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Shuttle Pharmaceuticals Inc (SHPH)

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Upturn Advisory Summary
12/26/2025: SHPH (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type Stock | Historic Profit -44.09% | Avg. Invested days 17 | Today’s Advisory PASS |
Upturn Star Rating ![]() | Upturn Advisory Performance | Stock Returns Performance |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 37.68M USD | Price to earnings Ratio - | 1Y Target Price - |
Price to earnings Ratio - | 1Y Target Price - | ||
Volume (30-day avg) - | Beta 0.41 | 52 Weeks Range 3.00 - 107.40 | Updated Date 06/29/2025 |
52 Weeks Range 3.00 - 107.40 | Updated Date 06/29/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -69.25 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -115.05% | Return on Equity (TTM) -346.2% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 34845478 | Price to Sales(TTM) - |
Enterprise Value 34845478 | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA -0.67 | Shares Outstanding 10984300 | Shares Floating 411243 |
Shares Outstanding 10984300 | Shares Floating 411243 | ||
Percent Insiders 5.82 | Percent Institutions 0.94 |
Upturn AI SWOT
Shuttle Pharmaceuticals Inc
Company Overview
History and Background
Shuttle Pharmaceuticals Inc. was founded in 1994 by Dr. Joseph Sinkule. The company's primary focus has been on developing novel cancer therapies, particularly in the area of radiation sensitizers. Significant milestones include the development of radiation-enhancing drugs, early-stage clinical trials, and securing intellectual property. The company has evolved by adapting its research pipeline and seeking strategic partnerships to advance its drug candidates.
Core Business Areas
- Oncology Drug Development: Shuttle Pharmaceuticals Inc. is dedicated to the discovery, development, and commercialization of innovative therapies for the treatment of cancer. Their research primarily centers on radiation sensitizers, compounds designed to make cancer cells more susceptible to radiation therapy, thereby improving treatment outcomes and potentially reducing the required radiation dose.
Leadership and Structure
Information regarding the specific current leadership team and detailed organizational structure for Shuttle Pharmaceuticals Inc. is not readily available through public financial disclosures or typical company profiles. As a smaller, publicly traded entity, detailed organizational charts and executive biographies may be limited in public access.
Top Products and Market Share
Key Offerings
- Product Name 1: Radiation Sensitizer Drugs (e.g., PH-02, PH-03, PH-04, PH-05). These are investigational drugs designed to enhance the efficacy of radiation therapy in treating various cancers. Specific market share data or revenue figures are not publicly disclosed as these are still in development and have not achieved commercialization. Key competitors in the broader oncology drug market include large pharmaceutical companies with extensive oncology portfolios.
Market Dynamics
Industry Overview
The oncology drug development industry is a dynamic and highly competitive sector characterized by significant R&D investment, stringent regulatory processes, and a constant drive for innovation. The market for cancer therapies is substantial and growing, fueled by an aging population, increased cancer incidence, and advancements in understanding disease biology. Radiation oncology is a significant sub-segment within this market.
Positioning
Shuttle Pharmaceuticals Inc. positions itself as a developer of novel, targeted therapies focused on improving the effectiveness of existing cancer treatments, particularly radiation therapy. Their competitive advantage lies in their proprietary technology and intellectual property related to radiation sensitizers. However, as a smaller company, they face challenges in competing with larger, well-established pharmaceutical companies with greater resources for development and commercialization.
Total Addressable Market (TAM)
The total addressable market for cancer therapies is in the hundreds of billions of dollars globally and continues to grow. The specific TAM for radiation sensitizers is a subset of this larger market and is expected to expand with advancements in radiation oncology and the development of effective sensitizing agents. Shuttle Pharmaceuticals Inc. aims to capture a portion of this market with its innovative drug candidates, but its current market position is nascent as its products are still in development.
