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Cogent Biosciences Inc(COGT)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for COGT
10/16/2026: COGT (3-star) is currently NOT-A-BUY. Pass it for now.
Cogent Biosciences is a clinical-stage biotechnology company developing targeted kinase inhibitors for patients with genetically defined cancers. The firm is best known for its Bezuclastinib program, which aims to improve standards of care for systemic mastocytosis and GIST. Its primary strength lies in a highly focused research strategy, though the company remains in a loss-making phase dependent on the outcome of clinical trials. The most significant risks include high volatility associated with clinical-stage biotech and intense competition from larger established firms. The stock is best suited for growth-oriented investors with a high risk tolerance who are looking for exposure to targeted, precision medicine development.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Strong fit | Investors focusing on long-term value creation through clinical innovation may find the potential in the pipeline compelling. |
| Momentum investor | Mixed fit | Momentum fit is conditional on positive clinical data readouts or regulatory milestones driving stock price upturns. |
| Value investor | Weak fit | As a loss-making clinical-stage company, traditional value metrics like P/E ratios are not applicable. |
| Dividend investor | Weak fit | The company does not pay dividends and retains all capital for R&D. |
| Low-risk investor | Weak fit | The high volatility and binary nature of clinical trial success make this unsuitable for low-risk portfolios. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | Clinical-stage biotech stocks are subject to extreme swings based on trial results and market sentiment. |
| Valuation risk | High | Valuations are highly speculative as they depend on the potential future success of unapproved products. |
| Competition risk (KIT-inhibitor market) | High | Established competitors with larger resources, such as Blueprint Medicines, pose a significant barrier to entry. |
| Business quality | Medium | The company possesses a focused, high-potential asset, though it lacks the diversified revenue streams of larger firms. |
| Dividend income | Low / none | There is no expectation of dividend income for the foreseeable future. |
| Execution risk | High | Success depends entirely on the company's ability to navigate complex clinical trials and regulatory pathways successfully. |
Price Behavior
Downtrend
The stock has experienced a sustained decline in price over recent periods.
Moderately Choppy
The stock has experienced noticeable price swings while retaining some directional structure.
Analysis of Past Performance
Type Stock | Historic Profit 57.1% | Avg. Invested days 45 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  3.0 | Stock Returns Performance  3.0 |
| Profits based on simulation | Last Close 10/16/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Mid-Cap Stock | Market Capitalization 5.12B USD | Price to earnings Ratio - | 1Y Target Price 55.82 |
Price to earnings Ratio - | 1Y Target Price 55.82 | ||
Volume (30-day avg) 2.2M shares | Beta 0.31 | 52 Weeks Range 13.78 - 43.73 | Updated Date 10/16/2026 |
52 Weeks Range 13.78 - 43.73 | Updated Date 10/16/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -2.16 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Clinical Development | Developing Bezuclastinib and other kinase inhibitors for market approval. | The company currently spends money rather than making it, with the goal of creating a valuable medicine. |
Analyzing Revenue: Products, Geography and Growth
Revenue by Products
Product revenue - Year on Year
Valuation
Trailing PE - | Forward PE - | Enterprise Value 4.97B | Price to Sales(TTM) 861.15 |
Enterprise Value 4.97B | Price to Sales(TTM) 861.15 | ||
Enterprise Value to Revenue 929.31 | Enterprise Value to EBITDA -3.89 | Shares Outstanding 173.52M | Shares Floating 172.56M |
Shares Outstanding 173.52M | Shares Floating 172.56M | ||
Percent Insiders 0.42 | Percent Institutions 115.19 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
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