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Upturn AI Summary - About
Upstream Bio, Inc.(UPB)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for UPB
10/13/2026: UPB (1-star) is currently NOT-A-BUY. Pass it for now.
Upstream Bio, Inc. is a clinical-stage biotechnology company focused on developing novel treatments for inflammatory and respiratory diseases. Its primary asset is a monoclonal antibody targeting the TSLP receptor, aiming to compete in a high-value market segment. While the company benefits from an experienced leadership team and a focused scientific strategy, it remains pre-revenue and faces significant risks, including the inherent uncertainty of clinical trial success and intense competition from large pharmaceutical incumbents. The stock is best suited for growth-oriented investors with high risk tolerance who are looking to monitor the progress of clinical data readouts as the primary indicator of potential future value.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Strong fit | The company offers high-growth potential linked to the clinical success of its innovative immunology pipeline. |
| Momentum investor | Mixed fit | Momentum is conditional on positive clinical data readouts and potential regulatory breakthroughs. |
| Value investor | Weak fit | The stock is in an early, pre-revenue stage, making traditional value metrics inapplicable. |
| Dividend investor | Weak fit | The company is a clinical-stage entity that does not pay dividends. |
| Low-risk investor | Weak fit | Clinical-stage biotechnology stocks inherently involve high volatility and significant binary trial risk. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | Clinical-stage biotech stocks often experience sharp price swings based on trial data and market sentiment. |
| Valuation risk | High | Valuations are heavily dependent on long-term projections of drug commercialization that remain highly uncertain. |
| Competition risk (Large Pharma) | High | The company faces significant competition from established players with massive resources and existing drug portfolios. |
| Business quality | Medium | The quality is currently defined by its R&D focus and intellectual property rather than operational cash flow. |
| Dividend income | Low / none | There is no expectation of dividend income for the foreseeable future. |
| Execution risk | High | Success depends entirely on the effective management and positive outcome of complex, multi-year clinical trials. |
Price Behavior
Steep Decline
The stock price has dropped sharply with strong downward pressure.
Extreme Price Shocks
The stock has experienced exceptionally large and disruptive price movements during the period.
Analysis of Past Performance
Type Stock | Historic Profit 62.28% | Avg. Invested days 40 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  4.0 | Stock Returns Performance  3.0 |
| Profits based on simulation | Last Close 10/13/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 228.40M USD | Price to earnings Ratio - | 1Y Target Price 31.14 |
Price to earnings Ratio - | 1Y Target Price 31.14 | ||
Volume (30-day avg) 796.5K shares | Beta 1.39 | 52 Weeks Range 3.52 - 33.68 | Updated Date 10/13/2026 |
52 Weeks Range 3.52 - 33.68 | Updated Date 10/13/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -2.88 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Clinical Development | Advancement of UPB-101 and other pipeline assets toward regulatory approval. | The company does not currently generate revenue and is spending capital to prove its drug candidates work. |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 25.00M | Price to Sales(TTM) 72.32 |
Enterprise Value 25.00M | Price to Sales(TTM) 72.32 | ||
Enterprise Value to Revenue 7.92 | Enterprise Value to EBITDA - | Shares Outstanding 54.77M | Shares Floating 42.81M |
Shares Outstanding 54.77M | Shares Floating 42.81M | ||
Percent Insiders 14.78 | Percent Institutions 92.44 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
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