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Xilio Development Inc (XLO)

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Upturn Advisory Summary
01/09/2026: XLO (1-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $2
1 Year Target Price $2
| 1 | Strong Buy |
| 0 | Buy |
| 0 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit -16.39% | Avg. Invested days 29 | Today’s Advisory PASS |
Upturn Star Rating ![]() | Upturn Advisory Performance | Stock Returns Performance |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 47.63M USD | Price to earnings Ratio - | 1Y Target Price 2 |
Price to earnings Ratio - | 1Y Target Price 2 | ||
Volume (30-day avg) 1 | Beta -0.04 | 52 Weeks Range 0.61 - 1.70 | Updated Date 01/8/2026 |
52 Weeks Range 0.61 - 1.70 | Updated Date 01/8/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.61 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -183.9% | Operating Margin (TTM) -10.12% |
Management Effectiveness
Return on Assets (TTM) -26.26% | Return on Equity (TTM) -908.28% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value -48871137 | Price to Sales(TTM) 1.5 |
Enterprise Value -48871137 | Price to Sales(TTM) 1.5 | ||
Enterprise Value to Revenue 1.95 | Enterprise Value to EBITDA -0.11 | Shares Outstanding 67540930 | Shares Floating 21283108 |
Shares Outstanding 67540930 | Shares Floating 21283108 | ||
Percent Insiders 35.16 | Percent Institutions 23.34 |
Upturn AI SWOT
Xilio Development Inc

Company Overview
History and Background
Xilio Development Inc. is a clinical-stage biotechnology company focused on developing novel immunotherapies for cancer. Founded in 2017, the company has rapidly advanced its pipeline of cytokine-based therapeutics, targeting unmet needs in various solid tumors.
Core Business Areas
- Oncology Immunotherapy: Xilio Development Inc. is dedicated to pioneering innovative therapies that harness the body's own immune system to fight cancer. Their primary focus is on developing engineered cytokines designed to activate and expand tumor-specific immune cells while minimizing off-target toxicities.
Leadership and Structure
Information regarding Xilio Development Inc.'s specific leadership team and organizational structure is proprietary and not publicly disclosed in detail. As a clinical-stage company, it is structured to prioritize research and development, clinical trial management, and regulatory affairs.
Top Products and Market Share
Key Offerings
- Product Name 1: Xilio's lead product candidates are engineered cytokines designed to reprogram the tumor microenvironment and enhance anti-tumor immunity. These candidates are in various stages of clinical development for advanced solid tumors. Specific market share data is not applicable at this pre-commercial stage. Competitors in the broader oncology immunotherapy space include companies like Bristol Myers Squibb (Opdivo), Merck (Keytruda), and Pfizer (Inlyta), among many others.
Market Dynamics
Industry Overview
The oncology immunotherapy market is a rapidly growing and highly competitive sector within the pharmaceutical and biotechnology industry. Driven by significant advancements in understanding the immune system's role in cancer, there's a continuous effort to develop more effective and targeted therapies. The market is characterized by substantial investment in R&D, strategic partnerships, and increasing regulatory approvals for novel treatments.
Positioning
Xilio Development Inc. positions itself as a leader in developing next-generation engineered cytokines. Their competitive advantage lies in their proprietary cytokine engineering platform, which aims to overcome the limitations of conventional cytokines by improving efficacy and safety profiles. The company targets specific patient populations with limited treatment options.
Total Addressable Market (TAM)
The total addressable market for oncology immunotherapies is vast and continues to expand with new indications and drug approvals. While Xilio Development Inc.'s current focus is on specific solid tumors, the broader TAM for cancer treatments is in the hundreds of billions of dollars. Xilio is positioned to capture a significant share of its targeted indications as its pipeline matures.
Upturn SWOT Analysis
Strengths
- Proprietary cytokine engineering platform.
- Experienced scientific and management team.
- Focus on a significant unmet need in oncology.
- Strong preclinical and early-stage clinical data.
Weaknesses
- Clinical-stage company with no approved products.
- Dependence on successful clinical trial outcomes.
- Significant funding requirements for ongoing R&D.
- Limited brand recognition and market presence.
Opportunities
- Growing demand for innovative cancer therapies.
- Potential for strategic partnerships and collaborations.
- Expansion into new cancer indications.
- Advancements in biomarker identification for patient selection.
Threats
- High attrition rate in drug development.
- Intense competition in the immunotherapy space.
- Regulatory hurdles and delays.
- Pricing pressures and reimbursement challenges.
Competitors and Market Share
Key Competitors
- Immunocore Ltd. (IMCR)
- Gritstone Oncology, Inc. (GRTS)
- Alpine Immune Sciences, Inc. (ALPN)
Competitive Landscape
Xilio Development Inc. operates in a highly competitive landscape. Its advantages lie in its differentiated cytokine engineering technology. However, it faces challenges from established players with approved therapies and a longer track record. Its success depends on demonstrating superior efficacy and safety in clinical trials.
Growth Trajectory and Initiatives
Historical Growth: Xilio Development Inc.'s growth has been marked by the progression of its lead drug candidates through preclinical and early-stage clinical trials, alongside securing significant funding rounds to support these endeavors. Growth is measured in pipeline advancement and successful fundraising.
Future Projections: Future projections are heavily reliant on successful clinical trial outcomes and subsequent regulatory approvals. Analyst estimates would focus on the potential peak sales of its lead candidates, the timing of market entry, and the overall growth of the oncology immunotherapy market.
Recent Initiatives: Recent initiatives likely include the advancement of its clinical programs, potential strategic partnerships or collaborations, and ongoing efforts to secure further funding to support its development activities.
Summary
Xilio Development Inc. is a promising clinical-stage biotechnology company with a strong focus on developing innovative immunotherapies for cancer. Its proprietary technology for engineered cytokines offers a potential advantage in a highly competitive market. However, as a pre-commercial entity, it faces significant risks associated with clinical trial success and the substantial capital required for drug development. The company needs to demonstrate robust clinical efficacy and secure substantial funding to navigate the path to market and establish a strong position.
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Sources and Disclaimers
Data Sources:
- Company press releases and investor relations materials (where available)
- Industry research reports
- Financial news outlets
Disclaimers:
This JSON output is based on publicly available information and general industry knowledge. It is not financial advice and should not be used for investment decisions. The biotechnology sector is highly volatile and speculative. All data is subject to change and may not be exhaustive.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Xilio Development Inc
Exchange NASDAQ | Headquaters Waltham, MA, United States | ||
IPO Launch date 2021-10-22 | President, CEO & Director Dr. Rene Russo BCPS, Pharm.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 64 | Website https://xiliotx.com |
Full time employees 64 | Website https://xiliotx.com | ||
Xilio Therapeutics, Inc., a clinical-stage biotechnology company, engages in the discovery and development of tumor-activated immuno-oncology therapies. The company's checkpoint inhibitor program includes XTX101, an investigational Fc-enhanced, tumor-activated anti-CTLA-4 mAb that is in Phase 2 clinical trial for patients with advanced solid tumors. It also develops cytokine programs, which comprises XTX202, a tumor-activated beta-gamma biased IL-2, currently under Phase 2 clinal trials; and XTX301, an investigational tumor-activated, engineered IL-12 molecule, currently under Phase 1 studies. The company was founded in 2016 and is headquartered in Waltham, Massachusetts.

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