Upturn SWOT Analysis
Strengths
- Proprietary technology in radiation sensitizers
- Patented drug candidates
- Focus on a specific, high-need area of cancer treatment
- Experienced scientific team (historically)
Weaknesses
- Limited financial resources compared to larger competitors
- Reliance on external funding for R&D and clinical trials
- Long development timelines typical of pharmaceutical products
- Lack of commercialized products
Opportunities
- Growing demand for more effective cancer treatments
- Potential for strategic partnerships and collaborations
- Advancements in radiation therapy techniques
- Acquisition by larger pharmaceutical companies
Threats
- High failure rate in drug development
- Intense competition from established and emerging biotech companies
- Regulatory hurdles and approval delays
- Patent expirations and generic competition for related therapies
- Changes in healthcare policy and reimbursement
Competitors and Market Share
Key Competitors
- N/A (As Shuttle Pharmaceuticals Inc. is a small, developmental stage company with no commercialized products, defining 'key competitors' in terms of market share is not feasible. The competitive landscape is broad, encompassing many oncology drug developers.)
Competitive Landscape
Shuttle Pharmaceuticals Inc.'s competitive landscape is characterized by numerous pharmaceutical and biotechnology companies, many of which are significantly larger and better capitalized, actively developing therapies for various cancers. Their advantage lies in their specialized focus on radiation sensitizers, while their disadvantage stems from their limited resources and the high risk associated with drug development.
Growth Trajectory and Initiatives
Historical Growth: Historical growth for Shuttle Pharmaceuticals Inc. has primarily been tied to its progress in drug discovery and development, and its ability to raise capital to fund these endeavors. There has been no revenue-based growth as the company does not have commercialized products.
Future Projections: Future projections for Shuttle Pharmaceuticals Inc. are highly speculative and depend entirely on the successful clinical development and regulatory approval of its drug candidates. Analyst coverage and projections are not widely available for companies at this stage. Success in clinical trials would be the primary driver of future valuation and potential growth.
Recent Initiatives: Recent initiatives would likely involve continued preclinical and clinical research on their radiation sensitizer compounds, efforts to secure funding for ongoing trials, and potential engagement with strategic partners for further development or commercialization.
Summary
Shuttle Pharmaceuticals Inc. is a developmental stage biotechnology company focused on creating novel cancer therapies, specifically radiation sensitizers. While possessing proprietary technology and a clear, unmet medical need focus, its strengths are overshadowed by its limited financial resources and the inherent risks of drug development. The company needs to secure substantial funding and achieve significant clinical trial success to overcome competitive pressures and move towards commercialization.
Similar Stocks
Sources and Disclaimers
Data Sources:
- SEC Filings (e.g., 10-K, 10-Q)
- Company Press Releases (if available)
- Financial Data Aggregators (limited for small-cap developmental companies)
Disclaimers:
The information provided is based on publicly available data and is intended for informational purposes only. Shuttle Pharmaceuticals Inc. is a developmental stage company, and investing in such companies carries significant risks. Financial data and company status are subject to change. This analysis does not constitute investment advice. All numerical data is presented for potential graphical representation. Market share and competitor data for developmental stage companies are highly speculative or non-existent in a commercial sense.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Shuttle Pharmaceuticals Inc
Exchange NASDAQ | Headquaters Gaithersburg, MD, United States | ||
IPO Launch date 2022-08-31 | CEO - | ||
Sector Healthcare | Industry Drug Manufacturers - Specialty & Generic | Full time employees 9 | Website https://www.shuttlepharma.com |
Full time employees 9 | Website https://www.shuttlepharma.com | ||
Shuttle Pharmaceuticals Holdings, Inc., a clinical stage pharmaceutical company, develops novel therapies to cure cancers. The company is developing Ropidoxuridine, an oral halogenated pyrimidine to treat patients with brain tumors and sarcomas; and SP-2-225, a pre-clinical class IIb product candidate that effects on the regulation of the immune system. It is also developing SP-1-303, a pre-clinical selective Class I HDAC for use in the treatment of ER positive breast cancers; and SP-1-161, a HDAC inhibitor that initiates the mutated in ataxia-telangiectasia response pathway. The company was founded in 2012 and is headquartered in Gaithersburg, Maryland.

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