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Upturn stock ratingUpturn stock rating
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Fulcrum Therapeutics Inc (FULC)

Upturn stock ratingUpturn stock rating
$6.88
Last Close (24-hour delay)
Profit since last BUY-1.71%
upturn advisory
Consider higher Upturn Star rating
BUY since 7 days
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Upturn Advisory Summary

06/30/2025: FULC (1-star) has a low Upturn Star Rating. Not recommended to BUY.

Upturn Star Rating

rating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

7 Analysts rated it

Moderately tracked stock, growing coverage, gaining market and investor attention.

1 Year Target Price $7.57

1 Year Target Price $7.57

Analysts Price Target For last 52 week
$7.57Target price
Low$2.31
Current$6.88
high$10.13

Analysis of Past Performance

Type Stock
Historic Profit 4.21%
Avg. Invested days 31
Today’s Advisory Consider higher Upturn Star rating
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 3.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 06/30/2025

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 383.25M USD
Price to earnings Ratio -
1Y Target Price 7.57
Price to earnings Ratio -
1Y Target Price 7.57
Volume (30-day avg) 7
Beta 2.42
52 Weeks Range 2.31 - 10.13
Updated Date 06/30/2025
52 Weeks Range 2.31 - 10.13
Updated Date 06/30/2025
Dividends yield (FY) -
Basic EPS (TTM) -0.01

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -0.64%
Operating Margin (TTM) -13%

Management Effectiveness

Return on Assets (TTM) -2.74%
Return on Equity (TTM) -0.23%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 164755072
Price to Sales(TTM) 4.79
Enterprise Value 164755072
Price to Sales(TTM) 4.79
Enterprise Value to Revenue 2.06
Enterprise Value to EBITDA -3.09
Shares Outstanding 53979300
Shares Floating 24721982
Shares Outstanding 53979300
Shares Floating 24721982
Percent Insiders 1.82
Percent Institutions 96.2

Analyst Ratings

Rating 3
Target Price 7.57
Buy 1
Strong Buy 2
Buy 1
Strong Buy 2
Hold 3
Sell 1
Strong Sell -
Strong Sell -

ai summary icon Upturn AI SWOT

Fulcrum Therapeutics Inc

stock logo

Company Overview

overview logo History and Background

Fulcrum Therapeutics, founded in 2016, is a clinical-stage biopharmaceutical company focused on developing therapies for genetically defined diseases. They leverage their product engine to identify and validate novel targets that modulate disease-causing gene expression.

business area logo Core Business Areas

  • Drug Development: Fulcrum's core business revolves around discovering, developing, and commercializing novel therapeutics for rare genetic diseases.
  • Research and Discovery: A significant portion of their resources is dedicated to research and discovery efforts to identify new targets and develop potential drug candidates.

leadership logo Leadership and Structure

Robert J. Gould, Ph.D. is the President and Chief Executive Officer. The company has a standard organizational structure with departments like research, development, clinical operations, and commercial.

Top Products and Market Share

overview logo Key Offerings

  • Losmapimod: Losmapimod is an oral selective p38u03b1/u03b2 mitogen-activated protein kinase (MAPK) inhibitor being developed for the treatment of facioscapulohumeral muscular dystrophy (FSHD). Currently in Phase 3 trials. Competitors in the FSHD space are limited, with no approved disease-modifying therapies.
  • Other Pipeline Programs: Fulcrum also has other preclinical and clinical programs targeting other genetically defined diseases.

Market Dynamics

industry overview logo Industry Overview

The biopharmaceutical industry focused on rare diseases is experiencing significant growth, driven by increased awareness, orphan drug incentives, and advancements in genetic research.

Positioning

Fulcrum Therapeutics is positioned as a company specializing in genetically defined diseases, using a differentiated approach to drug discovery and development. Their competitive advantage lies in their expertise in modulating gene expression.

Total Addressable Market (TAM)

The TAM for FSHD and other rare genetic diseases is substantial, estimated to be in the billions of dollars. Fulcrum is positioned to capture a significant share of this market with successful development and commercialization of its pipeline programs.

Upturn SWOT Analysis

Strengths

  • Proprietary drug discovery platform
  • Focus on genetically defined diseases
  • Strong intellectual property portfolio
  • Experienced management team

Weaknesses

  • Limited product pipeline
  • Dependence on clinical trial success
  • High cash burn rate
  • No currently approved products

Opportunities

  • Expansion of pipeline through internal discovery and partnerships
  • Potential for orphan drug designation and market exclusivity
  • Increasing awareness and diagnosis of rare genetic diseases
  • Advancements in gene therapy technologies

Threats

  • Clinical trial failures
  • Competition from other biopharmaceutical companies
  • Regulatory hurdles
  • Pricing and reimbursement pressures

Competitors and Market Share

competitor logo Key Competitors

  • CRIS
  • DTIL
  • VIRX

Competitive Landscape

Fulcrum's advantages lie in their focus on genetically defined diseases and their proprietary drug discovery platform. Their disadvantages include their limited product pipeline and dependence on clinical trial success. Competitors have more product diversity.

Growth Trajectory and Initiatives

Historical Growth: Historical growth is tied to investment in the company over time and potential market share.

Future Projections: Future projections depend on the success of clinical trials and the commercialization of Losmapimod and other pipeline programs. Analyst estimates vary.

Recent Initiatives: Recent initiatives include advancing Losmapimod into Phase 3 clinical trials and expanding their research and discovery efforts.

Summary

Fulcrum Therapeutics is a clinical-stage company with a promising drug candidate (Losmapimod) targeting a significant unmet need (FSHD). Its success hinges on positive Phase 3 results and navigating the complex regulatory landscape. Limited diversity and reliance on one major drug candidate are key challenges to be considered. The company has a unique value proposition that has the potential to generate substantial returns.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Fulcrum Therapeutics Inc. Investor Relations
  • SEC Filings
  • Analyst Reports
  • Company Press Releases

Disclaimers:

This analysis is for informational purposes only and should not be considered investment advice. Market share estimates are approximate and may vary. Financial data needs to be updated with the latest filings. The AI-Based rating is based on publicly available information and may not reflect all factors.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Fulcrum Therapeutics Inc

Exchange NASDAQ
Headquaters Cambridge, MA, United States
IPO Launch date 2019-07-18
CEO, President & Director Mr. Alexander C. Sapir
Sector Healthcare
Industry Biotechnology
Full time employees 45
Full time employees 45

Fulcrum Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops small molecules to improve the lives of patients with genetically defined diseases in the areas of high unmet medical need in the United States. Its clinical-stage product candidate is pociredir, a fetal hemoglobin inducer, which is in phase 1b clinical trial for the treatment of sickle cell disease and beta-thalassemia. The company also discovers drug targets for potential treatment inherited aplastic anemias, such as of diamond-blackfan anemia, shwachman-diamond syndrome, and fanconi anemia, as well as novel fetal hemoglobin inducers, fibrotic disorders, and cardiomyopathies which is in preclinical trial. It has collaboration and license agreement with MyoKardia, Inc. to identify biological targets that are capable of modulating genes of interest with relevance to cardiomyopathies; and licensce agreement with CAMP4 which includes certain small molecule compounds, composition of matter and method of use patent rights, and know-how to research, develop, manufacture, use, and commercialize; and Sanofi for the development and commercialization of losmapimod, an oral small molecule being investigated for the treatment of facioscapulohumeral muscular dystrophy. Fulcrum Therapeutics, Inc. was Incorporated in 2015 and is headquartered in Cambridge, Massachusetts.