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Lyra Therapeutics Inc (LYRA)

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Upturn Advisory Summary
12/12/2025: LYRA (1-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $11.5
1 Year Target Price $11.5
| 0 | Strong Buy |
| 0 | Buy |
| 4 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit -10.25% | Avg. Invested days 25 | Today’s Advisory PASS |
Upturn Star Rating ![]() | Upturn Advisory Performance | Stock Returns Performance |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 6.45M USD | Price to earnings Ratio - | 1Y Target Price 11.5 |
Price to earnings Ratio - | 1Y Target Price 11.5 | ||
Volume (30-day avg) 4 | Beta -0.01 | 52 Weeks Range 2.84 - 34.00 | Updated Date 12/14/2025 |
52 Weeks Range 2.84 - 34.00 | Updated Date 12/14/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -22.9 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -25032% |
Management Effectiveness
Return on Assets (TTM) -33.08% | Return on Equity (TTM) -404.48% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 15775696 | Price to Sales(TTM) 10.75 |
Enterprise Value 15775696 | Price to Sales(TTM) 10.75 | ||
Enterprise Value to Revenue 26.29 | Enterprise Value to EBITDA 0.66 | Shares Outstanding 1774882 | Shares Floating 1506591 |
Shares Outstanding 1774882 | Shares Floating 1506591 | ||
Percent Insiders 0.62 | Percent Institutions 19.77 |
About Lyra Therapeutics Inc
Exchange NASDAQ | Headquaters Watertown, MA, United States | ||
IPO Launch date 2020-05-01 | CEO, President & Chairman Dr. Maria Palasis Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 30 | Website https://lyratherapeutics.com |
Full time employees 30 | Website https://lyratherapeutics.com | ||
Lyra Therapeutics, Inc., a clinical-stage biotechnology company, focuses on the development and commercialization of anti-inflammatory therapies for the treatment of patients with chronic rhinosinusitis. Its technology is designed to deliver medicines directly to the affected tissue for sustained periods with a single administration. The company's product candidates include LYR-210, an anti-inflammatory implantable drug matrix which is in Phase III clinical trial for the treatment of chronic rhinosinusitis (CRS); and LYR-220 for CRS patients who have failed previous medical management and continue to require treatment to manage CRS symptoms. It has a collaboration agreement with LianBio Inflammatory Limited to develop and commercialize LYR-210 in mainland China, Hong Kong, Taiwan, Macau, South Korea, Singapore, and Thailand. The company was formerly known as 480 Biomedical, Inc. and changed its name to Lyra Therapeutics, Inc. in July 2018. Lyra Therapeutics, Inc. was incorporated in 2005 and is headquartered in Watertown, Massachusetts.

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