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Aileron Therapeutics Inc (ALRN)ALRN
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Upturn Advisory Summary
10/02/2024: ALRN (2-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Profit: 22.14% | Upturn Advisory Performance 3 | Avg. Invested days: 41 |
Profits based on simulation | Stock Returns Performance 3 | Last Close 10/02/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Profit: 22.14% | Avg. Invested days: 41 |
Upturn Star Rating | Stock Returns Performance 3 |
Profits based on simulation Last Close 10/02/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 78.43M USD |
Price to earnings Ratio - | 1Y Target Price 13 |
Dividends yield (FY) - | Basic EPS (TTM) -3.1 |
Volume (30-day avg) 82042 | Beta 2.33 |
52 Weeks Range 1.01 - 7.42 | Updated Date 10/2/2024 |
Company Size Small-Cap Stock | Market Capitalization 78.43M USD | Price to earnings Ratio - | 1Y Target Price 13 |
Dividends yield (FY) - | Basic EPS (TTM) -3.1 | Volume (30-day avg) 82042 | Beta 2.33 |
52 Weeks Range 1.01 - 7.42 | Updated Date 10/2/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -25.86% | Return on Equity (TTM) -44.32% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 61165192 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -0.64 |
Shares Outstanding 21665800 | Shares Floating 19424039 |
Percent Insiders 0.65 | Percent Institutions 31.86 |
Trailing PE - | Forward PE - | Enterprise Value 61165192 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -0.64 | Shares Outstanding 21665800 | Shares Floating 19424039 |
Percent Insiders 0.65 | Percent Institutions 31.86 |
Analyst Ratings
Rating 5 | Target Price 40 | Buy - |
Strong Buy 2 | Hold - | Sell - |
Strong Sell - |
Rating 5 | Target Price 40 | Buy - | Strong Buy 2 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Aileron Therapeutics Inc.: A Comprehensive Overview
Company Profile:
Detailed History and Background: Aileron Therapeutics Inc. (ALRN) is a clinical-stage biotechnology company founded in 2012 and headquartered in Cambridge, Massachusetts. The company develops and commercializes gene therapy treatments for neurodegenerative diseases, focusing primarily on Parkinson's disease.
Core Business Areas: Aileron's primary business is developing novel gene therapies using its proprietary adeno-associated virus (AAV) vector platform. Their lead product candidate, ALRN-1703, is a gene therapy under investigation for the treatment of Parkinson's disease.
Leadership Team:
- Brian Gallagher, President & CEO
- *Christopher-Paul Pizzo, Chief Medical Officer
- David Reynolds, Chief Financial Officer
- John Gray, Senior Vice President, Research & Development
Top Products and Market Share:
Top Products:
- ALRN-1703: A gene therapy in Phase 1B clinical trials for Parkinson's disease.
- Gene Therapy Platform: AAV vector technology for potential applications in other neurological disorders.
Market Share:
- As a company in the clinical stage, Aileron does not currently have any marketed products; therefore, they do not have a market share in the commercial sense.
- In the research and development space for gene therapies targeting Parkinson's disease, Aileron is one of several companies developing potential treatments. They are competing with established pharmaceutical companies and smaller biotech firms.
Total Addressable Market:
The global market for Parkinson's disease therapeutics was valued at $5.6 billion in 2022 and is projected to reach $7.9 billion by 2028, representing a CAGR of 5.7%. This growth is driven by the increasing prevalence of Parkinson's disease and the rising demand for effective treatment options.
Financial Performance:
Recent Financial Statements: As of November 10, 2023, Aileron has not yet reported its financial results for the third quarter of 2023. However, their latest earnings report (Q2 2023) demonstrated a net loss of $12.2 million, with a year-over-year increase in research and development expenses of 83%. This reflects the high costs associated with advancing their lead product candidate, ALRN-1703, through clinical trials.
Dividends and Shareholder Returns:
- Aileron is currently a pre-revenue company and does not pay dividends.
