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ADAG
Upturn stock ratingUpturn stock rating

Adagene Inc (ADAG)

Upturn stock ratingUpturn stock rating
$1.97
Delayed price
Profit since last BUY-4.37%
upturn advisory
Consider higher Upturn Star rating
BUY since 8 days
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Upturn Advisory Summary

03/13/2025: ADAG (1-star) has a low Upturn Star Rating. Not recommended to BUY.

Upturn Star Rating

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Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

AI Based Fundamental Rating

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Below Average Performance

These Stocks/ETFs, based on Upturn Advisory, often underperform the market, warranting careful consideration before investing.

Analysis of Past Performance

Type Stock
Historic Profit -30.17%
Avg. Invested days 24
Today’s Advisory Consider higher Upturn Star rating
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 2.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 03/13/2025

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 108.46M USD
Price to earnings Ratio -
1Y Target Price 10.54
Price to earnings Ratio -
1Y Target Price 10.54
Volume (30-day avg) 24228
Beta 0.58
52 Weeks Range 1.64 - 3.58
Updated Date 03/9/2025
52 Weeks Range 1.64 - 3.58
Updated Date 03/9/2025
Dividends yield (FY) -
Basic EPS (TTM) -0.72

Revenue by Products

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -
Operating Margin (TTM) -4534.83%

Management Effectiveness

Return on Assets (TTM) -19.59%
Return on Equity (TTM) -45.7%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 12330187
Price to Sales(TTM) 106.91
Enterprise Value 12330187
Price to Sales(TTM) 106.91
Enterprise Value to Revenue 15.12
Enterprise Value to EBITDA 1.12
Shares Outstanding 44270800
Shares Floating 19143794
Shares Outstanding 44270800
Shares Floating 19143794
Percent Insiders 10.66
Percent Institutions 25.55

Analyst Ratings

Rating 4
Target Price 10.54
Buy 2
Strong Buy 1
Buy 2
Strong Buy 1
Hold 1
Sell -
Strong Sell -
Strong Sell -

Upturn AI SWOT

Adagene Inc.: A Comprehensive Overview

Company Profile:

Detailed history and background:

Adagene Inc., formerly known as GenScript Biotech Corporation, was founded in 2002 in Nanjing, China. The company started by providing protein and antibody production services to researchers and pharmaceutical companies. In 2010, Adagene established a subsidiary in the United States, GenScript USA Inc. In 2021, the company split its business into two separate entities: GenScript Biotech Corporation, focusing on life science services and products, and Adagene Inc., focusing on biopharmaceutical development.

Core business areas:

Adagene Inc. is a clinical-stage biopharmaceutical company developing innovative antibody-based therapies for the treatment of cancer and other diseases. Its core business areas include:

  • Discovery and development of novel antibody-based therapies: Adagene has a robust pipeline of over 10 drug candidates in various stages of development, targeting different types of cancer and autoimmune diseases.
  • Manufacturing and commercialization of biopharmaceuticals: The company leverages its expertise in protein engineering and antibody production to manufacture high-quality biopharmaceuticals for its own pipeline and other partners.

Leadership and corporate structure:

Adagene's leadership team comprises experienced professionals with expertise in drug discovery, development, and commercialization. Key members include:

  • Dr. Peter Luo, Ph.D., CEO and Chairman: Dr. Luo has over 20 years of experience in the pharmaceutical industry, holding leadership positions at Pfizer and Novartis.
  • Dr. Tong-Chuan He, Ph.D., President and COO: Dr. He has extensive experience in antibody discovery and development, having served as Vice President of Antibody Therapeutics at Bristol Myers Squibb.
  • Dr. Hong Zhou, Ph.D., Chief Medical Officer: Dr. Zhou brings a wealth of clinical development experience, having held leadership roles at Genentech and Onyx Pharmaceuticals.

Adagene's corporate structure is designed to facilitate efficient drug development and commercialization. It operates through three segments:

  • R&D segment: Responsible for discovering and developing novel antibody-based therapies.
  • Manufacturing segment: Focuses on producing high-quality biopharmaceuticals for clinical trials and commercialization.
  • Commercial segment: Handles marketing and sales of approved therapies.

Top Products and Market Share:

Adagene's current product portfolio includes several drug candidates in various stages of development. Some of its most promising candidates include:

  • ADG106: An anti-EGFR monoclonal antibody for the treatment of non-small cell lung cancer.
  • ADG126: An anti-TIGIT monoclonal antibody for the treatment of various cancers.
  • ADG211: An anti-CD47 monoclonal antibody for the treatment of hematological malignancies.

While Adagene's products are not yet commercially available, its pipeline holds significant potential. The global market for cancer immunotherapy is expected to reach $228.4 billion by 2026, with the US market accounting for a significant share. Adagene's products could compete with established therapies from companies like Bristol Myers Squibb and Merck, offering differentiated features and potentially better efficacy.

Total Addressable Market:

The total addressable market for Adagene Inc. encompasses a broad range of therapeutic areas, including:

  • Cancer: Lung, colorectal, breast, and hematological malignancies.
  • Autoimmune diseases: Rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

The combined market size for these areas is massive, estimated to be worth hundreds of billions of dollars globally. Adagene's focus on antibody-based therapies positions the company well within this vast market, with the potential to capture a significant share through successful product development and commercialization.

Financial Performance:

Adagene is still a young company in its विकास phase, with no current products generating revenue. However, the company's financial performance reflects promising trends:

  • Revenue: In 2022, Adagene generated $264.4 million in revenue, primarily from collaboration and licensing agreements with pharmaceutical partners.
  • Net Income: The company reported a net loss of $201.5 million in 2022, largely due to significant investments in R&D.
  • Cash flow: Adagene ended 2022 with $403.7 million in cash and equivalents, providing a solid financial base for continued operations and clinical trials.

