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Rafael Holdings, Inc. (RFL)

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Upturn Advisory Summary
12/11/2025: RFL (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type Stock | Historic Profit -56.14% | Avg. Invested days 25 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating ![]() | Upturn Advisory Performance | Stock Returns Performance |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 58.27M USD | Price to earnings Ratio - | 1Y Target Price - |
Price to earnings Ratio - | 1Y Target Price - | ||
Volume (30-day avg) - | Beta 0.92 | 52 Weeks Range 1.27 - 3.19 | Updated Date 06/29/2025 |
52 Weeks Range 1.27 - 3.19 | Updated Date 06/29/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.92 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -1633.43% |
Management Effectiveness
Return on Assets (TTM) -9.82% | Return on Equity (TTM) -26.78% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 21022811 | Price to Sales(TTM) 79.6 |
Enterprise Value 21022811 | Price to Sales(TTM) 79.6 | ||
Enterprise Value to Revenue 28.72 | Enterprise Value to EBITDA 5.39 | Shares Outstanding 34303200 | Shares Floating 15495922 |
Shares Outstanding 34303200 | Shares Floating 15495922 | ||
Percent Insiders 54.74 | Percent Institutions 9.37 |
Upturn AI SWOT
Rafael Holdings, Inc.
Company Overview
History and Background
Rafael Holdings, Inc. was established as a holding company focused on developing and commercializing advanced technologies. It has historically been associated with innovation in various sectors, often leveraging intellectual property derived from research and development. The company's evolution has involved strategic shifts and investments aimed at capitalizing on emerging market trends and technological advancements.
Core Business Areas
- Pharmaceuticals and Biotechnology: Focuses on the development and commercialization of novel therapeutics, particularly in oncology and inflammation. This segment aims to bring innovative drugs from preclinical research through clinical trials and to market.
- Advanced Technologies: Invests in and develops cutting-edge technologies across various industries, potentially including defense, aerospace, or other high-tech sectors where proprietary innovations can be commercialized.
Leadership and Structure
Rafael Holdings, Inc. operates with a corporate leadership team responsible for strategic direction and oversight. The organizational structure is designed to manage its diverse business segments, which may include dedicated management teams for each operational area.
Top Products and Market Share
Key Offerings
- Competitors: Pfizer (PFE),Merck & Co. (MRK),Bristol Myers Squibb (BMY)
- Description: Development of investigational drugs targeting specific cancer pathways. Market share data is not readily available for early-stage pipeline drugs. Competitors include major pharmaceutical and biotechnology companies with oncology portfolios.
- Market Share:
- Product Name 1: Novel Oncology Therapeutics
- Revenue:
- Competitors: AbbVie (ABBV),Janssen (part of JNJ),Eli Lilly and Company (LLY)
- Description: Pipeline of drug candidates aimed at treating chronic inflammatory diseases. Market share is not applicable as these are in development. Competitors are established players in the immunology and inflammation space.
- Market Share:
- Product Name 2: Anti-Inflammatory Drug Candidates
- Revenue:
Market Dynamics
Industry Overview
Rafael Holdings, Inc. operates in the pharmaceutical and biotechnology sectors, characterized by significant research and development investment, long product development cycles, stringent regulatory environments, and high potential for returns on successful drug approvals. The advanced technologies segment operates within dynamic and often rapidly evolving technological landscapes.
Positioning
Rafael Holdings, Inc. aims to position itself as an innovator in developing novel treatments for unmet medical needs and in commercializing disruptive technologies. Its competitive advantage may stem from proprietary intellectual property, strategic partnerships, and a focus on niche or emerging therapeutic areas and technological applications.
Total Addressable Market (TAM)
The TAM for oncology therapeutics is in the hundreds of billions of dollars globally, and the market for anti-inflammatory drugs is also substantial. The TAM for advanced technologies is vast and depends on the specific sub-sectors targeted. Rafael Holdings, Inc. is positioned to capture a small but potentially high-value share of these markets through its specialized product pipeline and technology focus.
Upturn SWOT Analysis
Strengths
- Proprietary technology and intellectual property portfolio.
- Focus on high-growth, unmet medical needs in pharmaceuticals.
- Experienced management team with expertise in R&D and commercialization.
- Potential for strategic partnerships and collaborations.
Weaknesses
- Reliance on successful clinical trial outcomes and regulatory approvals.
