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TriSalus Life Sciences Inc. (TLSI)

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Upturn Advisory Summary
01/09/2026: TLSI (1-star) has a low Upturn Star Rating. Not recommended to BUY.
1 Year Target Price $11.5
1 Year Target Price $11.5
| 6 | Strong Buy |
| 2 | Buy |
| 0 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit -36.79% | Avg. Invested days 49 | Today’s Advisory WEAK BUY |
Upturn Star Rating ![]() | Upturn Advisory Performance | Stock Returns Performance |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 289.79M USD | Price to earnings Ratio - | 1Y Target Price 11.5 |
Price to earnings Ratio - | 1Y Target Price 11.5 | ||
Volume (30-day avg) 8 | Beta 0.43 | 52 Weeks Range 3.42 - 7.95 | Updated Date 01/10/2026 |
52 Weeks Range 3.42 - 7.95 | Updated Date 01/10/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -2.12 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -98.45% | Operating Margin (TTM) -77.94% |
Management Effectiveness
Return on Assets (TTM) -61.1% | Return on Equity (TTM) -496.21% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 301230003 | Price to Sales(TTM) 7.21 |
Enterprise Value 301230003 | Price to Sales(TTM) 7.21 | ||
Enterprise Value to Revenue 7.49 | Enterprise Value to EBITDA -5.96 | Shares Outstanding 49964311 | Shares Floating 39539258 |
Shares Outstanding 49964311 | Shares Floating 39539258 | ||
Percent Insiders 42.41 | Percent Institutions 19.47 |
Upturn AI SWOT
TriSalus Life Sciences Inc.

