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Lixte Biotechnology Holdings Inc (LIXTW)



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Upturn Advisory Summary
06/30/2025: LIXTW (1-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $0
1 Year Target Price $0
0 | Strong Buy |
0 | Buy |
0 | Hold |
0 | Sell |
0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit -60% | Avg. Invested days 26 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Small-Cap Stock | Market Capitalization 39.49M USD | Price to earnings Ratio - | 1Y Target Price - |
Price to earnings Ratio - | 1Y Target Price - | ||
Volume (30-day avg) - | Beta 0.37 | 52 Weeks Range 0.02 - 0.09 | Updated Date 06/21/2025 |
52 Weeks Range 0.02 - 0.09 | Updated Date 06/21/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) - |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -81.14% | Return on Equity (TTM) -155.14% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value - | Price to Sales(TTM) - |
Enterprise Value - | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA - | Shares Outstanding - | Shares Floating 2527941 |
Shares Outstanding - | Shares Floating 2527941 | ||
Percent Insiders - | Percent Institutions - |
Analyst Ratings
Rating - | Target Price - | Buy - | Strong Buy - |
Buy - | Strong Buy - | ||
Hold - | Sell - | Strong Sell - | |
Strong Sell - |
Upturn AI SWOT
Lixte Biotechnology Holdings Inc

Company Overview
History and Background
Lixte Biotechnology Holdings Inc. was founded in 2005 and is focused on discovering and developing novel small molecule drugs for use in cancer treatment. The company's primary focus has been on developing drugs that target protein phosphatase 2A (PP2A).
Core Business Areas
- Drug Development: Lixte Biotechnology is focused on the research and development of new drugs for cancer treatment. Their main focus is on PP2A inhibition.
- Clinical Trials: The company engages in clinical trials to test the safety and effectiveness of its drug candidates.
- Licensing: Lixte seeks to license its drug candidates to larger pharmaceutical companies for further development and commercialization.
Leadership and Structure
The leadership team is comprised of experienced scientists and business executives. The company operates with a research-focused organizational structure.
Top Products and Market Share
Key Offerings
- LB-100: LB-100 is Lixte's lead drug candidate, a PP2A inhibitor. It's currently in clinical trials for various cancer types. Market share data specific to LB-100 is not available due to its developmental stage. Competitors are larger pharmaceutical companies developing cancer therapies, such as Pfizer, Merck, and Novartis
Market Dynamics
Industry Overview
The pharmaceutical industry, particularly the oncology segment, is highly competitive and characterized by significant research and development investments. Demand for new and effective cancer treatments is high.
Positioning
Lixte is a small biotechnology company focusing on a specific target (PP2A) within the oncology space. Its competitive advantage, if any, lies in the uniqueness and potential efficacy of its PP2A inhibitor.
Total Addressable Market (TAM)
The global oncology market is estimated to be worth hundreds of billions of dollars. Lixte is positioned to capture a small fraction of this market if LB-100 proves successful. The success of Lixte depends on positive clinical trial results.
Upturn SWOT Analysis
Strengths
- Novel drug target (PP2A)
- Lead drug candidate in clinical trials
- Experienced scientific team
Weaknesses
- Limited financial resources
- Reliance on a single drug candidate
- Small company size
Opportunities
- Positive clinical trial results
- Partnership with a larger pharmaceutical company
- Expansion to other cancer types
Threats
- Clinical trial failures
- Competition from larger pharmaceutical companies
- Regulatory hurdles
- Financial constraints
Competitors and Market Share
Key Competitors
- PFE
- MRK
- NVS
- BMY
- AZN
Competitive Landscape
Lixte is a small player compared to its larger competitors. Its success depends on demonstrating superior efficacy or safety with its PP2A inhibitor.
Growth Trajectory and Initiatives
Historical Growth: Historical growth is characterized by research and development milestones, rather than revenue growth.
Future Projections: Future growth is contingent on the success of LB-100 and other drug candidates in clinical trials. Analyst estimates are speculative and subject to significant uncertainty.
Recent Initiatives: Recent initiatives include progressing LB-100 through clinical trials and seeking partnerships for further development.
Summary
Lixte Biotechnology is a high-risk, high-reward development-stage company focused on novel cancer therapeutics. The company's fate hinges on the success of its lead drug candidate, LB-100. Limited financial resources and intense competition pose significant challenges. Positive clinical trial results and strategic partnerships are crucial for future growth and survival.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Company filings, Press releases, Analyst reports (where available)
Disclaimers:
This analysis is based on publicly available information and is not financial advice. Investment decisions should be made after consulting with a qualified financial advisor.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Lixte Biotechnology Holdings Inc
Exchange NASDAQ | Headquaters Pasadena, CA, United States | ||
IPO Launch date 2020-11-25 | CEO & Chairman Mr. Geordan G. Pursglove | ||
Sector Healthcare | Industry Biotechnology | Full time employees 2 | Website https://lixte.com |
Full time employees 2 | Website https://lixte.com |
Lixte Biotechnology Holdings, Inc., a clinical-stage biopharmaceutical company, focuses on identifying targets for cancer drug development, and developing and commercializing cancer therapies. Its lead product candidate, LB-100 is in phase 1b clinical trials combined with Atezolizumab for patients with microsatellite stable metastatic colorectal cancer. The company's LB-100 combined with doxorubicin in advanced soft tissue sarcoma is under Phase 1b portion; and LB-100 combined with dostarlimab that is in phase 1b/2 for ovarian clear cell carcinoma. The company has a clinical trial research agreement with the Netherlands Cancer Institute; collaboration agreement for an investigator-initiated clinical trial with the Spanish Sarcoma Group; and a development collaboration agreement with the Netherlands Cancer Institute. Lixte Biotechnology Holdings, Inc. was founded in 2005 and is based in Pasadena, California.
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