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Penumbra Inc (PEN)

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Upturn Advisory Summary
01/09/2026: PEN (1-star) has a low Upturn Star Rating. Not recommended to BUY.
1 Year Target Price $335.33
1 Year Target Price $335.33
| 12 | Strong Buy |
| 2 | Buy |
| 4 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit 4.34% | Avg. Invested days 45 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating ![]() | Upturn Advisory Performance | Stock Returns Performance |
Key Highlights
Company Size Large-Cap Stock | Market Capitalization 12.36B USD | Price to earnings Ratio 75.13 | 1Y Target Price 335.33 |
Price to earnings Ratio 75.13 | 1Y Target Price 335.33 | ||
Volume (30-day avg) 18 | Beta 0.71 | 52 Weeks Range 221.26 - 325.02 | Updated Date 01/9/2026 |
52 Weeks Range 221.26 - 325.02 | Updated Date 01/9/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) 4.2 |
Analyzing Revenue: Products, Geography and Growth
Revenue by Products
Product revenue - Year on Year
Revenue by Geography
Geography revenue - Year on Year
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin 12.3% | Operating Margin (TTM) 13.77% |
Management Effectiveness
Return on Assets (TTM) 6.7% | Return on Equity (TTM) 13.32% |
Valuation
Trailing PE 75.13 | Forward PE 61.73 | Enterprise Value 12103982330 | Price to Sales(TTM) 9.26 |
Enterprise Value 12103982330 | Price to Sales(TTM) 9.26 | ||
Enterprise Value to Revenue 9.07 | Enterprise Value to EBITDA 59.18 | Shares Outstanding 39162177 | Shares Floating 37979871 |
Shares Outstanding 39162177 | Shares Floating 37979871 | ||
Percent Insiders 3.73 | Percent Institutions 98.48 |
Upturn AI SWOT
Penumbra Inc

