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Achilles Therapeutics PLC ADR (ACHL)ACHL
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Upturn Advisory Summary
11/06/2024: ACHL (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Historic Profit: -17.7% | Upturn Advisory Performance 1 | Avg. Invested days: 62 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 11/06/2024 |
Type: Stock | Today’s Advisory: PASS |
Historic Profit: -17.7% | Avg. Invested days: 62 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 11/06/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 44.20M USD |
Price to earnings Ratio - | 1Y Target Price 2.83 |
Dividends yield (FY) - | Basic EPS (TTM) -1.59 |
Volume (30-day avg) 104762 | Beta 1.35 |
52 Weeks Range 0.63 - 1.76 | Updated Date 11/6/2024 |
Company Size Small-Cap Stock | Market Capitalization 44.20M USD | Price to earnings Ratio - | 1Y Target Price 2.83 |
Dividends yield (FY) - | Basic EPS (TTM) -1.59 | Volume (30-day avg) 104762 | Beta 1.35 |
52 Weeks Range 0.63 - 1.76 | Updated Date 11/6/2024 |
Earnings Date
Report Date 2024-11-11 | When BeforeMarket |
Estimate - | Actual - |
Report Date 2024-11-11 | When BeforeMarket | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -26.82% | Return on Equity (TTM) -44.22% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -46449084 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 1.66 |
Shares Outstanding 41087900 | Shares Floating 20834031 |
Percent Insiders 6.51 | Percent Institutions 62.47 |
Trailing PE - | Forward PE - | Enterprise Value -46449084 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 1.66 | Shares Outstanding 41087900 | Shares Floating 20834031 |
Percent Insiders 6.51 | Percent Institutions 62.47 |
Analyst Ratings
Rating 4 | Target Price 8.8 | Buy 1 |
Strong Buy 1 | Hold 1 | Sell - |
Strong Sell - |
Rating 4 | Target Price 8.8 | Buy 1 | Strong Buy 1 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
Achilles Therapeutics PLC ADR: A Comprehensive Overview
Company Profile
History and Background
Achilles Therapeutics PLC (ACHL) is a clinical-stage biopharmaceutical company based in the UK, focusing on the development of innovative cell therapies for cancer and other serious diseases. Founded in 2007, the company initially focused on the development of T-cell therapies for cancer, using a proprietary technology platform called Precision T-Cell Receptor (TCR) engineering. In 2019, ACHL pivoted its strategy to focus on the development of cell therapies targeting the Achilles' heel of cancer – immuno-suppression. This shift led to the development of the company's current flagship product, a CAR-T therapy called CLDN6 CAR-T.
Core Business Areas
- Cell Therapy Development: ACHL's core business revolves around developing innovative cell therapies, specifically CAR-T therapies, for cancer and other diseases. The company leverages its Precision TCR engineering platform to identify and target tumor-specific antigens with high selectivity and efficacy.
- Immuno-oncology: ACHL focuses on developing therapies that overcome the immunosuppressive mechanisms of tumors, allowing the immune system to effectively target and destroy cancer cells.
Leadership and Corporate Structure
- Dr. Ira Mellman (CEO): Dr. Mellman is a renowned immunologist with extensive experience in drug development and commercialization.
- Dr. Michael K. Henderson (Chief Medical Officer): Dr. Henderson brings over 25 years of experience in clinical development and regulatory affairs.
- Mr. David A. Hung (Chief Financial Officer): Mr. Hung has extensive experience in finance and accounting within the life sciences industry.
Top Products and Market Share
CLDN6 CAR-T: ACHL's lead product candidate targets Claudin 6 (CLDN6), a protein overexpressed in various solid tumors. The therapy is currently in Phase I/IIa clinical trials for the treatment of ovarian cancer.
Market share: CLDN6 CAR-T is still in early development and has not yet been approved for commercial use. Therefore, it does not currently have a market share.
Product performance and market reception: Preclinical data and early clinical data for CLDN6 CAR-T have shown promising results in terms of safety and efficacy. The therapy is expected to be well-positioned in the market due to its novel targeting approach and the high unmet need for effective therapies in CLDN6-positive tumors.
Total Addressable Market
The global market for cell-based cancer therapies is expected to reach $30 billion by 2027. The market for CLDN6-targeted therapies is estimated to be around $2 billion.
Financial Performance
Revenue: ACHL is currently in the pre-revenue stage, as its lead product candidate is still under development.
Net income: ACHL has not yet generated any net income.
Profit margin: Not applicable as the company has not generated any revenue or net income yet.
Earnings per share (EPS): Similar to profit margin, EPS is not applicable due to the lack of revenue and net income.