Company Overview
History and Background
TriSalus Life Sciences Inc. is a privately held company focused on developing novel therapies for cancer. Founded with the goal of transforming cancer treatment, the company has been dedicated to advancing its proprietary platform for delivering therapeutics directly to tumors. Significant milestones include the development of its targeted drug delivery technology and ongoing clinical trials for its lead candidates. The company's evolution has been driven by scientific innovation and a commitment to addressing unmet needs in oncology.
Core Business Areas
- Oncology Therapeutics Development: TriSalus Life Sciences focuses on the research and development of innovative drug candidates designed to treat various forms of cancer. Their approach aims to improve efficacy and reduce systemic toxicity by delivering therapies directly to the tumor site.
- Targeted Drug Delivery Technology: A core component of TriSalus's business is its proprietary drug delivery platform, which is designed to enhance the concentration of therapeutic agents within tumors while minimizing exposure to healthy tissues.
Leadership and Structure
TriSalus Life Sciences is led by a team of experienced professionals in oncology, drug development, and business operations. The company operates under a traditional corporate structure with functional departments dedicated to research and development, clinical operations, regulatory affairs, and business development.
Top Products and Market Share
Key Offerings
- Description: TSL-1101 is a novel therapeutic candidate being developed for the treatment of pancreatic cancer. It is designed to be delivered directly to pancreatic tumors via the company's proprietary delivery system. Market share data is not publicly available as it is an investigational therapy. Key competitors in pancreatic cancer treatment include established chemotherapy regimens, targeted therapies, and immunotherapies from companies like Amgen, Bristol Myers Squibb, and Pfizer.
- Name: TSL-1101 (Pancreatic Cancer)
- Description: TSL-2101 is another investigational therapy targeting glioblastoma multiforme (GBM), a highly aggressive brain cancer. Similar to TSL-1101, it leverages TriSalus's drug delivery platform. Market share data is not available. Competitors in GBM treatment include companies like Novocure (TTFields), Merck, and other pharmaceutical giants developing novel chemotherapy and targeted agents.
- Name: TSL-2101 (Glioblastoma Multiforme)
Market Dynamics
Industry Overview
The oncology therapeutics market is characterized by rapid innovation, significant investment in research and development, and a growing demand for more effective and targeted treatments. The personalized medicine trend and advancements in understanding cancer biology continue to drive the development of novel therapies. The market is highly competitive, with both large pharmaceutical companies and smaller biotechnology firms actively pursuing new treatments.
Positioning
TriSalus Life Sciences positions itself as an innovator in targeted cancer therapy, aiming to overcome the limitations of traditional systemic drug delivery. Their proprietary platform offers a potential competitive advantage by enhancing drug efficacy and reducing side effects. The company focuses on specific unmet needs within challenging cancer indications.
Total Addressable Market (TAM)
The TAM for oncology drugs is vast and continues to grow, estimated to be in the hundreds of billions of dollars globally. TriSalus Life Sciences is targeting specific sub-segments within this market, such as pancreatic cancer and glioblastoma, which represent significant unmet needs. Their positioning within these specific indications aims to capture a meaningful share of their respective markets as their therapies progress through clinical development and gain regulatory approval.
Upturn SWOT Analysis
Strengths
- Proprietary targeted drug delivery platform
- Focus on significant unmet medical needs in oncology
- Experienced leadership team
- Potential for improved therapeutic outcomes and reduced side effects
Weaknesses
- As a private company, limited public financial data
- Clinical trial risks and regulatory hurdles
- Dependence on successful clinical development of lead candidates
- Potential for high research and development costs
Opportunities
- Growing demand for effective cancer treatments
- Advancements in cancer biology and drug discovery
- Potential for strategic partnerships and collaborations
- Expansion into other oncology indications
Threats
- Intense competition in the oncology drug market
- Failure of clinical trials
- Regulatory challenges and delays
- Changes in healthcare policy and reimbursement
Competitors and Market Share
Key Competitors
- Companies developing pancreatic cancer treatments (e.g., Amgen Inc. (AMGN), Bristol Myers Squibb (BMY), Pfizer Inc. (PFE))
- Companies developing glioblastoma treatments (e.g., Merck & Co., Inc. (MRK), Novocure Limited (NVCR))
Competitive Landscape
TriSalus Life Sciences competes in a highly dynamic and competitive oncology market. Its key advantage lies in its novel drug delivery platform, which could offer a differentiated approach to treatment. However, it faces competition from established pharmaceutical giants with extensive resources and established product portfolios, as well as other emerging biotechnology companies developing innovative therapies.
Growth Trajectory and Initiatives
Historical Growth: TriSalus Life Sciences' historical growth has likely been driven by scientific advancements, successful preclinical studies, and the securing of investment capital to fund its research and development efforts.
Future Projections: Future projections for TriSalus Life Sciences are contingent on the successful outcomes of its ongoing clinical trials and subsequent regulatory approvals. Analyst estimates are not publicly available for private companies.
Recent Initiatives: Recent initiatives likely involve the advancement of its lead drug candidates through clinical trials, potential expansion of its research pipeline, and securing additional funding to support its development programs.
Summary
TriSalus Life Sciences Inc. is a privately held biotechnology company focused on developing targeted cancer therapies. Its proprietary drug delivery platform presents a promising avenue for improving treatment efficacy and reducing side effects. The company's success hinges on the outcomes of its clinical trials for pancreatic cancer and glioblastoma. Significant challenges include navigating the highly competitive oncology market and securing sufficient funding for continued research and development.
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Sources and Disclaimers
Data Sources:
- Company press releases (as reported by financial news outlets)
- Industry analysis reports
- Clinical trial databases
Disclaimers:
This information is based on publicly available data and general industry knowledge. As TriSalus Life Sciences Inc. is a privately held company, comprehensive financial and operational details may not be accessible. This analysis is for informational purposes only and should not be considered investment advice.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About TriSalus Life Sciences Inc.
Exchange NASDAQ | Headquaters Westminster, CO, United States | ||
IPO Launch date 2023-08-10 | CEO, President & Director Ms. Mary T. Szela B.S.N., M.B.A. | ||
Sector Healthcare | Industry Medical Devices | Full time employees 110 | Website https://trisaluslifesci.com |
Full time employees 110 | Website https://trisaluslifesci.com | ||
TriSalus Life Sciences, Inc. engages in the research, development, and commercialization of drug delivery technology platform and immuno-oncology therapeutics to improve outcomes for patients with difficult-to-treat liver and pancreatic cancers. It offers Pressure Enabled Drug Delivery infusion systems, such as the TriNav infusion system, which is used in transarterial radioembolization and chemoembolization procedures for patients with liver cancer and metastases; and the Pancreatic Retrograde Venous Infusion device, which is in Phase 1 clinical trial for treating locally advanced pancreatic cancer. The company is also developing nelitolimod, an investigational immunotherapeutic in Phase 1 clinical trial for the treatment of uveal melanoma, intrahepatic cholangiocarcinoma, hepatocellular carcinoma, and pancreatic cancer. It serves interventional radiologists, IR technicians, medical oncologists, nursing support, value analysis committee staff, and patients through its sales representatives and sales managers. The company was founded in 2009 and is headquartered in Westminster, Colorado.

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