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APLS logo APLS
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Apellis Pharmaceuticals Inc (APLS)

Upturn stock ratingUpturn stock rating
$28.17
Last Close (24-hour delay)
Profit since last BUY40.57%
upturn advisory
Regular Buy
BUY since 33 days
  • BUY Advisory
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  • SELL Advisory (Loss)​
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Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
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Upturn Advisory Summary

09/02/2025: APLS (3-star) is a STRONG-BUY. BUY since 33 days. Simulated Profits (40.57%). Updated daily EoD!

Upturn Star Rating

rating

Moderate Performance

These Stocks/ETFs, based on Upturn Advisory, typically align with the market average, offering steady but unremarkable returns.

Number of Analysts

rating

22 Analysts rated it

Well-followed company, solid analyst reports, reliable data for confident investing.

1 Year Target Price $38.56

1 Year Target Price $38.56

Analysts Price Target For last 52 week
$38.56 Target price
52w Low $16.1
Current$28.17
52w High $41.94

Analysis of Past Performance

Type Stock
Historic Profit 87.68%
Avg. Invested days 68
Today’s Advisory Regular Buy
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 4.0
Stock Returns Performance Upturn Returns Performance 4.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 09/02/2025

Key Highlights

Company Size Mid-Cap Stock
Market Capitalization 3.48B USD
Price to earnings Ratio -
1Y Target Price 38.56
Price to earnings Ratio -
1Y Target Price 38.56
Volume (30-day avg) 22
Beta 0.77
52 Weeks Range 16.10 - 41.94
Updated Date 09/1/2025
52 Weeks Range 16.10 - 41.94
Updated Date 09/1/2025
Dividends yield (FY) -
Basic EPS (TTM) -1.83

Analyzing Revenue: Products, Geography and Growth

Revenue by Products

Product revenue - Year on Year

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -30.24%
Operating Margin (TTM) -18.65%

Management Effectiveness

Return on Assets (TTM) -13.77%
Return on Equity (TTM) -108.49%

Valuation

Trailing PE -
Forward PE 48.08
Enterprise Value 3581543818
Price to Sales(TTM) 4.61
Enterprise Value 3581543818
Price to Sales(TTM) 4.61
Enterprise Value to Revenue 4.75
Enterprise Value to EBITDA -12.12
Shares Outstanding 126290000
Shares Floating 78125464
Shares Outstanding 126290000
Shares Floating 78125464
Percent Insiders 13.62
Percent Institutions 105.71

ai summary icon Upturn AI SWOT

Apellis Pharmaceuticals Inc

stock logo

Company Overview

overview logo History and Background

Apellis Pharmaceuticals, Inc. was founded in 2009. The company focuses on the discovery, development, and commercialization of therapeutic compounds for autoimmune and inflammatory diseases with high unmet medical needs. Key milestones include the development and approval of Empaveli and Syfovre.

business area logo Core Business Areas

  • Complement Therapies: Apellis focuses on developing complement-targeted therapies for various diseases.
  • Hematology: Develops treatments for hematologic diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH).
  • Ophthalmology: Develops treatments for ophthalmologic diseases, especially geographic atrophy (GA).

leadership logo Leadership and Structure

The leadership team includes Cedric Francois, M.D., Ph.D. (CEO), and various VPs heading R&D, commercial operations, and finance. The organizational structure is typical of a biotechnology company, with departments focused on research, clinical development, regulatory affairs, and commercialization.

Top Products and Market Share

overview logo Key Offerings

  • Empaveli (pegcetacoplan): Empaveli is a C3 inhibitor approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). Competitors include Soliris (eculizumab) and Ultomiris (ravulizumab) from Alexion Pharmaceuticals (now part of AstraZeneca). Market share for Empaveli is growing but remains smaller than Alexion's products. It is difficult to have the market share or revenue.
  • Syfovre (pegcetacoplan injection): Syfovre is the first approved treatment for geographic atrophy (GA) secondary to age-related macular degeneration. Competitors include Iveric Bio's Izervay (avacincaptad pegol). Market Share currently favors Apellis due to first-to-market advantage, though Iveric Bio will compete heavily. It is difficult to have the market share or revenue.

