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Lexicon Pharmaceuticals Inc (LXRX)



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Upturn Advisory Summary
08/29/2025: LXRX (2-star) has a low Upturn Star Rating. Not recommended to BUY.
1 Year Target Price $2.75
1 Year Target Price $2.75
1 | Strong Buy |
2 | Buy |
2 | Hold |
0 | Sell |
0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit 23.76% | Avg. Invested days 31 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Small-Cap Stock | Market Capitalization 417.91M USD | Price to earnings Ratio - | 1Y Target Price 2.75 |
Price to earnings Ratio - | 1Y Target Price 2.75 | ||
Volume (30-day avg) 5 | Beta 1.18 | 52 Weeks Range 0.28 - 2.17 | Updated Date 08/30/2025 |
52 Weeks Range 0.28 - 2.17 | Updated Date 08/30/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.32 |
Analyzing Revenue: Products, Geography and Growth
Revenue by Products
Earnings Date
Report Date 2025-08-06 | When - | Estimate -0.09 | Actual 0.01 |
Profitability
Profit Margin -206.43% | Operating Margin (TTM) 12.94% |
Management Effectiveness
Return on Assets (TTM) -22.14% | Return on Equity (TTM) -65.3% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 317747746 | Price to Sales(TTM) 7.15 |
Enterprise Value 317747746 | Price to Sales(TTM) 7.15 | ||
Enterprise Value to Revenue 5.44 | Enterprise Value to EBITDA -2.58 | Shares Outstanding 363399008 | Shares Floating 183890725 |
Shares Outstanding 363399008 | Shares Floating 183890725 | ||
Percent Insiders 1.17 | Percent Institutions 72.07 |
Upturn AI SWOT
Lexicon Pharmaceuticals Inc

Company Overview
History and Background
Lexicon Pharmaceuticals, Inc. is a biopharmaceutical company founded in 1995, focused on discovering and developing treatments for human diseases. It utilizes its gene knockout technology to identify and validate drug targets.
Core Business Areas
- Drug Discovery and Development: Lexicon focuses on discovering and developing small molecule drugs, primarily in the areas of diabetes, oncology, and neuropathic pain. They leverage their proprietary gene knockout technology to identify novel drug targets and accelerate the drug development process.
- Commercialization: Lexicon has a commercialized product, XERISPA (ibrexafungerp tablets), for the treatment of vulvovaginal candidiasis (VVC). They are actively involved in its marketing and sales.
Leadership and Structure
The leadership team is comprised of experienced pharmaceutical executives and scientists. The organizational structure includes research and development, clinical operations, commercial operations, and administrative functions.
Top Products and Market Share
Key Offerings
- XERISPA (ibrexafungerp): XERISPA is an oral antifungal medication approved for the treatment of vulvovaginal candidiasis (VVC). Launch started in June 2023. Revenue is still being generated and the market share is still low relative to other treatments. Competitors include fluconazole (Diflucan), and topical treatments.
Market Dynamics
Industry Overview
The biopharmaceutical industry is characterized by high R&D costs, long development timelines, and stringent regulatory requirements. The market for antifungal medications is growing, driven by increasing prevalence of fungal infections.
Positioning
Lexicon is positioned as an innovative biopharmaceutical company with a unique drug discovery platform. Its competitive advantage lies in its gene knockout technology and its ability to identify novel drug targets.
Total Addressable Market (TAM)
The TAM for antifungal therapies is estimated to be billions of dollars globally. Lexicon aims to capture a significant share of this market with XERISPA and future products.
Upturn SWOT Analysis
Strengths
- Proprietary gene knockout technology
- Experienced management team
- Commercialized product (XERISPA)
- Focus on novel drug targets
Weaknesses
- Limited financial resources compared to larger pharmaceutical companies
- Dependence on XERISPA for revenue
- History of net losses
- Susceptible to competitive responses.
Opportunities
- Expanding XERISPA's market reach
- Developing new products based on gene knockout technology
- Partnering with larger pharmaceutical companies
- Expanding into new therapeutic areas
Threats
- Competition from established pharmaceutical companies
- Regulatory hurdles
- Patent expirations
- Unsuccessful clinical trials
Competitors and Market Share
Key Competitors
- PFE
- MRK
- GILD
Competitive Landscape
Lexicon faces significant competition from larger pharmaceutical companies with greater resources. Lexicon's competitive advantage lies in their innovation and potentially superior products.
Growth Trajectory and Initiatives
Historical Growth: Please refer to Lexicon Pharmaceutical's SEC filings for historical growth data. I do not have real time access to that information.
Future Projections: Future growth projections depend on XERISPA sales and development of new products, which are subject to clinical and regulatory risk. Analyst estimates vary.
Recent Initiatives: Recent initiatives include commercializing XERISPA, advancing other pipeline products, and exploring partnerships.
Summary
Lexicon Pharmaceuticals is a developing biopharmaceutical company with a promising drug discovery platform and a recently launched product. While XERISPA presents a growth opportunity, the company's limited resources and competition pose challenges. Successful pipeline development and commercialization are crucial for long-term success. Financial performance data and continued focus on strategic partnerships is important. Overcoming regulatory and clinical trial hurdles remain high priority.
Peer Comparison
Sources and Disclaimers
Data Sources:
- Lexicon Pharmaceuticals Investor Relations
- SEC Filings
- Third-party Pharmaceutical Market Reports
- Public financial analysis websites
Disclaimers:
The information provided is for informational purposes only and should not be construed as financial advice. Investment decisions should be based on thorough research and consultation with a qualified financial advisor. Market share data is approximate and may vary.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Lexicon Pharmaceuticals Inc
Exchange NASDAQ | Headquaters The Woodlands, TX, United States | ||
IPO Launch date 2000-04-07 | CEO & Director Dr. Michael S. Exton Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 103 | Website https://www.lexpharma.com |
Full time employees 103 | Website https://www.lexpharma.com |
Lexicon Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of pharmaceutical products for the treatment of human disease. The company offers Sotagliflozin, an orally-delivered small molecule drug to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits in adults with heart failure or type 2 diabetes mellitus, chronic kidney disease or CKD, and other cardiovascular risk factors. Its orally-delivered small molecule drug candidates under development include sotagliflozin for the treatment of hypertrophic cardiomyopathy or HCM and type 1 diabetes that is in Phase 3 clinical trial; LX9211, which has completed Phase II clinical trials for the treatment of neuropathic pain; and LX9851 for the treatment of obesity and associated cardiometabolic disorders, as well as for weight management. Lexicon Pharmaceuticals, Inc. has strategic collaboration and license agreements with Viatris Inc. and Bristol-Myers Squibb Company. The company was incorporated in 1995 and is headquartered in The Woodlands, Texas.

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