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Centessa Pharmaceuticals PLC ADR (CNTA)

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Upturn Advisory Summary
01/09/2026: CNTA (5-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $39.23
1 Year Target Price $39.23
| 7 | Strong Buy |
| 4 | Buy |
| 0 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit 114.4% | Avg. Invested days 42 | Today’s Advisory PASS |
Upturn Star Rating ![]() | Upturn Advisory Performance | Stock Returns Performance |
Key Highlights
Company Size Mid-Cap Stock | Market Capitalization 3.22B USD | Price to earnings Ratio - | 1Y Target Price 39.23 |
Price to earnings Ratio - | 1Y Target Price 39.23 | ||
Volume (30-day avg) 11 | Beta 1.57 | 52 Weeks Range 9.60 - 30.58 | Updated Date 01/9/2026 |
52 Weeks Range 9.60 - 30.58 | Updated Date 01/9/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -1.89 |
Analyzing Revenue: Products, Geography and Growth
Revenue by Products
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -1425.33% |
Management Effectiveness
Return on Assets (TTM) -25.26% | Return on Equity (TTM) -60.62% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 3131474434 | Price to Sales(TTM) 214.73 |
Enterprise Value 3131474434 | Price to Sales(TTM) 214.73 | ||
Enterprise Value to Revenue 208.76 | Enterprise Value to EBITDA 1.12 | Shares Outstanding 146075743 | Shares Floating 80094609 |
Shares Outstanding 146075743 | Shares Floating 80094609 | ||
Percent Insiders 0.39 | Percent Institutions 87.55 |
Upturn AI SWOT
Centessa Pharmaceuticals PLC ADR