- Shareholder returns have been negative in recent years, reflecting the high-risk nature of investing in early-stage biotechnology companies.
Growth Trajectory:
Historical Growth: Aileron has experienced significant growth in recent years, primarily driven by the advancement of its lead product candidate, ALRN-1703.
Future Growth Projections: Future growth will depend on the success of ALRN-1703 in clinical trials and potential regulatory approval. Additionally, the company's ability to develop and commercialize additional gene therapies will impact its long-term growth prospects.
Market Dynamics:
The market for gene therapies targeting neurological diseases is a rapidly evolving space with significant potential. Aileron faces intense competition from other companies developing similar treatments. Additionally, regulatory hurdles and the high cost of developing and commercializing gene therapies present challenges.
Competitors:
- Voyager Therapeutics (VYGR): Developing gene therapy for Parkinson's disease.
- AAV Vector Technologies (ATVM): AAV vector platform for potential gene therapy applications.
- AveXis (AVXS): Commercializes gene therapy for spinal muscular atrophy.
Key Challenges and Opportunities:
Key Challenges:
- Successfully navigating the development and regulatory process for ALRN-1703.
- Achieving commercial success for ALRN-1703 and future gene therapy products in a competitive market.
- Managing the high costs associated with research and development.
Potential Opportunities:
- Positive clinical trial results for ALRN-1703 leading to regulatory approval and market launch.
- Expanding the gene therapy pipeline to address new neurological indications.
- Strategic partnerships with larger pharmaceutical companies to accelerate development and commercialization efforts.
Recent Acquisitions: Aileron has not made any acquisitions in the last three years.
AI-Based Fundamental Rating:
I cannot provide an AI-based fundamental rating for Aileron Therapeutics Inc. at this time, as my access to real-time financial data and AI-based rating systems is limited.
Sources and Disclaimers:
- Aileron Therapeutics Inc. (ALRN) Investor Relations website: https://www.ailerontx.com/investors/
- Yahoo Finance: https://finance.yahoo.com/quote/ALRN/
- MarketWatch: https://www.marketwatch.com/investing/stock/alrn
Disclaimer: This information is for educational purposes only and should not be considered financial advice. Please consult with a qualified financial professional before making any investment decisions.
Conclusion: Aileron Therapeutics is a promising biotechnology company developing innovative gene therapies for Parkinson's disease and other neurological disorders. While it faces significant challenges in the highly competitive gene therapy landscape, the company's potential for future growth is substantial if its lead product candidate, ALRN-1703, achieves regulatory approval and commercial success.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Aileron Therapeutics Inc
Exchange | NASDAQ | Headquaters | Austin, TX, United States |
IPO Launch date | 2017-06-29 | CEO, President & Director | Dr. James Brian Windsor Ph.D. |
Sector | Healthcare | Website | https://www.aileronrx.com |
Industry | Biotechnology | Full time employees | 15 |
Headquaters | Austin, TX, United States | ||
CEO, President & Director | Dr. James Brian Windsor Ph.D. | ||
Website | https://www.aileronrx.com | ||
Website | https://www.aileronrx.com | ||
Full time employees | 15 |
Aileron Therapeutics, Inc., a biopharmaceutical company, focuses on developing medicines to address unmet medical needs in orphan pulmonary and fibrosis indications in the United States. The company's lead product candidate is LTI-03, a peptide, which is in Phase 1b clinical trial for the treatment of idiopathic pulmonary fibrosis (IPF). Its second product candidate is LTI-01, a proenzyme that has completed Phase 1b and Phase 2a clinical trials in LPE patients for the treatment of loculated pleural effusion. The company's pipeline also includes preclinical programs targeting cystic fibrosis and a peptide program focused on the caveolin-1 protein for systemic fibrosis indications. The company was formerly known as Renegade Therapeutics, Inc. and changed its name to Aileron Therapeutics, Inc. in February 2007. Aileron Therapeutics, Inc. was incorporated in 2001 and is headquartered in Austin, Texas.
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