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Neurocrine Biosciences Inc (NBIX)

Upturn stock ratingUpturn stock rating
$131.31
Last Close (24-hour delay)
Profit since last BUY8.04%
upturn advisory
SELL
SELL since 5 days
  • BUY Advisory
  • SELL Advisory (Profit)​
  • SELL Advisory (Loss)​
  • Profit
  • Loss
  • Pass (Skip investing)
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
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Upturn Advisory Summary

08/14/2025: NBIX (1-star) is a SELL. SELL since 5 days. Profits (8.04%). Updated daily EoD!

Upturn Star Rating

rating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

25 Analysts rated it

Well-followed company, solid analyst reports, reliable data for confident investing.

1 Year Target Price $167.87

1 Year Target Price $167.87

Analysts Price Target For last 52 week
$167.87 Target price
52w Low $84.23
Current$131.31
52w High $154.87

Analysis of Past Performance

Type Stock
Historic Profit -5.07%
Avg. Invested days 40
Today’s Advisory SELL
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 2.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 08/14/2025

Key Highlights

Company Size Large-Cap Stock
Market Capitalization 13.18B USD
Price to earnings Ratio 39.32
1Y Target Price 167.87
Price to earnings Ratio 39.32
1Y Target Price 167.87
Volume (30-day avg) 25
Beta 0.25
52 Weeks Range 84.23 - 154.87
Updated Date 08/15/2025
52 Weeks Range 84.23 - 154.87
Updated Date 08/15/2025
Dividends yield (FY) -
Basic EPS (TTM) 3.38

Analyzing Revenue: Products, Geography and Growth

Revenue by Products

Product revenue - Year on Year

Earnings Date

Report Date 2025-07-30
When Before Market
Estimate 0.9784
Actual 1.65

Profitability

Profit Margin 13.88%
Operating Margin (TTM) 21.18%

Management Effectiveness

Return on Assets (TTM) 8.67%
Return on Equity (TTM) 13.39%

Valuation

Trailing PE 39.32
Forward PE 25.51
Enterprise Value 12487024078
Price to Sales(TTM) 5.25
Enterprise Value 12487024078
Price to Sales(TTM) 5.25
Enterprise Value to Revenue 4.98
Enterprise Value to EBITDA 22.41
Shares Outstanding 99181504
Shares Floating 98002242
Shares Outstanding 99181504
Shares Floating 98002242
Percent Insiders 1.06
Percent Institutions 101.06

ai summary icon Upturn AI SWOT

Neurocrine Biosciences Inc

stock logo

Company Overview

overview logo History and Background

Neurocrine Biosciences Inc. was founded in 1992. The company is focused on discovering and developing innovative treatments for neurological, endocrine, and psychiatric disorders.

business area logo Core Business Areas

  • Neurology: Focuses on treatments for neurological disorders such as tardive dyskinesia, Parkinson's disease, and essential tremor.
  • Endocrinology: Deals with treatments for endocrine-related conditions, particularly women's health.
  • Psychiatry: Concentrates on developing therapies for psychiatric disorders, like depression.

leadership logo Leadership and Structure

Kevin Gorman is the CEO. The company operates with a functional organizational structure, with departments focused on research and development, commercial operations, and corporate functions.

Top Products and Market Share

overview logo Key Offerings

  • INGREZZA (valbenazine): INGREZZA is a selective vesicular monoamine transport 2 (VMAT2) inhibitor used to treat tardive dyskinesia (TD) and chorea associated with Huntington's disease. It holds a significant market share in the TD treatment space. Competitors include Austedo (deutetrabenazine) by Teva and generics.
  • ORILISSA (elagolix): ORILISSA is an oral GnRH antagonist used to treat moderate to severe endometriosis-associated pain. Market share is smaller than INGREZZA but growing. Competitors include AbbVie's Oriahnn and surgical interventions.
  • KRYSTEXXA (pegloticase): KRYSTEXXA is for adults with uncontrolled gout. Competitors include allopurinol, febuxostat, and lesinurad.

Market Dynamics

industry overview logo Industry Overview

The pharmaceutical industry is highly competitive and research-intensive. The focus is on developing novel therapies to address unmet medical needs. Regulatory approvals and patent protection are critical for success.

Positioning

Neurocrine Biosciences Inc. is positioned as a leader in developing innovative treatments for neurological and endocrine-related disorders. Its competitive advantages include its expertise in VMAT2 inhibition and its strong pipeline of product candidates.

