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AXSM
Upturn stock ratingUpturn stock rating

Axsome Therapeutics Inc (AXSM)

Upturn stock ratingUpturn stock rating
$102.89
Last Close (24-hour delay)
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PASS
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  • SELL Advisory (Loss)​
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Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
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  • ALL
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Upturn Advisory Summary

06/18/2025: AXSM (1-star) is currently NOT-A-BUY. Pass it for now.

Upturn Star Rating

ratingratingratingratingrating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

19 Analysts rated it

These Stocks/ETFs, based on Upturn Advisory, have historically outperformed the market, making them a top-tier choice for investors.

Year Target Price $178.1

Year Target Price $178.1

Analyst’s Price TargetsFor last 52 week
$178.1Target price
Low$72.21
Current$102.89
high$139.13

Analysis of Past Performance

Type Stock
Historic Profit -21.95%
Avg. Invested days 32
Today’s Advisory PASS
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 2.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 06/18/2025

Key Highlights

Company Size Mid-Cap Stock
Market Capitalization 5.09B USD
Price to earnings Ratio -
1Y Target Price 177.05
Price to earnings Ratio -
1Y Target Price 177.05
Volume (30-day avg) -
Beta 0.47
52 Weeks Range 72.21 - 139.13
Updated Date 06/29/2025
52 Weeks Range 72.21 - 139.13
Updated Date 06/29/2025
Dividends yield (FY) -
Basic EPS (TTM) -5.77

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -64.39%
Operating Margin (TTM) -45.67%

Management Effectiveness

Return on Assets (TTM) -26.17%
Return on Equity (TTM) -282.16%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 4999392686
Price to Sales(TTM) 11.78
Enterprise Value 4999392686
Price to Sales(TTM) 11.78
Enterprise Value to Revenue 11.57
Enterprise Value to EBITDA -14.81
Shares Outstanding 49236400
Shares Floating 38316232
Shares Outstanding 49236400
Shares Floating 38316232
Percent Insiders 16.43
Percent Institutions 77.28

Analyst Ratings

Rating 4.74
Target Price 178.1
Buy 5
Strong Buy 14
Buy 5
Strong Buy 14
Hold -
Sell -
Strong Sell -
Strong Sell -

ai summary icon Upturn AI SWOT

Axsome Therapeutics Inc

stock logo

Company Overview

overview logo History and Background

Axsome Therapeutics Inc. was founded in 2012. It is a biopharmaceutical company focused on developing novel therapies for central nervous system (CNS) disorders. Key milestones include the FDA approvals of Auvelity and Sunosi (acquired).

business area logo Core Business Areas

  • CNS Therapeutics Development: Focuses on developing and commercializing novel therapies for CNS conditions, including depression, Alzheimer's disease agitation, and narcolepsy.

leadership logo Leadership and Structure

Herriot Tabuteau, MD, is the CEO. The company has a board of directors overseeing strategic decisions. The organizational structure includes departments for research, clinical development, commercial operations, and finance.

Top Products and Market Share

overview logo Key Offerings

  • Auvelity: Auvelity is an oral NMDA receptor antagonist and sigma-1 receptor agonist indicated for the treatment of major depressive disorder (MDD). Competitors include SSRIs, SNRIs, and other antidepressants. Axsome is still growing its market share in this therapeutic area.
  • Sunosi: Sunosi is a dual-acting dopamine and norepinephrine reuptake inhibitor (DNRI) approved to improve wakefulness in adult patients with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea (OSA). Competitors include Wakix, Nuvigil, and Provigil. Axsome acquired Sunosi in 2022.
  • AXS-05 (dextromethorphan-bupropion): This is the same active ingredient as Auvelity, however it has indications for Alzheimer's disease agitation. This drug is in Phase 3 clinical trials.

Market Dynamics

industry overview logo Industry Overview

The CNS therapeutics market is large and growing, driven by unmet needs for effective treatments for various neurological and psychiatric disorders. This market faces significant regulatory hurdles and high R&D costs.

Positioning

Axsome is positioning itself as an innovator in CNS therapeutics, focusing on developing differentiated products with novel mechanisms of action. Its competitive advantage lies in its pipeline of innovative therapies and successful FDA approvals.

Total Addressable Market (TAM)

The TAM for depression and other CNS disorders is estimated to be in the billions of dollars. Axsome is positioned to capture a significant share of this market with its innovative therapies and targeted commercialization strategy.

