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Sarepta Therapeutics Inc (SRPT)

Upturn stock ratingUpturn stock rating
$17.1
Last Close (24-hour delay)
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PASS
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Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
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  • ALL
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Upturn Advisory Summary

06/30/2025: SRPT (1-star) is currently NOT-A-BUY. Pass it for now.

Upturn Star Rating

ratingratingratingratingrating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

26 Analysts rated it

These Stocks/ETFs, based on Upturn Advisory, have historically outperformed the market, making them a top-tier choice for investors.

Year Target Price $48.04

Year Target Price $48.04

Analyst’s Price TargetsFor last 52 week
$48.04Target price
Low$16.96
Current$17.1
high$156.7

Analysis of Past Performance

Type Stock
Historic Profit -20.44%
Avg. Invested days 30
Today’s Advisory PASS
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 2.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 06/30/2025

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 1.68B USD
Price to earnings Ratio -
1Y Target Price 48.04
Price to earnings Ratio -
1Y Target Price 48.04
Volume (30-day avg) 26
Beta 0.6
52 Weeks Range 16.96 - 156.70
Updated Date 06/30/2025
52 Weeks Range 16.96 - 156.70
Updated Date 06/30/2025
Dividends yield (FY) -
Basic EPS (TTM) -2.64

Analyzing Revenue: Products, Geography and Growth

Revenue by Geography

Geography revenue - Year on Year

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -11.12%
Operating Margin (TTM) -40.33%

Management Effectiveness

Return on Assets (TTM) -2.19%
Return on Equity (TTM) -23.61%

Valuation

Trailing PE -
Forward PE 9.84
Enterprise Value 2500541476
Price to Sales(TTM) 0.75
Enterprise Value 2500541476
Price to Sales(TTM) 0.75
Enterprise Value to Revenue 1.12
Enterprise Value to EBITDA 99.06
Shares Outstanding 98277000
Shares Floating 93857514
Shares Outstanding 98277000
Shares Floating 93857514
Percent Insiders 4.44
Percent Institutions 90.25

Analyst Ratings

Rating 5
Target Price 48.04
Buy 8
Strong Buy 14
Buy 8
Strong Buy 14
Hold 4
Sell -
Strong Sell -
Strong Sell -

ai summary icon Upturn AI SWOT

Sarepta Therapeutics Inc

stock logo

Company Overview

overview logo History and Background

Sarepta Therapeutics Inc. was founded in 1980 as AntiVirals, Inc. and later changed its name to Sarepta in 2012. It is focused on developing RNA-targeted therapeutics for rare diseases, primarily Duchenne muscular dystrophy (DMD).

business area logo Core Business Areas

  • Duchenne Muscular Dystrophy (DMD): Sarepta develops and commercializes therapies for treating Duchenne muscular dystrophy (DMD). This includes exon-skipping therapies and gene therapy approaches.
  • Genetic Diseases: Expanding pipeline into other genetic diseases, including Limb-girdle muscular dystrophy (LGMD) and other neuromuscular disorders.

leadership logo Leadership and Structure

The leadership team includes Douglas S. Ingram (President and CEO). The company is structured around research & development, commercial operations, and manufacturing.

Top Products and Market Share

overview logo Key Offerings

  • Exondys 51 (eteplirsen): Exondys 51 is an exon-skipping drug targeting DMD patients amenable to exon 51 skipping. While specific market share data is unavailable, it was the first approved exon-skipping drug for DMD. Competitors include NS Pharma's Viltolarsen and Amondys 45.
  • Amondys 45 (casimersen): Amondys 45 is another exon-skipping drug for DMD patients amenable to exon 45 skipping. Specific market share data is unavailable. It faces competition from NS Pharma and other potential gene therapies.
  • Vyondys 53 (golodirsen): Vyondys 53 is an exon-skipping drug for DMD patients amenable to exon 53 skipping. Specific market share data is unavailable. It competes with other DMD therapies and potential gene therapies.
  • Elevidys (delandistrogene moxeparvovec-rokl): Elevidys is a gene therapy for ambulatory DMD patients aged 4-5. Revenue from this product is in early stages of market introduction. Competitors are still emerging but include potentially other gene therapy approaches in the future

Market Dynamics

industry overview logo Industry Overview

The industry is characterized by high unmet needs in rare diseases, particularly in neuromuscular disorders. It is driven by advancements in genetic therapies and RNA-targeted approaches. Regulatory pathways are often accelerated due to the urgency of these diseases.

