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APLT logo APLT
Upturn stock ratingUpturn stock rating
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Applied Therapeutics Inc (APLT)

Upturn stock ratingUpturn stock rating
$0.31
Last Close (24-hour delay)
upturn advisory
PASS
  • BUY Advisory
  • SELL Advisory (Profit)​
  • SELL Advisory (Loss)​
  • Profit
  • Loss
  • Pass (Skip investing)
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
  • YEAR
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Upturn Advisory Summary

06/30/2025: APLT (1-star) is currently NOT-A-BUY. Pass it for now.

Upturn Star Rating

rating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

4 Analysts rated it

Limited analyst coverage, niche firm, research info may be scarce.

1 Year Target Price $5.62

1 Year Target Price $5.62

Analysts Price Target For last 52 week
$5.62Target price
Low$0.3
Current$0.31
high$10.62

Analysis of Past Performance

Type Stock
Historic Profit -60.34%
Avg. Invested days 26
Today’s Advisory PASS
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 2.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 06/30/2025

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 45.84M USD
Price to earnings Ratio -
1Y Target Price 5.62
Price to earnings Ratio -
1Y Target Price 5.62
Volume (30-day avg) 4
Beta 1.87
52 Weeks Range 0.29 - 10.62
Updated Date 06/30/2025
52 Weeks Range 0.29 - 10.62
Updated Date 06/30/2025
Dividends yield (FY) -
Basic EPS (TTM) -0.24

Analyzing Revenue: Products, Geography and Growth

Revenue by Products

Product revenue - Year on Year

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -
Operating Margin (TTM) -41030.57%

Management Effectiveness

Return on Assets (TTM) -65.3%
Return on Equity (TTM) -83.71%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 370987
Price to Sales(TTM) 172.99
Enterprise Value 370987
Price to Sales(TTM) 172.99
Enterprise Value to Revenue 1.4
Enterprise Value to EBITDA -9.71
Shares Outstanding 141576000
Shares Floating 117715803
Shares Outstanding 141576000
Shares Floating 117715803
Percent Insiders 5.49
Percent Institutions 83.05

Analyst Ratings

Rating 2
Target Price 5.62
Buy -
Strong Buy 2
Buy -
Strong Buy 2
Hold 2
Sell -
Strong Sell -
Strong Sell -

ai summary icon Upturn AI SWOT

Applied Therapeutics Inc

stock logo

Company Overview

overview logo History and Background

Applied Therapeutics, Inc. is a clinical-stage biopharmaceutical company founded in 2016. It focuses on developing novel therapies for unmet medical needs in rare, debilitating, and life-threatening diseases.

business area logo Core Business Areas

  • Drug Development: Development of small molecule drugs targeting specific diseases.
  • Clinical Trials: Conducting clinical trials to evaluate the safety and efficacy of its drug candidates.

leadership logo Leadership and Structure

Shoshana Shendelman is the CEO and President. The company has a standard organizational structure with departments focused on research, development, clinical operations, and finance.

Top Products and Market Share

overview logo Key Offerings

  • Govorestat: A central nervous system penetrant Aldose Reductase Inhibitor (ARI) currently undergoing trials for treatment of Sorbitol Dehydrogenase (SORD) Deficiency, and Galactosemia. The market is niche but addresses a critical unmet need. Competitors include companies developing gene therapies and other novel treatments for rare metabolic disorders.
  • Cafenoresone: A novel PPARu03b3 agonist being developed for Diabetic Cardiomyopathy (DCM). It is currently in Phase 3 trials. Competitors include existing heart failure medications and other companies developing therapies for DCM.

Market Dynamics

industry overview logo Industry Overview

The biopharmaceutical industry is characterized by high R&D costs, regulatory hurdles, and competition. Companies like Applied Therapeutics focus on niche markets with high unmet needs.

Positioning

Applied Therapeutics is positioned as a developer of therapies for rare and underserved diseases. Their competitive advantage lies in their targeted approach and novel drug candidates.

Total Addressable Market (TAM)

The TAM varies depending on the specific disease target. SORD Deficiency affects a small population, while Diabetic Cardiomyopathy has a larger patient base. The company is positioned to capture a significant share of these niche markets if their therapies are approved.

Upturn SWOT Analysis

Strengths

  • Novel drug candidates
  • Focus on unmet medical needs
  • Experienced management team

Weaknesses

  • Limited financial resources
  • Dependence on clinical trial success
  • Single clinical failure can reduce the stock value significantly

Opportunities

  • Regulatory approvals
  • Expansion into new therapeutic areas
  • Partnerships with larger pharmaceutical companies

Threats

  • Clinical trial failures
  • Competition from other pharmaceutical companies
  • Regulatory changes

Competitors and Market Share

competitor logo Key Competitors

  • VRTX
  • BMY
  • LLY

Competitive Landscape

Applied Therapeutics faces competition from established pharmaceutical companies with greater resources and expertise. However, its focus on niche markets and novel drug candidates provides a competitive advantage.

Growth Trajectory and Initiatives

Historical Growth: Historical growth is primarily driven by pipeline advancements and stock price appreciation. Requires Data Updates.

Future Projections: Future growth depends on the successful completion of clinical trials and regulatory approvals. Analyst estimates vary but generally positive if drugs are approved.

Recent Initiatives: Focusing on completing pivotal trials for Govorestat and Cafenoresone, and advancing other pipeline programs.

Summary

Applied Therapeutics is a clinical-stage biopharmaceutical company with promising drug candidates targeting rare diseases. The company's success hinges on the outcome of its clinical trials and regulatory approvals. While it faces financial challenges common to biotech companies, its focus on unmet needs and innovative therapies offers growth potential. Investors should closely monitor clinical trial results and regulatory decisions.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Applied Therapeutics Investor Relations
  • SEC Filings
  • Analyst Reports

Disclaimers:

This analysis is for informational purposes only and should not be considered investment advice. Data accuracy is not guaranteed. Consult with a financial advisor before making any investment decisions.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Applied Therapeutics Inc

Exchange NASDAQ
Headquaters New York, NY, United States
IPO Launch date 2019-05-14
Interm CEO, CFO, Principal Financial Officer & Director Mr. Les D. Funtleyder
Sector Healthcare
Industry Biotechnology
Full time employees 36
Full time employees 36

Applied Therapeutics, Inc., a clinical-stage biopharmaceutical company, engages in the development of a pipeline of novel product candidates against validated molecular targets in indications of high unmet medical need in the United States. The company's lead product candidate is AT-007 that has completed phase 3 for the treatment of galactosemia in healthy volunteers and adults, in pediatric clinical study for the treatment of galactosemia in kids, for treating enzyme sorbitol dehydrogenase, and for the treatment of phosphomannomutase enzyme-CDG. It develops AT-001 that is in phase 3 clinical trials to treat diabetic cardiomyopathy, as well as for the treatment of diabetic peripheral neuropathy; and AT-003, which is in preclinical studies for the treatment diabetic retinopathy. The company has exclusive license and supply agreement with Mercury Pharma Group Limited to commercialize drug products containing AT-007. Applied Therapeutics, Inc. was incorporated in 2016 and is headquartered in New York, New York.