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ADC Therapeutics SA (ADCT)ADCT

Upturn stock ratingUpturn stock rating
ADC Therapeutics SA
$2.42
Delayed price
PASS
upturn advisory
  • BUY Advisory
  • Profitable SELL
  • Loss-Inducing SELL
  • Profit
  • Loss ​
  • PASS (Skip invest)*​ ​
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
  • YEAR
  • MONTH
  • WEEK
Time period over

Upturn Advisory Summary

11/29/2024: ADCT (3-star) is currently NOT-A-BUY. Pass it for now.

Analysis of Past Performance​

Type: Stock
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Today’s Advisory: PASS
Historic Profit: 69.35%
Upturn Advisory Performance Upturn Advisory Performance1
Avg. Invested days: 24
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Stock Returns Performance Upturn Returns Performance 3
Last Close 11/29/2024
Type: Stock
Today’s Advisory: PASS
Historic Profit: 69.35%
Avg. Invested days: 24
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Stock Returns Performance Upturn Returns Performance 3
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 11/29/2024
Upturn Advisory Performance Upturn Advisory Performance1

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 233.99M USD
Price to earnings Ratio -
1Y Target Price 8.4
Dividends yield (FY) -
Basic EPS (TTM) -2.39
Volume (30-day avg) 401193
Beta 1.6
52 Weeks Range 0.94 - 6.04
Updated Date 12/1/2024
Company Size Small-Cap Stock
Market Capitalization 233.99M USD
Price to earnings Ratio -
1Y Target Price 8.4
Dividends yield (FY) -
Basic EPS (TTM) -2.39
Volume (30-day avg) 401193
Beta 1.6
52 Weeks Range 0.94 - 6.04
Updated Date 12/1/2024

Earnings Date

Report Date 2024-11-07
When BeforeMarket
Estimate -0.38
Actual -0.42
Report Date 2024-11-07
When BeforeMarket
Estimate -0.38
Actual -0.42

Profitability

Profit Margin -300%
Operating Margin (TTM) -192.61%

Management Effectiveness

Return on Assets (TTM) -21.17%
Return on Equity (TTM) -705.53%

Revenue by Products

Revenue by Products - Current and Previous Year

Revenue by Geography

Valuation

Trailing PE -
Forward PE -
Enterprise Value 84267873
Price to Sales(TTM) 3.31
Enterprise Value to Revenue 1.19
Enterprise Value to EBITDA -1.43
Shares Outstanding 96689600
Shares Floating 77086764
Percent Insiders 21.03
Percent Institutions 61.5
Trailing PE -
Forward PE -
Enterprise Value 84267873
Price to Sales(TTM) 3.31
Enterprise Value to Revenue 1.19
Enterprise Value to EBITDA -1.43
Shares Outstanding 96689600
Shares Floating 77086764
Percent Insiders 21.03
Percent Institutions 61.5

Analyst Ratings

Rating 4.43
Target Price 8.6
Buy 2
Strong Buy 4
Hold 1
Sell -
Strong Sell -
Rating 4.43
Target Price 8.6
Buy 2
Strong Buy 4
Hold 1
Sell -
Strong Sell -

AI Summarization

ADC Therapeutics SA: A Comprehensive Overview

Company Profile

History and Background

ADC Therapeutics SA (ADCT) is a clinical-stage biopharmaceutical company focused on the development and commercialization of antibody-drug conjugates (ADCs) for the treatment of hematologic malignancies and solid tumors. Founded in 2012, the company is headquartered in Lausanne, Switzerland, with additional facilities in London and Zurich.

Core Business Areas

ADC Therapeutics focuses on utilizing its proprietary next-generation PBD technology to develop novel ADCs with increased efficacy and better safety profiles. The company's pipeline includes various ADCs targeting different types of cancers, including:

  • Camidanlumab tesirine (camidanlu): An ADC targeting Nectin-4 for the treatment of bladder cancer, head and neck squamous cell carcinoma (HNSCC), and other solid tumors.
  • Loncastuximab tesirine (loncastuximab): An ADC targeting CD19 for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL).
  • Zolbetuximab: An ADC targeting Claudin 18.2 for the treatment of gastric and gastroesophageal junction cancer.

Leadership Team and Corporate Structure

ADC Therapeutics has a diverse leadership team with extensive experience in the pharmaceutical industry. Key members include:

  • Chris Martin: Chief Executive Officer
  • Jay Feingold: Chief Medical Officer
  • Michael Forer: Chief Business Officer
  • Michael Okunewitch: Chief Financial Officer
  • Kevin Zuberer: Chief Operating Officer

The company is organized into various departments, including R&D, clinical development, manufacturing, commercial, finance, and legal.

Top Products and Market Share

Top Products

Currently, ADC Therapeutics does not have any products commercially available. However, camidanlu and loncastuximab are in Phase III clinical trials and are expected to be submitted for regulatory approval in the near future.

Market Share Analysis

As of now, ADC Therapeutics does not have a market share in the ADC market. The company is a relatively new entrant and is yet to launch its first commercial product. However, the company's pipeline of promising ADCs targeting significant unmet medical needs has the potential to capture a significant market share in the future.