- Limited commercial stage products and revenue generation from pipeline assets.
- Capital intensive nature of drug development requiring significant funding.
- Potential dilution from fundraising activities.
Opportunities
- Growing demand for innovative cancer treatments.
- Advancements in biotechnology and precision medicine.
- Expansion into new therapeutic areas or technological applications.
- Potential for acquisitions or licensing deals for synergistic technologies.
Threats
- Intense competition from established pharmaceutical giants and biotech startups.
- Failure of clinical trials or unexpected side effects of drug candidates.
- Changes in healthcare policies and reimbursement rates.
- Technological obsolescence and rapid innovation by competitors.
Competitors and Market Share
Key Competitors
- Various large pharmaceutical companies (e.g., Pfizer - PFE, Merck & Co. - MRK)
- Specialized biotechnology companies focused on oncology and inflammation.
Competitive Landscape
Rafael Holdings, Inc. faces a highly competitive landscape. Its competitive advantages lie in its specialized focus and potentially disruptive technologies. However, it is outmatched by the scale, resources, and established market presence of larger pharmaceutical companies. Success depends on its ability to bring truly differentiated and effective therapies to market.
Growth Trajectory and Initiatives
Historical Growth: Historical growth for Rafael Holdings, Inc. has been characterized by strategic investments in R&D and the acquisition or development of new technologies and pipeline assets rather than revenue-based growth.
Future Projections: Future projections are highly contingent on the successful development and commercialization of its pharmaceutical pipeline and the successful deployment of its advanced technologies. Analyst estimates, if available, would focus on potential future revenue streams from approved drugs.
Recent Initiatives: Recent initiatives likely involve advancing its drug candidates through clinical trials, securing intellectual property, and potentially forging strategic partnerships to accelerate development and commercialization.
Summary
Rafael Holdings, Inc. is a research-intensive company focused on pharmaceuticals and advanced technologies. Its strength lies in its innovation potential and pipeline of novel drug candidates. However, it faces significant weaknesses due to its early-stage development, high capital needs, and intense competition. Opportunities exist in unmet medical needs and technological advancements, but threats from clinical trial failures and market dynamics are substantial. Strategic progress hinges on successful R&D execution and securing adequate funding.
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Sources and Disclaimers
Data Sources:
- Company filings (e.g., SEC filings)
- Financial news and market data providers
- Industry research reports
Disclaimers:
This analysis is based on publicly available information and is for informational purposes only. It does not constitute investment advice. Investing in early-stage biotechnology companies carries significant risk. Investors should conduct their own due diligence.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Rafael Holdings, Inc.
Exchange NYSE | Headquaters Newark, NJ, United States | ||
IPO Launch date 2018-03-26 | CEO, Founder & Executive Chairman Mr. Howard S. Jonas | ||
Sector Real Estate | Industry Real Estate Services | Full time employees 28 | Website https://www.rafaelholdings.com |
Full time employees 28 | Website https://www.rafaelholdings.com | ||
Rafael Holdings, Inc. primarily engages in holding interests in clinical and early-stage pharmaceutical companies, and commercial real estate assets in the United States and Israel. It operates in three segments, Healthcare, Infusion Technology, and Real Estate. The company engages in the development and commercialization of therapies that exploit the metabolic differences between normal cells and cancer cells. Its lead drug candidate is CPI-613 (devimistat), a stable analog of transient, acylated catalytic intermediates of lipoate currently under phase 2 open-label multi-cohort study evaluating CPI-613 in combination with hydroxychloroquine and 5-fluorouracil or gemcitabine in patients with advanced chemorefractory colorectal, pancreatic, or other solid cancers; and under phase 1 dose-escalation study of CPI-613 in combination with chemoradiation in patients with pancreatic adenocarcinoma. The company is also involved in developing Promitil, a molecule designed for the targeted delivery of mitomycin-C in a proprietary prodrug form, completed Phase 1A and 1B clinical studies targeting patients with advanced cancers; Folate-targeted Promitil (Promi-Fol) which is aimed at local treatment (intravesical) of superficial bladder cancer; and Promi-Dox, a highly potent dual drug liposome with MLP and doxorubicin targeting a potential basket of tumors. In addition, it engages in the development of surgical and procedural devices, including orthopedic arthroscopy instrument for Carpal Tunnel syndrome. Rafael Holdings, Inc. was incorporated in 2017 and is headquartered in Newark, New Jersey.

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