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Upturn AI Summary - About
Annovis Bio Inc(ANVS)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for ANVS
11/06/2026: ANVS (1-star) is currently NOT-A-BUY. Pass it for now.
Annovis Bio Inc is a clinical-stage biotechnology company focused on developing therapies for Alzheimer's and Parkinson's disease. Its primary strength lies in a unique therapeutic approach that targets multiple toxic proteins simultaneously, which has shown promise in early clinical trials. The company's growth story depends entirely on the successful progression of its lead candidate, Buntanetap, through late-stage testing. However, as a pre-revenue firm, Annovis faces high risks, including the potential for clinical trial failure, the need for ongoing capital to fund operations, and fierce competition from larger, well-capitalized pharmaceutical entities. It is a highly speculative stock best suited for investors with a high risk tolerance.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Mixed fit | The company offers high growth potential linked to clinical success but lacks the established revenue growth typical of mature growth stocks. |
| Momentum investor | Mixed fit | The stock can experience high momentum based on clinical trial news, but this is highly speculative and conditional. |
| Value investor | Weak fit | As a pre-revenue clinical biotech, the company does not fit traditional value metrics like P/E ratios or dividends. |
| Dividend investor | Weak fit | The company does not pay a dividend and focuses entirely on research and development. |
| Low-risk investor | Weak fit | The stock is subject to extreme volatility and binary clinical trial outcomes, making it unsuitable for low-risk portfolios. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | Clinical-stage biotech stocks often experience extreme price swings based on trial results and regulatory news. |
| Valuation risk | Medium / high | Valuation is highly speculative and based on the projected success of future drug commercialization. |
| Competition risk (Pharmaceutical incumbents) | High | The company competes against much larger firms with greater resources for trial recruitment and commercialization. |
| Business quality | Medium | The business relies on a single lead asset, creating high concentration risk. |
| Dividend income | Low / none | The company provides no income to shareholders. |
| Execution risk | High | Clinical trials are notoriously difficult to execute and carry a high risk of failure. |
Price Behavior
Steep Decline
The stock price has dropped sharply with strong downward pressure.
Extreme Price Shocks
The stock has experienced exceptionally large and disruptive price movements during the period.
Analysis of Past Performance
Type Stock | Historic Profit -39.96% | Avg. Invested days 15 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  3.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 11/06/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 36.35M USD | Price to earnings Ratio - | 1Y Target Price 10.5 |
Price to earnings Ratio - | 1Y Target Price 10.5 | ||
Volume (30-day avg) 2.2M shares | Beta 1.35 | 52 Weeks Range 0.62 - 5.50 | Updated Date 11/08/2026 |
52 Weeks Range 0.62 - 5.50 | Updated Date 11/08/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -1.75 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Clinical Research and Development | Currently the company has no revenue-generating products and focuses entirely on advancing its pipeline. | This is a speculative pre-revenue stock where investors bet on the eventual success of its drug pipeline. |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 17.62M | Price to Sales(TTM) - |
Enterprise Value 17.62M | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA -3.57 | Shares Outstanding 43.02M | Shares Floating 32.87M |
Shares Outstanding 43.02M | Shares Floating 32.87M | ||
Percent Insiders 11.69 | Percent Institutions 22.03 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
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