Positioning

Sarepta is a leader in developing RNA-targeted therapies for DMD. Its competitive advantage lies in its established portfolio of exon-skipping drugs and its early entry into DMD gene therapy.

Total Addressable Market (TAM)

The total addressable market for DMD therapies is estimated to be in the billions of dollars annually. Sarepta is well-positioned to capture a significant portion of this TAM with its portfolio of approved therapies and pipeline products.

Upturn SWOT Analysis

Strengths

  • Early mover advantage in DMD therapies
  • Established portfolio of approved products
  • Strong focus on RNA-targeted approaches
  • Gene therapy platform

Weaknesses

  • High development costs
  • Regulatory uncertainties
  • Dependence on DMD market
  • Reimbursement challenges for expensive therapies

Opportunities

  • Expanding pipeline into other genetic diseases
  • Developing next-generation RNA-targeted therapies
  • Partnering with other companies to expand market reach
  • Acquiring complementary technologies or companies

Threats

  • Competition from other companies developing DMD therapies
  • Potential safety issues with RNA-targeted therapies
  • Changes in regulatory environment
  • Pricing pressures from payers

Competitors and Market Share

competitor logo Key Competitors

  • VTRS
  • PFE
  • BMY

Competitive Landscape

Sarepta has a strong position in the DMD market, but faces increasing competition. Its advantage lies in its established portfolio and gene therapy platform. The competitors advantages are in size and legacy

Major Acquisitions

Lysogene

  • Year: 2023
  • Acquisition Price (USD millions): 53.4
  • Strategic Rationale: Expand gene therapy capabilities and pipeline in central nervous system (CNS) disorders.

Growth Trajectory and Initiatives

Historical Growth: Historical growth has been driven by regulatory approvals and commercial launches of DMD therapies.

Future Projections: Future growth is projected to be driven by continued commercialization of DMD therapies and expansion into new indications.

Recent Initiatives: Recent initiatives include the launch of Elevidys, expansion of the gene therapy pipeline, and strategic partnerships.

Summary

Sarepta Therapeutics is a strong player in the rare disease market, especially in DMD, due to its early market presence and focus on RNA-targeted therapies and gene therapy. Its approved drugs drive revenue, but high R&D costs affect profitability. Sarepta needs to manage competition, reimbursement challenges, and regulatory uncertainties while expanding into new genetic diseases to sustain growth.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Sarepta Therapeutics Investor Relations
  • SEC Filings
  • Analyst Reports

Disclaimers:

This analysis is based on publicly available information and is not financial advice. Market share figures are estimates and may not be precise.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Sarepta Therapeutics Inc

Exchange NASDAQ
Headquaters Cambridge, MA, United States
IPO Launch date 1997-06-03
President, CEO & Director Mr. Douglas S. Ingram Esq.
Sector Healthcare
Industry Biotechnology
Full time employees 1372
Full time employees 1372

Sarepta Therapeutics, Inc., a commercial-stage biopharmaceutical company, focuses on the discovery and development of RNA-targeted therapeutics, gene therapies, and other genetic therapeutic modalities for the treatment of rare diseases. It offers EXONDYS 51 injection to treat Duchenne muscular dystrophy (Duchenne) in patients with confirmed mutation of the dystrophin gene that is amenable to exon 51 skipping; VYONDYS 53 for the treatment of Duchenne in patients with confirmed mutation of the dystrophin gene that is amenable to exon 53 skipping; AMONDYS 45 for the treatment of Duchenne in patients with confirmed mutation of the dystrophin gene that is amenable to exon 45 skipping; and ELEVIDYS, an adeno-associated virus based gene therapy for the treatment of ambulatory pediatric patients with Duchenne with a confirmed mutation in the Duchenne gene. The company is also developing SRP-9003, a limb-girdle muscular dystrophies gene therapy program. It has collaboration and license agreements with F. Hoffman-La Roche Ltd; Arrowhead Pharmaceuticals, Inc.; University of Western Australia; Catalent Maryland, Inc.; Nationwide Children's Hospital; Dyno Therapeutics; Hansa Biopharma; Duke University; and Genethon. The company was incorporated in 1980 and is headquartered in Cambridge, Massachusetts.