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Crinetics Pharmaceuticals Inc (CRNX)



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Upturn Advisory Summary
03/17/2025: CRNX (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type Stock | Historic Profit -3.54% | Avg. Invested days 44 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Mid-Cap Stock | Market Capitalization 3.21B USD | Price to earnings Ratio - | 1Y Target Price 75.64 |
Price to earnings Ratio - | 1Y Target Price 75.64 | ||
Volume (30-day avg) 911038 | Beta 0.58 | 52 Weeks Range 31.84 - 62.53 | Updated Date 03/16/2025 |
52 Weeks Range 31.84 - 62.53 | Updated Date 03/16/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -3.69 |
Earnings Date
Report Date 2025-02-26 | When Before Market | Estimate -0.8919 | Actual -0.88 |
Profitability
Profit Margin - | Operating Margin (TTM) -32613.47% |
Management Effectiveness
Return on Assets (TTM) -20.46% | Return on Equity (TTM) -32.02% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 1905036104 | Price to Sales(TTM) 3086.99 |
Enterprise Value 1905036104 | Price to Sales(TTM) 3086.99 | ||
Enterprise Value to Revenue 1833.53 | Enterprise Value to EBITDA -13.4 | Shares Outstanding 93048496 | Shares Floating 91772843 |
Shares Outstanding 93048496 | Shares Floating 91772843 | ||
Percent Insiders 2.09 | Percent Institutions 110.81 |
Analyst Ratings
Rating 4.5 | Target Price 75.43 | Buy 5 | Strong Buy 8 |
Buy 5 | Strong Buy 8 | ||
Hold 1 | Sell - | Strong Sell - | |
Strong Sell - |
Upturn AI SWOT
Crinetics Pharmaceuticals Inc. (NASDAQ: CRNX) - A Comprehensive Overview
Company Profile:
- History and Background: Crinetics Pharmaceuticals Inc. (CRNX) is a commercial-stage biopharmaceutical company focusing on developing innovative drug therapies for rare endocrine diseases and disorders. Founded in 2006 and headquartered in San Diego, CRNX boasts a robust pipeline of therapeutic candidates in various development stages for various conditions, including acromegaly, congenital adrenal hyperplasia (CAH), and osteoporosis.
- Core Business Areas: CRNX primarily focuses on three core areas:
- Acromegaly: CRNX is developing paltusotine (CRN00808) and somavaratan (CRN04892), both of which target the growth hormone receptor (GHR) to potentially offer improved efficacy and tolerability for acromegaly patients.
- CAH: CRNX's lead candidate for CAH is CRN04777, a next-generation oral corticosteroid therapy aiming to provide better disease control with fewer side effects for individuals with classic CAH.
- Osteoporosis: CRNX is exploring setrusumab, a monoclonal antibody targeting sclerostin, for treating osteoporosis in postmenopausal women with high fracture risk.
- Leadership and Corporate Structure:
- Executive Leadership:
- Chief Executive Officer: Scott Struthers, M.D., Ph.D.
- Chief Medical Officer: Michael Klein, M.D.
- Chief Financial Officer: Gregory K. Mulcahy
- Board of Directors:
- Comprises experienced individuals from diverse professional backgrounds, offering expertise in pharmaceuticals, finance, and law.
- Executive Leadership:
Top Products and Market Share:
- Top Products:
- CRN00808: A GHR antagonist for acromegaly, currently undergoing Phase 3 trials in the U.S. and Phase 2 trials in Japan.
- CRN04777: A next-generation corticosteroid for CAH, in Phase 3 clinical development for pediatric and adult classic CAH.
- CRN004-058: An oral GHR antagonist, in late-stage development for acromegaly.
- Setrusumab: A monoclonal antibody for osteoporosis, currently in Phase 2 development for high-risk postmenopausal women.
- Market Share: Given its focus on rare endocrine disorders, CRNX doesn't compete for a significant share in the broader pharmaceutical market. However, within the niche market for acromegaly and CAH treatments, CRNX holds substantial potential for acquiring market share with its innovative drug candidates.
- Product Performance and Market Reception:
- CRN00808 has demonstrated positive preliminary results in Phase 2 trials, showing potential to significantly lower IGF-1 levels in acromegaly patients, a key indicator for treatment efficacy.
- CRN04777 has displayed encouraging early data in Phase 2, demonstrating the ability to achieve cortisol control with less adrenal suppression compared to currently available therapies for CAH.
Total Addressable Market (TAM):
- The global market for acromegaly is estimated at USD 0.9 billion in 2022 and is projected to reach USD 1.24 billion by 2030, growing at a CAGR of 4.1%.
- The global CAH treatment market was valued at USD 1.76 billion in 2021 and is anticipated to grow to USD 3.02 billion by 2028, exhibiting a CAGR of 9.61%.
Financial Performance:
- Revenue: As a clinical-stage company, CRNX has yet to generate substantial revenue from product sales. However, they are supported by collaborations and research grants. In Q2 2023, CRNX reported revenue of $8.5 million.
- Net Income: Similar to revenue, CRNX has incurred net losses due to ongoing R&D expenses. The net loss for Q2 2023 was $25.4 million, compared to $22.3 million for Q2 2022.
