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RZLT 
Rezolute Inc (RZLT)
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Upturn Advisory Summary
11/05/2025: RZLT (5-star) is a STRONG-BUY. BUY since 7 days. Simulated Profits (-1.48%). Updated daily EoD!
Upturn Star Rating
Outstanding Performance
These Stocks/ETFs, based on Upturn Advisory, have historically outperformed the market, making them a top-tier choice for investors.
Number of Analysts
10 Analysts rated it
Moderately tracked stock, growing coverage, gaining market and investor attention.
1 Year Target Price $15
1 Year Target Price $15
| 7 | Strong Buy |
| 3 | Buy |
| 0 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit 216.74% | Avg. Invested days 34 | Today’s Advisory Strong Buy |
Upturn Star Rating | Upturn Advisory Performance  3.0 | Stock Returns Performance  5.0 |
| Profits based on simulation | Last Close 11/05/2025 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 977.31M USD | Price to earnings Ratio - | 1Y Target Price 15 |
Price to earnings Ratio - | 1Y Target Price 15 | ||
Volume (30-day avg) 10 | Beta 0.22 | 52 Weeks Range 2.21 - 10.94 | Updated Date 11/7/2025 |
52 Weeks Range 2.21 - 10.94 | Updated Date 11/7/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.98 |
Earnings Date
Report Date 2025-11-06 | When - | Estimate -0.2234 | Actual -0.18 |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -32.4% | Return on Equity (TTM) -52.56% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 668313471 | Price to Sales(TTM) - |
Enterprise Value 668313471 | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA -0.01 | Shares Outstanding 90828052 | Shares Floating 76929942 |
Shares Outstanding 90828052 | Shares Floating 76929942 | ||
Percent Insiders 9.96 | Percent Institutions 92.73 |
Upturn AI SWOT
Rezolute Inc
Company Overview
History and Background
Rezolute, Inc. is a clinical stage biopharmaceutical company dedicated to developing novel therapies for metabolic diseases. Founded in 2010, it initially focused on developing treatments for diabetes and related complications. The company is headquartered in Redwood City, California.
Core Business Areas
- Hypoglycemia Programs: Rezolute is developing therapies focused on congenital hyperinsulinism (CHI) and other causes of severe hypoglycemia. These programs aim to address unmet needs in patients experiencing dangerously low blood sugar levels.
Leadership and Structure
The leadership team includes individuals with experience in pharmaceutical development and commercialization. The company operates with a functional structure, focusing on research and development, clinical trials, and regulatory affairs.
Top Products and Market Share
Key Offerings
- RZ358 (onisemtide): RZ358 is a monoclonal antibody being developed for the treatment of congenital hyperinsulinism (CHI). There are no market share numbers available as of October 26, 2024 because the drug is not approved by the FDA. The competitors are surgical removal of the pancreas.
Market Dynamics
Industry Overview
The biopharmaceutical industry is characterized by high research and development costs, long regulatory approval timelines, and intense competition. The metabolic disease therapeutics market is driven by the increasing prevalence of conditions such as diabetes and hypoglycemia.
Positioning
Rezolute is positioned as a specialty pharmaceutical company focused on addressing rare and underserved metabolic disease markets. Its competitive advantage lies in its targeted therapeutic approach and potential to address significant unmet medical needs.
Total Addressable Market (TAM)
The TAM for CHI and severe hypoglycemia therapies is substantial, given the lack of effective treatments and the potential for significant clinical benefit. Rezolute is positioned to capture a meaningful share of this market with successful development and commercialization of its lead candidate, RZ358.
Upturn SWOT Analysis
Strengths
- Targeted therapeutic approach
- Focus on underserved market segments
- Experienced leadership team
- Positive preclinical and clinical data for lead candidate
Weaknesses
- Limited financial resources
- Dependence on single lead candidate
- High regulatory risk
- Potential for competition from larger pharmaceutical companies
Opportunities
- Expansion into new metabolic disease indications
- Partnerships with larger pharmaceutical companies
- Positive clinical trial results
- Fast Track or Breakthrough Therapy designation from regulatory agencies
Threats
- Failure to obtain regulatory approval
- Competition from alternative therapies
- Adverse clinical trial results
- Changes in regulatory landscape
Competitors and Market Share
Key Competitors
- SURGICAL REMOVAL OF PANCREAS
- Diazoxide
Competitive Landscape
Rezolute's competitive advantage lies in its targeted therapeutic approach compared to current off label treatments or surgical removal of the pancreas. Its disadvantage is its lack of an approved therapy and dependence on clinical trial success.
Growth Trajectory and Initiatives
Historical Growth: Historical growth is minimal as the company is pre-revenue and focused on drug development.
Future Projections: Future growth is highly dependent on the successful development and commercialization of RZ358 and other pipeline candidates. Analyst estimates vary widely.
Recent Initiatives: Recent initiatives include advancing RZ358 through clinical trials and seeking partnerships to support development.
Summary
Rezolute Inc. is a clinical-stage biopharmaceutical company focused on developing therapies for metabolic diseases. Its lead candidate, RZ358, targets congenital hyperinsulinism (CHI). The company's success depends on positive clinical trial results and regulatory approval. Rezolute's lack of revenue and reliance on R&D funding pose significant risks. Potential for growth exists if RZ358 proves effective and gains market acceptance. The success of the company depends highly on RZ358 getting approved.
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Sources and Disclaimers
Data Sources:
- Company Website
- SEC Filings
- Analyst Reports
- Company Press Releases
Disclaimers:
This analysis is for informational purposes only and should not be considered investment advice. Investment decisions should be based on individual research and due diligence.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Rezolute Inc
Exchange NASDAQ | Headquaters Redwood City, CA, United States | ||
IPO Launch date 2014-05-01 | Founder, CEO, Principal Financial Officer & Acting Chairman of the Board Mr. Nevan Charles Elam J.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 71 | Website https://www.rezolutebio.com |
Full time employees 71 | Website https://www.rezolutebio.com | ||
Rezolute, Inc., a late-stage rare disease company, focused on improving outcomes for individuals with hypoglycemia caused by hyperinsulinism in the United States. Its lead clinical asset is ersodetug, an intravenously administered human monoclonal antibody that is in Phase 3 clinical trial for the treatment of congenital hyperinsulinism, an ultra-rare pediatric genetic disorder, as well as for the treatment of hypoglycemia; and clinical trials of ersodetug for tumor hyperinsulinism. The company was formerly known as AntriaBio, Inc. and changed its name to Rezolute, Inc. in December 2017. Rezolute, Inc. was founded in 2010 and is headquartered in Redwood City, California.
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