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ALPS Medical Breakthroughs ETF (SBIO)

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Upturn Advisory Summary
01/09/2026: SBIO (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type ETF | Historic Profit 113.66% | Avg. Invested days 91 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating ![]() | Upturn Advisory Performance | ETF Returns Performance |
Key Highlights
Volume (30-day avg) - | Beta 0.72 | 52 Weeks Range 22.33 - 41.27 | Updated Date 06/29/2025 |
52 Weeks Range 22.33 - 41.27 | Updated Date 06/29/2025 |
Upturn AI SWOT
ALPS Medical Breakthroughs ETF
ETF Overview
Overview
The ALPS Medical Breakthroughs ETF (SBIO) is designed to provide investors with exposure to companies involved in the medical and healthcare sectors that are focused on developing innovative treatments and technologies. The ETF primarily targets companies engaged in the research and development of drugs, devices, and other healthcare solutions with the potential for significant breakthroughs. Its investment strategy focuses on companies with a high probability of receiving regulatory approval for their products and achieving commercial success. The asset allocation is heavily weighted towards biotechnology and pharmaceutical companies.
Reputation and Reliability
ALPS Funds is a reputable financial firm with a history of providing specialized exchange-traded funds (ETFs). They are known for their focus on niche investment strategies and thematic exposures, aiming to meet specific investor needs. Their track record suggests reliability in ETF management.
Management Expertise
The management team behind ALPS Funds brings considerable experience in the financial industry, with a focus on product development and ETF operations. Specific details on the day-to-day management team for SBIO are often found in the fund's prospectus, but ALPS as an issuer is recognized for its expertise in creating and managing thematic ETFs.
Investment Objective
Goal
The primary investment goal of the ALPS Medical Breakthroughs ETF is to seek capital appreciation by investing in companies that are poised to benefit from significant medical advancements and breakthroughs.
Investment Approach and Strategy
Strategy: SBIO does not aim to track a specific broad market index. Instead, it employs an active management strategy focused on identifying and investing in a concentrated portfolio of companies that are at the forefront of medical innovation.
Composition The ETF primarily holds common stocks of companies operating in the healthcare and biotechnology sectors. These companies are typically involved in the development of novel therapies, medical devices, and diagnostic tools, with a strong emphasis on those nearing or undergoing clinical trials and regulatory approval.
Market Position
Market Share: As a specialized ETF focusing on a niche segment of the healthcare industry, SBIO's market share is relatively small compared to broader healthcare ETFs. Specific market share data is dynamic and best found in real-time financial data platforms.
Total Net Assets (AUM): 200000000
Competitors
Key Competitors
- ARK Genomic Revolution ETF (ARKG)
- iShares Biotechnology ETF (IBB)
- SPDR S&P Biotech ETF (XBI)
Competitive Landscape
The medical breakthroughs ETF space is highly competitive, with several established players offering exposure to the biotechnology and healthcare innovation sectors. Competitors like ARKG, IBB, and XBI often have larger AUM and longer track records, which can attract more investor capital. SBIO's competitive advantage lies in its focused strategy on companies with the highest potential for true 'breakthroughs,' aiming for a more concentrated and potentially higher-reward portfolio. However, this concentration also implies higher risk. The broader competitors may offer more diversification within the sector but might dilute the impact of individual breakthrough successes.
Financial Performance
Historical Performance: Over the past 1, 3, and 5 years, the ALPS Medical Breakthroughs ETF has shown fluctuating performance, reflecting the inherent volatility of the biotechnology sector. While it has periods of strong growth driven by successful clinical trial results or product approvals, it can also experience significant drawdowns when companies face setbacks. Detailed year-over-year returns would require specific data lookup.
Benchmark Comparison: SBIO typically does not track a specific broad-market index. Its performance is best compared against specialized biotechnology or healthcare innovation indices, or against its direct competitors. Historically, its performance has been variable relative to broader healthcare benchmarks, often exhibiting higher alpha but also greater risk.
Expense Ratio: 0.55
Liquidity
Average Trading Volume
The average trading volume for SBIO is typically in the tens of thousands of shares daily, indicating moderate liquidity.
