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Compass Therapeutics Inc. (CMPX)

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Upturn Advisory Summary
01/09/2026: CMPX (5-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $13.23
1 Year Target Price $13.23
| 7 | Strong Buy |
| 2 | Buy |
| 0 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit 326.33% | Avg. Invested days 44 | Today’s Advisory PASS |
Upturn Star Rating ![]() | Upturn Advisory Performance | Stock Returns Performance |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 919.55M USD | Price to earnings Ratio - | 1Y Target Price 13.23 |
Price to earnings Ratio - | 1Y Target Price 13.23 | ||
Volume (30-day avg) 9 | Beta 1.26 | 52 Weeks Range 1.33 - 5.86 | Updated Date 01/9/2026 |
52 Weeks Range 1.33 - 5.86 | Updated Date 01/9/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.45 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -23.47% | Return on Equity (TTM) -37.82% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 709519067 | Price to Sales(TTM) 439.25 |
Enterprise Value 709519067 | Price to Sales(TTM) 439.25 | ||
Enterprise Value to Revenue 109.28 | Enterprise Value to EBITDA -8.92 | Shares Outstanding 177862102 | Shares Floating 107898266 |
Shares Outstanding 177862102 | Shares Floating 107898266 | ||
Percent Insiders 11.14 | Percent Institutions 83.72 |
Upturn AI SWOT
Compass Therapeutics Inc.

