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Upturn stock ratingUpturn stock rating
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Cyclacel Pharmaceuticals Inc (CYCC)

Upturn stock ratingUpturn stock rating
$7.82
Last Close (24-hour delay)
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PASS
  • BUY Advisory
  • SELL Advisory (Profit)​
  • SELL Advisory (Loss)​
  • Profit
  • Loss
  • Pass (Skip investing)
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
  • YEAR
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Upturn Advisory Summary

08/28/2025: CYCC (1-star) is currently NOT-A-BUY. Pass it for now.

Upturn Star Rating

rating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

1 Analysts rated it

Very few follow this stock; limited insights, higher-risk early investing.

1 Year Target Price $1

1 Year Target Price $1

Analysts Price Target For last 52 week
$1 Target price
52w Low $3.08
Current$7.82
52w High $283.4

Analysis of Past Performance

Type Stock
Historic Profit -87.79%
Avg. Invested days 15
Today’s Advisory PASS
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 1.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 08/28/2025

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 17.51M USD
Price to earnings Ratio -
1Y Target Price 1
Price to earnings Ratio -
1Y Target Price 1
Volume (30-day avg) 1
Beta 0.09
52 Weeks Range 3.08 - 283.40
Updated Date 08/29/2025
52 Weeks Range 3.08 - 283.40
Updated Date 08/29/2025
Dividends yield (FY) -
Basic EPS (TTM) 7123.5

Earnings Date

Report Date 2025-08-13
When -
Estimate -
Actual -0.98

Profitability

Profit Margin -
Operating Margin (TTM) -103580%

Management Effectiveness

Return on Assets (TTM) -102.83%
Return on Equity (TTM) -276.8%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 13806600
Price to Sales(TTM) 1750.88
Enterprise Value 13806600
Price to Sales(TTM) 1750.88
Enterprise Value to Revenue 1380.66
Enterprise Value to EBITDA 0.02
Shares Outstanding 2238980
Shares Floating 312562
Shares Outstanding 2238980
Shares Floating 312562
Percent Insiders 65.45
Percent Institutions 0.99

ai summary icon Upturn AI SWOT

Cyclacel Pharmaceuticals Inc

stock logo

Company Overview

overview logo History and Background

Cyclacel Pharmaceuticals, Inc. (CYCC) is a biopharmaceutical company focused on developing innovative medicines for cancer and other proliferative diseases. Founded in 1996, the company has progressed through various stages of research and development, focusing on cyclin-dependent kinases (CDKs) and polo-like kinases (PLKs) as therapeutic targets. It has faced challenges in clinical trials but continues to refine its approach.

business area logo Core Business Areas

  • Drug Development: Cyclacel focuses on developing and commercializing novel cancer therapies. This includes discovering, developing, and testing new drug candidates.
  • Clinical Trials: Conducting clinical trials to evaluate the safety and efficacy of its drug candidates. This involves various phases of clinical trials to gain regulatory approvals.

leadership logo Leadership and Structure

Cyclacel's leadership team consists of a board of directors and executive officers. Spiro Rombotis is the current President and Chief Executive Officer. The organizational structure comprises departments focused on research, development, clinical operations, and business development.

Top Products and Market Share

overview logo Key Offerings

  • Fadraciclib: An oral cyclin-dependent kinase (CDK) inhibitor being investigated for hematological malignancies and solid tumors. Data is being actively presented and tested. The market share and revenue is still early and hard to predict. Competitors include companies developing other CDK inhibitors, such as Eli Lilly (Verzenio), Novartis (Kisqali), and Pfizer (Ibrance).
  • CYC140: A selective inhibitor of spleen tyrosine kinase (SYK) for hematological malignancies. Phase 1/2 studies are underway. Revenue data is not yet available, market share is pending clinical success. Competitors include companies developing other SYK inhibitors, such as Gilead Sciences (Entospletinib) and Rigel Pharmaceuticals (Tavalisse).

Market Dynamics

industry overview logo Industry Overview

The biopharmaceutical industry is characterized by high research and development costs, lengthy regulatory approval processes, and intense competition. Market trends include increasing demand for targeted therapies and personalized medicine, advancements in drug discovery technologies, and evolving regulatory landscapes.

Positioning

Cyclacel focuses on niche markets within the oncology space, targeting specific kinases with its drug candidates. Its competitive advantage lies in its innovative approach to kinase inhibition and its potential to develop therapies for unmet medical needs.

Total Addressable Market (TAM)

The total addressable market for cancer therapies is estimated to be in the hundreds of billions of dollars globally. Cyclacel is positioning itself to capture a segment of this market by focusing on specific kinase targets and developing targeted therapies. CYCC aims to develop innovative medicines for cancer and other proliferative diseases. Their products address this target market, but it is small

Upturn SWOT Analysis

Strengths

  • Novel drug candidates with potential for targeted therapies
  • Experienced management team
  • Focus on specific kinase targets
  • Partnerships and collaborations for research and development

Weaknesses

  • Limited financial resources
  • High dependence on clinical trial outcomes
  • Concentration of risk in a few drug candidates
  • Market capitalization

Opportunities

  • Potential for breakthrough therapies in oncology
  • Strategic partnerships for commercialization
  • Expansion into new indications
  • Positive clinical trial results leading to regulatory approvals

Threats

  • Clinical trial failures
  • Regulatory hurdles
  • Competition from larger pharmaceutical companies
  • Patent expirations

Competitors and Market Share

competitor logo Key Competitors

  • LLY
  • NVS
  • PFE
  • GILD
  • RIGL

Competitive Landscape

Cyclacel operates in a highly competitive landscape dominated by larger pharmaceutical companies. Its advantages include its novel drug candidates and focus on specific kinase targets. Disadvantages include limited financial resources and dependence on clinical trial outcomes. The company's strategy focuses on securing strategic partnerships to enhance its market position.

Growth Trajectory and Initiatives

Historical Growth: Cyclacel's growth has been driven by its drug development programs. Growth trajectory is variable and depends on clinical trial data releases.

Future Projections: Future growth projections are highly dependent on the success of its drug candidates in clinical trials and subsequent regulatory approvals. Analyst estimates vary widely based on clinical trial outcomes.

Recent Initiatives: Recent initiatives include advancing its clinical trials for fadraciclib and CYC140, and seeking partnerships for further development and commercialization.

Summary

Cyclacel Pharmaceuticals is a biopharmaceutical company focused on developing innovative cancer therapies. Its strength lies in its targeted kinase inhibition approach, but it faces challenges due to its limited financial resources and reliance on clinical trial success. The company needs to effectively manage its clinical trials and secure strategic partnerships to achieve future growth. It will need to watch out for clinical trail setbacks and competition.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Company Website
  • SEC Filings
  • Analyst Reports
  • Market Data

Disclaimers:

This analysis is based on publicly available information and is for informational purposes only. It does not constitute investment advice. Investment decisions should be based on thorough research and consultation with a qualified financial advisor. Market share estimates are approximate and may vary. Live financials and updates are constantly in flux.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Cyclacel Pharmaceuticals Inc

Exchange NASDAQ
Headquaters -
IPO Launch date 2004-05-05
Chairman, CEO & President Dr. Sing Ee Wong
Sector Healthcare
Industry Biotechnology
Full time employees -
Full time employees -

Cyclacel Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops cancer medicines based on cell cycle, transcriptional regulation, epigenetics, and mitosis control biology in the United States. Its lead product Plogosertib or plogo, a solid tumors and hematological malignancies, which is in Phase 1/2 clinical trial. The company was founded in 1996 and is headquartered in Kuala Lumpur, Malaysia.