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SYRE
Upturn stock ratingUpturn stock rating

Spyre Therapeutics Inc. (SYRE)

Upturn stock ratingUpturn stock rating
$15.22
Last Close (24-hour delay)
Profit since last BUY-4.84%
upturn advisory
SELL
SELL since 3 days
  • BUY Advisory
  • SELL Advisory (Profit)​
  • SELL Advisory (Loss)​
  • Profit
  • Loss
  • Pass (Skip investing)
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
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Upturn Advisory Summary

06/27/2025: SYRE (1-star) is a SELL. SELL since 3 days. Profits (-4.84%). Updated daily EoD!

Upturn Star Rating

ratingratingratingratingrating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

11 Analysts rated it

These Stocks/ETFs, based on Upturn Advisory, have historically outperformed the market, making them a top-tier choice for investors.

Year Target Price $54.44

Year Target Price $54.44

Analyst’s Price TargetsFor last 52 week
$54.44Target price
Low$10.91
Current$15.22
high$40.26

Analysis of Past Performance

Type Stock
Historic Profit -44.3%
Avg. Invested days 23
Today’s Advisory SELL
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 1.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 06/27/2025

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 918.58M USD
Price to earnings Ratio -
1Y Target Price 53.9
Price to earnings Ratio -
1Y Target Price 53.9
Volume (30-day avg) -
Beta 2.73
52 Weeks Range 10.91 - 40.26
Updated Date 06/29/2025
52 Weeks Range 10.91 - 40.26
Updated Date 06/29/2025
Dividends yield (FY) -
Basic EPS (TTM) -3.06

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -
Operating Margin (TTM) -

Management Effectiveness

Return on Assets (TTM) -25.34%
Return on Equity (TTM) -65.82%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 764231198
Price to Sales(TTM) 650.22
Enterprise Value 764231198
Price to Sales(TTM) 650.22
Enterprise Value to Revenue 1964.91
Enterprise Value to EBITDA -7.96
Shares Outstanding 60353600
Shares Floating 46623126
Shares Outstanding 60353600
Shares Floating 46623126
Percent Insiders 8.71
Percent Institutions 106.07

Analyst Ratings

Rating 4.82
Target Price 54.44
Buy -
Strong Buy 10
Buy -
Strong Buy 10
Hold 1
Sell -
Strong Sell -
Strong Sell -

ai summary icon Upturn AI SWOT

Spyre Therapeutics Inc.

stock logo

Company Overview

overview logo History and Background

Spyre Therapeutics, Inc. is a clinical-stage biotechnology company founded in 2022. It focuses on developing antibody therapies to treat inflammatory bowel disease (IBD). The company's strategy involves acquiring and advancing promising clinical-stage assets.

business area logo Core Business Areas

  • Antibody Therapeutics Development: Spyre focuses on the development of antibody therapeutics targeting key inflammatory pathways in IBD.
  • Clinical Trials: The company conducts clinical trials to evaluate the safety and efficacy of its therapeutic candidates.
  • Drug Discovery and Acquisition: Spyre actively seeks to acquire and develop novel therapies for IBD.

leadership logo Leadership and Structure

Spyre Therapeutics is led by a management team with experience in drug development and biotechnology. The organizational structure includes teams focused on research, clinical development, and business operations.

Top Products and Market Share

overview logo Key Offerings

  • SPY001 (Satralizumab Biosimilar): SPY001 is a biosimilar candidate to Roche's Satralizumab, designed for subcutaneous administration. It aims to target the IL-6 pathway. There is currently no market share data since it is in development. Competitors include Roche (Satralizumab) and other companies developing IL-6 inhibitors.
  • SPY002 (TL1A antibody): SPY002 is a monoclonal antibody targeting TL1A. There is currently no market share data since it is in development. Competitors include Roivant Sciences (RVT) and other companies developing TL1A inhibitors.

Market Dynamics

industry overview logo Industry Overview

The IBD therapeutics market is characterized by significant unmet needs and ongoing innovation, with a mix of established therapies and emerging biological treatments. The market is driven by the increasing prevalence of IBD and the demand for more effective and targeted therapies.

Positioning

Spyre Therapeutics aims to establish a leading position in the IBD therapeutics market by developing innovative antibody therapies that address key unmet needs. Their strategy involves acquiring and advancing clinical-stage assets to accelerate development timelines.

Total Addressable Market (TAM)

The global IBD market is expected to reach approximately $25 billion by 2030. Spyre is positioned to capture a portion of this market by focusing on novel therapeutic targets and differentiated antibody therapies.

Upturn SWOT Analysis

Strengths

  • Experienced Management Team
  • Focus on a high unmet need market (IBD)
  • Promising clinical-stage pipeline

Weaknesses

  • Early stage company with limited financial resources
  • High dependence on clinical trial outcomes
  • Reliance on acquisitions for pipeline growth

Opportunities

  • Acquisition of additional assets
  • Positive clinical trial results leading to regulatory approval
  • Partnerships with larger pharmaceutical companies

Threats

  • Clinical trial failures
  • Competition from established pharmaceutical companies
  • Regulatory hurdles
  • Patent disputes

Competitors and Market Share

competitor logo Key Competitors

  • JNJ
  • PFE
  • BMY
  • RVT

Competitive Landscape

Spyre faces competition from established pharmaceutical companies with approved IBD therapies, as well as other biotech companies developing novel treatments. Spyre's advantage lies in its focus on differentiated antibody therapies and its acquisition strategy.

Major Acquisitions

Ad u09aau09cbu09b0u09cdu099f Sciences, Inc

  • Year: 2023
  • Acquisition Price (USD millions): 22.5
  • Strategic Rationale: The acquisition of Ad u09aau09cbu09b0u09cdu099f Sciences strengthened their IP portfolio and lead to SPY002.

Growth Trajectory and Initiatives

Historical Growth: Historical growth is defined by preclinical and clinical trial milestones, as well as acquisitions of pipeline assets.

Future Projections: Future growth depends on successful clinical trial outcomes, regulatory approvals, and commercialization of therapeutic candidates. Analyst estimates would focus on projected peak sales for key products.

Recent Initiatives: Recent initiatives include advancing the clinical development of SPY001 and SPY002, and evaluating potential acquisitions of additional assets.

Summary

Spyre Therapeutics is an early-stage biotech company with a focus on IBD therapies, showing promise through its pipeline of antibody therapeutics. Its success hinges on positive clinical trial results and effective pipeline expansion through strategic acquisitions. Key watch-outs include clinical trial risks, competition from established players, and managing financial resources. However the company may not be able to compete with the much larger pharmaceutical companies and may become an acquisition target in the future.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Spyre Therapeutics Inc. website
  • SEC filings
  • Analyst reports
  • Industry publications

Disclaimers:

This analysis is for informational purposes only and should not be considered financial advice. Investment decisions should be based on individual research and consultation with a qualified financial advisor. Market share data is estimated.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Spyre Therapeutics Inc.

Exchange NASDAQ
Headquaters Waltham, MA, United States
IPO Launch date 2016-04-07
CEO & Director Dr. Cameron Turtle DPHIL, Ph.D.
Sector Healthcare
Industry Biotechnology
Full time employees 73
Full time employees 73

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. The company was incorporated in 2013 and is based in Waltham, Massachusetts.