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GHRS
Upturn stock ratingUpturn stock rating

GH Research PLC (GHRS)

Upturn stock ratingUpturn stock rating
$12.19
Last Close (24-hour delay)
Profit since last BUY-0.4%
upturn advisory
SELL
SELL since 3 days
  • BUY Advisory
  • SELL Advisory (Profit)​
  • SELL Advisory (Loss)​
  • Profit
  • Loss
  • Pass (Skip investing)
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
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Upturn Advisory Summary

06/30/2025: GHRS (1-star) is a SELL. SELL since 3 days. Profits (-0.40%). Updated daily EoD!

Upturn Star Rating

rating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

8 Analysts rated it

Moderately tracked stock, growing coverage, gaining market and investor attention.

1 Year Target Price $33.14

1 Year Target Price $33.14

Analysts Price Target For last 52 week
$33.14Target price
Low$6
Current$12.19
high$20.5

Analysis of Past Performance

Type Stock
Historic Profit 69.01%
Avg. Invested days 45
Today’s Advisory SELL
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 4.0
Stock Returns Performance Upturn Returns Performance 3.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 06/30/2025

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 771.65M USD
Price to earnings Ratio -
1Y Target Price 33.14
Price to earnings Ratio -
1Y Target Price 33.14
Volume (30-day avg) 8
Beta 0.97
52 Weeks Range 6.00 - 20.50
Updated Date 06/30/2025
52 Weeks Range 6.00 - 20.50
Updated Date 06/30/2025
Dividends yield (FY) -
Basic EPS (TTM) -0.79

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -
Operating Margin (TTM) -

Management Effectiveness

Return on Assets (TTM) -11.97%
Return on Equity (TTM) -16.2%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 480336379
Price to Sales(TTM) -
Enterprise Value 480336379
Price to Sales(TTM) -
Enterprise Value to Revenue -
Enterprise Value to EBITDA -11.97
Shares Outstanding 62029400
Shares Floating 19743559
Shares Outstanding 62029400
Shares Floating 19743559
Percent Insiders 33.88
Percent Institutions 68.88

Analyst Ratings

Rating 3
Target Price 33.14
Buy 3
Strong Buy 5
Buy 3
Strong Buy 5
Hold -
Sell -
Strong Sell -
Strong Sell -

ai summary icon Upturn AI SWOT

GH Research PLC

stock logo

Company Overview

overview logo History and Background

GH Research PLC, founded in 2019, is a biopharmaceutical company focused on developing novel therapies for mental health disorders using 5-MeO-DMT. It went public in 2021.

business area logo Core Business Areas

  • GH001: A proprietary formulation of 5-MeO-DMT administered via inhalation for Treatment-Resistant Depression (TRD).
  • GH002: An intravenous formulation of 5-MeO-DMT being explored for potential use in other mental health indications.

leadership logo Leadership and Structure

The company is led by CEO Mike Petrone. The organizational structure includes research and development, clinical operations, and business development departments.

Top Products and Market Share

overview logo Key Offerings

  • GH001: A proprietary inhaled formulation of 5-MeO-DMT being developed for Treatment-Resistant Depression (TRD). Market share is currently 0% as the product is still in clinical trials. The primary competitors include companies developing psilocybin-based therapies, such as COMPASS Pathways and Atai Life Sciences.
  • GH002: An intravenous formulation of 5-MeO-DMT in clinical trials. Competitors are similar to GH001, focusing on psychedelic-assisted therapies.

Market Dynamics

industry overview logo Industry Overview

The industry is focused on developing novel treatments for mental health disorders, including psychedelic-assisted therapies. There is growing interest and investment in this area, driven by the limitations of existing treatments.

Positioning

GH Research PLC is positioned as a leader in developing 5-MeO-DMT-based therapies, focusing on efficient delivery methods and rigorous clinical trials. Its competitive advantage lies in its proprietary formulations and experienced leadership.

Total Addressable Market (TAM)

The estimated TAM for depression and other mental health disorders is in the billions of dollars. GH Research PLC aims to capture a significant share of this market with its innovative therapies. Current projections range from $5B to $10B by 2030.

Upturn SWOT Analysis

Strengths

  • Proprietary 5-MeO-DMT formulations
  • Experienced leadership team
  • Strong intellectual property portfolio
  • Focus on efficient delivery methods
  • Robust clinical trial design

Weaknesses

  • High cash burn rate
  • Reliance on successful clinical trial outcomes
  • Regulatory hurdles
  • Limited commercial infrastructure
  • Concentrated product pipeline

Opportunities

  • Expanding indications for 5-MeO-DMT
  • Partnerships with pharmaceutical companies
  • Positive clinical trial results
  • Favorable regulatory changes
  • Increasing awareness of mental health issues

Threats

  • Clinical trial failures
  • Regulatory rejection
  • Competition from other psychedelic therapies
  • Negative public perception
  • Intellectual property infringement

Competitors and Market Share

competitor logo Key Competitors

  • CMPS
  • ATAI

Competitive Landscape

GH Research faces competition from other companies developing psychedelic therapies. Its advantage lies in its focus on 5-MeO-DMT and efficient delivery methods, while its disadvantage is its reliance on a single molecule.

Growth Trajectory and Initiatives

Historical Growth: Historical growth is limited due to the company's early stage. Growth is primarily reflected in the expansion of its clinical trial programs.

Future Projections: Future growth depends on successful clinical trial outcomes and regulatory approval. Analyst estimates vary widely, with some projecting significant revenue growth if GH001 is approved.

Recent Initiatives: Recent initiatives include enrolling patients in Phase 2b trials for GH001 in TRD and expanding research into other potential indications.

Summary

GH Research PLC is an early-stage biopharmaceutical company with a focus on innovative mental health treatments. It's in a high-risk, high-reward sector. The company has promising initial trials, but successful clinical trials and regulatory approval are vital. Its high cash burn rate and the need for more revenue sources pose significant challenges.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Company SEC Filings (10-K, 10-Q)
  • Company Website
  • Analyst Reports
  • ClinicalTrials.gov

Disclaimers:

This analysis is for informational purposes only and should not be considered financial advice. Investment decisions should be based on thorough research and consultation with a qualified financial advisor. Data is based on information available as of the current date and is subject to change.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About GH Research PLC

Exchange NASDAQ
Headquaters -
IPO Launch date 2021-06-25
CEO -
Sector Healthcare
Industry Biotechnology
Full time employees 50
Full time employees 50

GH Research PLC, together with its subsidiary, a clinical-stage biopharmaceutical company, engages in developing treatments for depression in the United States. Its lead product candidate is GH001, an inhalable mebufotenin product candidate, which is in phase 2b clinical trial for treating patients with treatment-resistant depression; and in phase 2a clinical trial for treating bipolar II disorder and a current major depressive episode, as well as female patients with postpartum depression. The company also develops GH002, an intravenous mebufotenin product candidate, which is in phase 1 clinical pharmacology trial in healthy volunteers focusing on psychiatric and neurological disorders. The company was founded in 2018 and is based in Dublin, Ireland.