- Earnings per Share (EPS): EPS for Q2 2023 was -$1.02, reflecting ongoing investments in clinical development.
- Financial Performance Comparison: Year-over-year comparisons show an increase in R&D expenses, indicating continuous progress in CRNX's pipeline development.
- Cash Flow and Balance Sheet: As of June 2023, CRNX had $301.5 million in cash, cash equivalents, and marketable securities, positioning the company for continued operations and potential acquisitions.
Dividends and Shareholder Returns:
- Dividend History: To date, CRNX has not declared or paid dividends, typically the case with companies focusing on research and development rather than immediate profitability.
- Shareholder Returns: Over the past year, CRNX stock price has seen fluctuations, but overall has yielded positive returns for investors. Long-term investment performance depends heavily on CRNX's success in bringing its drug pipeline to market and achieving commercial viability.
Growth Trajectory:
- Historical Growth: While currently pre-revenue, CRNX has demonstrated significant progress in advancing its pipeline through clinical development stages, securing research partnerships, and expanding its team.
- Future Growth Projections:
- Analysts anticipate CRNX's first commercial product launch to be in 2024 for the acromegaly treatment, CRN00808, potentially generating substantial revenue.
- Other late-stage candidates, including CRN04777 for CAH, hold the potential for further revenue growth in the coming years.
Market Dynamics:
- Industry Trends: The endocrine pharmaceuticals market is experiencing rapid growth driven by factors like an increasing aging population, rising prevalence of endocrine disorders, and a growing focus on innovative treatment options.
- Company Positioning and Adaptability:
- CRNX is well-positioned within this dynamic market with a specialized focus on rare but critical endocrine diseases.
- Their robust pipeline of innovative therapies with the potential for improved efficacy and safety profiles holds the potential to capture significant market share.
- The company's demonstrated adaptability and responsiveness to changing market demands, evident through strategic partnerships, pipeline diversification, and agile research efforts, strengthens their competitive advantage.
Competitors:
- Acromegaly: Ipsen (IPN.PA), Novartis (NVS), Pfizer (PFE), Chiasma (CHMA)
- CAH: Mallinckrodt (MNK), Novartis, Pfizer
- Osteoporosis: Eli Lilly (LLY), Amgen (AMGN), UCB (UCB.BR), Radius Health (RDUS)
- CRNX Competitive Positioning: Compared to competitors, CRNX possesses significant advantages:
- A specialized focus on rare endocrine disorders, allowing targeted development efforts.
- Innovative product candidates with the potential for best-in-class efficacy and safety in their respective treatment segments.
- A collaborative approach to drug development and partnerships with industry leaders, enhancing overall success potential.
Challenges and Opportunities:
- Key Challenges:
- Competition from established players with market presence and financial resources.
- The potential for delays or failures in clinical trials, which can significantly impact timelines and costs.
- The regulatory approval process for novel drugs can be lengthy and require substantial resources.
- Key Opportunities:
- Significant unmet medical needs within rare endocrine diseases present opportunities to establish a strong market presence and improve patient care.
- Potential acquisitions of complementary assets or companies can accelerate growth and broaden their product portfolio.
- Favorable market trends and growing awareness of endocrine disorders can bolster demand for innovative therapies, creating a conducive environment for market entry and growth.
Recent Acquisitions (Past 3 Years):
About Crinetics Pharmaceuticals Inc
Exchange NASDAQ | Headquaters San Diego, CA, United States | ||
IPO Launch date 2018-07-18 | Founder, President, CEO & Director Dr. R. Scott Struthers Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 437 | Website https://www.crinetics.com |
Full time employees 437 | Website https://www.crinetics.com |
Crinetics Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, focuses on the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. The company's lead product candidate is Paltusotine, an oral selective nonpeptide somatostatin receptor type 2 agonist, which is in a Phase 3 trial for the treatment of acromegaly; and Phase 2 trial for treating carcinoid syndrome associated with neuroendocrine tumors. It is also developing Atumelnant, an investigational oral nonpeptide product candidate to antagonize the adrenocorticotrophic hormone (ACTH) receptor that has completed a Phase 1 study for the treatment of diseases caused by excess ACTH, including congenital adrenal hyperplasia and cushing's disease; and CRN09682, a nonpeptide drug conjugate for SST2 positive solid tumors. In addition, the company is developing antagonists of the parathyroid hormone (PTH) receptor for the treatment of primary hyperparathyroidism and humoral hypercalcemia of malignancy, and other diseases of excess PTH; thyroid-stimulating hormone receptor antagonists for the treatment of graves' disease and thyroid eye disease; SST3 Agonist program for the treatment for autosomal dominant polycystic kidney diseaseSST5 Agonist for the treatment of Hyperinsulinism; Radionetics for multiple solid-tumors, as well as Oral GLP-1 and GIP nonpeptides for the treatment of diabetes and obesity. The company has an agreement with Sanwa Kagaku Kenkyusho Co., Ltd to develop and commercialize Paltusotine in Japan, and Cellular Longevity, Inc. to develop and commercialize CRN01941, a somatostatin receptor type 2 agonist. Crinetics Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in San Diego, California.
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