Company Overview
History and Background
Compass Therapeutics Inc. was founded in 2014 by a team of experienced drug developers and clinicians focused on identifying and advancing novel immunotherapies for cancer. The company has a history of building a pipeline of drug candidates through strategic collaborations and internal research, aiming to address unmet needs in oncology. Significant milestones include the progression of its lead candidates through preclinical and early-stage clinical development.
Core Business Areas
- Oncology Drug Discovery and Development: Compass Therapeutics is primarily engaged in the discovery, development, and potential commercialization of novel antibody-based immunotherapies for cancer. Their focus is on developing therapies that modulate the immune system to recognize and attack cancer cells.
Leadership and Structure
Compass Therapeutics is led by a management team with extensive experience in biotechnology and pharmaceutical development. The organizational structure is typical for a clinical-stage biotechnology company, emphasizing research and development, clinical operations, and business development.
Top Products and Market Share
Key Offerings
- Description: CTX-009 is a bispecific antibody designed to simultaneously inhibit PD-1 and VEGF, pathways known to be crucial in tumor immune evasion and angiogenesis. It aims to overcome resistance to current immunotherapies. Competitors in the PD-1 and VEGF inhibitor space include established players like Merck (Keytruda), Bristol Myers Squibb (Opdivo), and Regeneron Pharmaceuticals (Avastin).
- Product Name 1: CTX-009
- Description: CTX-101 is a novel antibody targeting a specific tumor antigen involved in immune suppression. Further details on its specific mechanism and target are proprietary but it is aimed at enhancing anti-tumor immunity. Competitors would depend on the specific target and mechanism, potentially including companies developing novel immuno-oncology agents.
- Product Name 2: CTX-101
Market Dynamics
Industry Overview
The oncology immunotherapy market is a rapidly growing and highly competitive sector within the pharmaceutical industry. Driven by significant advancements in understanding the immune system and cancer biology, new therapeutic modalities are continuously emerging. The market is characterized by substantial R&D investment, strategic partnerships, and a high rate of clinical trial activity.
Positioning
Compass Therapeutics is positioned as a clinical-stage biotechnology company focused on developing next-generation immunotherapies. Their strategy involves targeting complex mechanisms of immune resistance and developing bispecific antibodies and novel agents that aim to improve efficacy and address unmet needs in cancer treatment. Their competitive advantage lies in their differentiated pipeline of wholly-owned drug candidates with novel mechanisms of action.
Total Addressable Market (TAM)
The total addressable market for cancer immunotherapies is vast and continues to expand as new indications are explored and efficacy in various cancer types is demonstrated. While specific TAM figures vary by cancer type and therapeutic approach, it is measured in hundreds of billions of dollars globally. Compass Therapeutics is positioned to address specific segments within this large market, particularly those where existing therapies have limited efficacy or resistance is a significant challenge.
Upturn SWOT Analysis
Strengths
- Proprietary pipeline of novel immunotherapies.
- Experienced management and scientific team.
- Focus on differentiated mechanisms of action to address unmet needs.
- Wholly-owned assets, providing control over development and commercialization.
Weaknesses
- Clinical-stage company with no approved products, leading to inherent development risk.
- Dependence on successful clinical trial outcomes.
- Limited financial resources compared to large pharmaceutical companies.
- Need for significant capital investment for late-stage development and commercialization.
Opportunities
- Growing market for oncology immunotherapies.
- Potential for strategic partnerships and collaborations with larger pharmaceutical companies.
- Advancements in understanding tumor immunology and resistance mechanisms.
- Expansion into new cancer indications and combination therapies.
Threats
- High failure rate of drugs in clinical trials.
- Intense competition from established and emerging biotechnology companies.
- Regulatory hurdles and challenges in drug approval processes.
- Pricing pressures and reimbursement challenges for novel therapies.
Competitors and Market Share
Key Competitors
- Merck & Co., Inc. (MRK)
- Bristol Myers Squibb Company (BMY)
- Roche Holding AG (RHHBY)
- Pfizer Inc. (PFE)
Competitive Landscape
Compass Therapeutics faces a highly competitive landscape dominated by large pharmaceutical companies with significant resources and established oncology portfolios. Its advantage lies in its focus on novel mechanisms and potentially differentiated therapies for specific patient populations, aiming to carve out niche markets or provide superior alternatives to existing treatments.
Growth Trajectory and Initiatives
Historical Growth: Compass Therapeutics' historical growth has been characterized by the progression of its drug candidates from preclinical research to early-stage clinical trials, and the expansion of its scientific and operational capabilities. This growth is typically measured by pipeline advancement and the accumulation of intellectual property.
Future Projections: Future growth projections for Compass Therapeutics are contingent on the successful completion of clinical trials, regulatory approvals, and potential commercialization of its product candidates. Analyst estimates, if available, would focus on potential peak sales and market penetration for its lead programs.
Recent Initiatives: Recent initiatives likely include advancements in ongoing clinical trials, potential new drug candidate development, and strategic collaborations or partnerships aimed at accelerating development and expanding the company's reach.
Summary
Compass Therapeutics is a clinical-stage biotechnology company with a promising pipeline of novel immunotherapies in oncology. Its strengths lie in its differentiated drug candidates and experienced team. However, it faces significant risks associated with clinical development and intense competition from larger players. Success hinges on positive clinical trial outcomes and the ability to secure future funding or partnerships for commercialization.
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Sources and Disclaimers
Data Sources:
- Company filings (SEC)
- Financial news outlets
- Biotechnology industry reports
- Market research databases
Disclaimers:
This analysis is based on publicly available information and is for informational purposes only. It does not constitute investment advice. Financial data and market share estimations are subject to change and inherent limitations. Investors should conduct their own due diligence before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Compass Therapeutics Inc.
Exchange NASDAQ | Headquaters Boston, MA, United States | ||
IPO Launch date 2021-04-05 | CEO & Vice Chairman Dr. Thomas J. Schuetz M.D., Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 35 | |
Full time employees 35 | |||
Compass Therapeutics, Inc., a clinical-stage oncology-focused biopharmaceutical company, engages in the development of antibody-based therapeutics for the treatment of various human diseases in the United States. The company's lead product candidates include tovecimig, a bispecific antibody that blocks Delta-like ligand 4 (DLL4) and vascular endothelial growth factor A (VEGF-A) signaling pathways, which are critical to angiogenesis and tumor vascularization; CTX-471, an IgG4 monoclonal antibody that is an agonist of CD137, a key co-stimulatory receptor on immune cells; and CTX-8371, a bispecific inhibitor that targets programmed cell death protein-1 (PD-1) and ligand PD-L1 checkpoint inhibitor antibodies. It also develops CTX-10726, a bispecific antibody that targets PD-1 and VEFG-A; and VEGF-IO Bispecific / Multiple, a bispecific antibody for angiogenesis pathway and anti-tumor immune that targets, including immune checkpoints, as well as analyzes VEGF combinations with other immune response-related proteins. Compass Therapeutics, Inc. was founded in 2014 and is headquartered in Boston, Massachusetts.

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