Upturn SWOT Analysis

Strengths

  • Innovative pipeline
  • Approved therapies (Auvelity and Sunosi)
  • Strong intellectual property
  • Experienced management team

Weaknesses

  • Limited commercial infrastructure (still expanding)
  • Reliance on a few key products
  • High R&D expenses
  • Dependence on successful clinical trials and regulatory approvals

Opportunities

  • Expansion of Auvelity and Sunosi into new markets
  • Development of new CNS therapies
  • Potential for strategic partnerships and acquisitions
  • Addressing unmet needs in CNS disorders

Threats

  • Competition from established pharmaceutical companies
  • Clinical trial failures
  • Regulatory setbacks
  • Patent expirations

Competitors and Market Share

competitor logo Key Competitors

  • LLY
  • VRTX
  • TEVA

Competitive Landscape

Axsome faces competition from established pharmaceutical companies with larger commercial infrastructure and broader product portfolios. Its advantage lies in its innovative therapies and focus on unmet needs in CNS disorders.

Major Acquisitions

Sunosi (from Jazz Pharmaceuticals)

  • Year: 2022
  • Acquisition Price (USD millions): 50
  • Strategic Rationale: The acquisition of Sunosi expanded Axsome's portfolio of CNS therapies and provided access to an established commercial infrastructure in the sleep disorder market.

Growth Trajectory and Initiatives

Historical Growth: Axsome's historical growth has been driven by successful clinical trials and regulatory approvals. The approval and launch of Auvelity marked a significant milestone.

Future Projections: Analyst estimates project continued revenue growth driven by Auvelity and Sunosi sales. Future growth depends on pipeline progress and successful commercialization efforts.

Recent Initiatives: Recent initiatives include expanding the commercial reach of Auvelity, advancing the clinical development of AXS-05 in Alzheimer's disease agitation, and exploring new therapeutic areas.

Summary

Axsome Therapeutics is a promising biopharmaceutical company focused on CNS disorders, particularly in depression and sleep disorders. The company's approval and commercialization of Auvelity represents a major achievement. The company's weakness lies in limited commercial infrastructure and heavy dependence on Auvelity and Sunosi. Key risks include competition and the results of the AXS-05 clinical trials.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Axsome Therapeutics Inc. investor relations
  • SEC filings
  • Analyst reports
  • Company press releases

Disclaimers:

This analysis is for informational purposes only and should not be considered financial advice. Investment decisions should be based on thorough research and consultation with a qualified financial advisor. Market share data is estimated and may vary.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Axsome Therapeutics Inc

Exchange NASDAQ
Headquaters New York, NY, United States
IPO Launch date 2015-11-19
Founder, Chairman, CEO & President Dr. Herriot Tabuteau M.D.
Sector Healthcare
Industry Biotechnology
Full time employees 712
Full time employees 712

Axsome Therapeutics, Inc., a biopharmaceutical company, develops and delivers novel therapies for the management of central nervous system (CNS) disorders in the United States. The company's commercial product portfolio includes Auvelity (dextromethorphan-bupropion), a N-methyl-D-aspartate receptor antagonist, sigma-1 receptor agonist, aminoketone, and CYP2D6 inhibitor indicated for the treatment of major depressive disorder in adults; Sunosi (solriamfetol), a dopamine and norepinephrine reuptake inhibitor, trace amine-associated receptor 1 agonist, and 5-HT1A agonist indicated for the treatment of excessive daytime sleepiness in patients with narcolepsy or obstructive sleep apnea; and Symbravo (MoSEIC meloxicam rizatriptan), or AXS-07, a rapidly absorbed, multi-mechanistic, selective COX-2 inhibitor, and 5-HT1B/1D agonist indicated for the acute treatment of migraine with or without aura. It also develops AXS-05 (dextromethorphan-bupropion), an investigational N-methyl-D-aspartate receptor antagonist, which has completed Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation; AXS-12 (reboxetine), a highly selective and potent norepinephrine reuptake inhibitor and cortical dopamine modulator, which has completed Phase III trial to treat narcolepsy; AXS-14 (esreboxetine), a selective and potent norepinephrine reuptake inhibitor that has completed Phase III trial for the treatment of fibromyalgia and other conditions; and Solriamfetol, a dopamine and norepinephrine reuptake inhibitor, which is in Phase III trial for treating attention deficit hyperactivity, major depressive, binge eating, and excessive sleepiness associated with shift work disorder. The company has a research collaboration agreement with Duke University for evaluating AXS-05 in a Phase 2 clinical trial in smoking cessation. Axsome Therapeutics, Inc. was incorporated in 2012 and is based in New York, New York.