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Nautilus Biotechnology Inc (NAUT)

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Upturn Advisory Summary
02/27/2026: NAUT (1-star) has a low Upturn Star Rating. Not recommended to BUY.
1 Year Target Price $4
1 Year Target Price $4
| 2 | Strong Buy |
| 0 | Buy |
| 2 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 305.66M USD | Price to earnings Ratio - | 1Y Target Price 4 |
Price to earnings Ratio - | 1Y Target Price 4 | ||
Volume (30-day avg) 4 | Beta 1.36 | 52 Weeks Range 0.62 - 3.08 | Updated Date 02/27/2026 |
52 Weeks Range 0.62 - 3.08 | Updated Date 02/27/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.5 |
Earnings Date
Report Date 2026-02-19 | When - | Estimate -0.155 | Actual -0.11 |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -19.37% | Return on Equity (TTM) -32% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value -9918219 | Price to Sales(TTM) - |
Enterprise Value -9918219 | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA -2 | Shares Outstanding 126305122 | Shares Floating 45999062 |
Shares Outstanding 126305122 | Shares Floating 45999062 | ||
Percent Insiders 33.5 | Percent Institutions 45.32 |
Upturn AI SWOT
Nautilus Biotechnology Inc

Company Overview
History and Background
Nautilus Biotechnology Inc. was founded in 2018 with the mission to democratize proteomics. The company has focused on developing a single-molecule protein-detection platform that promises unprecedented sensitivity, specificity, and speed. Significant milestones include the development of its proprietary assay technology and ongoing clinical validation studies.
Core Business Areas
- Proteomics Platform Development: Nautilus is developing a novel, single-molecule protein-based detection platform. This platform aims to enable high-throughput, sensitive, and specific analysis of proteins, which is crucial for understanding disease biology, drug discovery, and diagnostics.
Leadership and Structure
Nautilus Biotechnology Inc. is led by a management team with experience in biotechnology, engineering, and business. The organizational structure is typical for a growth-stage biotech company, with departments focused on research and development, operations, and corporate functions.
Top Products and Market Share
Key Offerings
- Proteomics Platform (Under Development): Nautilus's core offering is its yet-to-be-fully-commercialized proteomics platform. This platform aims to detect and quantify proteins at the single-molecule level. Market share data is not yet applicable as the platform is in development. Competitors in the broader proteomics and protein analysis market include companies like Thermo Fisher Scientific, Agilent Technologies, and Illumina, though Nautilus's single-molecule approach offers a distinct differentiation.
Market Dynamics
Industry Overview
The proteomics and biotechnology industries are characterized by rapid innovation, significant investment in R&D, and a strong demand for advanced diagnostic and therapeutic tools. The market is driven by a growing understanding of the role of proteins in disease and the need for more precise and personalized medicine.
Positioning
Nautilus Biotechnology Inc. positions itself as a disruptive innovator in the proteomics space with its unique single-molecule detection technology. Its competitive advantage lies in the potential for significantly higher sensitivity and specificity compared to existing methods, enabling the detection of low-abundance proteins relevant to early disease detection and drug response.
Total Addressable Market (TAM)
The total addressable market for proteomics and protein analysis is substantial and growing, with estimates ranging in the tens of billions of dollars globally. Nautilus is positioned to capture a significant share of this market by providing a foundational technology that can be applied across drug discovery, diagnostics, and basic research.
Upturn SWOT Analysis
Strengths
- Novel single-molecule protein detection technology
- Potential for unprecedented sensitivity and specificity
- Experienced leadership team
- Focus on a critical and growing area of biotechnology
Weaknesses
- Technology is still in development and not yet commercialized
- Significant R&D investment required
- Dependence on successful clinical validation and regulatory approval
- Limited historical financial track record
Opportunities
- Partnerships with pharmaceutical and diagnostic companies
- Expansion into various disease areas for diagnostic development
- Leveraging AI and machine learning for proteomic data analysis
- Growing demand for personalized medicine
Threats
- Competition from established players with existing technologies
- Technical challenges in scaling up and commercializing the platform
- Long development cycles and high R&D costs
- Changes in regulatory landscape for diagnostics and therapeutics
Competitors and Market Share
Key Competitors
- Thermo Fisher Scientific (TMO)
- Agilent Technologies (A)
- Illumina (ILMN)
- Bio-Rad Laboratories (BIO)
Competitive Landscape
Nautilus's competitive advantage lies in its disruptive single-molecule approach to proteomics. However, it faces strong competition from established companies with broad portfolios and existing customer bases in the broader life sciences and diagnostics markets. Nautilus's success will depend on demonstrating superior performance and scalability of its technology.
Growth Trajectory and Initiatives
Historical Growth: Historically, Nautilus has focused on achieving key technological development milestones and securing funding to support its ambitious R&D roadmap. Growth has been measured by progress in platform development and scientific validation.
Future Projections: Future growth projections are highly dependent on the successful commercialization of its proteomics platform. Analyst estimates, if available, would focus on the potential market penetration once the technology is proven and adopted.
Recent Initiatives: Recent initiatives likely involve ongoing development and validation of the Nautilus platform, strategic partnerships for clinical studies, and efforts to build out its scientific and commercial teams.
Summary
Nautilus Biotechnology Inc. is a speculative investment focused on a novel, single-molecule proteomics platform. Its core strength is its disruptive technology with the potential for high sensitivity and specificity. However, it faces significant weaknesses as the technology is still under development and unproven in the market. Opportunities lie in strategic partnerships and addressing unmet needs in diagnostics and drug discovery, but threats from established competitors and technical hurdles are substantial.
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Sources and Disclaimers
Data Sources:
- Company filings with the U.S. Securities and Exchange Commission (SEC)
- Financial news outlets and market data providers
- Industry analysis reports
Disclaimers:
This analysis is based on publicly available information and is for informational purposes only. It does not constitute financial advice. Investors should conduct their own due diligence before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Nautilus Biotechnology Inc
Exchange NASDAQ | Headquaters Seattle, WA, United States | ||
IPO Launch date 2021-06-10 | Co-Founder, CEO, President, Secretary & Director Mr. Sujal M. Patel | ||
Sector Healthcare | Industry Biotechnology | Full time employees 124 | Website https://www.nautilus.bio |
Full time employees 124 | Website https://www.nautilus.bio | ||
Nautilus Biotechnology, Inc., a development stage life sciences company, engages in creating a platform technology for quantifying and unlocking the complexity of the proteome. The company develops Nautilus Platform, a proteomics platform that includes an end-to-end solution comprising instruments, consumables, and software analysis. It also offers a proteome analysis system, a high-resolution optical imaging system with integrated fluidics and liquid handling sub-system to deposit protein libraries onto a flow cell and to process labeled multi-affinity reagent probe binding and imaging cycles rapidly to decode and quantify the proteins present in biological samples. In addition, the company offers reagent kits, which include sample preparation, flow cells, multi-affinity probe reagents, and instrument buffer system to perform multi-cycle analysis runs. Nautilus Biotechnology, Inc. and Weill Cornell Medicine"Qatar have a research collaboration with The Michael J. Fox Foundation to study the connection between the alpha-synuclein (aSyn) protein and Parkinson's disease (PD). Nautilus Biotechnology, Inc. was founded in 2016 and is headquartered in Seattle, Washington.

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