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HCW Biologics Inc (HCWB)



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Upturn Advisory Summary
09/16/2025: HCWB (2-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $35
1 Year Target Price $35
0 | Strong Buy |
1 | Buy |
0 | Hold |
0 | Sell |
0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit 33.03% | Avg. Invested days 44 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Small-Cap Stock | Market Capitalization 10.54M USD | Price to earnings Ratio - | 1Y Target Price 35 |
Price to earnings Ratio - | 1Y Target Price 35 | ||
Volume (30-day avg) 1 | Beta 0.7 | 52 Weeks Range 2.77 - 62.40 | Updated Date 09/16/2025 |
52 Weeks Range 2.77 - 62.40 | Updated Date 09/16/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -16.41 |
Earnings Date
Report Date 2025-08-18 | When After Market | Estimate 1.8 | Actual -6.79 |
Profitability
Profit Margin - | Operating Margin (TTM) -52886.67% |
Management Effectiveness
Return on Assets (TTM) -30.41% | Return on Equity (TTM) -27725.96% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 16376876 | Price to Sales(TTM) 12.66 |
Enterprise Value 16376876 | Price to Sales(TTM) 12.66 | ||
Enterprise Value to Revenue 19.66 | Enterprise Value to EBITDA -3.63 | Shares Outstanding 2151610 | Shares Floating 1135661 |
Shares Outstanding 2151610 | Shares Floating 1135661 | ||
Percent Insiders 27.3 | Percent Institutions 1 |
Upturn AI SWOT
HCW Biologics Inc

