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XORTX Therapeutics Inc (XRTX)


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Upturn Advisory Summary
10/17/2025: XRTX (1-star) has a low Upturn Star Rating. Not recommended to BUY.
1 Year Target Price $13.74
1 Year Target Price $13.74
1 | Strong Buy |
0 | Buy |
0 | Hold |
0 | Sell |
0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit -3.39% | Avg. Invested days 17 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Small-Cap Stock | Market Capitalization 5.73M USD | Price to earnings Ratio - | 1Y Target Price 13.74 |
Price to earnings Ratio - | 1Y Target Price 13.74 | ||
Volume (30-day avg) 1 | Beta -0.18 | 52 Weeks Range 0.66 - 1.99 | Updated Date 10/18/2025 |
52 Weeks Range 0.66 - 1.99 | Updated Date 10/18/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.46 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -42.15% | Return on Equity (TTM) -79.44% |
Valuation
Trailing PE - | Forward PE 0.96 | Enterprise Value 3204483 | Price to Sales(TTM) - |
Enterprise Value 3204483 | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.09 | Shares Outstanding 5212218 | Shares Floating 5069038 |
Shares Outstanding 5212218 | Shares Floating 5069038 | ||
Percent Insiders 2.63 | Percent Institutions 4.64 |
Upturn AI SWOT
XORTX Therapeutics Inc
Company Overview
History and Background
XORTX Therapeutics Inc. is a biopharmaceutical company focused on developing therapies to treat progressive kidney disease, with a focus on orphan diseases. Founded to address unmet needs in kidney health, the company is developing treatments for diseases such as focal segmental glomerulosclerosis (FSGS).
Core Business Areas
- Drug Development: XORTX focuses on developing and commercializing therapies for progressive kidney disease, specifically treatments targeting purine metabolism and uric acid production.
Leadership and Structure
The leadership team consists of experienced professionals in drug development, clinical trials, and regulatory affairs. The organizational structure includes departments for research and development, clinical operations, and corporate management.
Top Products and Market Share
Key Offerings
- XRx-008: XRx-008 is XORTX's lead product candidate, a selective xanthine oxidase inhibitor (sXOI) being developed for the treatment of ADPKD and other progressive kidney diseases. Market share data is not publicly available as it is still in development stage. Competitors include companies developing therapies for ADPKD.
Market Dynamics
Industry Overview
The biopharmaceutical industry focused on kidney disease is characterized by a growing need for effective therapies, especially for progressive and rare kidney conditions. There is a rising prevalence of chronic kidney disease worldwide, driving the demand for new treatment options.
Positioning
XORTX is positioned as a company focused on developing innovative therapies for progressive kidney disease, with a focus on purine metabolism. Its competitive advantage lies in its targeted approach and potential to address unmet medical needs.
Total Addressable Market (TAM)
The market for kidney disease therapies is substantial and growing, estimated to be in the billions of dollars. XORTX is positioned to capture a share of this market with its pipeline of product candidates.
Upturn SWOT Analysis
Strengths
- Focus on unmet needs in kidney disease
- Proprietary technology and intellectual property
- Experienced management team
Weaknesses
- Limited financial resources
- Dependence on successful clinical trials
- Small company size compared to competitors
Opportunities
- Potential for orphan drug designation
- Partnerships and collaborations with larger pharmaceutical companies
- Expansion of product pipeline
Threats
- Regulatory hurdles
- Competition from established pharmaceutical companies
- Failure of clinical trials
Competitors and Market Share
Key Competitors
- VRTX
- ALNY
Competitive Landscape
XORTX is disadvantaged compared to major pharmaceutical companies due to smaller size and resources. However, it has an advantage of focusing on one target, whereas others have many things to consider.
Growth Trajectory and Initiatives
Historical Growth: Growth is related to the successful advancement of clinical trials. There has not been any revenue history to speak of as of yet.
Future Projections: Future growth depends on successful clinical trials and potential regulatory approvals. Analyst estimates suggest potential upside if XRx-008 is successful.
Recent Initiatives: Recent initiatives include advancing XRx-008 through clinical trials and seeking partnerships.
Summary
XORTX Therapeutics Inc. is a biopharmaceutical company focused on kidney diseases, particularly ADPKD. As a small company with limited resources, they are highly dependent on successful clinical trial outcomes for XRx-008 and future funding. The company faces competition from larger, established pharmaceutical companies, making partnerships crucial. While focused on an unmet need, the company's future growth hinges on navigating regulatory hurdles and achieving positive clinical trial results.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Company website
- SEC filings
- Analyst reports
Disclaimers:
The information provided is for informational purposes only and should not be considered investment advice. The analysis is based on publicly available information and may not be complete or accurate. Investing in XORTX Therapeutics Inc. involves significant risks, including the risk of loss.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About XORTX Therapeutics Inc
Exchange NASDAQ | Headquaters Calgary, AB, Canada | ||
IPO Launch date 2018-11-28 | Founder, CEO, President & Director Dr. Allen Warren Davidoff Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees - | Website https://www.xortx.com |
Full time employees - | Website https://www.xortx.com |
XORTX Therapeutics Inc., a late-stage clinical pharmaceutical company, engages in the development and commercialization of therapies to treat gout and progressive kidney disease. Its drug development programs include XRx-026, which is in the third phase for the treatment of gout; XRx-008, which is in the second phase to treat autosomal dominant polycystic kidney disease; XRx-101, which is in the second phase to treat acute kidney injury associated with respiratory virus infection; and XRX-225, which is in the preclinical stage for the treatment of type 2 diabetic nephropathy. It has a license agreement with the University of Florida Research Foundation, Inc. for the use of uric acid lowering agent to treat insulin resistance. The company is based in Calgary, Canada.

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