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NAUT 1-star rating from Upturn Advisory
Nautilus Biotechnology Inc (NAUT) company logo

Nautilus Biotechnology Inc (NAUT)

Nautilus Biotechnology Inc (NAUT) 1-star rating from Upturn Advisory
$2.42
Last Close (24-hour delay)
Profit since last BUY10.5%
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Upturn Advisory Summary

02/27/2026: NAUT (1-star) has a low Upturn Star Rating. Not recommended to BUY.

Upturn Star Rating

Upturn 1 star rating for performance

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

1 star rating from financial analysts

4 Analysts rated it

Very few follow this stock; limited insights, higher-risk early investing.

1 Year Target Price $4

1 Year Target Price $4

Analysts Price Target For last 52 week
$4 Target price
52w Low $0.62
Current$2.42
52w High $3.08
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Key Highlights

Company Size Small-Cap Stock
Market Capitalization 305.66M USD
Price to earnings Ratio -
1Y Target Price 4
Price to earnings Ratio -
1Y Target Price 4
Volume (30-day avg) 4
Beta 1.36
52 Weeks Range 0.62 - 3.08
Updated Date 02/27/2026
52 Weeks Range 0.62 - 3.08
Updated Date 02/27/2026
Dividends yield (FY) -
Basic EPS (TTM) -0.5
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Earnings Date

Report Date 2026-02-19
When -
Estimate -0.155
Actual -0.11

Profitability

Profit Margin -
Operating Margin (TTM) -

Management Effectiveness

Return on Assets (TTM) -19.37%
Return on Equity (TTM) -32%

Valuation

Trailing PE -
Forward PE -
Enterprise Value -9918219
Price to Sales(TTM) -
Enterprise Value -9918219
Price to Sales(TTM) -
Enterprise Value to Revenue -
Enterprise Value to EBITDA -2
Shares Outstanding 126305122
Shares Floating 45999062
Shares Outstanding 126305122
Shares Floating 45999062
Percent Insiders 33.5
Percent Institutions 45.32

Icon representing Upturn AI-generated SWOT analysis summary Upturn AI SWOT

Nautilus Biotechnology Inc

Nautilus Biotechnology Inc(NAUT) company logo displayed in Upturn AI summary

Company Overview

Company history and background logo History and Background

Nautilus Biotechnology Inc. was founded in 2018 with the mission to democratize proteomics. The company has focused on developing a single-molecule protein-detection platform that promises unprecedented sensitivity, specificity, and speed. Significant milestones include the development of its proprietary assay technology and ongoing clinical validation studies.

Company business area logo Core Business Areas

  • Proteomics Platform Development: Nautilus is developing a novel, single-molecule protein-based detection platform. This platform aims to enable high-throughput, sensitive, and specific analysis of proteins, which is crucial for understanding disease biology, drug discovery, and diagnostics.

leadership logo Leadership and Structure

Nautilus Biotechnology Inc. is led by a management team with experience in biotechnology, engineering, and business. The organizational structure is typical for a growth-stage biotech company, with departments focused on research and development, operations, and corporate functions.

Top Products and Market Share

Product Key Offerings logo Key Offerings

  • Proteomics Platform (Under Development): Nautilus's core offering is its yet-to-be-fully-commercialized proteomics platform. This platform aims to detect and quantify proteins at the single-molecule level. Market share data is not yet applicable as the platform is in development. Competitors in the broader proteomics and protein analysis market include companies like Thermo Fisher Scientific, Agilent Technologies, and Illumina, though Nautilus's single-molecule approach offers a distinct differentiation.

Market Dynamics

industry overview logo Industry Overview

The proteomics and biotechnology industries are characterized by rapid innovation, significant investment in R&D, and a strong demand for advanced diagnostic and therapeutic tools. The market is driven by a growing understanding of the role of proteins in disease and the need for more precise and personalized medicine.

Positioning

Nautilus Biotechnology Inc. positions itself as a disruptive innovator in the proteomics space with its unique single-molecule detection technology. Its competitive advantage lies in the potential for significantly higher sensitivity and specificity compared to existing methods, enabling the detection of low-abundance proteins relevant to early disease detection and drug response.

Total Addressable Market (TAM)

The total addressable market for proteomics and protein analysis is substantial and growing, with estimates ranging in the tens of billions of dollars globally. Nautilus is positioned to capture a significant share of this market by providing a foundational technology that can be applied across drug discovery, diagnostics, and basic research.

