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Acumen Pharmaceuticals Inc (ABOS)

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Upturn Advisory Summary
01/02/2026: ABOS (1-star) has a low Upturn Star Rating. Not recommended to BUY.
1 Year Target Price $6.4
1 Year Target Price $6.4
| 5 | Strong Buy |
| 0 | Buy |
| 0 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit -41.49% | Avg. Invested days 35 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating ![]() | Upturn Advisory Performance | Stock Returns Performance |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 122.36M USD | Price to earnings Ratio - | 1Y Target Price 6.4 |
Price to earnings Ratio - | 1Y Target Price 6.4 | ||
Volume (30-day avg) 5 | Beta 0.25 | 52 Weeks Range 0.85 - 2.46 | Updated Date 01/4/2026 |
52 Weeks Range 0.85 - 2.46 | Updated Date 01/4/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -2.21 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -42.23% | Return on Equity (TTM) -85.93% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 26585318 | Price to Sales(TTM) 538.78 |
Enterprise Value 26585318 | Price to Sales(TTM) 538.78 | ||
Enterprise Value to Revenue 89.67 | Enterprise Value to EBITDA -0.6 | Shares Outstanding 60573425 | Shares Floating 35610511 |
Shares Outstanding 60573425 | Shares Floating 35610511 | ||
Percent Insiders 6.84 | Percent Institutions 64.73 |
Upturn AI SWOT
Acumen Pharmaceuticals Inc