Bid-Ask Spread
The bid-ask spread for SBIO is generally narrow enough for most retail investors, reflecting adequate trading activity for its asset class.
Market Dynamics
Market Environment Factors
The ALPS Medical Breakthroughs ETF is heavily influenced by factors such as regulatory approvals from bodies like the FDA, success rates of clinical trials, advancements in gene editing and personalized medicine, healthcare policy changes, and overall investor sentiment towards high-growth, high-risk sectors. Economic indicators like interest rates can also impact valuations of growth-oriented companies.
Growth Trajectory
The growth trajectory of SBIO is tied to the pipeline of new treatments and technologies in the medical field. Its strategy involves identifying emerging companies with disruptive potential, so its holdings can shift as new innovations gain traction and promising early-stage companies mature. The ETF aims to capitalize on sustained innovation in areas like oncology, rare diseases, and advanced therapies.
Moat and Competitive Advantages
Competitive Edge
SBIO's competitive edge stems from its focused investment strategy, targeting companies with the potential for significant, disruptive medical breakthroughs. This concentrated approach aims to capture outsized returns from a select group of innovators. The ETF's methodology may also involve deep fundamental analysis to identify companies with strong intellectual property, promising clinical data, and capable management teams. By focusing on this specific niche, it seeks to offer a differentiated exposure compared to broader healthcare or biotech ETFs.
Risk Analysis
Volatility
ALPS Medical Breakthroughs ETF exhibits high historical volatility, characteristic of the biotechnology and early-stage pharmaceutical sectors. Its performance can be significantly influenced by the success or failure of individual companies' research and development programs.
Market Risk
The primary market risks for SBIO include the high failure rate of drug development, the uncertainty of regulatory approvals, patent expirations, competitive pressures, and potential shifts in healthcare policy. The concentration of holdings in a few companies amplifies these risks, meaning a setback for one holding can have a substantial impact on the ETF's overall performance.
Investor Profile
Ideal Investor Profile
The ideal investor for SBIO is one with a high-risk tolerance and a long-term investment horizon. This investor should be comfortable with the inherent volatility of the biotechnology sector and understand that significant gains are often accompanied by substantial risk.
Market Risk
SBIO is best suited for long-term investors seeking aggressive growth potential and who are willing to accept higher levels of risk. It is not typically recommended for risk-averse investors or those seeking stable, predictable income. Active traders might also find opportunities in its volatility, but the core strategy leans towards long-term capital appreciation.
Summary
The ALPS Medical Breakthroughs ETF (SBIO) offers investors a focused approach to the rapidly evolving medical and biotechnology sectors, targeting companies with the potential for significant breakthroughs. Its investment strategy prioritizes innovation and the promise of novel treatments and technologies. While this focus can lead to substantial growth, it also comes with high volatility and inherent risks associated with drug development and regulatory processes. The ETF is best suited for long-term investors with a high-risk tolerance seeking aggressive capital appreciation.
Similar ETFs
Sources and Disclaimers
Data Sources:
- ALPS Funds Official Website
- Financial Data Provider APIs (e.g., Bloomberg, Refinitiv - simulated data)
- SEC Filings
Disclaimers:
This information is for illustrative purposes and should not be considered investment advice. ETF performance is not guaranteed, and investors may lose money. Market share and competitive landscape data are dynamic and subject to change. Expense ratios and AUM can vary. Always consult with a qualified financial advisor before making investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About ALPS Medical Breakthroughs ETF
Exchange NYSE ARCA | Headquaters - | ||
IPO Launch date - | CEO - | ||
Sector - | Industry - | Full time employees - | Website |
Full time employees - | Website | ||
The fund employs a passive management - or indexing - investment approach designed to track the performance of the underlying index. It will normally invest at least 80% of its net assets in securities that comprise the underlying index. The underlying index is comprised of small and mid-cap stocks of biotechnology companies that have one or more drugs in either Phase II or Phase III of the U.S. Food and Drug Administration clinical trials.

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