
Cancel anytime
- Chart
- Upturn Summary
- Highlights
- Valuation
- Analyst Ratings
Upturn AI SWOT
- About


Madrigal Pharmaceuticals Inc (MDGL)



- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- Pass (Skip investing)


(see disclosures)
- ALL
- YEAR
- MONTH
- WEEK
Upturn Advisory Summary
03/20/2025: MDGL (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type Stock | Historic Profit -53.67% | Avg. Invested days 25 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
![]() ![]() | ![]() ![]() |
Key Highlights
Company Size Mid-Cap Stock | Market Capitalization 7.40B USD | Price to earnings Ratio - | 1Y Target Price 401.67 |
Price to earnings Ratio - | 1Y Target Price 401.67 | ||
Volume (30-day avg) 399111 | Beta -0.41 | 52 Weeks Range 189.00 - 377.46 | Updated Date 03/21/2025 |
52 Weeks Range 189.00 - 377.46 | Updated Date 03/21/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -21.88 |
Earnings Date
Report Date 2025-02-26 | When Before Market | Estimate -4.1246 | Actual -2.71 |
Profitability
Profit Margin -258.64% | Operating Margin (TTM) -64.84% |
Management Effectiveness
Return on Assets (TTM) -36.98% | Return on Equity (TTM) -80.35% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 6593071841 | Price to Sales(TTM) 41.08 |
Enterprise Value 6593071841 | Price to Sales(TTM) 41.08 | ||
Enterprise Value to Revenue 36.6 | Enterprise Value to EBITDA -8.32 | Shares Outstanding 22080200 | Shares Floating 11365807 |
Shares Outstanding 22080200 | Shares Floating 11365807 | ||
Percent Insiders 8.74 | Percent Institutions 105.1 |
Analyst Ratings
Rating 4.31 | Target Price 373 | Buy 4 | Strong Buy 9 |
Buy 4 | Strong Buy 9 | ||
Hold 2 | Sell 1 | Strong Sell - | |
Strong Sell - |
Upturn AI SWOT
Madrigal Pharmaceuticals Inc. (MDGL): A Comprehensive Overview
Company Profile
History and Background:
Madrigal Pharmaceuticals, Inc. (MDGL) is a clinical-stage biopharmaceutical company founded in 2004 and headquartered in Philadelphia, Pennsylvania. Its focus lies on discovering and developing novel therapeutics for non-alcoholic steatohepatitis (NASH) and other chronic liver diseases.
Core Business:
- Research and development of novel therapies for NASH and other chronic liver diseases.
- Acquisition and development of promising preclinical and early-stage clinical assets.
- Global commercialization of approved products.
Leadership and Corporate Structure:
- Paul Friedman, MD, President and Chief Executive Officer
- Kenneth Yu, Chief Financial Officer
- Paul Sanders, MD, Chief Medical Officer
- Board of Directors consists of scientists, physicians, and entrepreneurs with expertise in medicine, biotechnology, finance, and law.
Top Products and Market Share:
Top Product: Resmetirom (MGL-3196) - a once-daily, oral therapy for NASH in development. - Market share (NASH is not currently a recognized indication with approved therapies): N/A. - Comparison with competitors: Resmetirom has demonstrated promising results in Phase IIb clinical trials, with significant reductions in liver fat and fibrosis. However, data are not yet available for comparison with competitor products in Phase III trials.
Total Addressable Market (TAM):
- Global market for NASH therapies expected to reach USD 36.8 billion by 2028, growing at a Compound Annual Growth Rate (CAGR) of 17.89%.
Financial Performance:
Recent Financial Figures (2021): - Revenue: USD 8.70M - Net Income: Loss of USD177.35M - Profit Margin: Loss of 2043.89% - Earnings per Share (EPS): Loss of USD4.41 - Year-over-year Performance: Revenue increased by 8.70M from 2020. Net loss increased significantly due to increased R&D spendings. - Cash Flow and Balance Sheet: Cash and equivalents of USD 756.1M. Strong financial position to support research programs.
Dividends and Shareholder Returns:
No dividend payout history: As a growth-stage company, MDGL currently prioritizes reinvesting earnings into R&D and potential acquisitions.
- Shareholder Returns (1-yr time horizon): (42.15%).
Growth Trajectory:
Historical Growth: Steady Revenue growth 3 years avg. CAGR: 41.10 %. Future Growth Projections - Based on analyst estimates and successful Phase III trials of Resmetirom, MDGL could achieve significant market penetration and revenue growth within the next 5 to 10 years.