Company Overview
History and Background
Penumbra, Inc. was founded in 2007 by Adam Elsesser. The company is dedicated to creating innovative therapies for cerebrovascular and cardiovascular diseases. A significant milestone was the development and commercialization of its thrombectomy devices for stroke treatment, which has revolutionized patient care. The company has consistently expanded its product portfolio and global reach since its inception.
Core Business Areas
- Neuro Interventional: This segment focuses on devices and therapies for treating a wide range of neurovascular conditions, including ischemic stroke, hemorrhagic stroke, and brain aneurysms. Products include thrombectomy devices, aspiration systems, and embolization agents.
- Peripheral Interventional: This segment offers solutions for treating peripheral arterial disease (PAD), deep vein thrombosis (DVT), and pulmonary embolism (PE). It encompasses devices for clot removal, vascular access, and advanced imaging.
- Vascular Intervention and Diagnostic: This segment provides products for diagnostic imaging and therapeutic intervention in both the coronary and peripheral vasculature. This includes diagnostic catheters, guidewires, and embolization coils.
Leadership and Structure
Penumbra, Inc. is led by Adam Elsesser as Chairman and CEO. The company operates as a publicly traded entity with a corporate structure typical of medical device companies, including research and development, manufacturing, sales, and marketing divisions. Specific details on the full leadership team and departmental structure are best obtained from their official investor relations materials.
Top Products and Market Share
Key Offerings
- Competitors: Medtronic,Stryker,Boston Scientific
- Description: These are advanced mechanical thrombectomy devices used to physically remove blood clots from the brain and peripheral arteries. They are a cornerstone of Penumbra's neuro and peripheral intervention portfolios. Competitors include Medtronic (Solitaire), Stryker (Stryker Neuro Thrombectomy System), and Boston Scientific (FETCH Thrombectomy System). Market share data is not publicly disclosed but is considered a leading offering in the stroke treatment market.
- Market Share:
- Product Name 1: Penumbra System (ACE, RECON, etc.)
- Competitors: AngioDynamics,Inari Medical
- Description: An aspiration thrombectomy system designed for effective and efficient clot removal in various vascular beds. It is a key product in their Peripheral Interventional segment. Competitors include AngioDynamics (AlphaVac), Inari Medical (Clotriever, FlowTriever).
- Market Share:
- Product Name 2: Lightning System
- Competitors: Stryker,Medtronic
- Description: A soft, conformable platinum coil used for the embolization of intracranial aneurysms. This product is part of their Neuro Interventional offerings. Competitors include Stryker (HydroCoil), Medtronic (Codman).
- Market Share:
- Product Name 3: Penumbra Coil 400 System
Market Dynamics
Industry Overview
Penumbra operates within the highly competitive and rapidly evolving medical device industry, specifically in the neurovascular and peripheral vascular intervention markets. These markets are driven by an aging global population, increasing incidence of chronic diseases like stroke and PAD, and technological advancements in minimally invasive treatments. Regulatory approvals and reimbursement policies are significant factors.
Positioning
Penumbra is recognized as a leader in interventional treatment of cerebrovascular and cardiovascular diseases, particularly in thrombectomy for stroke. Its competitive advantages stem from its innovative product development, strong clinical evidence, and a dedicated focus on complex vascular pathologies. The company has successfully carved out significant market share in key areas.
Total Addressable Market (TAM)
The total addressable market for neurovascular and peripheral vascular intervention is substantial and growing, estimated to be in the tens of billions of dollars globally. Penumbra is well-positioned to capture a significant portion of this TAM through its diverse product portfolio addressing unmet clinical needs in stroke, PAD, and other vascular conditions.
Upturn SWOT Analysis
Strengths
- Innovative product portfolio with a focus on unmet clinical needs.
- Strong clinical evidence supporting product efficacy.
- Established presence and reputation in the neurovascular market.
- Experienced leadership team with a clear strategic vision.
- Global commercialization capabilities.
Weaknesses
- High R&D investment required for continuous innovation.
- Dependence on a limited number of key product lines.
- Potential for pricing pressure from competitors and payers.
- Reliance on physician adoption and training for new technologies.
Opportunities
- Expansion into emerging markets with growing healthcare infrastructure.
- Development of next-generation technologies for stroke and PAD.
- Strategic acquisitions to broaden product offerings or market reach.
- Increasing adoption of minimally invasive procedures.
- Growth in the treatment of complex vascular diseases.
Threats
- Intensifying competition from established and new players.
- Changes in regulatory approvals and reimbursement policies.
- Potential product recalls or adverse events impacting reputation.
- Economic downturns affecting healthcare spending.
- Intellectual property challenges and litigation.
Competitors and Market Share
Key Competitors
- Medtronic plc (MDT)
- Stryker Corporation (SYK)
- Boston Scientific Corporation (BSX)
- Johnson & Johnson (JNJ) (through its medical device segment)
- Terumo Corporation (TRUM)
Competitive Landscape
Penumbra holds a strong position in the neurovascular thrombectomy market and is a significant player in peripheral vascular interventions. Its advantage lies in its specialized focus and innovative technology. Competitors like Medtronic and Stryker are larger, diversified medical device companies with broader product portfolios, offering significant scale and established relationships. Boston Scientific is also a major competitor with a strong interventional portfolio. Penumbra's challenge is to maintain its technological edge and market share against these larger, well-resourced entities.
Growth Trajectory and Initiatives
Historical Growth: Penumbra has exhibited robust historical growth, consistently increasing its revenue and expanding its market presence. This growth has been fueled by the successful commercialization of its innovative thrombectomy and vascular intervention products, coupled with a strategic expansion of its sales force and geographic reach.
Future Projections: Analyst consensus for Penumbra's future growth is generally positive, with expectations for continued strong revenue increases driven by the expanding indications for its devices, new product introductions, and increasing adoption in both the neurovascular and peripheral vascular markets. Projections vary but often indicate double-digit annual revenue growth.
Recent Initiatives: Recent initiatives likely include expanding the clinical evidence base for its products through further trials, developing next-generation thrombectomy and intervention technologies, and increasing its commercial footprint in key international markets. They may also be pursuing regulatory approvals for new indications or expanded use of existing devices.
Summary
Penumbra Inc. is a strong player in the interventional neurovascular and peripheral vascular markets, driven by its innovative thrombectomy devices. The company exhibits robust historical growth and positive future projections, supported by a dedicated focus and expanding clinical evidence. While facing intense competition from larger medical device firms, Penumbra's technological leadership and targeted strategy position it well for continued success. Key areas to monitor include ongoing R&D investments and the ever-evolving regulatory and reimbursement landscape.
Similar Stocks
Sources and Disclaimers
Data Sources:
- Company Investor Relations websites (SEC filings: 10-K, 10-Q)
- Reputable financial news outlets and market data providers (e.g., Yahoo Finance, Bloomberg, Refinitiv)
- Industry analysis reports
Disclaimers:
This analysis is based on publicly available information and AI interpretation. It is not financial advice. Investors should conduct their own due diligence and consult with a qualified financial advisor before making any investment decisions. Market share data is estimated and may not reflect precise current figures.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Penumbra Inc
Exchange NYSE | Headquaters Alameda, CA, United States | ||
IPO Launch date 2015-09-18 | Co-Founder, Chairman & CEO Mr. Adam Elsesser J.D. | ||
Sector Healthcare | Industry Medical Devices | Full time employees 4500 | Website https://www.penumbrainc.com |
Full time employees 4500 | Website https://www.penumbrainc.com | ||
Penumbra, Inc., together with its subsidiaries, designs, develops, manufactures, and markets medical devices in the United States and internationally. The company offers peripheral thrombectomy products, including the Indigo System for power aspiration of thrombus in the body; Lightning Flash, a mechanical thrombectomy system; Lightning Bolt 7, an arterial thrombectomy system; and CAT RX. It also provides access products, including guide catheters and the Penumbra distal delivery catheters under the Neuron, Neuron MAX, BENCHMARK, BMX, DDC, MIDWAY, and PX SLIM brands; Penumbra System, an integrated mechanical thrombectomy system comprising reperfusion catheters and separators, the 3D Revascularization device, aspiration tubing, and aspiration pump under the Penumbra RED, SENDit, JET, ACE, BMX, Max, 3D Revascularization Device, and Penumbra ENGINE brands; and neuro embolization coiling systems that includes the Penumbra Coil 400, a detachable coil that provides an alternative for the treatment of aneurysms and other complex lesions, as well as detachable coils to treat patients with a wide range of neurovascular lesions under the Penumbra SMART COIL and Penumbra SwiftPAC Coil brands; and POD400 and PAC400 brands. In addition, the company provides peripheral embolization products, such as Ruby Coil System consisting of detachable coils for peripheral applications; Penumbra LANTERN Delivery Microcatheter, a low-profile microcatheter with a high-flow lumen; POD (Penumbra Occlusion Device) System, a single device solution; and Packing Coil, a complementary device for use in other peripheral embolization products. Further, it offers neurosurgical tools comprising Artemis Neuro Evacuation Device for surgical removal of fluid and tissue from the ventricles and cerebrum. The company sells its products through direct sales organizations and distributors. Penumbra, Inc. was incorporated in 2004 and is headquartered in Alameda, California.

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