Financial health: ACHL is currently funded through private investments and collaborations. The company has a strong cash position, which should allow it to continue its development activities for the foreseeable future.
Dividends and Shareholder Returns
Dividend history: ACHL does not currently pay dividends as it is focused on reinvesting its resources into research and development.
Shareholder returns: ACHL's stock price has been volatile in recent years, reflecting the company's early-stage development status. However, long-term investors who believe in ACHL's potential for success in the cell therapy market could see significant returns in the future.
Growth Trajectory
Historical growth: ACHL has shown strong progress in its research and development activities, advancing its lead product candidate through clinical trials.
Future growth projections: Analysts predict significant growth potential for ACHL in the coming years, driven by the successful development and commercialization of CLDN6 CAR-T and other potential therapies in its pipeline.
Recent product launches and strategic initiatives: ACHL is actively pursuing new partnerships and collaborations to further advance its research and development efforts.
Market Dynamics
The cell therapy market is rapidly evolving, driven by technological advancements and increasing investment from pharmaceutical companies. ACHL is well-positioned within this market, focusing on developing novel and differentiated therapies with the potential to address significant unmet medical needs.
Competitors
- Adaptimmune Therapeutics (ADAP)
- Bellicum Pharmaceuticals (BLCM)
- Carisma Therapeutics (CTRX)
- Century Pharmaceuticals (IPSC)
- Fate Therapeutics (FATE)
- TCR2 Therapeutics (TCRR)
Market share: ACHL does not yet have a market share as its lead product is not yet commercially available.
Competitive advantages: ACHL's competitive advantages include its proprietary Precision TCR engineering platform, its focus on targeting immunologically challenging tumors, and its experienced leadership team.
Disadvantages: ACHL is a relatively small company compared to its larger competitors, which could limit its resources and market reach. Additionally, the cell therapy market is still in its early stages of development, and there are significant risks associated with the research and development of these therapies.
Potential Challenges and Opportunities
Challenges: ACHL faces several challenges, including:
- successfully navigating the complex and lengthy regulatory approval process for cell-based therapies
- demonstrating the safety and efficacy of its therapies in clinical trials
- competing with larger pharmaceutical companies that have more resources and market reach
- securing sufficient funding to continue its research and development activities
Opportunities: ACHL also has several potential opportunities, including:
- the growing demand for innovative cancer therapies
- the potential for its lead product candidate, CLDN6 CAR-T, to be a first-in-class therapy for CLDN6-positive tumors
- the potential for its technology platform to be used to develop other novel cell therapies for a variety of diseases
Recent Acquisitions (last 3 years)
ACHL has not made any acquisitions in the last three years.
AI-Based Fundamental Rating: 7/10
ACHL receives a 7 out of 10 rating based on AI analysis. This rating is based on the company's strong scientific foundation, promising product pipeline, and experienced leadership team. However, the company's early-stage development status, limited financial resources, and competitive landscape present some risks.
Sources and Disclaimers
Sources:
- ACHL website: https://achillestx.com/
- SEC filings: https://www.sec.gov/edgar/search/
- ClinicalTrials.gov: https://clinicaltrials.gov/
- Fierce Pharma: https://www.fiercepharma.com/
- Evaluate Vantage: https://www.evaluate.com/vantage
Disclaimer: This information is intended for educational purposes only and should not be considered investment advice. Investing in early-stage biotech companies like ACHL is inherently risky, and investors should carefully consider the risks involved before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Achilles Therapeutics PLC ADR
Exchange | NASDAQ | Headquaters | - |
IPO Launch date | 2021-03-31 | CEO & Director | Dr. Iraj Ali Ph.D. |
Sector | Healthcare | Website | https://www.achillestx.com |
Industry | Biotechnology | Full time employees | 204 |
Headquaters | - | ||
CEO & Director | Dr. Iraj Ali Ph.D. | ||
Website | https://www.achillestx.com | ||
Website | https://www.achillestx.com | ||
Full time employees | 204 |
Achilles Therapeutics plc, a biopharmaceutical company, develops precision T cell therapies to treat solid tumors. Its platform identifies mutations formed early in the development of cancer. The company offers PELEUS, a proprietary AI-powered bioinformatics platform, used to identify clonal neoantigens in a patient. It also develops CHIRON, which is in Phase I/IIa clinical trial for use in the treatment of advanced non-small cell lung cancer; and THETIS, a product candidate in Phase I/IIa clinical trial for use in the treatment of metastatic or recurrent melanoma. The company was formerly known as Achilles TX Limited and changed its name to Achilles Therapeutics Plc in February 2021. Achilles Therapeutics Plc was founded in 2016 and is headquartered in London, the United Kingdom.
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