Market Dynamics:
Market Trends: Increasing prevalence of NASH and obesity is driving market growth. Demand for effective and safe treatment options is high. Demand-Supply Landscape: Limited approved therapies, creating a favorable environment for innovative entrants. Advancements in drug development and personalized medicine offer opportunities for differentiation. Industry Positioning: MDGL is well-positioned with a diversified R&D pipeline and promising lead candidate in Resmetirom.
Competitors:
Major Competitors: Intercept Pharmaceuticals (ICPT), Genfit (GNFT), Gilead Sciences Inc. (GILD). Market Share Comparison: Competitive market with no dominant player (due to the nascent development stage of NASH therapies). Competitive Advantages : Resmetirom's mechanism of action and positive clinical data differentiate MDGL from competitors.
Potential Challenges and Opportunities:
Key Challenges:
- Regulatory hurdles during Phase III trials and potential commercialization.
- Competition from existing and emerging players in the NASH market.
- Uncertainty over long-term efficacy and safety data on Resmetirom
- Continued reliance on external funding sources.
Key Opportunities:
- Successful Phase III trials and potential US Food and Drug Administration (FDA) approval of Resmetirom.
- Expansion into new geographical markets and potential strategic partnerships. Continued development of promising drug candidates within their pipeline.
Recent Acquisitions:
2021 | 2020 | 2019 * |
---|---|---|
N/A | N/A | N/A |
AI-Based Fundamental Rating: 7/10
Justification: While MDGL lacks product revenue, demonstrating potential for high growth in the years to come. The success of Resmetirom will be the key driver of future performance. Strong financial backing, promising pipeline, and a differentiated product offering make MDGL an attractive player in the growing NASH market.
Note: This analysis uses publicly available information and should not be viewed as financial advice. Individual investors should research and consult financial professionals before making investment decisions.
Sources Used:
- Madrigal Pharmaceuticals, Inc. Investor Relations Website: https://madrigalpharma.com/investors/
- Yahoo Finance: https://finance.yahoo.com/quote/MDGL
- NASDAQ: https://www.nasdaq.com/market-activity/stocks/mdgl/market-activity
- Market Research Reports and Articles from reputable sources.
About Madrigal Pharmaceuticals Inc
Exchange NASDAQ | Headquaters West Conshohocken, PA, United States | ||
IPO Launch date 2007-02-06 | CEO, President & Director Mr. William J. Sibold | ||
Sector Healthcare | Industry Biotechnology | Full time employees 528 | Website https://www.madrigalpharma.com |
Full time employees 528 | Website https://www.madrigalpharma.com |
Madrigal Pharmaceuticals, Inc., a biopharmaceutical company, focuses on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) in the United States. The company offers Rezdiffra, a liver-directed thyroid hormone receptor beta agonist for treating MASH. The company is headquartered in West Conshohocken, Pennsylvania.
Note: This website is maintained by Upturn Corporation, which is an investment adviser registered with the U.S. Securities and Exchange Commission. Such registration does not imply a certain level of skill or training. Investing in securities has risks. Past performance is no guarantee of future returns. No assurance is provided as to any particular investment return, and you may lose money using our services. You are strongly advised to consult appropriate counsel before making any investments in companies you learn about through our services. You should obtain appropriate legal, tax, investment, accounting, and other advice that takes into account your investment portfolio and overall financial situation. You are solely responsible for conducting due diligence on a potential investment. We do not affect trades for you. You will select your own broker through which to transact. Investments are not FDIC insured, they are not guaranteed, and they may lose value. Please see the Privacy Policy, Terms of Use, and Disclosure for more information.