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ATHE logo ATHE
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Alterity Therapeutics Ltd (ATHE)

Upturn stock ratingUpturn stock rating
$4.47
Last Close (24-hour delay)
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PASS
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  • SELL Advisory (Loss)​
  • Profit
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Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
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Upturn Advisory Summary

09/17/2025: ATHE (1-star) is currently NOT-A-BUY. Pass it for now.

Upturn Star Rating

rating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

3 Analysts rated it

Very few follow this stock; limited insights, higher-risk early investing.

1 Year Target Price $11

1 Year Target Price $11

Analysts Price Target For last 52 week
$11 Target price
52w Low $1
Current$4.47
52w High $7

Analysis of Past Performance

Type Stock
Historic Profit -51.42%
Avg. Invested days 26
Today’s Advisory PASS
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 2.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 09/17/2025

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 68.30M USD
Price to earnings Ratio -
1Y Target Price 11
Price to earnings Ratio -
1Y Target Price 11
Volume (30-day avg) 3
Beta 0.36
52 Weeks Range 1.00 - 7.00
Updated Date 09/17/2025
52 Weeks Range 1.00 - 7.00
Updated Date 09/17/2025
Dividends yield (FY) -
Basic EPS (TTM) -0.76

Earnings Date

Report Date 2025-08-28
When -
Estimate -0.67
Actual -

Profitability

Profit Margin -223.35%
Operating Margin (TTM) -185.73%

Management Effectiveness

Return on Assets (TTM) -28.09%
Return on Equity (TTM) -43.23%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 34295822
Price to Sales(TTM) 12.56
Enterprise Value 34295822
Price to Sales(TTM) 12.56
Enterprise Value to Revenue 113.99
Enterprise Value to EBITDA 0.75
Shares Outstanding 15347900
Shares Floating 7349871458
Shares Outstanding 15347900
Shares Floating 7349871458
Percent Insiders -
Percent Institutions 1.23

ai summary icon Upturn AI SWOT

Alterity Therapeutics Ltd

stock logo

Company Overview

overview logo History and Background

Alterity Therapeutics Ltd, formerly known as Neurodiscovery Ltd, focuses on developing treatments for neurodegenerative diseases. Founded with the goal of creating novel therapeutics, the company has evolved through various research phases and clinical trials.

business area logo Core Business Areas

  • Drug Development: Developing small molecule therapeutics targeting iron-mediated neurodegeneration.
  • Clinical Trials: Conducting clinical trials to assess the safety and efficacy of their drug candidates.

leadership logo Leadership and Structure

The leadership team consists of a CEO, CFO, and various scientific and clinical officers. The organizational structure includes departments for research, development, clinical operations, and finance.

Top Products and Market Share

overview logo Key Offerings

  • ATH434: ATH434, also known as davunetide, is Alterity's lead drug candidate. It is designed to treat Multiple System Atrophy (MSA) and potentially other synucleinopathies. Currently, ATH434 is in clinical development and does not have a market share or revenue. Competitors include companies developing therapies for MSA, such as those focusing on symptomatic treatment or other novel approaches.

Market Dynamics

industry overview logo Industry Overview

The neurodegenerative disease treatment market is large and growing, driven by an aging population and increasing prevalence of diseases like MSA and Parkinson's. The market is competitive, with many companies pursuing different therapeutic strategies.

Positioning

Alterity Therapeutics is positioned as a company focused on addressing the underlying mechanisms of neurodegenerative diseases, particularly iron dysregulation. Its competitive advantage lies in its targeted approach and potentially disease-modifying therapies.

Total Addressable Market (TAM)

The TAM for neurodegenerative disease treatments is estimated to be in the billions of dollars. Alterity is focused on specific segments within this large market, such as MSA, and is positioning itself to capture a portion of this market with its disease-modifying approach.

Upturn SWOT Analysis

Strengths

  • Novel therapeutic approach targeting iron dysregulation
  • Lead drug candidate in clinical development
  • Experienced management team

Weaknesses

  • Limited financial resources
  • Single lead product reliance
  • High clinical trial risk

Opportunities

  • Positive clinical trial results
  • Partnerships with larger pharmaceutical companies
  • Expansion into other neurodegenerative diseases

Threats

  • Clinical trial failure
  • Competition from established pharmaceutical companies
  • Regulatory hurdles

Competitors and Market Share

competitor logo Key Competitors

  • BIIB
  • ABBV
  • LLY

Competitive Landscape

Alterity Therapeutics faces competition from larger pharmaceutical companies with more resources and established pipelines. Its advantage lies in its specific focus on iron dysregulation and potential for disease-modifying therapies.

Growth Trajectory and Initiatives

Historical Growth: Historical growth is characterized by expansion in research and development activities.

Future Projections: Future growth depends on successful clinical trial outcomes and subsequent regulatory approval. Analyst estimates vary widely, reflecting the high-risk nature of drug development.

Recent Initiatives: Recent initiatives include advancing ATH434 through clinical trials and exploring partnerships for future development and commercialization.

Summary

Alterity Therapeutics is a clinical-stage biopharmaceutical company focused on developing treatments for neurodegenerative diseases. The company's success is heavily dependent on the clinical outcomes of ATH434. The company needs to be mindful of its cash position and funding strategies. Positive clinical results and partnerships could significantly improve its prospects.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Company Website
  • SEC Filings
  • Analyst Reports
  • Industry News

Disclaimers:

The information provided is for informational purposes only and should not be considered financial advice. Investment decisions should be based on individual research and consultation with a financial professional. Market share data is an approximation.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Alterity Therapeutics Ltd

Exchange NASDAQ
Headquaters Melbourne, VIC, Australia
IPO Launch date 2002-09-05
CEO -
Sector Healthcare
Industry Biotechnology
Full time employees 9
Full time employees 9

Alterity Therapeutics Limited engages in the research and development of therapeutic drugs to treat Alzheimer's disease, Huntington disease, Parkinson's disease, and other neurological disorders in Australia. The company's lead drug candidate is ATH434, a small molecule drug candidate that has completed Phase I clinical trial for the treatment of Parkinson's disease. It is also developing ATH434-201, which is in Phase II clinical trial to treat multiple system atrophy early stage; ATH434-202 that is in Phase II clinical trial to treat multiple system atrophy; and PBT2 that has completed Phase 2a clinical trial to treat Alzheimer's disease. The company was formerly known as Prana Biotechnology Limited and changed its name to Alterity Therapeutics Limited in April 2019. Alterity Therapeutics Limited was incorporated in 1997 and is headquartered in Melbourne, Australia.