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Septerna, Inc. Common Stock (SEPN)



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Upturn Advisory Summary
08/14/2025: SEPN (1-star) is a SELL. SELL since 5 days. Profits (15.06%). Updated daily EoD!
1 Year Target Price $23.67
1 Year Target Price $23.67
2 | Strong Buy |
1 | Buy |
1 | Hold |
0 | Sell |
0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit 15.06% | Avg. Invested days 59 | Today’s Advisory SELL |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Small-Cap Stock | Market Capitalization 444.25M USD | Price to earnings Ratio - | 1Y Target Price 23.67 |
Price to earnings Ratio - | 1Y Target Price 23.67 | ||
Volume (30-day avg) 4 | Beta - | 52 Weeks Range 4.17 - 28.99 | Updated Date 08/10/2025 |
52 Weeks Range 4.17 - 28.99 | Updated Date 08/10/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -1.78 |
Earnings Date
Report Date 2025-08-11 | When - | Estimate -0.63 | Actual -0.56 |
Profitability
Profit Margin - | Operating Margin (TTM) -11831.05% |
Management Effectiveness
Return on Assets (TTM) - | Return on Equity (TTM) -30.96% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 133267629 | Price to Sales(TTM) 454.7 |
Enterprise Value 133267629 | Price to Sales(TTM) 454.7 | ||
Enterprise Value to Revenue 136.4 | Enterprise Value to EBITDA - | Shares Outstanding 44558300 | Shares Floating 18175792 |
Shares Outstanding 44558300 | Shares Floating 18175792 | ||
Percent Insiders 6.74 | Percent Institutions 102.92 |
Upturn AI SWOT
Septerna, Inc. Common Stock
Company Overview
History and Background
Septerna, Inc. is a privately held biotechnology company founded in 2019 focused on developing new medicines targeting G protein-coupled receptors (GPCRs). It was founded by leading scientists in the field and backed by venture capital firms.
Core Business Areas
- GPCR-Targeted Drug Discovery: Septerna focuses on discovering and developing new therapies targeting GPCRs, a large family of receptors involved in many diseases.
- Native Complex Platformu2122: Septerna leverages its proprietary Native Complexu2122 platform to study GPCRs in their native form, aiming to overcome limitations of traditional drug discovery approaches.
Leadership and Structure
Septerna is led by a management team with experience in drug discovery and development. The company has a scientific advisory board of experts in GPCR biology.
Top Products and Market Share
Key Offerings
- GPCR-Targeted Therapies (pipeline): Septerna's pipeline consists of drug candidates targeting various GPCRs. As a private company in clinical trials and research, market share is not applicable. Competition includes companies targeting the same GPCRs using different approaches.
Market Dynamics
Industry Overview
The pharmaceutical industry is highly competitive, with a focus on developing novel therapies for unmet medical needs. The GPCR-targeted drug market is substantial, given the involvement of GPCRs in many diseases.
Positioning
Septerna is positioned as a leader in GPCR-targeted drug discovery, leveraging its Native Complex platform to develop differentiated therapies.
Total Addressable Market (TAM)
The TAM for GPCR-targeted therapies is estimated to be billions of dollars annually. Septerna aims to capture a significant portion of this market by developing innovative therapies that address limitations of existing treatments.
Upturn SWOT Analysis
Strengths
- Proprietary Native Complex Platformu2122
- Experienced management team
- Strong scientific advisory board
- Focus on a large and important drug target class (GPCRs)
Weaknesses
- Early stage company with no approved products
- High risk of drug development failure
- Reliance on venture capital funding
- Limited resources compared to larger pharmaceutical companies
Opportunities
- Partnering with larger pharmaceutical companies
- Expanding the Native Complex Platformu2122 to other drug target classes
- Advancing pipeline candidates into clinical development
- Addressing unmet medical needs in GPCR-related diseases
Threats
- Competition from other companies targeting GPCRs
- Regulatory hurdles
- Clinical trial failures
- Intellectual property challenges
Competitors and Market Share
Key Competitors
- Amgen (AMGN)
- Novartis (NVS)
- Merck & Co. (MRK)
- Structure Therapeutics (GPCR)
Competitive Landscape
Septerna's competitive advantage lies in its Native Complex Platformu2122, which allows it to study GPCRs in their native form and potentially develop differentiated therapies. However, larger pharmaceutical companies have greater resources and more advanced clinical pipelines.
Growth Trajectory and Initiatives
Historical Growth: Septerna's growth is reflected in its ability to raise funding rounds, expand its pipeline, and advance programs towards clinical trials.
Future Projections: Future growth depends on successful clinical trials, partnerships, and potential acquisition by a larger pharmaceutical company.
Recent Initiatives: Recent initiatives include advancing lead programs into clinical trials and expanding the Native Complex Platformu2122 capabilities.
Summary
Septerna is a promising private biotechnology company focused on developing novel therapies targeting GPCRs. Its innovative Native Complex Platformu2122 provides a competitive advantage in drug discovery. As an early-stage company, it faces the inherent risks of drug development, but holds significant potential if it can successfully advance its pipeline into clinical development and commercialization. Septerna's future hinges on clinical trial outcomes and its ability to secure partnerships or funding for continued growth.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Company Website
- Venture Capital Funding Announcements
- Industry Reports
- Analyst Reports
Disclaimers:
The information provided is for informational purposes only and should not be considered financial advice. Market share data is estimated and may vary. As a private company, certain information is not publicly available.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Septerna, Inc. Common Stock
Exchange NASDAQ | Headquaters South San Francisco, CA, United States | ||
IPO Launch date 2024-10-25 | CEO - | ||
Sector Healthcare | Industry Biotechnology | Full time employees 75 | Website https://septerna.com |
Full time employees 75 | Website https://septerna.com |
Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease. The company also develops oral small molecule single- and multi-incretin receptor agonists for metabolic disorders, including obesity and type 2 diabetes. In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

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