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Upturn AI Summary - About
Agenus Inc(AGEN)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for AGEN
10/23/2026: AGEN (1-star) is currently NOT-A-BUY. Pass it for now.
Agenus Inc is a clinical-stage biotechnology company developing immuno-oncology therapies designed to activate the immune system against cancer. Its business strengths lie in a robust pipeline of checkpoint inhibitors, like botensilimab, and a proven adjuvant technology used by vaccine partners. The primary investment story rests on the potential regulatory success of its late-stage clinical assets. However, the company faces significant execution, financial, and competitive risks, as it currently lacks commercial-stage products and relies on external funding. Agenus best suits risk-tolerant investors who monitor clinical trial data and partnership updates, keeping in mind that valuation is highly speculative due to the absence of consistent profitability.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Mixed fit | The company offers high-growth potential if clinical assets succeed, but it carries the significant risk of a speculative biotech. |
| Momentum investor | Strong fit while signal remains positive | Momentum traders may focus on the stock during clinical trial reporting windows or significant partnership news. |
| Value investor | Weak fit | The company lacks the earnings and cash flow metrics required for traditional value-based investment strategies. |
| Dividend investor | Weak fit | Agenus does not pay a dividend and is not expected to in the near-term given its R&D requirements. |
| Low-risk investor | Weak fit | The company exhibits high volatility and clinical risk, making it unsuitable for capital preservation goals. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | Clinical-stage biotech stocks frequently experience sharp price swings based on trial results and regulatory updates. |
| Valuation risk | Medium / high | Without commercial revenue, valuation is highly dependent on subjective assessments of future pipeline success. |
| Competition risk (oncology immunotherapy) | High | Agenus competes against multi-billion dollar companies that have deeper resources to defend their market share. |
| Business quality | Medium | While the platform and intellectual property are robust, the business model currently depends on external funding. |
| Dividend income | Low / none | No dividends are paid, so investors rely entirely on capital appreciation. |
| Execution risk | High | Success depends on complex, multi-year clinical trial execution and favorable regulatory outcomes. |
Price Behavior
Strong Uptrend
The stock has maintained a strong upward price trend across the last three quarters.
Extreme Price Shocks
The stock has experienced exceptionally large and disruptive price movements during the period.
Analysis of Past Performance
Type Stock | Historic Profit -51.64% | Avg. Invested days 26 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  2.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 10/23/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 285.87M USD | Price to earnings Ratio 2.45 | 1Y Target Price 26.33 |
Price to earnings Ratio 2.45 | 1Y Target Price 26.33 | ||
Volume (30-day avg) 1.0M shares | Beta 1.32 | 52 Weeks Range 2.71 - 10.31 | Updated Date 10/25/2026 |
52 Weeks Range 2.71 - 10.31 | Updated Date 10/25/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) 2.58 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| License Fees and Royalties | Revenue from the QS-21 Stimulon adjuvant platform licensed to partners. | The company earns money by providing key ingredients for other companies' vaccines. |
| Research & Development Collaborations | Payments received for entering into strategic partnerships for drug development. | Big pharma pays Agenus to help share the cost and reward of developing new cancer drugs. |
Analyzing Revenue: Products, Geography and Growth
Revenue by Products
Product revenue - Year on Year
Revenue by Geography
Geography revenue - Year on Year
Valuation
Trailing PE 2.45 | Forward PE 3.73 | Enterprise Value 348.04M | Price to Sales(TTM) 2.15 |
Enterprise Value 348.04M | Price to Sales(TTM) 2.15 | ||
Enterprise Value to Revenue 2.62 | Enterprise Value to EBITDA 2.23 | Shares Outstanding 45.16M | Shares Floating 40.23M |
Shares Outstanding 45.16M | Shares Floating 40.23M | ||
Percent Insiders 6.27 | Percent Institutions 46.41 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
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