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Alterity Therapeutics Ltd (ATHE)



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Upturn Advisory Summary
09/17/2025: ATHE (1-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $11
1 Year Target Price $11
1 | Strong Buy |
1 | Buy |
1 | Hold |
0 | Sell |
0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit -51.42% | Avg. Invested days 26 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Small-Cap Stock | Market Capitalization 68.30M USD | Price to earnings Ratio - | 1Y Target Price 11 |
Price to earnings Ratio - | 1Y Target Price 11 | ||
Volume (30-day avg) 3 | Beta 0.36 | 52 Weeks Range 1.00 - 7.00 | Updated Date 09/17/2025 |
52 Weeks Range 1.00 - 7.00 | Updated Date 09/17/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.76 |
Earnings Date
Report Date 2025-08-28 | When - | Estimate -0.67 | Actual - |
Profitability
Profit Margin -223.35% | Operating Margin (TTM) -185.73% |
Management Effectiveness
Return on Assets (TTM) -28.09% | Return on Equity (TTM) -43.23% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 34295822 | Price to Sales(TTM) 12.56 |
Enterprise Value 34295822 | Price to Sales(TTM) 12.56 | ||
Enterprise Value to Revenue 113.99 | Enterprise Value to EBITDA 0.75 | Shares Outstanding 15347900 | Shares Floating 7349871458 |
Shares Outstanding 15347900 | Shares Floating 7349871458 | ||
Percent Insiders - | Percent Institutions 1.23 |
Upturn AI SWOT
Alterity Therapeutics Ltd

Company Overview
History and Background
Alterity Therapeutics Ltd, formerly known as Neurodiscovery Ltd, focuses on developing treatments for neurodegenerative diseases. Founded with the goal of creating novel therapeutics, the company has evolved through various research phases and clinical trials.
Core Business Areas
- Drug Development: Developing small molecule therapeutics targeting iron-mediated neurodegeneration.
- Clinical Trials: Conducting clinical trials to assess the safety and efficacy of their drug candidates.
Leadership and Structure
The leadership team consists of a CEO, CFO, and various scientific and clinical officers. The organizational structure includes departments for research, development, clinical operations, and finance.
Top Products and Market Share
Key Offerings
- ATH434: ATH434, also known as davunetide, is Alterity's lead drug candidate. It is designed to treat Multiple System Atrophy (MSA) and potentially other synucleinopathies. Currently, ATH434 is in clinical development and does not have a market share or revenue. Competitors include companies developing therapies for MSA, such as those focusing on symptomatic treatment or other novel approaches.
Market Dynamics
Industry Overview
The neurodegenerative disease treatment market is large and growing, driven by an aging population and increasing prevalence of diseases like MSA and Parkinson's. The market is competitive, with many companies pursuing different therapeutic strategies.
Positioning
Alterity Therapeutics is positioned as a company focused on addressing the underlying mechanisms of neurodegenerative diseases, particularly iron dysregulation. Its competitive advantage lies in its targeted approach and potentially disease-modifying therapies.
Total Addressable Market (TAM)
The TAM for neurodegenerative disease treatments is estimated to be in the billions of dollars. Alterity is focused on specific segments within this large market, such as MSA, and is positioning itself to capture a portion of this market with its disease-modifying approach.
Upturn SWOT Analysis
Strengths
- Novel therapeutic approach targeting iron dysregulation
- Lead drug candidate in clinical development
- Experienced management team
Weaknesses
- Limited financial resources
- Single lead product reliance
- High clinical trial risk
Opportunities
- Positive clinical trial results
- Partnerships with larger pharmaceutical companies
- Expansion into other neurodegenerative diseases
Threats
- Clinical trial failure
- Competition from established pharmaceutical companies
- Regulatory hurdles
Competitors and Market Share
Key Competitors
- BIIB
- ABBV
- LLY
Competitive Landscape
Alterity Therapeutics faces competition from larger pharmaceutical companies with more resources and established pipelines. Its advantage lies in its specific focus on iron dysregulation and potential for disease-modifying therapies.
Growth Trajectory and Initiatives
Historical Growth: Historical growth is characterized by expansion in research and development activities.
Future Projections: Future growth depends on successful clinical trial outcomes and subsequent regulatory approval. Analyst estimates vary widely, reflecting the high-risk nature of drug development.
Recent Initiatives: Recent initiatives include advancing ATH434 through clinical trials and exploring partnerships for future development and commercialization.
Summary
Alterity Therapeutics is a clinical-stage biopharmaceutical company focused on developing treatments for neurodegenerative diseases. The company's success is heavily dependent on the clinical outcomes of ATH434. The company needs to be mindful of its cash position and funding strategies. Positive clinical results and partnerships could significantly improve its prospects.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Company Website
- SEC Filings
- Analyst Reports
- Industry News
Disclaimers:
The information provided is for informational purposes only and should not be considered financial advice. Investment decisions should be based on individual research and consultation with a financial professional. Market share data is an approximation.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Alterity Therapeutics Ltd
Exchange NASDAQ | Headquaters Melbourne, VIC, Australia | ||
IPO Launch date 2002-09-05 | CEO - | ||
Sector Healthcare | Industry Biotechnology | Full time employees 9 | Website https://alteritytherapeutics.com |
Full time employees 9 | Website https://alteritytherapeutics.com |
Alterity Therapeutics Limited engages in the research and development of therapeutic drugs to treat Alzheimer's disease, Huntington disease, Parkinson's disease, and other neurological disorders in Australia. The company's lead drug candidate is ATH434, a small molecule drug candidate that has completed Phase I clinical trial for the treatment of Parkinson's disease. It is also developing ATH434-201, which is in Phase II clinical trial to treat multiple system atrophy early stage; ATH434-202 that is in Phase II clinical trial to treat multiple system atrophy; and PBT2 that has completed Phase 2a clinical trial to treat Alzheimer's disease. The company was formerly known as Prana Biotechnology Limited and changed its name to Alterity Therapeutics Limited in April 2019. Alterity Therapeutics Limited was incorporated in 1997 and is headquartered in Melbourne, Australia.

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