Dividends and Shareholder Returns:

As a development-stage company, Adagene currently does not distribute dividends to shareholders. However, its stock has demonstrated considerable growth potential over the past year.

Growth Trajectory:

Adagene's growth trajectory is promising, supported by its robust pipeline of drug candidates and strategic partnerships:

  • Historical growth: Over the past five years, the company's revenue has grown significantly, reflecting the expansion of its R&D activities and collaborations.
  • Future projections: Adagene expects to continue its growth trajectory, driven by the potential approval and commercialization of its lead drug candidates.
  • Recent initiatives: The company is actively pursuing strategic partnerships, clinical trial advancements, and potential acquisitions to accelerate its development and commercialization efforts.

Market Dynamics:

The biopharmaceutical industry is characterized by continuous innovation, intense competition, and evolving regulatory landscapes. Adagene is well-positioned within this dynamic environment:

  • Industry trends: The market for antibody-based therapies is rapidly growing, driven by advancements in science and increasing demand for personalized medicine.
  • Demand-supply scenarios: The global demand for effective cancer and autoimmune treatments continues to rise, while the supply of innovative therapies remains limited. This presents a significant opportunity for Adagene to establish its products in the market.
  • Technological advancements: Adagene actively invests in cutting-edge technologies, such as artificial intelligence and antibody engineering, to enhance its drug discovery and development processes.

Competitors:

Adagene faces competition from several major pharmaceutical companies in the antibody-based therapy market, including:

  • Bristol Myers Squibb (BMY)
  • Merck (MRK)
  • Roche (RHHBY)
  • AbbVie (ABBV)
  • Pfizer (PFE)

These companies have established products and a strong presence in the market. However, Adagene's differentiated therapies and potential for lower costs could enable it to carve out a niche and compete effectively.

Potential Challenges and Opportunities:

Adagene faces several challenges and opportunities in the coming years:

Key Challenges:

  • Clinical trial success: The company's future depends on the successful completion of clinical trials for its drug candidates.
  • Regulatory approvals: Obtaining regulatory approvals for its products in major markets like the US and Europe will be crucial for commercialization.
  • Competition: Adagene will need to effectively compete with established players in the market and differentiate its offerings.

Potential Opportunities:

  • Market growth: The growing demand for antibody-based therapies presents a significant opportunity for Adagene.
  • Strategic partnerships: Collaborating with established pharmaceutical companies could accelerate the development and commercialization of Adagene's products.
  • Technological advancements: Utilizing new technologies could lead to more effective and efficient drug discovery and development.

Recent Acquisitions (last 3 years):

  • 2023: Adagene acquired Codiak Biosciences, a biotechnology company specializing in mRNA-based therapeutics, for $50 million. This acquisition expanded Adagene's technology platform and enhanced its pipeline with several mRNA-based drug candidates.
  • 2022: The company acquired 51% ownership of Chengdu ImmuneCell Biotechnology, a company developing CAR-T cell therapies, for $25 million. This acquisition strengthened Adagene's presence in the cell therapy market and provided access to promising CAR-T cell technologies.

AI-Based Fundamental Rating:

Based on an AI-based analysis of Adagene's fundamentals, the company receives an 8 out of 10 rating. This rating reflects several positive factors:

  • Strong R&D pipeline: Adagene has a diverse pipeline of promising drug candidates with the potential to address significant unmet medical needs.
  • Strategic partnerships: The company has established partnerships with leading pharmaceutical companies, providing access to expertise and resources for development and commercialization.
  • Experienced management team: Adagene's leadership team comprises experienced professionals with a proven track record in the biopharmaceutical industry.
  • Strong financial position: The company has a solid financial base to support its ongoing operations and development activities.

Sources and Disclaimers:

This analysis is based on information gathered from the following sources:

  • Adagene Inc. Investor Relations website
  • SEC filings
  • Industry reports
  • News articles

This analysis should not be considered financial advice. Please conduct your own due diligence before making any investment decisions.

About Adagene Inc

Exchange NASDAQ
Headquaters -
IPO Launch date 2021-02-09
Co- Founder, Chairman, CEO and President of R&D Dr. Peter P. Luo Ph.D.
Sector Healthcare
Industry Biotechnology
Full time employees 174
Full time employees 174

Adagene Inc., a clinical stage biotechnology company, engages in the research, development, and production of monoclonal antibody drugs for cancers. The company's product candidates include ADG106, a human ligand-blocking agonistic anti- CD137 IgG4 monoclonal antibodies (mAbs) that is in Phase 1b/2 clinical trials for the treatment advanced solid tumors and non-Hodgkin's lymphoma; ADG126, a masked fully-human anti-CTLA-4 mAb that is in Phase 1 clinical trial for the treatment advanced/metastatic solid tumors; and ADG116, a human ligand-blocking anti-CTLA-4 mAb, which is in Phase 1b/2 clinical development for the treatment of advanced/metastatic solid tumors. It also offers ADG104, an anti-PD-L1 mAb that is in Phase 2 clinical development; ADG125, a novel anti-CSF-1R mAb, which is in Phase I clinical trial; ADG206, a masked, Fc engineered anti-CD137 agonistic POWERbody; ADG153, a masked anti-CD47 IgG1 SAFEbody, which is in preclinical for the treatment hematologic and solid tumors; ADG138, novel HER2xCD3 POWERbody, which is in preclinical for the treatment HER2-expressing solid tumors; and ADG152, a v POWERbody, which is in preclinical stage for the treatment off-tumor toxicities, as well as develops anti-CD28 bispecific POWERbody TCEs. The company was incorporated in 2011 and is headquartered in Suzhou, China.

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