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WVE 
Wave Life Sciences Ltd (WVE)
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Upturn Advisory Summary
11/11/2025: WVE (1-star) is currently NOT-A-BUY. Pass it for now.
Upturn Star Rating
Not Recommended Performance
These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.
Number of Analysts
13 Analysts rated it
Moderately tracked stock, growing coverage, gaining market and investor attention.
1 Year Target Price $19.8
1 Year Target Price $19.8
| 9 | Strong Buy |
| 3 | Buy |
| 1 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit -52.77% | Avg. Invested days 32 | Today’s Advisory PASS |
Upturn Star Rating | Upturn Advisory Performance  2.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 11/11/2025 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 1.21B USD | Price to earnings Ratio - | 1Y Target Price 19.8 |
Price to earnings Ratio - | 1Y Target Price 19.8 | ||
Volume (30-day avg) 13 | Beta -1.74 | 52 Weeks Range 5.28 - 16.38 | Updated Date 11/12/2025 |
52 Weeks Range 5.28 - 16.38 | Updated Date 11/12/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.65 |
Earnings Date
Report Date 2025-11-06 | When - | Estimate -0.2547 | Actual -0.32 |
Profitability
Profit Margin -111.64% | Operating Margin (TTM) -740.71% |
Management Effectiveness
Return on Assets (TTM) -28.33% | Return on Equity (TTM) -86.51% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 1037293751 | Price to Sales(TTM) 11.11 |
Enterprise Value 1037293751 | Price to Sales(TTM) 11.11 | ||
Enterprise Value to Revenue 9.5 | Enterprise Value to EBITDA -10.12 | Shares Outstanding 167181784 | Shares Floating 68915675 |
Shares Outstanding 167181784 | Shares Floating 68915675 | ||
Percent Insiders 15.79 | Percent Institutions 88.33 |
Upturn AI SWOT
Wave Life Sciences Ltd
Company Overview
History and Background
Wave Life Sciences Ltd was founded in 2012. It focuses on developing stereopure nucleic acid therapies for genetically defined diseases.
Core Business Areas
- RNA Editing: Developing therapies using RNA editing technology.
- Antisense Therapies: Developing antisense oligonucleotide (ASO) therapies for a range of genetic diseases.
- Stereopure Oligonucleotides: Focusing on the development of stereopure oligonucleotides to enhance therapeutic properties.
Leadership and Structure
Paul Bolno is the President and CEO. The company has a board of directors and a management team overseeing research, development, and operations.
Top Products and Market Share
Key Offerings
- WVE-N531: An exon-skipping therapy for Duchenne muscular dystrophy (DMD) amenable to exon 53 skipping. Currently in clinical trials. Competitors include Sarepta Therapeutics (SRPT).
- WVE-003: A therapy for Huntington's disease (HD) targeting the HTT gene. Currently in clinical trials. Competitors include Roche (RHHBY) and Ionis Pharmaceuticals (IONS).
Market Dynamics
Industry Overview
The industry focuses on developing therapies for genetically defined diseases, including rare and orphan diseases. Key trends include advancements in gene therapy, RNA editing, and oligonucleotide therapies.
Positioning
Wave Life Sciences is positioned as a company specializing in stereopure nucleic acid therapies. Its competitive advantage lies in its focus on stereochemistry to enhance therapeutic properties.
Total Addressable Market (TAM)
The total addressable market for genetic therapies is estimated to be in the tens of billions of dollars. Wave is positioned with multiple clinical-stage programs targeting significant unmet needs.
Upturn SWOT Analysis
Strengths
- Proprietary stereopure oligonucleotide platform
- Focus on genetically defined diseases
- Experienced management team
- Clinical-stage programs
Weaknesses
- High R&D costs
- Reliance on clinical trial success
- Limited revenue generation
- Competition from larger pharmaceutical companies
Opportunities
- Potential FDA approvals for key pipeline programs
- Partnerships with larger pharmaceutical companies
- Expansion into new therapeutic areas
- Advancements in oligonucleotide technologies
Threats
- Clinical trial failures
- Regulatory hurdles
- Competition from alternative therapies
- Patent challenges
Competitors and Market Share
Key Competitors
- IONS
- SRPT
- RHHBY
- CRIS
Competitive Landscape
Wave Life Sciences faces competition from larger, more established companies with greater resources. Its advantage lies in its unique stereopure oligonucleotide platform, which may offer improved therapeutic properties.
Growth Trajectory and Initiatives
Historical Growth: Growth has been driven by advancing pipeline programs and securing partnerships.
Future Projections: Future growth is dependent on successful clinical trial results and regulatory approvals.
Recent Initiatives: Focusing on advancing lead programs, exploring new therapeutic areas, and seeking strategic partnerships.
Summary
Wave Life Sciences is a clinical-stage biotechnology company focused on developing stereopure nucleic acid therapies. The company's strengths include its proprietary platform and focus on genetically defined diseases. However, it faces challenges related to high R&D costs, regulatory hurdles, and competition from larger companies. Successful clinical trials and strategic partnerships are crucial for future growth.
Similar Stocks
Sources and Disclaimers
Data Sources:
- Company website
- SEC filings
- Analyst reports
- ClinicalTrials.gov
Disclaimers:
This analysis is for informational purposes only and does not constitute investment advice. Financial data and market share estimates are subject to change and may not be entirely accurate.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Wave Life Sciences Ltd
Exchange NASDAQ | Headquaters - | ||
IPO Launch date 2015-11-11 | President, CEO & Director Dr. Paul B. Bolno M.B.A., M.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 287 | Website https://wavelifesciences.com |
Full time employees 287 | Website https://wavelifesciences.com | ||
Wave Life Sciences Ltd., a clinical-stage biotechnology company, designs, develops, and commercializes ribonucleic acid (RNA) medicines through PRISM, a discovery and drug development platform. The company's RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation, and deep insights into human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. It is developing WVE-006, an RNA editing oligonucleotide for the treatment of alpha-1 antitrypsin deficiency; WVE-007, a GalNAc-conjugated small interfering RNA designed to silence INHBE mRNA targeting obesity; WVE-N531, an exon skipping oligonucleotide for the treatment of Duchenne muscular dystrophy; and WVE-003, an allele-selective oligonucleotide for the treatment of Huntington's disease (HD). The company has collaboration agreements with GlaxoSmithKline for the research, development, and commercialization of oligonucleotide therapeutics; Takeda Pharmaceutical Company Limited for the research, development, and commercialization of oligonucleotide therapeutics for disorders of the Central Nervous System; and Asuragen, Inc. for the development and potential commercialization of companion diagnostics for investigational allele-selective therapeutic programs targeting HD. Wave Life Sciences Ltd. was incorporated in 2012 and is based in Singapore.
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