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Upturn AI SWOT - About
KYMR 
Kymera Therapeutics Inc (KYMR)
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Upturn Advisory Summary
06/20/2025: KYMR (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Upturn Star Rating
Not Recommended Performance
These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.
Analysis of Past Performance
Type Stock | Historic Profit 99.38% | Avg. Invested days 32 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating | Upturn Advisory Performance  2.0 | Stock Returns Performance  4.0 |
| Profits based on simulation | Last Close 06/20/2025 |
Key Highlights
Company Size Mid-Cap Stock | Market Capitalization 2.99B USD | Price to earnings Ratio - | 1Y Target Price 62.32 |
Price to earnings Ratio - | 1Y Target Price 62.32 | ||
Volume (30-day avg) 958322 | Beta 2.07 | 52 Weeks Range 19.45 - 53.27 | Updated Date 06/22/2025 |
52 Weeks Range 19.45 - 53.27 | Updated Date 06/22/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -3.11 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -336.77% |
Management Effectiveness
Return on Assets (TTM) -19.47% | Return on Equity (TTM) -32.17% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 2610214584 | Price to Sales(TTM) 50.73 |
Enterprise Value 2610214584 | Price to Sales(TTM) 50.73 | ||
Enterprise Value to Revenue 44.33 | Enterprise Value to EBITDA -9.49 | Shares Outstanding 65119600 | Shares Floating 41673919 |
Shares Outstanding 65119600 | Shares Floating 41673919 | ||
Percent Insiders 2.69 | Percent Institutions 111.66 |
Analyst Ratings
Rating 4.55 | Target Price 56.68 | Buy 3 | Strong Buy 14 |
Buy 3 | Strong Buy 14 | ||
Hold 3 | Sell - | Strong Sell - | |
Strong Sell - |
Upturn AI SWOT
Kymera Therapeutics Inc
Company Overview
History and Background
Kymera Therapeutics Inc. was founded in 2016. It is a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics that selectively degrade disease-causing proteins.
Core Business Areas
- Targeted Protein Degradation: Kymera's core business revolves around developing therapeutics based on targeted protein degradation using its proprietary protein degrader platform, Pegasus.
Leadership and Structure
Nello Mainolfi is the President and CEO. The company has a typical biotech organizational structure with research, development, clinical, and commercial teams.
Top Products and Market Share
Key Offerings
- KT-474 (SAR444229): An IRAK4 degrader being developed in partnership with Sanofi for atopic dermatitis, hidradenitis suppurativa, and other inflammatory diseases. Clinical trials are ongoing. Revenue is primarily milestone-based from Sanofi. Competitors include JAK inhibitors and biologics targeting inflammatory pathways. Market share and sales figures not available at this time.
- KT-333: A STAT3 degrader in Phase 1 clinical trials for hematologic malignancies and solid tumors. Competitors include other STAT3 inhibitors and standard cancer therapies. Market share and sales figures not available at this time.
Market Dynamics
Industry Overview
The biopharmaceutical industry is highly competitive and innovative, with a growing focus on targeted therapies. Targeted protein degradation is an emerging field with potential to address previously undruggable targets.
Positioning
Kymera is a leader in the targeted protein degradation field with a proprietary platform and a growing pipeline of drug candidates. Its competitive advantage lies in its expertise in E3 ligase biology and degrader design.
Total Addressable Market (TAM)
The TAM for targeted protein degradation is potentially very large, encompassing a broad range of diseases across oncology, immunology, and other therapeutic areas. Kymera is positioned to capture a significant portion of this market if its clinical programs are successful.
Upturn SWOT Analysis
Strengths
- Proprietary Pegasus platform for targeted protein degradation
- Strong intellectual property portfolio
- Experienced management team
- Partnership with Sanofi for KT-474
Weaknesses
- Clinical stage company with no approved products
- High cash burn rate
- Dependence on partnerships for funding and development
Opportunities
- Expansion of pipeline with new degrader programs
- Potential for partnerships with other pharmaceutical companies
- Successful clinical trials leading to regulatory approvals
- Expansion into new therapeutic areas
Threats
- Clinical trial failures
- Competition from other companies developing protein degraders
- Regulatory hurdles
- Patent challenges
- Economic downturn affecting funding for biotech companies
Competitors and Market Share
Key Competitors
- ARVN
- CRIS
- VRTX
- REGN
- MRNA
Competitive Landscape
Kymera is a leading player in the targeted protein degradation field, but faces competition from other biotech and pharmaceutical companies developing similar technologies. Its advantage lies in its expertise in E3 ligase biology and degrader design. Key players also include companies developing therapies for related disease indications.
Major Acquisitions
Growth Trajectory and Initiatives
Historical Growth: Kymera's growth has been driven by its advancement of degrader programs through preclinical and clinical development and its partnership with Sanofi. Revenue primarily consists of collaboration revenue.
Future Projections: Future growth is dependent on clinical trial success, regulatory approvals, and potential new partnerships. Analyst estimates vary depending on these factors.
Recent Initiatives: Advancement of KT-474 and KT-333 into later-stage clinical trials, expansion of pipeline with new degrader programs, and continued investment in the Pegasus platform.
Summary
Kymera Therapeutics is a clinical-stage biotech company pioneering targeted protein degradation. Its technology holds great promise, but it is high risk. The company has a partnership with Sanofi that provides needed capital to advance the IRAK4 degrading KT-474. Clinical trial successes will be needed to unlock value for the shareholders.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Kymera Therapeutics Inc. Investor Relations
- SEC Filings
- Analyst Reports
- Company Press Releases
Disclaimers:
The information provided is for informational purposes only and should not be construed as investment advice. Investment decisions should be based on your own research and due diligence.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Kymera Therapeutics Inc
Exchange NASDAQ | Headquaters Watertown, MA, United States | ||
IPO Launch date 2020-08-21 | Co-Founder, President, CEO & Director Dr. Nello Mainolfi M.D., Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 208 | Website https://www.kymeratx.com |
Full time employees 208 | Website https://www.kymeratx.com | ||
Kymera Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on discovering and developing small molecule therapeutics that selectively degrade disease-causing proteins by harnessing the body's own natural protein degradation system. It engages in developing IRAK4 program, which is in Phase II clinical trial for the treatment of immunology-inflammation diseases, including hidradenitis suppurativa and atopic dermatitis. The company also develops STAT6, a type 2 inflammation in allergic and atopic diseases; and TYK2 to treat autoimmune and inflammatory diseases. Kymera Therapeutics, Inc. was incorporated in 2015 and is headquartered in Watertown, Massachusetts.
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