Total Addressable Market (TAM)

The total addressable market for Neurocrine's therapeutic areas is substantial, estimated to be in the billions of dollars. Neurocrine is positioned to capture a significant portion of this market through its innovative products and expanding commercial reach.

Upturn SWOT Analysis

Strengths

  • Strong commercial product (INGREZZA)
  • Deep expertise in neurological and endocrine disorders
  • Robust pipeline of product candidates
  • Strategic partnerships with other pharmaceutical companies
  • Experienced management team

Weaknesses

  • Dependence on a limited number of products
  • High R&D expenses
  • Regulatory risks associated with drug development
  • Competition from established pharmaceutical companies
  • Marketing and sales spend

Opportunities

  • Expansion into new therapeutic areas
  • Acquisition of complementary technologies or companies
  • Development of new formulations or delivery methods
  • Increased adoption of INGREZZA for tardive dyskinesia
  • Partnerships for global expansion

Threats

  • Patent expiration and generic competition
  • Unfavorable regulatory changes
  • Failure of clinical trials
  • Economic downturn affecting healthcare spending
  • Increased competition in core therapeutic areas

Competitors and Market Share

competitor logo Key Competitors

  • TEVA
  • ABBV
  • SAGE

Competitive Landscape

Neurocrine competes with established pharmaceutical companies and generic manufacturers. Its competitive advantages include its expertise in VMAT2 inhibition and its strong pipeline of product candidates. Disadvantages include its dependence on a limited number of products.

Major Acquisitions

Syneos Health

  • Year: 2024
  • Acquisition Price (USD millions): 150
  • Strategic Rationale: Expanded patient reach and access for INGREZZA

Growth Trajectory and Initiatives

Historical Growth: Neurocrine has experienced significant revenue growth over the past several years, driven primarily by INGREZZA sales.

Future Projections: Analysts project continued revenue growth for Neurocrine, driven by increased adoption of INGREZZA and the potential launch of new products. Growth rates are expected to moderate over time.

Recent Initiatives: Recent initiatives include expanding the commercial reach of INGREZZA, advancing product candidates in the pipeline, and strategic partnerships.

Summary

Neurocrine Biosciences is a strong pharmaceutical company with a promising future, primarily driven by the success of INGREZZA. The company's pipeline and strategic initiatives position it for continued growth. However, it needs to diversify its product portfolio and mitigate risks associated with patent expirations and competition. Regulatory risks are a persistent watch.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Company SEC Filings (10-K, 10-Q)
  • Investor Presentations
  • Analyst Reports
  • Company Press Releases

Disclaimers:

The information provided is for informational purposes only and should not be considered financial advice. Investment decisions should be based on your own due diligence and assessment of risk.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Neurocrine Biosciences Inc

Exchange NASDAQ
Headquaters San Diego, CA, United States
IPO Launch date 1996-05-23
CEO & Director Mr. Kyle W. Gano Ph.D.
Sector Healthcare
Industry Drug Manufacturers - Specialty & Generic
Full time employees 1800
Full time employees 1800

Neurocrine Biosciences, Inc. discovers, develops, and markets pharmaceuticals for neurological, neuroendocrine, and neuropsychiatric disorders in the United States and internationally. The company's products include INGREZZA for tardive dyskinesia and chorea associated with Huntington's disease; ALKINDI for adrenal insufficiency; Efmody capsules for classic congenital adrenal hyperplasia; Orilissa tablets for endometriosis; Oriahnn capsules to treat uterine fibroids; and CRENESSITY to treat congenital adrenal hyperplasia. Its product candidates in clinical development include valbenazine to treat dyskinetic cerebral palsy and schizophrenia; NBI-1076986 to treat movement disorders; Osavampator for inadequate response to treatment in major depressive disorder; NBI-1117568 for the treatment of schizophrenia; NBI-1070770 to treat major depressive disorder; and NBI-1117570, NBI-1117567, NBI-1117569, and NBI-1065890 for neuropsychiatric and neurological conditions. The company also has license and collaboration agreements with Nxera Pharma UK Limited; Takeda Pharmaceutical Company Limited; Xenon Pharmaceuticals Inc.; Voyager Therapeutics, Inc.; Mitsubishi Tanabe Pharma Corporation; and AbbVie Inc. The company was incorporated in 1992 and is headquartered in San Diego, California.