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Aprea Therapeutics Inc(APRE)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for APRE
11/12/2026: APRE (1-star) is currently NOT-A-BUY. Pass it for now.
Aprea Therapeutics is a clinical-stage biotechnology company developing targeted therapies for solid tumors by focusing on DNA damage response pathways. The company relies on a lean operating model to advance its ATR and WEE1/PKMYT1 inhibitor programs. Its primary growth opportunity lies in successful clinical validation and potential licensing partnerships with larger pharmaceutical firms. However, investors must consider high risks, including the absence of commercial revenue, significant execution uncertainty in clinical trials, and intense competition from well-capitalized industry incumbents. The stock is best suited for speculative growth investors with a high risk tolerance who are closely monitoring upcoming clinical data releases for meaningful development milestones.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Mixed fit | The company offers high-risk, high-reward potential based on clinical success, but lacks the established growth metrics of mature firms. |
| Momentum investor | Mixed fit | Momentum may occur around specific clinical trial data releases, but the stock remains speculative and highly volatile. |
| Value investor | Weak fit | The company lacks earnings, book value, or cash flow to support traditional value investing methodologies. |
| Dividend investor | Weak fit | Aprea is a clinical-stage biotech that does not provide income through dividends. |
| Low-risk investor | Weak fit | The inherent risks of clinical-stage biotech development create extreme volatility unsuitable for risk-averse investors. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | Clinical-stage biotech stocks often experience extreme swings based on trial results and regulatory news. |
| Valuation risk | High | Without commercial revenue, valuation is speculative and highly sensitive to management execution. |
| Competition risk (Oncology/DDR) | High | Large incumbents with more resources are aggressively pursuing similar pathways, which could render Aprea's efforts obsolete. |
| Business quality | Medium | While the science is specialized, the company lacks the commercial infrastructure and balance sheet strength of larger peers. |
| Dividend income | Low / none | The company is focused on R&D and has no history or outlook for paying dividends. |
| Execution risk | High | Clinical trial success is highly uncertain, and failures can significantly impair shareholder value. |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 6.31M USD | Price to earnings Ratio - | 1Y Target Price 3.3 |
Price to earnings Ratio - | 1Y Target Price 3.3 | ||
Volume (30-day avg) 177.9K shares | Beta 1.69 | 52 Weeks Range 0.41 - 1.29 | Updated Date 11/12/2026 |
52 Weeks Range 0.41 - 1.29 | Updated Date 11/12/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.57 |
Sector & Industry Intelligence
Sector
Healthcare
Bullish- Sentiment
- Strong Bullish
- Momentum
- Momentum Steady
- BUY participation
- 62.6%
- Active BUY / eligible
- 72 / 115
- 30-Day BUY Count Change
- +35
- Market state
- Strong Bullish
The number of qualifying BUY stocks has remained relatively stable.
Industry
Biotechnology
- BUY participation
- 45.5%
- Active BUY / eligible
- 20 / 44
- 30-Day BUY Count Change
- +13
Sector signal summarizes BUY breadth conditions for the sector. It does not override this stock’s BUY, SELL, or PASS advisory.
Price Behavior
Steep Decline
The stock price has dropped sharply with strong downward pressure.
Extreme Price Shocks
The stock has experienced exceptionally large and disruptive price movements during the period.
Analysis of Past Performance
Type Stock | Historic Profit -44.49% | Avg. Invested days 22 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  2.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 11/12/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Clinical Development | Research, development, and eventual licensing or commercialization of oncology assets. | The company does not currently sell products; investors are betting on the future value of their experimental cancer drugs. |
Valuation
Trailing PE - | Forward PE - | Enterprise Value -31.54M | Price to Sales(TTM) 1216.58 |
Enterprise Value -31.54M | Price to Sales(TTM) 1216.58 | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.35 | Shares Outstanding 14.19M | Shares Floating 7.90M |
Shares Outstanding 14.19M | Shares Floating 7.90M | ||
Percent Insiders 9.17 | Percent Institutions 18.83 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
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