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Oculis Holding AG Ordinary shares (OCS)

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Upturn Advisory Summary
11/28/2025: OCS (1-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $43.15
1 Year Target Price $43.15
| 5 | Strong Buy |
| 2 | Buy |
| 0 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit 25.04% | Avg. Invested days 42 | Today’s Advisory PASS |
Upturn Star Rating ![]() | Upturn Advisory Performance | Stock Returns Performance |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 1.10B USD | Price to earnings Ratio - | 1Y Target Price 43.15 |
Price to earnings Ratio - | 1Y Target Price 43.15 | ||
Volume (30-day avg) 7 | Beta 0.14 | 52 Weeks Range 14.00 - 23.08 | Updated Date 11/30/2025 |
52 Weeks Range 14.00 - 23.08 | Updated Date 11/30/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -2.68 |
Earnings Date
Report Date 2025-11-11 | When - | Estimate -0.4116 | Actual -0.32 |
Profitability
Profit Margin - | Operating Margin (TTM) -8352.26% |
Management Effectiveness
Return on Assets (TTM) -33.35% | Return on Equity (TTM) -92.2% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 920984232 | Price to Sales(TTM) 1388.54 |
Enterprise Value 920984232 | Price to Sales(TTM) 1388.54 | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA -3.47 | Shares Outstanding 57806909 | Shares Floating 39940507 |
Shares Outstanding 57806909 | Shares Floating 39940507 | ||
Percent Insiders 5.72 | Percent Institutions 38.62 |
Upturn AI SWOT
Oculis Holding AG Ordinary shares

Company Overview
History and Background
Oculis Holding AG is a biopharmaceutical company focused on developing ophthalmic treatments. Founded with a vision to address unmet needs in eye care, Oculis has evolved through research, clinical trials, and strategic partnerships.
Core Business Areas
- Dry Eye Disease (DED): Developing innovative therapies for DED, a prevalent condition affecting tear production and ocular surface health.
- Diabetic Macular Edema (DME): Developing treatments for DME, a complication of diabetes that can lead to vision loss.
- Neuro-Ophthalmology: Researching and developing novel therapies for neuro-ophthalmic disorders.
Leadership and Structure
The leadership team comprises experienced pharmaceutical executives and scientists. The organizational structure includes research and development, clinical operations, regulatory affairs, and commercial functions.
Top Products and Market Share
Key Offerings
- OCS-01: OCS-01 is a high concentration preservative free topical formulation of dexamethasone, used to treat inflammation and pain following ocular surgery as well as DED. Market share is developing but aims to compete with established brands such as Lotemax. Competitors include Bausch + Lomb, Novartis, and Sun Pharma.
- OCS-02: OCS-02 is a novel TNFu03b1 inhibitor being developed for DME. Market share is developing. Competitors include Regeneron (Eylea), Roche (Vabysmo), and Novartis (Beovu).
Market Dynamics
Industry Overview
The ophthalmic pharmaceutical industry is experiencing growth driven by an aging population, increased prevalence of chronic diseases like diabetes, and advancements in drug delivery technologies.
Positioning
Oculis positions itself as an innovator in ophthalmic treatments, focusing on developing novel therapies that address unmet needs and improve patient outcomes. They target niche markets with high growth potential.
Total Addressable Market (TAM)
The global ophthalmology market is expected to reach hundreds of billions of USD. Oculis is positioned to capture a share of this TAM through its pipeline of innovative products, focusing on areas like dry eye and DME.
Upturn SWOT Analysis
Strengths
- Innovative pipeline of ophthalmic therapies
- Experienced management team
- Strong research and development capabilities
- Strategic partnerships
Weaknesses
- Reliance on clinical trial outcomes
- Competition from established pharmaceutical companies
- Need to secure regulatory approvals
- Limited commercial infrastructure
Opportunities
- Expanding into new ophthalmic indications
- Acquiring complementary technologies or products
- Collaborating with other pharmaceutical companies
- Capitalizing on the growing ophthalmic market
Threats
- Clinical trial failures
- Regulatory delays
- Generic competition
- Changes in healthcare policies
Competitors and Market Share
Key Competitors
- Regeneron (REGN)
- Novartis (NVS)
- Bausch + Lomb (BLCO)
Competitive Landscape
Oculis competes with established pharmaceutical companies in the ophthalmic market. Its competitive advantage lies in its innovative pipeline and focus on unmet needs. Disadvantages include limited commercial infrastructure and reliance on clinical trial success.
Growth Trajectory and Initiatives
Historical Growth: Historically, Oculis has focused on building its product pipeline and conducting clinical trials.
Future Projections: Future growth is projected to be driven by successful clinical trial results, regulatory approvals, and commercialization of its ophthalmic therapies. Analyst estimates vary depending on the success of the pipeline.
Recent Initiatives: Recent initiatives include advancing clinical trials for OCS-01 and OCS-02, forming strategic partnerships, and expanding the research and development team.
Summary
Oculis Holding AG Ordinary shares is an innovative biopharmaceutical company focusing on unmet needs in ophthalmology. The company's strength lies in its pipeline, but its future depends on successful clinical trials and commercialization. The competitive environment is challenging, and regulatory hurdles remain a key risk, however the company's niche market focus offers long-term growth potential.
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Sources and Disclaimers
Data Sources:
- Company Filings
- Analyst Reports
- Industry Publications
Disclaimers:
The information provided is for informational purposes only and does not constitute financial advice. Investment decisions should be based on thorough research and consultation with a qualified financial advisor.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Oculis Holding AG Ordinary shares
Exchange NASDAQ | Headquaters - | ||
IPO Launch date 2023-03-02 | CEO & Director Dr. Riad Sherif M.B.A., M.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 49 | Website https://oculis.com |
Full time employees 49 | Website https://oculis.com | ||
Oculis Holding AG, a clinical-stage biopharmaceutical company, develops drug candidates to treat ophthalmic diseases in Switzerland, Iceland, and internationally. The company's lead product candidate is OCS-01, a topical dexamethasone optireach formulation, which is in Phase 3 clinical trials for the treatment of diabetic macular edema; OCS-02, a topical biologic candidate that is in Phase 2b clinical trials for the treatment for dry eye disease; and OCS-05, a disease modifying neuroprotective agent for neurological damage with indications for glaucoma, dry age-related macular degeneration and diabetic retinopathy, and acute optic neuritis. Oculis Holding AG was formerly known as Oculis SA and changed its name to Oculis Holding AG in March 2023. The company was founded in 2017 and is based in Zug, Switzerland.

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