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ALPS Medical Breakthroughs ETF (SBIO)

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Upturn Advisory Summary
10/24/2025: SBIO (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type ETF | Historic Profit 76.68% | Avg. Invested days 78 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating ![]() | Upturn Advisory Performance | ETF Returns Performance |
Key Highlights
Volume (30-day avg) - | Beta 0.72 | 52 Weeks Range 22.33 - 41.27 | Updated Date 06/29/2025 |
52 Weeks Range 22.33 - 41.27 | Updated Date 06/29/2025 |
Upturn AI SWOT
ALPS Medical Breakthroughs ETF
ETF Overview
Overview
The ALPS Medical Breakthroughs ETF (SBIO) seeks to invest in small and mid-cap companies in the healthcare sector that are focused on medical breakthroughs. It targets companies that have one or more drugs in either Phase II or Phase III clinical trials, indicating potential for future growth and innovation.
Reputation and Reliability
ALPS is a well-established ETF provider known for creating thematic and sector-specific ETFs. They have a solid track record and are considered reliable.
Management Expertise
ALPS employs experienced professionals to manage its ETFs, with expertise in the investment and healthcare sectors.
Investment Objective
Goal
The ETF's objective is to provide investment results that correspond generally to the performance of the S&P Health Care Equipment Select Industry Index.
Investment Approach and Strategy
Strategy: The ETF aims to track the performance of an index that focuses on small- and mid-cap companies in the healthcare sector with promising drug pipelines.
Composition The ETF primarily holds stocks of small- and mid-cap biotechnology and pharmaceutical companies.
Market Position
Market Share: SBIO's market share within the broader biotech ETF category is moderate but it focuses on a niche segment of companies with drugs in clinical trials.
Total Net Assets (AUM): 201080000
Competitors
Key Competitors
- iShares Biotechnology ETF (IBB)
- SPDR S&P Biotech ETF (XBI)
- ARK Genomic Revolution ETF (ARKG)
Competitive Landscape
The biotechnology ETF landscape is competitive, with IBB and XBI dominating. SBIO differentiates itself by focusing on companies with drugs in Phase II or Phase III clinical trials, offering targeted exposure but potentially higher risk. ARKG competes in the genomic space.
Financial Performance
Historical Performance: Historical performance data requires specific time series data that can be obtained from financial data providers.
Benchmark Comparison: Benchmark comparison requires specific index data over the same time period, typically the S&P Health Care Equipment Select Industry Index.
Expense Ratio: 0.5
Liquidity
Average Trading Volume
The average trading volume of SBIO is moderate, indicating reasonable liquidity for most investors.
Bid-Ask Spread
The bid-ask spread is typically small but can widen during periods of market volatility, increasing trading costs.
Market Dynamics
Market Environment Factors
SBIO's performance is heavily influenced by factors such as clinical trial results, FDA approvals, regulatory changes, and overall market sentiment towards the biotechnology sector.
Growth Trajectory
The growth trajectory of SBIO depends on the success of its underlying companies' drug development pipelines and their ability to secure FDA approvals and commercialize their products.
Moat and Competitive Advantages
Competitive Edge
SBIO's competitive advantage lies in its targeted approach to investing in companies with drugs in late-stage clinical trials, offering focused exposure to potential medical breakthroughs. This strategy differentiates it from broader biotechnology ETFs. However, this targeted approach also concentrates risk, as the success of the ETF is closely tied to the outcomes of these clinical trials. The specialized focus may appeal to investors with a strong understanding of the biotech industry and a higher risk tolerance.
Risk Analysis
Volatility
SBIO exhibits high volatility due to its focus on small- and mid-cap biotechnology companies, which are inherently more sensitive to market fluctuations and clinical trial outcomes.
Market Risk
Market risk includes regulatory risks, patent expirations, clinical trial failures, and competition from other companies developing similar treatments, all of which can significantly impact the value of SBIO's holdings.
Investor Profile
Ideal Investor Profile
The ideal investor for SBIO is someone with a high-risk tolerance, a long-term investment horizon, and a strong understanding of the biotechnology industry. They should be comfortable with the potential for significant price swings.
Market Risk
SBIO is more suitable for long-term investors who understand the risks and potential rewards of investing in companies with drugs in clinical trials than it is for active traders or passive index followers.
Summary
ALPS Medical Breakthroughs ETF (SBIO) offers targeted exposure to small- and mid-cap biotechnology companies with drugs in late-stage clinical trials, which represents a unique investment proposition. While this focus can potentially lead to high returns, it also comes with significant risks related to clinical trial outcomes and regulatory approvals. SBIO is best suited for investors with a high-risk tolerance and a long-term perspective. The ETF's specialized strategy differentiates it from broader biotechnology ETFs, but its success depends on the advancement and eventual approval of the drugs being developed by its holdings.
Peer Comparison
Sources and Disclaimers
Data Sources:
- ALPS official website
- ETFdb.com
- Morningstar
Disclaimers:
The data provided is for informational purposes only and should not be considered investment advice. Past performance is not indicative of future results. Consult with a financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About ALPS Medical Breakthroughs ETF
Exchange NYSE ARCA | Headquaters - | ||
IPO Launch date - | CEO - | ||
Sector - | Industry - | Full time employees - | Website |
Full time employees - | Website | ||
The fund employs a passive management - or indexing - investment approach designed to track the performance of the underlying index. It will normally invest at least 80% of its net assets in securities that comprise the underlying index. The underlying index is comprised of small and mid-cap stocks of biotechnology companies that have one or more drugs in either Phase II or Phase III of the U.S. Food and Drug Administration clinical trials.

Note: This website is maintained by Upturn Corporation, which is an investment adviser registered with the U.S. Securities and Exchange Commission. Such registration does not imply a certain level of skill or training. Investing in securities has risks. Past performance is no guarantee of future returns. No assurance is provided as to any particular investment return, and you may lose money using our services. You are strongly advised to consult appropriate counsel before making any investments in companies you learn about through our services. You should obtain appropriate legal, tax, investment, accounting, and other advice that takes into account your investment portfolio and overall financial situation. You are solely responsible for conducting due diligence on a potential investment. We do not affect trades for you. You will select your own broker through which to transact. Investments are not FDIC insured, they are not guaranteed, and they may lose value. Please see the Privacy Policy, Terms of Use, and Disclosure for more information.
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