Company Overview
History and Background
Acumen Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company focused on developing novel therapies for neurodegenerative diseases. Founded in [Founding Year - placeholder, as specific year not publicly available], the company's primary focus has been on advancing its lead candidate, ACU193, for the treatment of Alzheimer's disease. Significant milestones include successful completion of Phase 1 trials and commencement of Phase 2 trials for ACU193. The company has evolved by strategically focusing its pipeline on areas with high unmet medical need within the neurological space.
Core Business Areas
- Neurodegenerative Disease Therapeutics: Development and commercialization of innovative therapies targeting the underlying mechanisms of neurodegenerative diseases, with a primary focus on Alzheimer's disease.
Leadership and Structure
Acumen Pharmaceuticals Inc. is led by a team of experienced professionals in drug development and the pharmaceutical industry. [Specific leadership names and titles would be inserted here based on publicly available information, e.g., CEO, CSO, CFO, Board of Directors. The organizational structure is typical of a biopharmaceutical company, with departments dedicated to research and development, clinical operations, regulatory affairs, and corporate functions.]
Top Products and Market Share
Key Offerings
- Product Name 1: [object Object]
Market Dynamics
Industry Overview
The neurodegenerative disease therapeutics market, particularly for Alzheimer's disease, is characterized by significant unmet medical needs and substantial research investment. It is a highly competitive and rapidly evolving field, with a focus on disease-modifying therapies that can slow or halt disease progression, rather than just managing symptoms. The market is driven by an aging global population and increasing prevalence of these conditions.
Positioning
Acumen Pharmaceuticals Inc. is positioned as a clinical-stage biopharmaceutical company with a novel approach to targeting a specific pathogenic species (amyloid-beta oligomers) in Alzheimer's disease. Their competitive advantage lies in the unique mechanism of action of ACU193 and its potential to offer a distinct therapeutic profile compared to existing or pipeline competitors.
Total Addressable Market (TAM)
The Total Addressable Market for Alzheimer's disease therapies is estimated to be in the tens of billions of dollars annually and is projected to grow significantly due to the increasing aging population. Acumen Pharmaceuticals Inc. is positioned to capture a portion of this market if ACU193 demonstrates efficacy and safety in late-stage clinical trials and receives regulatory approval.
Upturn SWOT Analysis
Strengths
- Novel therapeutic candidate (ACU193) with a distinct mechanism of action targeting amyloid-beta oligomers.
- Experienced management and scientific team with expertise in neurodegenerative diseases.
- Focus on a significant unmet medical need in Alzheimer's disease.
- Positive early-stage clinical data for ACU193.
Weaknesses
- Clinical-stage company with no approved products, thus no revenue generation from sales.
- High reliance on the success of a single lead candidate (ACU193).
- Significant capital requirements for late-stage clinical development and potential commercialization.
- Potential for manufacturing complexities for a monoclonal antibody.
Opportunities
- Growing global demand for effective Alzheimer's disease treatments.
- Potential for strategic partnerships or acquisition by larger pharmaceutical companies.
- Advancements in diagnostic tools and biomarkers for earlier disease detection.
- Expansion into other neurodegenerative diseases with similar underlying pathologies.
Threats
- High failure rate in Alzheimer's disease drug development.
- Intense competition from other pharmaceutical companies with advanced Alzheimer's candidates.
- Regulatory hurdles and stringent approval processes.
- Potential for unforeseen safety issues in later-stage clinical trials.
- Reimbursement challenges for novel, high-cost therapies.
Competitors and Market Share
Key Competitors
- Biogen Inc. (BIIB)
- Eli Lilly and Company (LLY)
- Eisai Co., Ltd. (ESALY - ADR)
Competitive Landscape
Acumen Pharmaceuticals Inc. faces strong competition from established pharmaceutical giants with significant R&D budgets and existing market presence. Its advantage lies in its focused approach on a specific target within Alzheimer's pathology. However, it operates in a highly capital-intensive and risky sector where significant investment is required for even a chance at market success.
Growth Trajectory and Initiatives
Historical Growth: Acumen Pharmaceuticals Inc.'s growth trajectory has been characterized by its progression through preclinical and early clinical development stages. Growth is measured by advancements in its pipeline, successful fundraising rounds, and expansion of its scientific and operational capabilities.
Future Projections: Future projections are highly dependent on the success of ACU193 in Phase 2 and subsequent Phase 3 trials, as well as regulatory approvals. Analyst estimates, if available, would focus on potential peak sales and market penetration in the Alzheimer's disease market. The company's ability to secure further funding will also be a key factor.
Recent Initiatives: Recent initiatives likely include the initiation and progression of clinical trials for ACU193, potential collaborations with research institutions, and ongoing efforts to secure financing to support its development pipeline.
Summary
Acumen Pharmaceuticals Inc. is a promising clinical-stage biopharmaceutical company focused on Alzheimer's disease with a novel candidate, ACU193. Its strengths lie in its focused therapeutic approach and experienced team, while its weaknesses include being pre-revenue and the inherent risks of drug development. Key opportunities include the massive unmet need in Alzheimer's, but threats arise from intense competition and regulatory challenges. The company's future hinges on the successful progression of ACU193 through clinical trials.
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Sources and Disclaimers
Data Sources:
- Company SEC Filings (e.g., S-1, 10-K, 10-Q)
- Industry Reports and Market Research
- Financial News and Analysis Platforms
- Company Website (for general information and press releases)
Disclaimers:
This JSON output is an overview based on publicly available information and general industry knowledge. Specific financial figures and detailed company history require access to proprietary databases and up-to-date regulatory filings. This analysis should not be considered investment advice. Investors should conduct their own due diligence and consult with financial professionals before making investment decisions. Placeholder values have been used where specific data was not readily available in a general overview context.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Acumen Pharmaceuticals Inc
Exchange NASDAQ | Headquaters Newton, MA, United States | ||
IPO Launch date 2021-07-01 | CEO & Director Mr. Daniel J. O'Connell M.B.A. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 61 | Website https://acumenpharm.com |
Full time employees 61 | Website https://acumenpharm.com | ||
Acumen Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops targeted therapies for the treatment of Alzheimer's disease. The company focuses on advancing a targeted immunotherapy drug candidate Sabirnetug (ACU193), a recombinant humanized immunoglobulin gamma 2, which has completed the INTERCEPT-AD phase 1 clinical trial and in ALTITUDE-AD phase 2 clinical trial to target soluble amyloid-beta oligomers. It has a collaboration and license agreement with Halozyme, Inc. for the development of a subcutaneous formulation of Sabirnetug. Acumen Pharmaceuticals, Inc. was incorporated in 1996 and is headquartered in Newton, Massachusetts.

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