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Upturn AI Summary - About
Fractyl Health, Inc. Common Stock(GUTS)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for GUTS
10/22/2026: GUTS (1-star) is currently NOT-A-BUY. Pass it for now.
Fractyl Health is a clinical-stage biotechnology company developing procedural and gene-therapy solutions for metabolic diseases. The company is characterized by its focus on addressing the underlying biological drivers of diabetes and obesity rather than mere symptom management. Its main growth story is centered on the success of its Revita and Rejuva platforms. However, investors face significant risks, including the lack of current commercial revenue, high clinical trial failure risks, and intense competition from established pharmaceutical companies producing GLP-1 drugs. The stock best suits risk-tolerant investors seeking exposure to breakthrough medical innovation, though development milestones should be monitored closely for signs of success.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Mixed fit | Fractyl offers high-risk, high-reward exposure for investors focused on emerging biotech innovation. |
| Momentum investor | Weak fit | Momentum is highly conditional on clinical trial success signals that are currently speculative. |
| Value investor | Weak fit | The company is not currently profitable and lacks traditional valuation metrics. |
| Dividend investor | Weak fit | No dividend is paid, and the company is reinvesting all capital into development. |
| Low-risk investor | Weak fit | The extreme volatility and clinical binary risk profile are unsuitable for low-risk strategies. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | Clinical-stage stocks often experience sharp swings based on trial results and regulatory news. |
| Valuation risk | High | Valuations are highly speculative as there are no current product sales to support the market cap. |
| Competition risk (GLP-1 drugs) | High | The success of injectable therapies like Wegovy and Zepbound creates a high bar for new entrants. |
| Business quality | Medium | The company has strong intellectual property but lacks a proven commercial business model. |
| Dividend income | Low / none | The company is in an early-stage development phase with no capacity for payouts. |
| Execution risk | High | The complexity of clinical development and regulatory approval is a major hurdle for company success. |
Price Behavior
Downtrend
The stock has experienced a sustained decline in price over recent periods.
Extreme Price Shocks
The stock has experienced exceptionally large and disruptive price movements during the period.
Analysis of Past Performance
Type Stock | Historic Profit 42.04% | Avg. Invested days 21 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  4.0 | Stock Returns Performance  3.0 |
| Profits based on simulation | Last Close 10/22/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 15.25M USD | Price to earnings Ratio - | 1Y Target Price 38.67 |
Price to earnings Ratio - | 1Y Target Price 38.67 | ||
Volume (30-day avg) 756.5K shares | Beta 2.42 | 52 Weeks Range 1.11 - 29.34 | Updated Date 10/22/2026 |
52 Weeks Range 1.11 - 29.34 | Updated Date 10/22/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -10.56 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Metabolic Therapeutics | Revita DMR procedure and Rejuva gene therapy research. | The company makes no money yet; it is burning cash to prove its science works in trials. |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 90.34M | Price to Sales(TTM) 4489.16 |
Enterprise Value 90.34M | Price to Sales(TTM) 4489.16 | ||
Enterprise Value to Revenue 14527.72 | Enterprise Value to EBITDA - | Shares Outstanding 13.26M | Shares Floating 12.14M |
Shares Outstanding 13.26M | Shares Floating 12.14M | ||
Percent Insiders 1.45 | Percent Institutions 53.16 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
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