Company Overview
History and Background
HCW Biologics Inc. is a biopharmaceutical company focused on discovering and developing innovative immunotherapeutics to address unmet medical needs in age-related diseases. Details on its founding year and early milestones are not widely available in public sources, suggesting it's a relatively young and emerging company. Its evolution revolves around the development of its TOBIu2122 platform.
Core Business Areas
- Drug Discovery and Development: HCW Biologics is focused on discovering and developing therapies using its TOBIu2122 (Tissue factOr of Biologic drug Innovation) platform. Their primary focus is on developing novel immunotherapies that address chronic, low-grade inflammation and declining tissue repair capacity that are hallmarks of aging.
- TOBIu2122 Platform: HCW Biologics' core technology platform, TOBIu2122, aims to generate novel, complex biologics that combine multiple therapeutic effects, targeting age-related diseases. This is their key revenue and value driver.
Leadership and Structure
Details about the specific leadership team and organizational structure are limited in publicly available data beyond general executive roles and board members. Refer to the company's investor relations page for detailed info.
Top Products and Market Share
Key Offerings
- HCW9218: HCW9218 is their lead clinical candidate, a novel immunotherapeutic targeting age-related diseases. As of now, it's in clinical development; market share and revenue data are not yet available. Competitors in this space include companies developing therapies for inflammaging and age-related diseases using different mechanisms, such as anti-inflammatory drugs and senolytics.
- TOBIu2122 Platform Derived Biologics: The TOBIu2122 platform generates a pipeline of preclinical assets, which are future revenue drivers. Market share is not applicable at this stage. Competitors are other biologics development platforms in the immunotherapy space. HCW is unique in addressing inflammaging.
Market Dynamics
Industry Overview
The biopharmaceutical industry is experiencing rapid growth driven by innovation in immunotherapy and increasing demand for treatments for age-related diseases. The landscape is competitive, with numerous companies pursuing novel therapeutic approaches.
Positioning
HCW Biologics is positioned as an innovator in the field of immunotherapies for age-related diseases, leveraging its proprietary TOBIu2122 platform. Its competitive advantage lies in the potential to develop complex biologics with multiple therapeutic effects that combat chronic inflammation and promote tissue repair.
Total Addressable Market (TAM)
The TAM for age-related disease therapeutics is substantial and growing, estimated to be in the tens of billions of dollars annually. HCW Biologics, with its focus on inflammaging, is strategically positioned to capture a portion of this market if its clinical trials are successful.
Upturn SWOT Analysis
Strengths
- Proprietary TOBIu2122 platform
- Focus on unmet needs in age-related diseases
- Potential for complex biologics with multiple therapeutic effects
- Innovative approach to immunotherapies
Weaknesses
- Early-stage clinical development (high risk)
- Limited financial resources compared to larger competitors
- Reliance on the success of the TOBIu2122 platform
- No currently marketed products (no revenue)
Opportunities
- Partnerships with larger pharmaceutical companies
- Expansion of the TOBIu2122 platform to new disease areas
- Positive clinical trial results for HCW9218
- Increasing demand for age-related disease therapies
Threats
- Clinical trial failures
- Competition from established pharmaceutical companies
- Regulatory hurdles
- Intellectual property challenges
- Difficulty in raising capital
Competitors and Market Share
Key Competitors
- ABBV
- LLY
- NVO
- GILD
Competitive Landscape
HCW Biologics faces intense competition from larger, more established pharmaceutical companies with broader product portfolios and greater financial resources. HCW Biologicsu2019 advantages lie in its innovative technology platform and focus on niche market, whereas the disadvantage comes in from being in early stage.
Growth Trajectory and Initiatives
Historical Growth: Historical growth is limited as the company is pre-revenue and focused on R&D.
Future Projections: Future growth is dependent on the success of clinical trials and potential partnerships. Analyst estimates would be necessary to provide specific growth projections.
Recent Initiatives: Recent initiatives would include ongoing clinical trials for HCW9218, expansion of the TOBIu2122 platform, and potential collaborations with research institutions and pharmaceutical companies.
Summary
HCW Biologics is an early-stage biopharmaceutical company with a promising technology platform targeting age-related diseases. While its focus on inflammaging is a key differentiator, the company faces significant risks associated with clinical development and competition from larger players. Success hinges on positive clinical trial results, strategic partnerships, and effective management of cash resources. Investors should be aware of the inherent uncertainties in the biopharmaceutical industry.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Company Website
- SEC Filings
- ClinicalTrials.gov
- Analyst Reports (where available)
Disclaimers:
The information provided is based on publicly available data and should not be considered investment advice. The biopharmaceutical industry is inherently risky, and investors should conduct their own due diligence before making any investment decisions. Market share data for specific companies is estimated and may vary based on different sources.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About HCW Biologics Inc
Exchange NASDAQ | Headquaters Miramar, FL, United States | ||
IPO Launch date 2021-07-20 | Founder, CEO, Director & Secretary Dr. Hing C. Wong Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 36 | Website https://www.hcwbiologics.com |
Full time employees 36 | Website https://www.hcwbiologics.com |
HCW Biologics Inc., a clinical-stage biopharmaceutical company, focuses on discovering and developing novel immunotherapies for chronic, low-grade inflammation, and age-related diseases in the United States. The company's lead products include HCW9218, a clinical-stage bifunctional molecule, which has completed Phase 1 to treat chemotherapy-refractory solid tumor cancers and Phase 1b/2 to treat pancreatic cancer; and HCW9302, injectable and interleukin 2 (IL-2) fusion protein complex, which is in phase 1 for autoimmune and proinflammatory diseases, such as alopecia areata diseases. It also develops HCW9201 and HCW9206, novel immunotherapeutic for memory-like natural killer cells, cancer, and pathogens; HCW11-006, an immune cell stimulator; HCW11-002 and HCW11-0027, which are immune checkpoint inhibitors to treat oncology and other senescence-associated indications; and HCW11-018, a fusions and immune cell engagers to treat cancer. The company has a license agreement with Wugen Inc. to develop cell therapy-based treatments; and a license, research and co-development agreement with WY Biotech Co., Ltd. for its preclinical molecules. HCW Biologics Inc. was incorporated in 2018 and is headquartered in Miramar, Florida.

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