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Shuttle Pharmaceuticals Inc (SHPH)



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Upturn Advisory Summary
09/16/2025: SHPH (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type Stock | Historic Profit -32.54% | Avg. Invested days 16 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Small-Cap Stock | Market Capitalization 37.68M USD | Price to earnings Ratio - | 1Y Target Price - |
Price to earnings Ratio - | 1Y Target Price - | ||
Volume (30-day avg) - | Beta 0.41 | 52 Weeks Range 3.00 - 107.40 | Updated Date 06/29/2025 |
52 Weeks Range 3.00 - 107.40 | Updated Date 06/29/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -69.25 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -115.05% | Return on Equity (TTM) -346.2% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 34845478 | Price to Sales(TTM) - |
Enterprise Value 34845478 | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA -0.67 | Shares Outstanding 10984300 | Shares Floating 411243 |
Shares Outstanding 10984300 | Shares Floating 411243 | ||
Percent Insiders 5.82 | Percent Institutions 0.94 |
Upturn AI SWOT
Shuttle Pharmaceuticals Inc
Company Overview
History and Background
Shuttle Pharmaceuticals, Inc. focuses on developing novel therapies to improve the outcomes of cancer patients undergoing radiation therapy. Founded to address unmet needs in cancer treatment, the company is relatively young and has been focusing on early-stage drug development and clinical trials.
Core Business Areas
- Radiation Sensitizers: Development of drugs that enhance the effectiveness of radiation therapy, making cancer cells more susceptible to radiation damage.
- Drug Development: Researching and developing novel therapeutic agents designed to protect normal tissue and minimize the toxicity to that normal tissue during radiation treatment of cancer.
- Clinical Trials: Conducting clinical trials to evaluate the safety and efficacy of its lead drug candidates.
Leadership and Structure
The leadership team consists of experienced pharmaceutical executives and scientists. The organizational structure is typical of a small biotech company, with focus on research and development.
Top Products and Market Share
Key Offerings
- Ropidoxuridine: A lead drug candidate being developed as a radiation sensitizer for various cancers. Market share is currently zero as the drug is still in clinical trials. The market potential depends on the drug's successful completion of clinical trials and regulatory approvals. Competitors include companies developing similar radiation sensitizers and improved radiation therapy techniques.
Market Dynamics
Industry Overview
The oncology market is large and growing, driven by increasing cancer incidence and advancements in cancer treatment. There is a significant need for therapies that improve the effectiveness and reduce the side effects of radiation therapy.
Positioning
Shuttle Pharmaceuticals is positioned as a developer of novel radiation sensitizers. Its competitive advantage lies in its specific drug candidates and their potential to enhance radiation therapy outcomes with reduced toxicity. The company is focused on addressing unmet clinical needs in specific cancer types.
Total Addressable Market (TAM)
The TAM for radiation sensitizers is estimated to be in the billions of dollars, depending on the success of clinical trials and regulatory approvals. Shuttle Pharmaceuticals is positioned to capture a portion of this market if its lead drug candidate is successfully developed and commercialized.
Upturn SWOT Analysis
Strengths
- Novel drug candidates with the potential to improve radiation therapy outcomes
- Experienced leadership team
- Focus on addressing unmet clinical needs in oncology
Weaknesses
- Early-stage drug development company with no marketed products
- High dependence on successful clinical trial outcomes
- Limited financial resources
Opportunities
- Potential to partner with larger pharmaceutical companies for drug development and commercialization
- Expansion into new cancer types and treatment modalities
- Increasing demand for improved cancer therapies with reduced side effects
Threats
- Clinical trial failures
- Regulatory hurdles
- Competition from other companies developing similar therapies
- Changes in the standard of care for cancer treatment
Competitors and Market Share
Key Competitors
- MRTX
- GSK
- AZN
Competitive Landscape
Shuttle Pharmaceuticals faces competition from established pharmaceutical companies with larger resources and more advanced drug development programs. Its advantage lies in its focus on novel radiation sensitizers and addressing unmet clinical needs.
Growth Trajectory and Initiatives
Historical Growth: Historical growth is reflected in the progress of drug development programs and fundraising efforts. As of the last update, the company is in early clinical trials.
Future Projections: Future growth depends on the successful completion of clinical trials and regulatory approvals. Analyst estimates, if available, would depend on these factors.
Recent Initiatives: Recent initiatives include initiating and advancing clinical trials for its lead drug candidate.
Summary
Shuttle Pharmaceuticals is an early-stage pharmaceutical company focused on developing radiation sensitizers to improve cancer therapy outcomes. The company's success hinges on the positive results of its clinical trials and regulatory approvals. They face high risks and competition, but could be rewarded if their drug shows promise. Key areas of focus are fundraising, trial execution, and potential partnerships.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Company website
- SEC filings
- Industry reports
- ClinicalTrials.gov
Disclaimers:
This analysis is for informational purposes only and should not be considered financial advice. Investment decisions should be based on thorough research and consultation with a qualified financial advisor. Data is based on publicly available information and may not be completely accurate or up-to-date. Market share estimations are subjective.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Shuttle Pharmaceuticals Inc
Exchange NASDAQ | Headquaters Gaithersburg, MD, United States | ||
IPO Launch date 2022-08-31 | CEO - | ||
Sector Healthcare | Industry Drug Manufacturers - Specialty & Generic | Full time employees 9 | Website https://www.shuttlepharma.com |
Full time employees 9 | Website https://www.shuttlepharma.com |
Shuttle Pharmaceuticals Holdings, Inc., a clinical stage pharmaceutical company, develops novel therapies to cure cancers. The company is developing Ropidoxuridine, an oral halogenated pyrimidine to treat patients with brain tumors and sarcomas; and SP-2-225, a pre-clinical class IIb product candidate that effects on the regulation of the immune system. It is also developing SP-1-303, a pre-clinical selective Class I HDAC for use in the treatment of ER positive breast cancers; and SP-1-161, a HDAC inhibitor that initiates the mutated in ataxia-telangiectasia response pathway. The company was founded in 2012 and is headquartered in Gaithersburg, Maryland.

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