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Kymera Therapeutics Inc (KYMR)



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Upturn Advisory Summary
09/11/2025: KYMR (1-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $62.21
1 Year Target Price $62.21
14 | Strong Buy |
3 | Buy |
3 | Hold |
0 | Sell |
0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit 72.93% | Avg. Invested days 31 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Mid-Cap Stock | Market Capitalization 3.30B USD | Price to earnings Ratio - | 1Y Target Price 62.21 |
Price to earnings Ratio - | 1Y Target Price 62.21 | ||
Volume (30-day avg) 20 | Beta 2.18 | 52 Weeks Range 19.45 - 53.27 | Updated Date 09/12/2025 |
52 Weeks Range 19.45 - 53.27 | Updated Date 09/12/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -3.49 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -736.82% |
Management Effectiveness
Return on Assets (TTM) -19.92% | Return on Equity (TTM) -33.26% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 2528984517 | Price to Sales(TTM) 73.88 |
Enterprise Value 2528984517 | Price to Sales(TTM) 73.88 | ||
Enterprise Value to Revenue 56.56 | Enterprise Value to EBITDA -9.49 | Shares Outstanding 71497600 | Shares Floating 46960337 |
Shares Outstanding 71497600 | Shares Floating 46960337 | ||
Percent Insiders 2.53 | Percent Institutions 109.99 |
Upturn AI SWOT
Kymera Therapeutics Inc

Company Overview
History and Background
Kymera Therapeutics Inc. was founded in 2016 and focuses on developing protein degradation therapies. It has achieved milestones in advancing its pipeline of targeted protein degraders and securing strategic partnerships.
Core Business Areas
- Targeted Protein Degradation: Kymera focuses on discovering and developing novel small molecule therapeutics that selectively degrade disease-causing proteins. This is their primary and almost sole business area.
Leadership and Structure
The leadership team consists of experienced executives in drug discovery and development. The organizational structure is typical of a biotech company, with research, development, and commercial functions.
Top Products and Market Share
Key Offerings
- KT-474 (IRAK4 degrader): KT-474 is a lead product candidate targeting IRAK4, currently in clinical trials for immune-inflammatory diseases. Market share data is not yet available as the product is pre-commercial. Competitors are companies developing therapies for immune-inflammatory diseases, including those targeting IRAK4 with different mechanisms (e.g., inhibitors).
- STAT3 degrader: Kymera is developing a STAT3 degrader. It is in preclinical stages and is intended for specific types of cancer. Market share data is not yet available. Competitors are companies developing STAT3 inhibitors or other cancer therapies.
Market Dynamics
Industry Overview
The industry is focused on developing innovative therapies for diseases with unmet medical needs. Targeted protein degradation is an emerging field with significant potential.
Positioning
Kymera is a leader in the targeted protein degradation space, with a proprietary platform and a pipeline of promising drug candidates. Its competitive advantage lies in its expertise and intellectual property in this field.
Total Addressable Market (TAM)
The TAM for targeted protein degradation therapies is potentially very large, addressing various diseases including oncology and immunology. Kymera is positioned to capture a significant portion of this market if its products are successful.
Upturn SWOT Analysis
Strengths
- Pioneer in targeted protein degradation
- Proprietary platform technology
- Strong pipeline of drug candidates
- Experienced management team
- Strategic partnerships with established pharmaceutical companies
Weaknesses
- High risk of drug development failure
- Limited commercial experience
- Dependence on key partnerships
- Cash burn rate associated with R&D
- Relatively early stage compared to larger pharmaceutical companies.
Opportunities
- Expanding into new therapeutic areas
- Securing additional partnerships
- Acquiring complementary technologies
- Advancing pipeline candidates through clinical trials
- Potential for breakthrough therapies in diseases with unmet needs.
Threats
- Competition from other drug developers
- Regulatory hurdles
- Patent challenges
- Clinical trial failures
- Changes in the market for targeted protein degradation therapies.
Competitors and Market Share
Key Competitors
- VRTX
- ARRY
- GILD
- BMY
- MRK
Competitive Landscape
Kymera's competitive advantage lies in its specialized focus on targeted protein degradation. However, it faces competition from larger pharmaceutical companies with broader pipelines and greater resources. Market share is negligible while in development stage.
Growth Trajectory and Initiatives
Historical Growth: Historical growth is measured by pipeline advancement and partnership deals.
Future Projections: Future growth is contingent on clinical trial success and regulatory approvals. Analyst estimates vary based on pipeline progress.
Recent Initiatives: Recent initiatives include advancing KT-474 into later-stage clinical trials and expanding its pipeline through internal discovery and partnerships.
Summary
Kymera Therapeutics is a pioneering company in the field of targeted protein degradation, with a promising pipeline of novel therapeutics. As a pre-revenue company, its success depends on the progress of its clinical trials and regulatory approvals. The company's strategic partnerships and strong platform technology provide a solid foundation, but it faces risks associated with drug development and competition from larger pharmaceutical companies.
Peer Comparison
Sources and Disclaimers
Data Sources:
- SEC Filings
- Company Website
- Analyst Reports
Disclaimers:
This analysis is for informational purposes only and does not constitute investment advice. Market share values are approximations and subject to change.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Kymera Therapeutics Inc
Exchange NASDAQ | Headquaters Watertown, MA, United States | ||
IPO Launch date 2020-08-21 | Co-Founder, President, CEO & Director Dr. Nello Mainolfi M.D., Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 218 | Website https://www.kymeratx.com |
Full time employees 218 | Website https://www.kymeratx.com |
Kymera Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on discovering and developing small molecule therapeutics that selectively degrade disease-causing proteins by harnessing the body's own natural protein degradation system. It engages in developing IRAK4 program, which is in Phase II clinical trial for the treatment of immunology-inflammation diseases, including hidradenitis suppurativa and atopic dermatitis. The company also develops STAT6, a type 2 inflammation in allergic and atopic diseases; and TYK2 to treat autoimmune and inflammatory diseases. The company has a strategic alliance with Sanofi S.A. for the development of drug candidates targeting IRAK4 outside of the oncology and immuno-oncology fields. Kymera Therapeutics, Inc. was incorporated in 2015 and is headquartered in Watertown, Massachusetts.

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