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Biomarin Pharmaceutical Inc (BMRN)

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$55.17
Last Close (24-hour delay)
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Upturn Advisory Summary

06/27/2025: BMRN (1-star) is currently NOT-A-BUY. Pass it for now.

Upturn Star Rating

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Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

29 Analysts rated it

These Stocks/ETFs, based on Upturn Advisory, have historically outperformed the market, making them a top-tier choice for investors.

Year Target Price $95.91

Year Target Price $95.91

Analyst’s Price TargetsFor last 52 week
$95.91Target price
Low$52.93
Current$55.17
high$94.85

Analysis of Past Performance

Type Stock
Historic Profit -26.98%
Avg. Invested days 28
Today’s Advisory PASS
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 1.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 06/27/2025

Key Highlights

Company Size Large-Cap Stock
Market Capitalization 10.58B USD
Price to earnings Ratio 20.43
1Y Target Price 95.91
Price to earnings Ratio 20.43
1Y Target Price 95.91
Volume (30-day avg) -
Beta 0.18
52 Weeks Range 52.93 - 94.85
Updated Date 06/29/2025
52 Weeks Range 52.93 - 94.85
Updated Date 06/29/2025
Dividends yield (FY) -
Basic EPS (TTM) 2.7

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin 17.76%
Operating Margin (TTM) 30.05%

Management Effectiveness

Return on Assets (TTM) 6.38%
Return on Equity (TTM) 9.64%

Valuation

Trailing PE 20.43
Forward PE 13.05
Enterprise Value 9913722951
Price to Sales(TTM) 3.59
Enterprise Value 9913722951
Price to Sales(TTM) 3.59
Enterprise Value to Revenue 3.36
Enterprise Value to EBITDA 12.76
Shares Outstanding 191776000
Shares Floating 179358191
Shares Outstanding 191776000
Shares Floating 179358191
Percent Insiders 0.85
Percent Institutions 98.97

Analyst Ratings

Rating 4.34
Target Price 95.91
Buy 7
Strong Buy 16
Buy 7
Strong Buy 16
Hold 6
Sell -
Strong Sell -
Strong Sell -

ai summary icon Upturn AI SWOT

Biomarin Pharmaceutical Inc

stock logo

Company Overview

overview logo History and Background

BioMarin Pharmaceutical Inc. was founded in 1997 and is headquartered in San Rafael, California. It focuses on developing and commercializing therapies for serious and life-threatening rare genetic diseases. It has grown through internal development, acquisitions, and partnerships.

business area logo Core Business Areas

  • Rare Genetic Diseases: Develops and commercializes therapies for patients with serious and life-threatening rare genetic diseases, primarily focusing on enzyme deficiencies, protein deficiencies, and other genetic disorders.

leadership logo Leadership and Structure

The leadership team includes Alexander J. Denner as CEO, with a management team overseeing research, development, commercial operations, and finance. The organizational structure is typical of a biotechnology company, with divisions focused on specific therapeutic areas and functions.

Top Products and Market Share

overview logo Key Offerings

  • Vimizim (elosulfase alfa): Vimizim is an enzyme replacement therapy for Morquio A syndrome (MPS IVA). While specific market share data is difficult to pinpoint, Vimizim holds a significant portion of the MPS IVA treatment market. Competitors are limited, as the market for MPS IVA treatments is niche. It has generated hundreds of millions in revenue annually.
  • Naglazyme (galsulfase): Naglazyme is an enzyme replacement therapy for Mucopolysaccharidosis VI (MPS VI). Naglazyme holds a significant share of the MPS VI treatment market. Competitors are limited. It also generates hundreds of millions in revenue annually.
  • Voxzogo (vosoritide): Voxzogo is a treatment for achondroplasia. Revenue is increasing significantly annually. Competitors include other treatments aimed at managing the complications of achondroplasia, but Voxzogo is the first to address the underlying cause directly. Competitors may include future gene therapies or other novel treatments.
  • Kuvan (sapropterin dihydrochloride): Kuvan is a medication used to reduce phenylalanine levels in patients with phenylketonuria (PKU). Competitors include other dietary management approaches and Palynziq (pegvaliase). While once BioMarin's leading product, its revenues have declined due to generic competition.

Market Dynamics

industry overview logo Industry Overview

The biotechnology industry is characterized by high research and development costs, long regulatory approval timelines, and significant competition. Focus is shifting to gene therapies and precision medicine.

Positioning

BioMarin is positioned as a leader in developing and commercializing therapies for rare genetic diseases. Its competitive advantage lies in its expertise in enzyme replacement therapies, gene therapies and its established infrastructure for developing and marketing rare disease treatments.

Total Addressable Market (TAM)

The total addressable market for rare genetic diseases is estimated to be very large, valued in the tens of billions of dollars. BioMarin is well-positioned to capture a significant share of this market, due to their product portfolio and development pipeline.

