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ALPS Medical Breakthroughs ETF (SBIO)

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Upturn Advisory Summary
12/11/2025: SBIO (2-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type ETF | Historic Profit 112.49% | Avg. Invested days 86 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating ![]() | Upturn Advisory Performance | ETF Returns Performance |
Key Highlights
Volume (30-day avg) - | Beta 0.72 | 52 Weeks Range 22.33 - 41.27 | Updated Date 06/29/2025 |
52 Weeks Range 22.33 - 41.27 | Updated Date 06/29/2025 |
Upturn AI SWOT
ALPS Medical Breakthroughs ETF
ETF Overview
Overview
The ALPS Medical Breakthroughs ETF (SBIO) focuses on companies involved in the research and development of treatments and technologies that have the potential to significantly advance medical care. Its target sector is primarily biotechnology and pharmaceuticals, with an emphasis on companies that are on the cusp of bringing innovative medical breakthroughs to market. The investment strategy involves identifying and investing in companies with strong clinical pipelines and significant growth potential.
Reputation and Reliability
ALPS Funds is a well-established issuer known for providing specialized ETFs. They have a track record of offering thematic and sector-specific investment products, aiming to provide investors with targeted exposure to various market segments.
Management Expertise
The management team behind SBIO typically comprises experienced professionals with expertise in the healthcare and biotechnology sectors, focusing on identifying companies with promising scientific advancements and regulatory pathways.
Investment Objective
Goal
The primary investment goal of the ALPS Medical Breakthroughs ETF is to provide capital appreciation by investing in companies that are expected to benefit from the development and commercialization of new medical treatments and technologies.
Investment Approach and Strategy
Strategy: SBIO aims to provide targeted exposure to the medical breakthroughs sector rather than tracking a broad market index. Its strategy is actively managed, selecting companies based on their innovation, clinical trial progress, and potential for significant market impact.
Composition The ETF primarily holds equities of companies within the biotechnology and pharmaceutical industries. These companies are typically small- to mid-cap, focused on research and development, and may not yet be profitable.
Market Position
Market Share: Specific market share data for thematic ETFs like SBIO is often not granularly reported in the same way as broad market ETFs. However, it occupies a niche within the broader healthcare ETF landscape.
Total Net Assets (AUM): As of recent data, the Total Net Assets (AUM) for SBIO are approximately $1.2 billion. (Note: This figure is subject to change and should be verified with the latest available data).
Competitors
Key Competitors
- VanEck Biotech ETF (BBH)
- iShares Biotechnology ETF (IBB)
- SPDR S&P Biotech ETF (XBI)
Competitive Landscape
The biotechnology ETF market is competitive, with several large, well-established ETFs dominating. SBIO's competitive advantage lies in its specific focus on 'breakthrough' companies, often smaller and earlier-stage than those held by broader biotech ETFs. However, this focus also presents a disadvantage in terms of liquidity and potentially higher volatility compared to larger, more diversified competitors.
Financial Performance
Historical Performance: Historical performance data for SBIO shows varied results, often reflecting the high-risk, high-reward nature of its holdings. For example, over the past 1-year, 3-year, and 5-year periods, returns have ranged significantly, with periods of substantial gains and losses. (Specific numerical data for all periods is not provided in this JSON for brevity but would typically be found on financial data platforms).
Benchmark Comparison: SBIO's benchmark is typically the Nasdaq Biotechnology Index (NBI). Its performance relative to the NBI can fluctuate, with SBIO sometimes outperforming due to successful individual company developments and sometimes underperforming due to the volatility of its specific focus.
Expense Ratio: 0.55
Liquidity
Average Trading Volume
The average trading volume for SBIO is moderate, indicating reasonable liquidity for most investors.
Bid-Ask Spread
The bid-ask spread for SBIO is generally tighter than for very small-cap stocks but can be wider than for larger, more actively traded ETFs.
Market Dynamics
Market Environment Factors
Factors influencing SBIO include FDA approval rates, advancements in gene editing and personalized medicine, overall healthcare spending, interest rate policies, and investor sentiment towards speculative growth stocks. The sector is highly sensitive to clinical trial results and regulatory news.
Growth Trajectory
The growth trajectory of SBIO is tied to the success of the companies it invests in. Recent trends show a continued interest in innovative healthcare solutions, but the fund's holdings can change as companies advance through clinical stages or are acquired.
Moat and Competitive Advantages
Competitive Edge
SBIO's competitive edge is its specialized focus on companies poised for significant medical breakthroughs. This niche strategy allows for concentrated exposure to potentially high-growth, disruptive innovators that might be diluted in broader healthcare or biotechnology ETFs. The fund's management team's expertise in identifying early-stage, promising scientific advancements is another key differentiator, aiming to capture outsized returns from these select companies.
Risk Analysis
Volatility
SBIO exhibits higher historical volatility compared to broad market ETFs due to its concentration in smaller, development-stage biotechnology companies. These companies are subject to significant price swings based on clinical trial outcomes and regulatory decisions.
Market Risk
The primary market risks for SBIO include regulatory hurdles, clinical trial failures, intense competition within the pharmaceutical and biotech industries, patent expirations, and adverse changes in healthcare policy. Furthermore, the individual stock risk within the ETF can be substantial, as the success or failure of a few key holdings can significantly impact overall fund performance.
Investor Profile
Ideal Investor Profile
The ideal investor for SBIO is an individual or institution with a high-risk tolerance, a long-term investment horizon, and a strong belief in the potential of disruptive medical innovation. Investors should understand the inherent volatility and speculative nature of the underlying companies.
Market Risk
SBIO is best suited for long-term investors seeking growth opportunities in the cutting-edge of healthcare. It is generally not recommended for short-term traders or investors seeking stable, income-generating investments.
Summary
The ALPS Medical Breakthroughs ETF (SBIO) offers targeted exposure to innovative companies in the biotechnology and pharmaceutical sectors, aiming for capital appreciation through medical advancements. While its specialized focus presents opportunities for high growth, it also carries significant volatility and risk, typical of early-stage biotech investments. Its competitive advantage lies in its niche strategy and management's expertise in identifying breakthrough potential, making it suitable for risk-tolerant, long-term investors focused on the future of healthcare.
Similar ETFs
Sources and Disclaimers
Data Sources:
- ALPS Funds Official Website
- Financial Data Providers (e.g., Yahoo Finance, Morningstar, Bloomberg)
Disclaimers:
This information is for illustrative purposes only and should not be considered investment advice. Past performance is not indicative of future results. Investors should conduct their own due diligence and consult with a financial advisor before making any investment decisions. Data points such as AUM and historical performance are subject to change.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About ALPS Medical Breakthroughs ETF
Exchange NYSE ARCA | Headquaters - | ||
IPO Launch date - | CEO - | ||
Sector - | Industry - | Full time employees - | Website |
Full time employees - | Website | ||
The fund employs a passive management - or indexing - investment approach designed to track the performance of the underlying index. It will normally invest at least 80% of its net assets in securities that comprise the underlying index. The underlying index is comprised of small and mid-cap stocks of biotechnology companies that have one or more drugs in either Phase II or Phase III of the U.S. Food and Drug Administration clinical trials.

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