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Upturn AI SWOT - About
TRVI 
Trevi Therapeutics Inc (TRVI)
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Upturn Advisory Summary
06/10/2025: TRVI (5-star) is currently NOT-A-BUY. Pass it for now.
Upturn Star Rating
Outstanding Performance
These Stocks/ETFs, based on Upturn Advisory, have historically outperformed the market, making them a top-tier choice for investors.
Analysis of Past Performance
Type Stock | Historic Profit 74.37% | Avg. Invested days 26 | Today’s Advisory PASS |
Upturn Star Rating | Upturn Advisory Performance  3.0 | Stock Returns Performance  4.0 |
| Profits based on simulation | Last Close 06/10/2025 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 841.17M USD | Price to earnings Ratio - | 1Y Target Price 21.22 |
Price to earnings Ratio - | 1Y Target Price 21.22 | ||
Volume (30-day avg) 1988427 | Beta 0.53 | 52 Weeks Range 2.36 - 7.48 | Updated Date 06/10/2025 |
52 Weeks Range 2.36 - 7.48 | Updated Date 06/10/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.41 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -34.41% | Return on Equity (TTM) -55.12% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 738862055 | Price to Sales(TTM) - |
Enterprise Value 738862055 | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA -4.92 | Shares Outstanding 119145000 | Shares Floating 79134027 |
Shares Outstanding 119145000 | Shares Floating 79134027 | ||
Percent Insiders 13.6 | Percent Institutions 75.65 |
Analyst Ratings
Rating 4.88 | Target Price 20.62 | Buy 1 | Strong Buy 7 |
Buy 1 | Strong Buy 7 | ||
Hold - | Sell - | Strong Sell - | |
Strong Sell - |
Upturn AI SWOT
Trevi Therapeutics Inc
Company Overview
History and Background
Trevi Therapeutics, Inc. is a biopharmaceutical company focused on developing and commercializing innovative therapies for chronic pruritus (itching) and other chronic conditions. Founded to address unmet medical needs, it has focused primarily on Haduviou2122 (nalbuphine ER) for pruritus associated with various conditions. Further background on exact founding year not available.
Core Business Areas
- Pruritus Therapeutics: Development and commercialization of Haduviou2122 (nalbuphine ER) for chronic pruritus associated with prurigo nodularis.
Leadership and Structure
Trevi Therapeutics has a management team led by its CEO and a board of directors providing oversight. Specific individuals' names and organizational chart unavailable without live data.
Top Products and Market Share
Key Offerings
- Haduviou2122 (nalbuphine ER): Haduviou2122 is an extended-release oral formulation of nalbuphine being developed for the treatment of chronic pruritus associated with prurigo nodularis. Market share data is not publicly available. Key competitors in the pruritus market include companies developing and marketing topical corticosteroids, antihistamines, calcineurin inhibitors, and other novel therapies. Specific competitor names with drugs for prurigo nodularis include Sanofi's Dupixent (dupilumab).
Market Dynamics
Industry Overview
The biopharmaceutical industry is competitive and research-intensive, marked by lengthy development timelines, regulatory hurdles, and high risk of failure. There's increasing demand for therapies addressing unmet needs in chronic conditions.
Positioning
Trevi Therapeutics is positioned as a company specializing in chronic pruritus, particularly prurigo nodularis, leveraging its Haduviou2122 product candidate. Its competitive advantage lies in targeting a specific patient population with a novel therapy.
Total Addressable Market (TAM)
The total addressable market for pruritus therapies is significant and growing, driven by the prevalence of chronic skin conditions. Trevi Therapeutics is positioned to capture a portion of this market by focusing on severe chronic itch associated with prurigo nodularis. Specific TAM not available.
Upturn SWOT Analysis
Strengths
- Novel therapy targeting unmet medical need
- Potential for first-in-class treatment
- Experienced management team
Weaknesses
- Single product reliance
- High development costs
- Regulatory risks
- Commercialization challenges
Opportunities
- Expansion to other pruritus indications
- Partnerships with larger pharmaceutical companies
- Positive clinical trial results
- Increasing awareness of prurigo nodularis
Threats
- Competition from established therapies
- Failure to obtain regulatory approval
- Unfavorable reimbursement environment
- Patent expiration
Competitors and Market Share
Key Competitors
- Sanofi (SNY)
- Regeneron (REGN)
- Galderma (Not Publicly Traded)
- Kyowa Kirin (KYKOF)
Competitive Landscape
Trevi faces competition from companies with established pruritus therapies and larger market presence. Its success depends on demonstrating the efficacy and safety of Haduviou2122.
Major Acquisitions
Growth Trajectory and Initiatives
Historical Growth: Historical growth trends depend on past financial performance. Requires real-time financial data.
Future Projections: Future projections depend on analyst estimates, clinical trial outcomes, and regulatory approvals. Unavailable without real-time analyst reports.
Recent Initiatives: Recent initiatives include advancing the clinical development program for Haduviou2122.
Summary
Trevi Therapeutics is a biopharmaceutical company focused on developing Haduviou2122 for chronic pruritus. The company addresses a significant unmet medical need. However, it faces challenges related to single product reliance, competition, and regulatory hurdles. Successful clinical trials and commercialization are essential for its future growth.
Peer Comparison
ITCI
Intracellular Th
ITCI
Intracellular Th
KALV
Kalvista Pharmaceuticals Inc
KALV
Kalvista Pharmaceuticals Inc
REGN
Regeneron Pharmaceuticals Inc
REGN
Regeneron Pharmaceuticals Inc
SNY
Sanofi ADR
SNY
Sanofi ADR
Sources and Disclaimers
Data Sources:
- Company Website
- SEC Filings
- Industry Reports
- Analyst Reports
Disclaimers:
This analysis is for informational purposes only and should not be considered investment advice. The data provided is based on publicly available information and may not be entirely accurate or complete. Market share percentages are estimates.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Trevi Therapeutics Inc
Exchange NASDAQ | Headquaters New Haven, CT, United States | ||
IPO Launch date 2019-05-07 | Co-Founder, CEO, President & Director Ms. Jennifer L. Good | ||
Sector Healthcare | Industry Biotechnology | Full time employees 31 | |
Full time employees 31 | |||
Trevi Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of investigational therapy for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and non-IPF interstitial lung disease, and refractory chronic cough. The company is developing Haduvio, an oral extended-release formulation of nalbuphine, which is in phase 2b Cough Reduction in IPF with nalbuphine ER clinical trial for treatment of chronic cough in patients with IPF; phase 2 clinical trial in patients with pruritus; and phase 2b/3 clinical trial in patients with prurigo nodularis. Trevi Therapeutics, Inc. has a license agreement with Endo Pharmaceuticals Inc. to develop and commercialize products incorporating nalbuphine hydrochloride in various formulations. The company was incorporated in 2011 and is headquartered in New Haven, Connecticut.
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