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Upturn AI SWOT - About
GH Research PLC (GHRS)
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Upturn Advisory Summary
07/11/2025: GHRS (2-star) has a low Upturn Star Rating. Not recommended to BUY.
Upturn Star Rating
Below Average Performance
These Stocks/ETFs, based on Upturn Advisory, often underperform the market, warranting careful consideration before investing.
Number of Analysts
8 Analysts rated it
Limited analyst coverage, niche firm, research info may be scarce.
1 Year Target Price $33.14
1 Year Target Price $33.14
| 5 | Strong Buy |
| 3 | Buy |
| 0 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit 78.46% | Avg. Invested days 38 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating | Upturn Advisory Performance  4.0 | Stock Returns Performance  4.0 |
| Profits based on simulation | Last Close 07/11/2025 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 984.41M USD | Price to earnings Ratio - | 1Y Target Price 33.14 |
Price to earnings Ratio - | 1Y Target Price 33.14 | ||
Volume (30-day avg) 8 | Beta 0.97 | 52 Weeks Range 6.00 - 20.50 | Updated Date 07/12/2025 |
52 Weeks Range 6.00 - 20.50 | Updated Date 07/12/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.79 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -11.97% | Return on Equity (TTM) -16.2% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 693717498 | Price to Sales(TTM) - |
Enterprise Value 693717498 | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA -11.97 | Shares Outstanding 62029400 | Shares Floating 19743559 |
Shares Outstanding 62029400 | Shares Floating 19743559 | ||
Percent Insiders 33.88 | Percent Institutions 68.88 |
Upturn AI SWOT
GH Research PLC
Company Overview
History and Background
GH Research PLC, founded in 2019, is a biopharmaceutical company focused on developing novel therapies for mental health disorders using 5-MeO-DMT. It went public in 2021.
Core Business Areas
- GH001: A proprietary formulation of 5-MeO-DMT administered via inhalation for Treatment-Resistant Depression (TRD).
- GH002: An intravenous formulation of 5-MeO-DMT being explored for potential use in other mental health indications.
Leadership and Structure
The company is led by CEO Mike Petrone. The organizational structure includes research and development, clinical operations, and business development departments.
Top Products and Market Share
Key Offerings
- GH001: A proprietary inhaled formulation of 5-MeO-DMT being developed for Treatment-Resistant Depression (TRD). Market share is currently 0% as the product is still in clinical trials. The primary competitors include companies developing psilocybin-based therapies, such as COMPASS Pathways and Atai Life Sciences.
- GH002: An intravenous formulation of 5-MeO-DMT in clinical trials. Competitors are similar to GH001, focusing on psychedelic-assisted therapies.
Market Dynamics
Industry Overview
The industry is focused on developing novel treatments for mental health disorders, including psychedelic-assisted therapies. There is growing interest and investment in this area, driven by the limitations of existing treatments.
Positioning
GH Research PLC is positioned as a leader in developing 5-MeO-DMT-based therapies, focusing on efficient delivery methods and rigorous clinical trials. Its competitive advantage lies in its proprietary formulations and experienced leadership.
Total Addressable Market (TAM)
The estimated TAM for depression and other mental health disorders is in the billions of dollars. GH Research PLC aims to capture a significant share of this market with its innovative therapies. Current projections range from $5B to $10B by 2030.
Upturn SWOT Analysis
Strengths
- Proprietary 5-MeO-DMT formulations
- Experienced leadership team
- Strong intellectual property portfolio
- Focus on efficient delivery methods
- Robust clinical trial design
Weaknesses
- High cash burn rate
- Reliance on successful clinical trial outcomes
- Regulatory hurdles
- Limited commercial infrastructure
- Concentrated product pipeline
Opportunities
- Expanding indications for 5-MeO-DMT
- Partnerships with pharmaceutical companies
- Positive clinical trial results
- Favorable regulatory changes
- Increasing awareness of mental health issues
Threats
- Clinical trial failures
- Regulatory rejection
- Competition from other psychedelic therapies
- Negative public perception
- Intellectual property infringement
Competitors and Market Share
Key Competitors
- CMPS
- ATAI
Competitive Landscape
GH Research faces competition from other companies developing psychedelic therapies. Its advantage lies in its focus on 5-MeO-DMT and efficient delivery methods, while its disadvantage is its reliance on a single molecule.
Growth Trajectory and Initiatives
Historical Growth: Historical growth is limited due to the company's early stage. Growth is primarily reflected in the expansion of its clinical trial programs.
Future Projections: Future growth depends on successful clinical trial outcomes and regulatory approval. Analyst estimates vary widely, with some projecting significant revenue growth if GH001 is approved.
Recent Initiatives: Recent initiatives include enrolling patients in Phase 2b trials for GH001 in TRD and expanding research into other potential indications.
Summary
GH Research PLC is an early-stage biopharmaceutical company with a focus on innovative mental health treatments. It's in a high-risk, high-reward sector. The company has promising initial trials, but successful clinical trials and regulatory approval are vital. Its high cash burn rate and the need for more revenue sources pose significant challenges.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Company SEC Filings (10-K, 10-Q)
- Company Website
- Analyst Reports
- ClinicalTrials.gov
Disclaimers:
This analysis is for informational purposes only and should not be considered financial advice. Investment decisions should be based on thorough research and consultation with a qualified financial advisor. Data is based on information available as of the current date and is subject to change.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About GH Research PLC
Exchange NASDAQ | Headquaters - | ||
IPO Launch date 2021-06-25 | CEO - | ||
Sector Healthcare | Industry Biotechnology | Full time employees 50 | Website https://www.ghres.com |
Full time employees 50 | Website https://www.ghres.com | ||
GH Research PLC, together with its subsidiary, a clinical-stage biopharmaceutical company, engages in developing treatments for depression in the United States. Its lead product candidate is GH001, an inhalable mebufotenin product candidate, which is in phase 2b clinical trial for treating patients with treatment-resistant depression; and in phase 2a clinical trial for treating bipolar II disorder and a current major depressive episode, as well as female patients with postpartum depression. The company also develops GH002, an intravenous mebufotenin product candidate, which is in phase 1 clinical pharmacology trial in healthy volunteers focusing on psychiatric and neurological disorders. The company was founded in 2018 and is based in Dublin, Ireland.
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