Market Dynamics

industry overview logo Industry Overview

The pharmaceutical industry, especially the segment focusing on complement-targeted therapies, is experiencing growth due to an increasing understanding of the role of the complement system in various diseases.

Positioning

Apellis is positioned as a leader in complement-targeted therapies, particularly in hematology and ophthalmology. Its competitive advantage lies in its innovative C3 inhibitor platform.

Total Addressable Market (TAM)

The TAM for geographic atrophy and paroxysmal nocturnal hemoglobinuria is estimated to be in the billions of dollars. Syfovre and Empaveli are positioned to capture a significant portion of this market.

Upturn SWOT Analysis

Strengths

  • Novel C3 inhibitor platform
  • First-mover advantage in GA treatment (Syfovre)
  • Strong intellectual property protection
  • Experienced management team

Weaknesses

  • Reliance on a limited number of products
  • Potential safety concerns with complement inhibition
  • High R&D expenses
  • Reimbursement challenges

Opportunities

  • Expansion into new indications for complement-targeted therapies
  • Strategic partnerships and collaborations
  • Geographic expansion
  • Advancements in drug delivery technologies

Threats

  • Competition from established pharmaceutical companies
  • Regulatory hurdles
  • Patent expirations
  • Adverse events impacting product approval or sales
  • Pricing and market access pressures

Competitors and Market Share

competitor logo Key Competitors

  • ALXN
  • IVERIC Bio (ISEE)

Competitive Landscape

Apellis has a competitive advantage in the geographic atrophy market with Syfovre, being the first approved treatment. However, it faces competition from established players like Iveric Bio. Empaveli faces competition from Alexion's Soliris and Ultomiris.

Growth Trajectory and Initiatives

Historical Growth: Historical growth has been driven by pipeline advancements and regulatory approvals.

Future Projections: Future growth is projected to be strong, driven by increased sales of Syfovre and Empaveli, and the development of new indications.

Recent Initiatives: Recent initiatives include expanding the commercial infrastructure for Syfovre and advancing clinical trials for new indications.

Summary

Apellis is a promising biotech company with innovative complement-targeted therapies, particularly in ophthalmology and hematology. The successful launch of Syfovre offers significant growth potential. However, the company faces competition, regulatory hurdles, and reimbursement challenges. Managing safety concerns and expanding the pipeline are crucial for sustained success.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Company filings
  • Analyst reports
  • Press releases
  • SEC Filings

Disclaimers:

This analysis is for informational purposes only and should not be considered financial advice. The data provided is based on publicly available information and may not be entirely accurate or complete. Investment decisions should be made after consulting with a qualified financial advisor.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Apellis Pharmaceuticals Inc

Exchange NASDAQ
Headquaters Waltham, MA, United States
IPO Launch date 2017-11-09
Co-Founder, President, CEO & Director Dr. Cedric Francois M.D., Ph.D.
Sector Healthcare
Industry Biotechnology
Full time employees 705
Full time employees 705

Apellis Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of novel therapeutic compounds to treat diseases with high unmet needs. It offers EMPAVELI for the treatment of paroxysmal nocturnal hemoglobinuria; and SYFOVRE for treating geographic atrophy secondary to age-related macular degeneration and geographic atrophy (GA). The company also develops EMPAVELI to treat C3 glomerulopathy and immune complex membranoproliferative glomerulonephritis, hematopoietic stem cell transplantation-associated thrombotic microangiopathy, focal segmental glomerulosclerosis, and delayed graft function; and APL-3007, a small interfering RNA, or siRNA for the treatment of GA. It has a collaboration and license agreement with Swedish Orphan Biovitrum AB (publ) for development and commercialization of pegcetacoplan; and a collaboration with Beam Therapeutics Inc. focused on the use of Beam's base editing technology to discover new treatments for complement-driven diseases. The company was incorporated in 2009 and is based in Waltham, Massachusetts.