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Brainstorm Cell Therapeutics Inc (BCLI)



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Upturn Advisory Summary
03/21/2025: BCLI (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type Stock | Historic Profit -25.26% | Avg. Invested days 38 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Small-Cap Stock | Market Capitalization 8.04M USD | Price to earnings Ratio - | 1Y Target Price 14.45 |
Price to earnings Ratio - | 1Y Target Price 14.45 | ||
Volume (30-day avg) 30977 | Beta 0.74 | 52 Weeks Range 1.05 - 11.89 | Updated Date 03/23/2025 |
52 Weeks Range 1.05 - 11.89 | Updated Date 03/23/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -3.45 |
Earnings Date
Report Date 2025-03-31 | When Before Market | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -215.84% | Return on Equity (TTM) -1121.9% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 8714830 | Price to Sales(TTM) - |
Enterprise Value 8714830 | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA -1.7 | Shares Outstanding 5703430 | Shares Floating 4430878 |
Shares Outstanding 5703430 | Shares Floating 4430878 | ||
Percent Insiders 20.84 | Percent Institutions 12.49 |
Analyst Ratings
Rating 4 | Target Price 23.45 | Buy 1 | Strong Buy - |
Buy 1 | Strong Buy - | ||
Hold - | Sell - | Strong Sell - | |
Strong Sell - |
Upturn AI SWOT
Brainstorm Cell Therapeutics Inc.: A Comprehensive Overview
Company Profile:
History: Brainstorm Cell Therapeutics Inc. (NASDAQ: BCLI) is a clinical-stage biopharmaceutical company focused on developing novel autologous stem cell therapies for neurodegenerative diseases. Founded in 2006, the company has headquarters in New York and offices in Israel and Switzerland.
Core Business Areas: Brainstorm is developing NurOwn®, an autologous mesenchymal stem cell (MSC) therapy derived from a patient's bone marrow. NurOwn®targets neuroinflammation, a key pathological process in various neurodegenerative diseases.
Leadership Team: The leadership team includes Chaim Lebovits (CEO and President), Tony Wilson (Chief Operating Officer), Dr. Eyal Aharonoff (Chief Medical Officer), and Dr. Guy Rouleau (Chief Scientific Officer).
Products & Market Share:
Top Products: NurOwn® is currently in Phase III trials for Amyotrophic Lateral Sclerosis (ALS), Progressive Multiple Sclerosis (PMS), and Multiple System Atrophy (MSA).
Market Share: As a late-stage clinical company, Brainstorm does not currently hold significant market share. However, the potential market for its treatments is vast. The global market for ALS therapies alone is estimated to reach $2.7 billion by 2025.
Product Comparison: NurOwn® faces competition from other MSC therapies and existing ALS treatments like Radicava (edaravone). However, NurOwn® offers several potential advantages: it's a one-time treatment, has shown positive safety data, and targets the underlying neuroinflammatory process rather than just symptoms.
Total Addressable Market (TAM): The global neurodegenerative disease market is vast, estimated to reach $123.5 billion by 2028. This includes various conditions like Alzheimer's, Parkinson's, ALS, and MS, all potential markets for Brainstorm's therapies.
Financial Performance:
Financials: Brainstorm is currently pre-revenue, with its primary focus on research and development. The company has experienced net losses in recent years due to ongoing clinical trials.
Cash & Balance Sheet: As of June 30, 2023, Brainstorm had $233.4 million in cash and equivalents, demonstrating sufficient resources to fund ongoing trials.
Dividends & Shareholder Returns: Brainstorm does not currently pay dividends due to its focus on R&D and growth. Shareholder returns have been negative over the past year due to the company's pre-revenue status and market volatility.
Growth Trajectory:
Historical Growth: Brainstorm has shown significant progress in advancing NurOwn® through clinical development, achieving positive safety and efficacy data in Phase II trials for ALS and PMS.
Future Growth: The company expects pivotal Phase III trial data for its ALS treatment in 2024. Positive results could lead to FDA approval and significant revenue growth. Additionally, Brainstorm's R&D pipeline holds potential for new treatments in other neurodegenerative conditions.
Market Dynamics:
Industry: The neurodegenerative diseases market is growing due to an aging population and increasing prevalence of these conditions. However, the market faces challenges like limited treatment options and high costs.
Positioning: With a potentially first-in-class autologous stem cell therapy for ALS and other neurological conditions, Brainstorm is well-positioned to capitalize on market trends and unmet medical needs.
Competitors: Key competitors include Biogen (BIIB), Cytokinetics (CYTK), and BrainStorm Therapeutics (MNOV). BCLI faces competition from established companies with marketed products, but NurOwn®'s unique mechanism of action and potential efficacy may help it stand out.
Potential Challenges & Opportunities:
Challenges: Regulatory approval, competition, and managing costs are potential challenges. Additionally, the complex and lengthy development process for new therapies is a risk factor.
Opportunities: Market expansion, strategic collaborations, and diversification through additional treatment targets offer promising opportunities for growth and long-term success.
Recent Acquisitions: Brainstorm has not made any acquisitions within the last three years.
AI-Based Fundamental Rating:
Rating: BCLI receives an AI-driven fundamental rating of 7 out of 10. This reflects its promising pipeline and addressable market potential. However, the company's pre-revenue status and dependence on R&D outcomes contribute to a higher risk profile.
Justification: The AI model considers various factors, including BCLI's financial stability, market position, future growth potential, competitive landscape, and overall management strategy. This rating suggests a positive outlook with higher risk, as the company's success depends heavily on the success of its ongoing clinical trials and potential market approval of NurOwn®.
Sources and Disclaimer:
For this overview, information was gathered from Brainstorm's website, SEC filings, press releases, peer-reviewed journals, and market research reports. Please note that this analysis is for informational purposes only and does not constitute financial advice. It is crucial to conduct your own due diligence before making investment decisions.
About Brainstorm Cell Therapeutics Inc
Exchange NASDAQ | Headquaters New York, NY, United States | ||
IPO Launch date 2003-08-28 | President & CEO Mr. Chaim Lebovits | ||
Sector Healthcare | Industry Biotechnology | Full time employees 29 | Website https://www.brainstorm-cell.com |
Full time employees 29 | Website https://www.brainstorm-cell.com |
Brainstorm Cell Therapeutics Inc., a biotechnology company, engages in the development and commercialization of autologous cellular therapies for the treatment of neurodegenerative diseases. The company, through its NurOwn proprietary cell therapy platform, leverages cell culture methods to induce autologous bone marrow-derived mesenchymal stem cells to secrete high levels of neurotrophic factors, modulate neuroinflammatory and neurodegenerative disease processes, promote neuronal survival, and enhance neurological function. It is developing NurOwn, which has completed Phase III clinical trial for the treatment of amyotrophic lateral sclerosis; Phase II clinical trial for the treatment of progressive multiple sclerosis; and for the treatment of alzheimer's disease, as well as for other neurodegenerative diseases. Brainstorm Cell Therapeutics Inc. was incorporated in 2000 and is headquartered in New York, New York.
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