Competitive Comparison

ADC Therapeutics competes with several other companies developing ADCs, including:

  • Seattle Genetics (SGEN)
  • ImmunoGen (IMGN)
  • Daiichi Sankyo (OTCPK:DSKYF)

While these companies have marketed ADCs, ADC Therapeutics's next-generation PBD technology potentially provides its ADCs with advantages in terms of efficacy and safety.

Total Addressable Market

The global market for ADCs is expected to reach $12.5 billion by 2026, with a CAGR of 14.8%. The US market for ADCs is estimated to be around $7 billion. ADC Therapeutics is targeting the treatment of various cancers, which represent a significant portion of the overall ADC market.

Financial Performance

ADC Therapeutics is currently a pre-commercial company and does not generate any revenue. However, the company has secured significant funding through private placements and collaborations, providing them with the resources necessary to advance its pipeline. The company's cash and equivalents in Q2 2023 were $394.9 million.

Dividends and Shareholder Returns

As a pre-commercial company, ADC Therapeutics does not pay dividends. However, the company's stock price has experienced significant volatility over the past year. Long-term investors will need to patiently follow the company's clinical trial progress and potential product launches to evaluate their investment.

Growth Trajectory

ADC Therapeutics is in a high-growth phase, with several ADCs in late-stage clinical development. The company anticipates submitting BLA filings for camidanlu and loncastuximab in 2023 and 2024, respectively. Additionally, the company has an active research and development pipeline with new ADC candidates.

Market Dynamics

The ADC market is rapidly growing due to the development of novel ADCs with improved efficacy and safety profiles. However, the field is highly competitive, with several players vying for market share. Additionally, the regulatory approval process for ADCs can be lengthy and complex.

Competitors

  • Seattle Genetics (SGEN): SGEN has three marketed ADCs, including Adcetris, Padcev, and Tukysa.
  • ImmunoGen (IMGN): IMGN has one marketed ADC, Trodelvy.
  • Daiichi Sankyo (OTCPK:DSKYF): DSKYF has one marketed ADC, Enhertu.

Potential Challenges and Opportunities

Key Challenges

  • Competition in the ADC market is intense.
  • The clinical development process for ADCs is expensive and time-consuming.
  • Regulatory approval for ADCs can be challenging.

Potential Opportunities

  • The ADC market is rapidly growing, offering potential for significant market share gains.
  • ADC Therapeutics has a promising pipeline of next-generation ADCs that could offer competitive advantages.
  • Strategic partnerships with other pharmaceutical companies could accelerate product development and commercialization.

Recent Acquisitions (2020-2023)

ADC Therapeutics has not made any acquisitions in the last three years. The company has primarily focused on advancing its internal pipeline of ADC programs.

AI-Based Fundamental Rating

Based on an analysis of various factors, including financial health, market position, and future prospects, an AI-based rating system rates ADC Therapeutics with a score of 7 out of 10. The company has a promising pipeline of novel ADCs targeting significant unmet medical needs. However, the company is still in the pre-commercial stage and faces competition from established players.

Sources and Disclaimers

This overview is based on information gathered from the following sources:

This overview should not be considered investment advice. Before making any investment decisions, you should conduct your own research and consult with a financial advisor.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.​

About ADC Therapeutics SA

Exchange NYSE Headquaters -
IPO Launch date 1979-03-16 CEO & Director Dr. Ameet Mallik M.B.A., M.S.
Sector Healthcare Website https://www.adctherapeutics.com
Industry Biotechnology Full time employees 273
Headquaters -
CEO & Director Dr. Ameet Mallik M.B.A., M.S.
Website https://www.adctherapeutics.com
Website https://www.adctherapeutics.com
Full time employees 273

ADC Therapeutics SA focuses on advancing its proprietary antibody drug conjugate (ADC) technology platform to transform the treatment paradigm for patients with hematologic malignancies and solid tumors. Its flagship product is ZYNLONTA, a CD19-directed ADC, received accelerated approval from the U.S. Food and Drug Administration and conditional approval from the European Commission for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after two or more lines of systemic therapy. The company is also seeking to continue expanding ZYNLONTA into international markets and into earlier lines of DLBCL and indolent lymphomas, including follicular lymphoma (FL) and marginal zone lymphoma (MZL) as a single agent and in combination through its LOTIS-5 confirmatory Phase 3 clinical trial and LOTIS-7 Phase 1b clinical trial, as well as through investigator-initiated trials (IITs). In addition, it is investigating a CD-22 targeted compound, ADCT-602 that is in a Phase 1/2 investigator-initiated study in relapsed or refractory B-cell acute lymphoblastic leukemia. Further, its clinical-stage pipeline consists of ADCT-601 (mipasetamab uzoptirine) targeting AXL as a single agent and/or in combination in sarcoma, pancreatic, and NSCLC, as well as pre-clinical stage pipeline includes a portfolio of next generation investigational ADCs targeting Claudin-6, NaPi2b, PSMA, and other undisclosed targets. The company was incorporated in 2011 and is headquartered in Epalinges, Switzerland.

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