Company Overview
History and Background
Centessa Pharmaceuticals PLC (ADR) is a global pharmaceutical company focused on developing and commercializing innovative medicines. It was formed through a significant transaction involving a SPAC merger with Nexus Pharmaceuticals and the subsequent acquisition of three additional companies, aiming to create a diversified portfolio across multiple therapeutic areas. The company's strategy is to build a portfolio of differentiated medicines with the potential to address significant unmet medical needs.
Core Business Areas
- Oncology: Focuses on developing novel therapies for various cancer types, with programs targeting specific molecular pathways and immunotherapies.
- Hematology: Develops treatments for blood disorders, aiming to improve patient outcomes and quality of life.
- Cardiovascular: Works on innovative solutions for cardiovascular diseases, a leading cause of mortality globally.
- Nephrology: Dedicated to advancing treatments for kidney diseases, addressing the growing burden of renal conditions.
Leadership and Structure
Centessa Pharmaceuticals is led by a management team with experience in drug development, commercialization, and corporate finance. The organizational structure is designed to support the development and integration of its diverse pipeline of drug candidates. Specific leadership roles and detailed organizational charts are typically found in the company's investor relations materials.
Top Products and Market Share
Key Offerings
- Product Name 1: Information on specific lead drug candidates and their development stages would require access to real-time company filings. Centessa has a diversified pipeline across multiple therapeutic areas, rather than a single dominant product. Competitors vary widely depending on the specific therapeutic indication and stage of development.
Market Dynamics
Industry Overview
The pharmaceutical industry is characterized by high R&D costs, stringent regulatory processes, and significant market opportunities driven by an aging global population and increasing prevalence of chronic diseases. The industry is highly competitive, with a constant drive for innovation and the development of novel therapies.
Positioning
Centessa Pharmaceuticals positions itself as a next-generation pharmaceutical company with a diversified pipeline of innovative medicines. Its strategy of acquiring and developing multiple promising drug candidates aims to create a robust portfolio with the potential for significant growth. The company aims to leverage its integrated platform to accelerate drug development and bring therapies to market efficiently.
Total Addressable Market (TAM)
The TAM for Centessa Pharmaceuticals is a composite of the various therapeutic areas it targets, including oncology, hematology, cardiovascular, and nephrology. These markets represent hundreds of billions of dollars globally. Centessa is positioned to capture a share of these markets by developing differentiated medicines that address unmet needs within these segments.
Upturn SWOT Analysis
Strengths
- Diversified pipeline across multiple therapeutic areas
- Experienced management team
- Potential for significant innovation through its acquisition strategy
- Integrated business model focused on efficient drug development
Weaknesses
- As a relatively new entity formed through acquisitions, it may face integration challenges
- Dependence on the success of its early-stage drug candidates
- Limited established commercial infrastructure compared to larger, established pharmaceutical companies
Opportunities
- Growing demand for novel therapies in oncology, hematology, and other target areas
- Potential for strategic partnerships and collaborations
- Expansion into new geographical markets
- Advancements in biotechnology and drug discovery platforms
Threats
- High failure rates in drug development
- Intense competition from established pharmaceutical giants and emerging biotechs
- Regulatory hurdles and delays in drug approval
- Pricing pressures and reimbursement challenges
- Economic downturns impacting healthcare spending
Competitors and Market Share
Key Competitors
- Bristol Myers Squibb (BMY)
- Pfizer Inc. (PFE)
- Merck & Co., Inc. (MRK)
- Johnson & Johnson (JNJ)
- Novartis AG (NVS)
- Roche Holding AG (RHHBY)
- Gilead Sciences, Inc. (GILD)
Competitive Landscape
Centessa operates in a highly competitive landscape against established pharmaceutical giants with extensive R&D capabilities and commercial reach. Its advantage lies in its focused approach to developing differentiated therapies and its potential to be agile due to its structure. However, it faces challenges in matching the scale and resources of its larger competitors.
Growth Trajectory and Initiatives
Historical Growth: As a relatively new entity formed through a series of acquisitions and mergers, historical growth is defined by its strategic expansion and pipeline development rather than traditional revenue growth from commercialized products. The growth trajectory is inherently tied to its R&D success.
Future Projections: Future projections for Centessa Pharmaceuticals are contingent on the successful progression of its drug candidates through clinical trials and subsequent regulatory approvals. Analyst estimates would focus on the potential market size and success rates of its lead programs.
Recent Initiatives: Centessa's recent initiatives have largely focused on the strategic consolidation of its pipeline through acquisitions and the ongoing development of its key drug candidates. This includes advancing programs through various stages of clinical trials.
Summary
Centessa Pharmaceuticals PLC ADR is a diversified biopharmaceutical company with a promising pipeline across multiple therapeutic areas. Its strength lies in its integrated R&D model and potential for innovative drug development. However, the company faces significant competition and the inherent risks of drug development. Its success will depend on its ability to navigate clinical trials, secure regulatory approvals, and effectively commercialize its therapies in a highly competitive market.
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Sources and Disclaimers
Data Sources:
- Company investor relations filings (e.g., 10-K, 10-Q)
- Financial news and analysis platforms (e.g., Yahoo Finance, Bloomberg)
- Industry research reports
Disclaimers:
This JSON output is generated based on publicly available information and general industry knowledge. It is not intended as financial advice. Investment decisions should be made after consulting with a qualified financial advisor and conducting independent research. Market share data is illustrative and subject to change.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Centessa Pharmaceuticals PLC ADR
Exchange NASDAQ | Headquaters - | ||
IPO Launch date 2021-05-28 | President of the Orexin Program, CEO & Director Dr. Mario Alberto Accardi Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 114 | Website https://centessa.com |
Full time employees 114 | Website https://centessa.com | ||
Centessa Pharmaceuticals plc, a clinical-stage pharmaceutical company, discovers, develops, and delivers medicines. Its lead clinical-stage program includes ORX750, an orally administered OX2R agonist in a Phase 2a study for the treatment of idiopathic hypersomnia and narcolepsy type 1 and 2. The company also develops ORX142 for the treatment of neurological and neurodegenerative disorders, as well as other potential symptoms, including excessive daytime sleepiness, impaired attention, cognitive deficits, and fatigue; and ORX489 for the treatment of neuropsychiatric disorders. In addition, it offers LockBody, which is designed to selectively drive potent effector function activity, such as CD3, into the tumor microenvironment. Centessa Pharmaceuticals plc was incorporated in 2020 and is headquartered in Altrincham, the United Kingdom.

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