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Upturn AI Summary - About
Lexicon Pharmaceuticals Inc(LXRX)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for LXRX
09/25/2026: LXRX (1-star) is currently NOT-A-BUY. Pass it for now.
Lexicon Pharmaceuticals is a specialized clinical-stage biotechnology company that recently transitioned into a commercial entity with the approval of INPEFA for heart failure. The firm's core strength lies in its proprietary drug discovery platform and its ability to advance therapies for high-unmet-need areas. The primary investment story rests on the successful commercial adoption of INPEFA and the potential future success of its neuropathic pain candidate, LX9211. Risks are significant, centered on the challenges of a first-time commercial launch, high cash burn, and intense competition from much larger pharmaceutical firms. This stock is best suited for growth-oriented investors with a high risk tolerance who are monitoring the sales trajectory of INPEFA and key clinical trial updates.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Mixed fit | The company offers potential upside through its clinical pipeline, but growth is highly dependent on binary clinical outcomes. |
| Momentum investor | Weak fit | The stock lacks consistent long-term upward momentum, making it less suitable for trend-following strategies. |
| Value investor | Weak fit | The company lacks the positive earnings history and asset-heavy stability typically required for value investing. |
| Dividend investor | Weak fit | Lexicon does not pay a dividend and is reinvesting all capital into development. |
| Low-risk investor | Weak fit | The high volatility and clinical risk inherent in biotech development are incompatible with low-risk investment profiles. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | Biotech stocks often experience extreme price swings based on clinical trial results and regulatory news. |
| Valuation risk | Medium / high | Valuations are often speculative and based on long-term projections of unproven drug assets. |
| Competition risk (Pharma) | High | Large incumbents with significant resources can outspend or out-market smaller firms. |
| Business quality | Medium | The company is transitioning to a commercial model, which is a complex and capital-intensive shift. |
| Dividend income | Low / none | There is no current yield, as the company prioritizes cash for growth. |
| Execution risk | High | The company must effectively launch its first major commercial product while advancing pipeline clinical trials. |
Price Behavior
Rolling Over
The price momentum is slowing down and beginning to turn downward.
Extreme Price Shocks
The stock has experienced exceptionally large and disruptive price movements during the period.
Analysis of Past Performance
Type Stock | Historic Profit -42.82% | Avg. Invested days 26 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  3.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 09/25/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 827.62M USD | Price to earnings Ratio - | 1Y Target Price 3.86 |
Price to earnings Ratio - | 1Y Target Price 3.86 | ||
Volume (30-day avg) 2.8M shares | Beta 1.03 | 52 Weeks Range 1.10 - 2.68 | Updated Date 09/25/2026 |
52 Weeks Range 1.10 - 2.68 | Updated Date 09/25/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.14 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Product Revenue | Direct sales of INPEFA in the United States. | Revenue comes from doctors prescribing their heart failure drug. |
| Licensing & Collaboration | Potential milestone payments and royalties from drug partnerships. | They may receive one-time payments for sharing development rights. |
Analyzing Revenue: Products, Geography and Growth
Revenue by Products
Product revenue - Year on Year
Valuation
Trailing PE - | Forward PE - | Enterprise Value 783.05M | Price to Sales(TTM) 19.96 |
Enterprise Value 783.05M | Price to Sales(TTM) 19.96 | ||
Enterprise Value to Revenue 18.88 | Enterprise Value to EBITDA 16.57 | Shares Outstanding 444.96M | Shares Floating 218.99M |
Shares Outstanding 444.96M | Shares Floating 218.99M | ||
Percent Insiders 1.12 | Percent Institutions 83.79 |
Upturn AI Summary
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
About Lexicon Pharmaceuticals Inc
Exchange NASDAQ | Headquarters The Woodlands, TX, United States | ||
IPO Launch date 2000-04-07 | CEO & Director Dr. Michael S. Exton Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 81 | Website https://www.lexpharma.com |
Full time employees 81 | Website https://www.lexpharma.com | ||
Lexicon Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of pharmaceutical products for the treatment of human disease. The company develops sotagliflozin, an orally-delivered small molecule drug for the treatment of hypertrophic cardiomyopathy, and ZYNQUISTA (sotagliflozin) for the treatment of type 1 diabetes. It also commercializes INPEFA (sotagliflozin), a once-daily oral tablet to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure or type 2 diabetes, CKD, and other cardiovascular risk factors. In addition, the company develops LX9851, an orally-delivered small molecule drug candidate for the treatment of obesity and associated cardiometabolic disorders, and pilavapadin (LX9211), an orally-delivered small molecule drug candidate for the treatment of neuropathic pain. It has strategic collaboration and license agreements with Viatris Inc. and Bristol-Myers Squibb Company. The company was incorporated in 1995 and is headquartered in The Woodlands, Texas.
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