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Upturn AI SWOT - About
Rafael Holdings, Inc. (RFL)
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Upturn Advisory Summary
09/16/2025: RFL (1-star) is currently NOT-A-BUY. Pass it for now.
Upturn Star Rating
Not Recommended Performance
These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.
Analysis of Past Performance
Type Stock | Historic Profit -56.14% | Avg. Invested days 28 | Today’s Advisory PASS |
Upturn Star Rating | Upturn Advisory Performance  1.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 09/16/2025 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 58.27M USD | Price to earnings Ratio - | 1Y Target Price - |
Price to earnings Ratio - | 1Y Target Price - | ||
Volume (30-day avg) - | Beta 0.92 | 52 Weeks Range 1.27 - 3.19 | Updated Date 06/29/2025 |
52 Weeks Range 1.27 - 3.19 | Updated Date 06/29/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.92 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -1633.43% |
Management Effectiveness
Return on Assets (TTM) -9.82% | Return on Equity (TTM) -26.78% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 21022811 | Price to Sales(TTM) 79.6 |
Enterprise Value 21022811 | Price to Sales(TTM) 79.6 | ||
Enterprise Value to Revenue 28.72 | Enterprise Value to EBITDA 5.39 | Shares Outstanding 34303200 | Shares Floating 15495922 |
Shares Outstanding 34303200 | Shares Floating 15495922 | ||
Percent Insiders 54.74 | Percent Institutions 9.37 |
Upturn AI SWOT
Rafael Holdings, Inc.
Company Overview
History and Background
Rafael Holdings, Inc. is focused on development and commercialization of oncology and immune-related products.
Core Business Areas
- Oncology Drug Development: Rafael Pharmaceuticals, Inc., a subsidiary, is focused on developing cancer therapies by exploiting the altered metabolism of cancer cells. This includes compounds targeting cell metabolism for cancer treatment.
- Real Estate: Rafael Holdings also holds interests in real estate assets.
Leadership and Structure
The company has a management team led by its CEO and a board of directors overseeing strategic direction.
Top Products and Market Share
Key Offerings
- CPI-613 (devimistat): Devimistat is Rafael Pharmaceutical's lead drug candidate targeting cancer cell metabolism. It's in clinical trials for several cancer types. Market share data is not publicly available as it is still in clinical stages. Competitors include companies developing similar metabolic inhibitors and standard cancer therapies.
- Real Estate Assets: Leasing and managing commercial and residential properties. Revenue and market share data depend on specific properties and local markets. Competitors vary based on location and property type.
Market Dynamics
Industry Overview
The pharmaceutical industry, particularly oncology, is highly competitive and innovative, with continuous research and development. The real estate market is cyclical and depends on economic conditions and location.
Positioning
Rafael Holdings is positioned as a pharmaceutical company specializing in cancer metabolism inhibitors. Its competitive advantage lies in its unique approach to targeting cancer cell metabolism. The real estate segment provides diversification.
Total Addressable Market (TAM)
The global oncology market is estimated to reach hundreds of billions of dollars. The company's TAM depends on the success of devimistat and its eventual market approval. The real estate TAM varies based on property locations.
Upturn SWOT Analysis
Strengths
- Novel approach to cancer treatment (metabolic inhibition)
- Diversified portfolio with real estate holdings
- Experienced management team
Weaknesses
- Drug development risks (clinical trial failures)
- Limited revenue stream currently
- Reliance on regulatory approvals
Opportunities
- Successful clinical trial outcomes for devimistat
- Partnerships with larger pharmaceutical companies
- Expansion of real estate portfolio
Threats
- Competition from established cancer therapies
- Regulatory hurdles and delays
- Economic downturn affecting real estate values
Competitors and Market Share
Key Competitors
- MRTX
- GILD
- BMY
Competitive Landscape
Rafael Holdings competes with established pharmaceutical companies with broader product portfolios and larger R&D budgets. Its advantage lies in its unique approach to cancer metabolism.
Major Acquisitions
Wavelength Pharmaceuticals
- Year: 2016
- Acquisition Price (USD millions): 0
- Strategic Rationale: Reverse merger to become a publicly traded company
Growth Trajectory and Initiatives
Historical Growth: Historical growth is characterized by R&D advancements and progress through clinical trials.
Future Projections: Future growth depends on the successful commercialization of devimistat and the performance of its real estate portfolio. Analyst estimates vary significantly.
Recent Initiatives: Recent strategic initiatives include advancing clinical trials for devimistat, securing funding for R&D, and managing real estate assets.
Summary
Rafael Holdings is a high-risk, high-reward pharmaceutical company focused on cancer metabolism. Its future hinges on the success of its drug development programs, particularly devimistat. Real estate holdings provide some stability, but regulatory hurdles and competition pose significant challenges. The company needs to secure more funding and show success in trials.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Company Filings (10K, 10Q), Press Releases, Analyst Reports, Market Research Reports
Disclaimers:
This analysis is for informational purposes only and does not constitute financial advice. Investment decisions should be based on individual research and consultation with a qualified financial advisor.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Rafael Holdings, Inc.
Exchange NYSE | Headquaters Newark, NJ, United States | ||
IPO Launch date 2018-03-26 | CEO, Founder & Executive Chairman Mr. Howard S. Jonas | ||
Sector Real Estate | Industry Real Estate Services | Full time employees 28 | Website https://www.rafaelholdings.com |
Full time employees 28 | Website https://www.rafaelholdings.com | ||
Rafael Holdings, Inc. primarily engages in holding interests in clinical and early-stage pharmaceutical companies, and commercial real estate assets in the United States and Israel. It operates in three segments, Healthcare, Infusion Technology, and Real Estate. The company engages in the development and commercialization of therapies that exploit the metabolic differences between normal cells and cancer cells. Its lead drug candidate is CPI-613 (devimistat), a stable analog of transient, acylated catalytic intermediates of lipoate currently under phase 2 open-label multi-cohort study evaluating CPI-613 in combination with hydroxychloroquine and 5-fluorouracil or gemcitabine in patients with advanced chemorefractory colorectal, pancreatic, or other solid cancers; and under phase 1 dose-escalation study of CPI-613 in combination with chemoradiation in patients with pancreatic adenocarcinoma. The company is also involved in developing Promitil, a molecule designed for the targeted delivery of mitomycin-C in a proprietary prodrug form, completed Phase 1A and 1B clinical studies targeting patients with advanced cancers; Folate-targeted Promitil (Promi-Fol) which is aimed at local treatment (intravesical) of superficial bladder cancer; and Promi-Dox, a highly potent dual drug liposome with MLP and doxorubicin targeting a potential basket of tumors. In addition, it engages in the development of surgical and procedural devices, including orthopedic arthroscopy instrument for Carpal Tunnel syndrome. Rafael Holdings, Inc. was incorporated in 2017 and is headquartered in Newark, New Jersey.
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