Upturn SWOT Analysis

Strengths

  • Novel single-molecule protein detection technology
  • Potential for unprecedented sensitivity and specificity
  • Experienced leadership team
  • Focus on a critical and growing area of biotechnology

Weaknesses

  • Technology is still in development and not yet commercialized
  • Significant R&D investment required
  • Dependence on successful clinical validation and regulatory approval
  • Limited historical financial track record

Opportunities

  • Partnerships with pharmaceutical and diagnostic companies
  • Expansion into various disease areas for diagnostic development
  • Leveraging AI and machine learning for proteomic data analysis
  • Growing demand for personalized medicine

Threats

  • Competition from established players with existing technologies
  • Technical challenges in scaling up and commercializing the platform
  • Long development cycles and high R&D costs
  • Changes in regulatory landscape for diagnostics and therapeutics

Competitors and Market Share

Key competitor logo Key Competitors

  • Thermo Fisher Scientific (TMO)
  • Agilent Technologies (A)
  • Illumina (ILMN)
  • Bio-Rad Laboratories (BIO)

Competitive Landscape

Nautilus's competitive advantage lies in its disruptive single-molecule approach to proteomics. However, it faces strong competition from established companies with broad portfolios and existing customer bases in the broader life sciences and diagnostics markets. Nautilus's success will depend on demonstrating superior performance and scalability of its technology.

Growth Trajectory and Initiatives

Historical Growth: Historically, Nautilus has focused on achieving key technological development milestones and securing funding to support its ambitious R&D roadmap. Growth has been measured by progress in platform development and scientific validation.

Future Projections: Future growth projections are highly dependent on the successful commercialization of its proteomics platform. Analyst estimates, if available, would focus on the potential market penetration once the technology is proven and adopted.

Recent Initiatives: Recent initiatives likely involve ongoing development and validation of the Nautilus platform, strategic partnerships for clinical studies, and efforts to build out its scientific and commercial teams.

Summary

Nautilus Biotechnology Inc. is a speculative investment focused on a novel, single-molecule proteomics platform. Its core strength is its disruptive technology with the potential for high sensitivity and specificity. However, it faces significant weaknesses as the technology is still under development and unproven in the market. Opportunities lie in strategic partnerships and addressing unmet needs in diagnostics and drug discovery, but threats from established competitors and technical hurdles are substantial.

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Sources and Disclaimers

Data Sources:

  • Company filings with the U.S. Securities and Exchange Commission (SEC)
  • Financial news outlets and market data providers
  • Industry analysis reports

Disclaimers:

This analysis is based on publicly available information and is for informational purposes only. It does not constitute financial advice. Investors should conduct their own due diligence before making any investment decisions.

Information icon for Upturn AI Summarization accuracy disclaimer AI Summarization is directionally correct and might not be accurate.

Information icon for Upturn AI Summarization data freshness disclaimer Summarized information shown could be a few years old and not current.

Information icon warning about Upturn AI Fundamental Rating based on potentially old data Fundamental Rating based on AI could be based on old data.

Information icon warning about potential inaccuracies or hallucinations in Upturn AI-generated summaries AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Nautilus Biotechnology Inc

Exchange NASDAQ
Headquaters Seattle, WA, United States
IPO Launch date 2021-06-10
Co-Founder, CEO, President, Secretary & Director Mr. Sujal M. Patel
Sector Healthcare
Industry Biotechnology
Full time employees 124
Full time employees 124

Nautilus Biotechnology, Inc., a development stage life sciences company, engages in creating a platform technology for quantifying and unlocking the complexity of the proteome. The company develops Nautilus Platform, a proteomics platform that includes an end-to-end solution comprising instruments, consumables, and software analysis. It also offers a proteome analysis system, a high-resolution optical imaging system with integrated fluidics and liquid handling sub-system to deposit protein libraries onto a flow cell and to process labeled multi-affinity reagent probe binding and imaging cycles rapidly to decode and quantify the proteins present in biological samples. In addition, the company offers reagent kits, which include sample preparation, flow cells, multi-affinity probe reagents, and instrument buffer system to perform multi-cycle analysis runs. Nautilus Biotechnology, Inc. and Weill Cornell Medicine"Qatar have a research collaboration with The Michael J. Fox Foundation to study the connection between the alpha-synuclein (aSyn) protein and Parkinson's disease (PD). Nautilus Biotechnology, Inc. was founded in 2016 and is headquartered in Seattle, Washington.