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Cyclacel Pharmaceuticals Inc (CYCC)



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Upturn Advisory Summary
08/28/2025: CYCC (1-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $1
1 Year Target Price $1
0 | Strong Buy |
0 | Buy |
1 | Hold |
0 | Sell |
0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit -87.79% | Avg. Invested days 15 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Small-Cap Stock | Market Capitalization 17.51M USD | Price to earnings Ratio - | 1Y Target Price 1 |
Price to earnings Ratio - | 1Y Target Price 1 | ||
Volume (30-day avg) 1 | Beta 0.09 | 52 Weeks Range 3.08 - 283.40 | Updated Date 08/29/2025 |
52 Weeks Range 3.08 - 283.40 | Updated Date 08/29/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) 7123.5 |
Earnings Date
Report Date 2025-08-13 | When - | Estimate - | Actual -0.98 |
Profitability
Profit Margin - | Operating Margin (TTM) -103580% |
Management Effectiveness
Return on Assets (TTM) -102.83% | Return on Equity (TTM) -276.8% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 13806600 | Price to Sales(TTM) 1750.88 |
Enterprise Value 13806600 | Price to Sales(TTM) 1750.88 | ||
Enterprise Value to Revenue 1380.66 | Enterprise Value to EBITDA 0.02 | Shares Outstanding 2238980 | Shares Floating 312562 |
Shares Outstanding 2238980 | Shares Floating 312562 | ||
Percent Insiders 65.45 | Percent Institutions 0.99 |
Upturn AI SWOT
Cyclacel Pharmaceuticals Inc

Company Overview
History and Background
Cyclacel Pharmaceuticals, Inc. (CYCC) is a biopharmaceutical company focused on developing innovative medicines for cancer and other proliferative diseases. Founded in 1996, the company has progressed through various stages of research and development, focusing on cyclin-dependent kinases (CDKs) and polo-like kinases (PLKs) as therapeutic targets. It has faced challenges in clinical trials but continues to refine its approach.
Core Business Areas
- Drug Development: Cyclacel focuses on developing and commercializing novel cancer therapies. This includes discovering, developing, and testing new drug candidates.
- Clinical Trials: Conducting clinical trials to evaluate the safety and efficacy of its drug candidates. This involves various phases of clinical trials to gain regulatory approvals.
Leadership and Structure
Cyclacel's leadership team consists of a board of directors and executive officers. Spiro Rombotis is the current President and Chief Executive Officer. The organizational structure comprises departments focused on research, development, clinical operations, and business development.
Top Products and Market Share
Key Offerings
- Fadraciclib: An oral cyclin-dependent kinase (CDK) inhibitor being investigated for hematological malignancies and solid tumors. Data is being actively presented and tested. The market share and revenue is still early and hard to predict. Competitors include companies developing other CDK inhibitors, such as Eli Lilly (Verzenio), Novartis (Kisqali), and Pfizer (Ibrance).
- CYC140: A selective inhibitor of spleen tyrosine kinase (SYK) for hematological malignancies. Phase 1/2 studies are underway. Revenue data is not yet available, market share is pending clinical success. Competitors include companies developing other SYK inhibitors, such as Gilead Sciences (Entospletinib) and Rigel Pharmaceuticals (Tavalisse).
Market Dynamics
Industry Overview
The biopharmaceutical industry is characterized by high research and development costs, lengthy regulatory approval processes, and intense competition. Market trends include increasing demand for targeted therapies and personalized medicine, advancements in drug discovery technologies, and evolving regulatory landscapes.
Positioning
Cyclacel focuses on niche markets within the oncology space, targeting specific kinases with its drug candidates. Its competitive advantage lies in its innovative approach to kinase inhibition and its potential to develop therapies for unmet medical needs.
Total Addressable Market (TAM)
The total addressable market for cancer therapies is estimated to be in the hundreds of billions of dollars globally. Cyclacel is positioning itself to capture a segment of this market by focusing on specific kinase targets and developing targeted therapies. CYCC aims to develop innovative medicines for cancer and other proliferative diseases. Their products address this target market, but it is small
Upturn SWOT Analysis
Strengths
- Novel drug candidates with potential for targeted therapies
- Experienced management team
- Focus on specific kinase targets
- Partnerships and collaborations for research and development
Weaknesses
- Limited financial resources
- High dependence on clinical trial outcomes
- Concentration of risk in a few drug candidates
- Market capitalization
Opportunities
- Potential for breakthrough therapies in oncology
- Strategic partnerships for commercialization
- Expansion into new indications
- Positive clinical trial results leading to regulatory approvals
Threats
- Clinical trial failures
- Regulatory hurdles
- Competition from larger pharmaceutical companies
- Patent expirations
Competitors and Market Share
Key Competitors
- LLY
- NVS
- PFE
- GILD
- RIGL
Competitive Landscape
Cyclacel operates in a highly competitive landscape dominated by larger pharmaceutical companies. Its advantages include its novel drug candidates and focus on specific kinase targets. Disadvantages include limited financial resources and dependence on clinical trial outcomes. The company's strategy focuses on securing strategic partnerships to enhance its market position.
Growth Trajectory and Initiatives
Historical Growth: Cyclacel's growth has been driven by its drug development programs. Growth trajectory is variable and depends on clinical trial data releases.
Future Projections: Future growth projections are highly dependent on the success of its drug candidates in clinical trials and subsequent regulatory approvals. Analyst estimates vary widely based on clinical trial outcomes.
Recent Initiatives: Recent initiatives include advancing its clinical trials for fadraciclib and CYC140, and seeking partnerships for further development and commercialization.
Summary
Cyclacel Pharmaceuticals is a biopharmaceutical company focused on developing innovative cancer therapies. Its strength lies in its targeted kinase inhibition approach, but it faces challenges due to its limited financial resources and reliance on clinical trial success. The company needs to effectively manage its clinical trials and secure strategic partnerships to achieve future growth. It will need to watch out for clinical trail setbacks and competition.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Company Website
- SEC Filings
- Analyst Reports
- Market Data
Disclaimers:
This analysis is based on publicly available information and is for informational purposes only. It does not constitute investment advice. Investment decisions should be based on thorough research and consultation with a qualified financial advisor. Market share estimates are approximate and may vary. Live financials and updates are constantly in flux.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Cyclacel Pharmaceuticals Inc
Exchange NASDAQ | Headquaters - | ||
IPO Launch date 2004-05-05 | Chairman, CEO & President Dr. Sing Ee Wong | ||
Sector Healthcare | Industry Biotechnology | Full time employees - | Website https://www.cyclacel.com |
Full time employees - | Website https://www.cyclacel.com |
Cyclacel Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops cancer medicines based on cell cycle, transcriptional regulation, epigenetics, and mitosis control biology in the United States. Its lead product Plogosertib or plogo, a solid tumors and hematological malignancies, which is in Phase 1/2 clinical trial. The company was founded in 1996 and is headquartered in Kuala Lumpur, Malaysia.

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