with XBI, IBB, ARKG, and BBH being major players. XBI's equal-weighting approach differentiates it from IBB's market-cap weighting. ARKG offers exposure to genomics, making it distinct. BBH offers exposure to large cap Biotech, making it distinct. XBI offers broad exposure to the Biotech industry, and is more sensitive to smaller companies than IBB and BBH.
Financial Performance
Historical Performance: Historical performance data for XBI is as follows: [{"Year": "2019", "Return": 18.4}, {"Year": "2020", "Return": 54.4}, {"Year": "2021", "Return": -15.2}, {"Year": "2022", "Return": -9.8}, {"Year": "2023", "Return": 3.7}]
Benchmark Comparison: XBI's performance relative to the S&P Biotechnology Select Industry Index is very close, reflecting its passive tracking strategy. Any difference is primarily attributable to expense ratio.
Expense Ratio: 0.35
Liquidity
Average Trading Volume
XBI exhibits high liquidity with a substantial average daily trading volume, facilitating easy buying and selling of shares.
Bid-Ask Spread
The bid-ask spread for XBI is generally tight, reflecting its high liquidity and minimizing trading costs.
Market Dynamics
Market Environment Factors
Economic indicators, FDA regulatory decisions, clinical trial outcomes, and overall market sentiment toward the healthcare sector significantly impact XBI.
Growth Trajectory
XBI's growth is influenced by the biotechnology industry's innovation cycle, drug development pipeline, and regulatory landscape. It periodically rebalances and reconstitutes its holdings to maintain alignment with the underlying index.
Moat and Competitive Advantages
Competitive Edge
XBI's equal-weighting methodology provides exposure to a broader range of biotech companies, including smaller and mid-cap firms, differentiating it from market-cap-weighted competitors. This approach can potentially capture higher growth opportunities from emerging biotech companies. However, it can also lead to higher volatility. State Street's proven ETF management expertise further strengthens its competitive position. Equal weighting provides a more balanced representation of the biotech sector than IBB, BBH and other funds.
Risk Analysis
Volatility
XBI is subject to high volatility due to the inherent risks associated with the biotechnology industry, including regulatory hurdles, clinical trial failures, and market sentiment swings.
Market Risk
Market risk is significant for XBI, as biotechnology stocks are sensitive to economic conditions, interest rate changes, and broader market trends. Regulatory risk and technological obsolescence are also concerns.
Investor Profile
Ideal Investor Profile
XBI is suitable for investors with a high-risk tolerance seeking exposure to the biotechnology sector and willing to accept significant price fluctuations. Investors should understand the risks associated with biotech investments.
Market Risk
XBI is best suited for long-term investors or active traders seeking tactical exposure to the biotechnology sector. It is less suitable for passive index followers seeking broad market exposure.
Summary
The SPDRu00ae S&P Biotech ETF (XBI) offers exposure to the US biotechnology sector through an equal-weighted index. Its equal-weighting approach can result in higher volatility but also offers potential for higher growth from smaller companies. While XBI offers diversification within the biotech sector, investors should be aware of the inherent risks associated with the industry, including regulatory hurdles and clinical trial failures. XBI is well-suited to high risk investors.
Similar ETFs
Sources and Disclaimers
Data Sources:
- State Street Global Advisors
- FactSet
- Morningstar
- Bloomberg
Disclaimers:
The data and analysis provided are for informational purposes only and should not be considered financial advice. Investors should conduct their own due diligence before making any investment decisions. Market conditions can change rapidly, and past performance is not indicative of future results.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About SPDR® S&P Biotech ETF
Exchange NYSE ARCA | Headquaters - | ||
IPO Launch date - | CEO - | ||
Sector - | Industry - | Full time employees - | Website |
Full time employees - | Website | ||
In seeking to track the performance of the S&P Biotechnology Select Industry Index (the index), the fund employs a sampling strategy. It generally invests substantially all, but at least 80%, of its total assets in the securities comprising the index. The index represents the biotechnology segment of the S&P Total Market Index (S&P TMI).

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