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Upturn AI Summary - About
Cardiff Oncology Inc(CRDF)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for CRDF
09/25/2026: CRDF (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Cardiff Oncology is a clinical-stage biotechnology company focused on developing onvansertib, a PLK1 inhibitor aimed at treating difficult-to-address solid tumors. The company's strength lies in its specialized focus on a specific therapeutic target and an experienced management team, though it currently lacks commercial products or revenue. The investment story centers on the potential for clinical trial success to unlock significant value through future licensing or commercialization. Primary risks include the high failure rates inherent in drug development, the need for continued capital raises, and intense competition from large-cap pharmaceutical firms. It is best suited for growth-oriented investors with high risk tolerance who are monitoring specific clinical data milestones.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Mixed fit | The company offers speculative growth potential based on clinical trial outcomes rather than established revenue growth. |
| Momentum investor | Strong fit while signal remains positive | The stock can experience significant volatility and price swings based on clinical data releases and sector sentiment. |
| Value investor | Weak fit | The company has no earnings or positive cash flow, making standard value metrics inapplicable. |
| Dividend investor | Weak fit | There is no dividend income and none is expected in the foreseeable future. |
| Low-risk investor | Weak fit | The high binary risk associated with clinical trial failure makes this unsuitable for conservative investors. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | Clinical-stage biotech stocks fluctuate wildly based on news regarding trial results and regulatory updates. |
| Valuation risk | High | Valuation is speculative and heavily dependent on subjective expectations of future clinical success. |
| Competition risk (oncology therapeutics) | High | The company competes with global pharmaceutical giants that have significantly more resources. |
| Business quality | Medium | The company is a single-asset-focused developer, which limits its diversification and resilience. |
| Dividend income | Low / none | No dividend is paid as capital is consumed for research. |
| Execution risk | High | Success depends entirely on the technical and regulatory achievement of its clinical pipeline. |
Price Behavior
Steep Decline
The stock price has dropped sharply with strong downward pressure.
Extreme Price Shocks
The stock has experienced exceptionally large and disruptive price movements during the period.
Analysis of Past Performance
Type Stock | Historic Profit 15.58% | Avg. Invested days 31 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Advisory Rating  | Upturn Advisory Performance  2.0 | Stock Returns Performance  2.0 |
| Profits based on simulation | Last Close 09/25/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 99.58M USD | Price to earnings Ratio - | 1Y Target Price 5.81 |
Price to earnings Ratio - | 1Y Target Price 5.81 | ||
Volume (30-day avg) 812.8K shares | Beta 1.46 | 52 Weeks Range 0.76 - 3.31 | Updated Date 09/25/2026 |
52 Weeks Range 0.76 - 3.31 | Updated Date 09/25/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.58 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Clinical Development | Research and development of onvansertib for cancer treatment. | The company does not generate consistent revenue; it spends capital on research and is looking to develop a drug that can eventually be sold or licensed. |
Analyzing Revenue: Products, Geography and Growth
Revenue by Products
Product revenue - Year on Year
Valuation
Trailing PE - | Forward PE - | Enterprise Value 69.40M | Price to Sales(TTM) 196.02 |
Enterprise Value 69.40M | Price to Sales(TTM) 196.02 | ||
Enterprise Value to Revenue 136.62 | Enterprise Value to EBITDA -3.66 | Shares Outstanding 77.80M | Shares Floating 75.38M |
Shares Outstanding 77.80M | Shares Floating 75.38M | ||
Percent Insiders 6.2 | Percent Institutions 21.24 |
Upturn AI Summary
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
About Cardiff Oncology Inc
Exchange NASDAQ | Headquarters San Diego, CA, United States | ||
IPO Launch date 2004-07-27 | President, CEO & Director Dr. Mani Mohindru Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 30 | Website https://www.cardiffoncology.com |
Full time employees 30 | Website https://www.cardiffoncology.com | ||
Cardiff Oncology, Inc., a clinical-stage biotechnology company, develops novel therapies for the treatment of various cancers in the United States. Its lead drug candidate is Onvansertib, an oral and selective polo-like kinase 1 inhibitor for treating RAS-mutated metastatic colorectal cancer. The company also focuses on the clinical program in indications, such as investigator-initiated trials in metastatic pancreatic ductal adenocarcinoma, small cell lung cancer, metastatic triple negative breast cancer, and chronic myelomonocytic leukemia; CRDF-004, a Phase 2 open-label randomized multi-center clinical trial of onvansertib in combination with FOLFIRI and bevacizumab or FOLFOX and bevacizumab for the treatment of patients confirmed metastatic and unresectable colorectal cancer in patients with a KRAS or NRAS mutation; and TROV-054, a Phase 1b/2 single-arm clinical trial in KRAS-mutated metastatic colorectal cancer. The company was formerly known as Trovagene, Inc. and changed its name to Cardiff Oncology, Inc. in May 2012. Cardiff Oncology, Inc. was founded in 1999 and is headquartered in San Diego, California.
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