Upturn SWOT Analysis

Strengths

  • Strong pipeline of rare disease therapies
  • Expertise in enzyme replacement and gene therapies
  • Established commercial infrastructure for rare disease products
  • History of successful product launches
  • Robust intellectual property portfolio

Weaknesses

  • High dependency on a small number of products
  • Risk associated with clinical trial outcomes
  • High R&D costs
  • Exposure to generic competition for established products

Opportunities

  • Expansion into new rare disease markets
  • Development of gene therapies for broader indications
  • Acquisition of complementary technologies or product candidates
  • Partnerships with other pharmaceutical companies
  • Geographic expansion

Threats

  • Competition from other biotechnology and pharmaceutical companies
  • Regulatory hurdles and delays
  • Pricing pressures from payers
  • Patent challenges
  • Changes in reimbursement policies

Competitors and Market Share

competitor logo Key Competitors

  • RDHL
  • SGEN
  • ALNY
  • REGN

Competitive Landscape

BioMarin holds a strong position in the rare disease market. Its competitive advantage lies in its expertise in enzyme replacement therapies and gene therapies. However, it faces competition from other biotechnology and pharmaceutical companies that are also developing therapies for rare diseases.

Major Acquisitions

Prosensa Holding N.V.

  • Year: 2014
  • Acquisition Price (USD millions): 840
  • Strategic Rationale: To acquire drisapersen, a potential treatment for Duchenne muscular dystrophy (DMD).

Growth Trajectory and Initiatives

Historical Growth: BioMarin has experienced strong growth in revenue and product sales over the past decade, driven by the launch of new products and expansion into new markets.

Future Projections: Analysts predict continued growth in revenue and earnings, driven by the company's pipeline of new products and its focus on rare genetic diseases. Growth rates vary based on projections.

Recent Initiatives: Recent initiatives include the development of new gene therapies, the expansion of its commercial operations into new markets, and strategic acquisitions.

Summary

BioMarin is a strong player in the rare disease market, with a solid portfolio and pipeline. Its focus on enzyme replacement and gene therapies provides a competitive edge. It needs to manage R&D costs and pricing pressures. Competitors' activities and any potential regulatory changes will need to be closely monitored for risk mitigation.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Company SEC Filings (10-K, 10-Q)
  • Company Website
  • Analyst Reports (e.g., from Yahoo Finance, Bloomberg)
  • Industry Reports (e.g., from EvaluatePharma, GlobalData)

Disclaimers:

The information provided is for informational purposes only and should not be considered financial advice. Investment decisions should be based on thorough research and consultation with a qualified financial advisor. Market share data is approximate and may vary depending on the source.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Biomarin Pharmaceutical Inc

Exchange NASDAQ
Headquaters San Rafael, CA, United States
IPO Launch date 1999-07-23
President, CEO & Director Mr. Alexander Hardy
Sector Healthcare
Industry Biotechnology
Full time employees 3040
Full time employees 3040

BioMarin Pharmaceutical Inc., a biotechnology company, engages in the development and commercialization of therapies for life-threatening rare diseases and medical conditions in the United States, Europe, Latin America, the Middle East, the Asia Pacific, and internationally. The company's products include VIMIZIM, an enzyme replacement therapy for the treatment of mucopolysaccharidosis (MPS) IV type A, a lysosomal storage disorder; VOXZOGO, a once daily injection analog of c-type natriuretic peptide (CNP) for the treatment of achondroplasia; NAGLAZYME, a recombinant form of N- acetylgalactosamine 4-sulfatase for patients with MPS VI; and PALYNZIQ, a PEGylated recombinant phenylalanine (Phe) ammonia lyase enzyme delivered through subcutaneous injection to reduce blood Phe concentrations. It also develops BRINEURA, a recombinant human tripeptidyl peptidase 1 for the treatment of patients with ceroid lipofuscinosis type 2, a form of Batten disease; ALDURAZYME, a purified protein designed to be identical to a naturally occurring form of the human enzyme alpha-L-iduronidase; KUVAN, a proprietary synthetic oral form of 6R-BH4 that is used to treat patients with phenylketonuria, an inherited metabolic disease; and ROCTAVIAN, an adeno associated virus vector for the treatment of severe hemophilia A. The company's products under development include BMN 333, a longer-acting CNP for the treatment of multiple growth disorders, such as achondroplasia and hypochondroplasia; BMN 349, an oral therapeutic for the treatment of liver disease associated with alpha-1 antitrypsin deficiency; and BMN 351, an oligonucleotide for the treatment of duchenne muscular dystrophy. It serves specialty pharmacies, hospitals, non-U.S. government agencies, distributors, and pharmaceutical wholesalers. The company has license and collaboration agreements with Catalyst Pharmaceutical Partners, Inc., and Ares Trading S.A. The company was incorporated in 1996 and is based in San Rafael, California.