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Roundhill GLP-1 & Weight Loss ETF (OZEM)



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Upturn Advisory Summary
08/14/2025: OZEM (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type ETF | Historic Profit -7.04% | Avg. Invested days 28 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | ETF Returns Performance ![]() |
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Key Highlights
Volume (30-day avg) - | Beta - | 52 Weeks Range 20.01 - 29.15 | Updated Date 06/30/2025 |
52 Weeks Range 20.01 - 29.15 | Updated Date 06/30/2025 |
Upturn AI SWOT
Roundhill GLP-1 & Weight Loss ETF
ETF Overview
Overview
The Roundhill GLP-1 & Weight Loss ETF (OZEM) seeks to provide investment results that correspond to the Roundhill GLP-1 & Weight Loss Index. The fund invests in companies that are engaged in the development, production, or sale of GLP-1 receptor agonists and other weight loss drugs.
Reputation and Reliability
Roundhill Investments is known for its thematic ETFs focusing on emerging and disruptive technologies and trends. They have a moderate track record, with some successful niche funds.
Management Expertise
Roundhill's management team has experience in ETF creation and thematic investing, leveraging market trends to build targeted investment products.
Investment Objective
Goal
The ETF aims to provide investors with exposure to companies involved in the rapidly growing GLP-1 and weight loss drug market.
Investment Approach and Strategy
Strategy: The ETF tracks the Roundhill GLP-1 & Weight Loss Index, a rules-based index designed to capture the performance of companies focused on weight loss treatments.
Composition The ETF primarily holds stocks of pharmaceutical companies, biotechnology firms, and other healthcare companies involved in the development, manufacturing, and distribution of GLP-1 receptor agonists and other weight loss related products and services.
Market Position
Market Share: OZEM is one of the first ETFs focusing specifically on GLP-1 and weight loss, giving it a relatively high market share in this nascent niche.
Total Net Assets (AUM): 116900000
Competitors
Key Competitors
- DRUG
- IHE
- PJP
- XHE
Competitive Landscape
The ETF industry for the GLP-1 and weight loss market is still in its early stages. OZEM, as one of the first entrants, benefits from a first-mover advantage. Competitors are more broadly diversified healthcare ETFs which don't focus solely on weight loss, providing less concentrated exposure. OZEM's specific focus is an advantage for investors seeking targeted exposure, but it can also be a disadvantage if the weight loss sector underperforms the broader healthcare market.
Financial Performance
Historical Performance: Historical performance data is relatively limited given the ETF's recent inception. Performance should be tracked against the Roundhill GLP-1 & Weight Loss Index.
Benchmark Comparison: The ETF's performance should be compared to its underlying index, the Roundhill GLP-1 & Weight Loss Index, to assess tracking error.
Expense Ratio: 0.59
Liquidity
Average Trading Volume
The average trading volume is moderate, which might impact the ease of buying and selling large blocks of shares.
Bid-Ask Spread
The bid-ask spread is generally reasonable, reflecting moderate liquidity, but investors should be mindful of this cost, especially for larger trades.
Market Dynamics
Market Environment Factors
Growth in the GLP-1 drug market is being driven by increasing awareness of obesity and diabetes, advancements in pharmaceutical research, and increased regulatory approvals. Changing demographics, such as aging populations and rising obesity rates, also contribute to growth.
Growth Trajectory
The ETF's growth trajectory is closely tied to the success and adoption of GLP-1 drugs. Potential changes in strategy could include expanding the index to include adjacent markets or modifying the weighting methodology.
Moat and Competitive Advantages
Competitive Edge
OZEM's primary advantage is its highly specialized focus on the GLP-1 and weight loss drug market, providing targeted exposure that broader healthcare ETFs cannot replicate. As a first mover in the thematic ETF space, it benefits from greater visibility and potential for asset growth. Furthermore, the association with Roundhill investments and their specialized ETF structure provides a competitive edge. The ETF may attract investors seeking a concentrated bet on the future of weight loss treatments.
Risk Analysis
Volatility
The ETF's volatility is expected to be relatively high, reflecting the growth-oriented nature of the companies it holds.
Market Risk
Specific risks include regulatory hurdles for new drugs, competition among pharmaceutical companies, and potential side effects or safety concerns related to GLP-1 drugs. Market sentiment towards the weight loss sector and overall healthcare industry can also impact performance.
Investor Profile
Ideal Investor Profile
The ideal investor is someone who is interested in the biotechnology and pharmaceutical industries, has a high-risk tolerance, and believes in the growth potential of the weight loss market.
Market Risk
This ETF is best suited for long-term investors who are comfortable with the potential volatility and are looking for targeted exposure to a specific growth area within the healthcare sector.
Summary
The Roundhill GLP-1 & Weight Loss ETF (OZEM) offers targeted exposure to companies involved in the burgeoning GLP-1 and weight loss drug market. As a thematic ETF, OZEM presents a focused investment opportunity with significant growth potential, although it's subject to higher volatility. Ideal investors are those with a high-risk tolerance and a long-term investment horizon. The success of OZEM is dependent on the continued growth and adoption of GLP-1 therapies, but also presents certain risk related to regulatory and political factors.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Roundhill Investments website
- ETF.com
- Bloomberg
Disclaimers:
The data provided is for informational purposes only and should not be considered financial advice. Past performance is not indicative of future results. Investors should consult with a qualified financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Roundhill GLP-1 & Weight Loss ETF
Exchange NASDAQ | Headquaters - | ||
IPO Launch date - | CEO - | ||
Sector - | Industry - | Full time employees - | Website |
Full time employees - | Website |
The fund's manager will invest at least 80% of its net assets (plus any borrowings for investment purposes) in the equity securities of GLP-1 & Weight Loss Companies or any derivative instruments (such as swap agreements or forward contracts) that utilize one or more GLP-1 & Weight Loss Companies as the reference asset. The fund is non-diversified.

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