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Alx Oncology Holdings (ALXO)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for ALXO
10/26/2026: ALXO (2-star) is currently NOT-A-BUY. Pass it for now.
ALX Oncology is a clinical-stage biotechnology company focused on developing therapies to treat cancer by blocking the CD47 checkpoint pathway. Its primary asset, evorpacept, is currently in clinical testing, and the firm lacks commercial revenue, making it a high-risk investment tied to clinical outcomes. The company's main strength lies in its proprietary technology platform, while its primary growth story centers on successfully proving efficacy in solid tumor indications. Major risks include significant competition, financial dilution, and the high hurdle of clinical trial success. This stock is best suited for growth-oriented investors with high risk tolerance who are closely monitoring clinical trial updates and development timelines.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Mixed fit | The company offers high-risk, high-reward exposure to biotechnology innovation, suitable only for those comfortable with binary clinical outcomes. |
| Momentum investor | Strong fit while signal remains positive | The stock can exhibit high volatility around clinical data readouts, which may attract momentum traders when positive news cycles emerge. |
| Value investor | Weak fit | The company lacks earnings or revenue, making traditional value metrics inapplicable. |
| Dividend investor | Weak fit | The company does not pay dividends and reinvests all capital into R&D. |
| Low-risk investor | Weak fit | The high inherent risk of clinical-stage biotechnology makes this unsuitable for conservative portfolios. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | The share price is highly sensitive to clinical trial updates and biotech market sentiment. |
| Valuation risk | High | Valuations for pre-revenue biotech companies are speculative and can swing wildly based on trial expectations. |
| Competition risk (CD47 pathway) | High | Larger, better-funded competitors are also developing CD47-targeted therapies that could render ALXO's product obsolete. |
| Business quality | Medium | The company relies heavily on its proprietary platform, representing a narrow operational focus. |
| Dividend income | Low / none | Investors should expect no income, only potential capital appreciation. |
| Execution risk | High | Success depends entirely on the ability to execute complex, expensive clinical trials and achieve regulatory approval. |
Price Behavior
Steep Decline
The stock price has dropped sharply with strong downward pressure.
Highly Choppy
The stock has experienced frequent, large price swings that make its near-term movement less predictable.
Analysis of Past Performance
Type Stock | Historic Profit 90.11% | Avg. Invested days 25 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  2.0 | Stock Returns Performance  4.0 |
| Profits based on simulation | Last Close 10/26/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 161.78M USD | Price to earnings Ratio - | 1Y Target Price 4.6 |
Price to earnings Ratio - | 1Y Target Price 4.6 | ||
Volume (30-day avg) 1.4M shares | Beta 0.48 | 52 Weeks Range 0.86 - 2.66 | Updated Date 10/25/2026 |
52 Weeks Range 0.86 - 2.66 | Updated Date 10/25/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -1.13 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Clinical Development | Research and development of drug candidates. | The company does not currently sell products; investors are betting on the future success of their drug development programs. |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 137.66M | Price to Sales(TTM) 5085.96 |
Enterprise Value 137.66M | Price to Sales(TTM) 5085.96 | ||
Enterprise Value to Revenue 4287.72 | Enterprise Value to EBITDA -2.35 | Shares Outstanding 138.28M | Shares Floating 94.96M |
Shares Outstanding 138.28M | Shares Floating 94.96M | ||
Percent Insiders 0.99 | Percent Institutions 93.57 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
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