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Nautilus Biotechnology Inc (NAUT)

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Upturn Advisory Summary
12/29/2025: NAUT (1-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $2.5
1 Year Target Price $2.5
| 2 | Strong Buy |
| 0 | Buy |
| 2 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit 25.8% | Avg. Invested days 28 | Today’s Advisory PASS |
Upturn Star Rating ![]() | Upturn Advisory Performance | Stock Returns Performance |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 250.08M USD | Price to earnings Ratio - | 1Y Target Price 2.5 |
Price to earnings Ratio - | 1Y Target Price 2.5 | ||
Volume (30-day avg) 4 | Beta 1.39 | 52 Weeks Range 0.62 - 2.54 | Updated Date 12/29/2025 |
52 Weeks Range 0.62 - 2.54 | Updated Date 12/29/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.5 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -19.37% | Return on Equity (TTM) -32% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 145660141 | Price to Sales(TTM) - |
Enterprise Value 145660141 | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA -2 | Shares Outstanding 126305122 | Shares Floating 45999062 |
Shares Outstanding 126305122 | Shares Floating 45999062 | ||
Percent Insiders 33.5 | Percent Institutions 44.82 |
Upturn AI SWOT
Nautilus Biotechnology Inc

Company Overview
History and Background
Nautilus Biotechnology Inc. was founded in 2006 with the goal of revolutionizing protein analysis. The company has focused on developing a novel platform for high-throughput, ultra-deep proteome analysis, aiming to enable unprecedented insights into biological systems. Significant milestones include the development and commercialization of their Nautilus Platform, which promises to detect and quantify millions of proteins with exceptional sensitivity and scale, addressing limitations of current proteomic technologies.
Core Business Areas
- Proteomics Analysis Platform: Nautilus Biotechnology Inc. is primarily focused on the development and commercialization of its proprietary Nautilus Platform. This platform is designed to enable scientists to comprehensively analyze the proteome, the entire set of proteins expressed by an organism or system. The platform utilizes a novel approach to protein detection and quantification, aiming for a significant leap in sensitivity, speed, and scale compared to existing technologies.
Leadership and Structure
Nautilus Biotechnology Inc. is led by a management team with expertise in biotechnology, drug discovery, and commercialization. The specific leadership roles and organizational structure are typically detailed in their investor relations materials and SEC filings, including the CEO, CTO, CFO, and heads of research and development, operations, and commercialization. The company operates as a publicly traded entity with a board of directors overseeing corporate governance.
Top Products and Market Share
Key Offerings
- Competitors: Thermo Fisher Scientific, Illumina, Agilent Technologies (broader life sciences tools), Seer Inc. (emerging proteomics technology competitor).
- Description: The Nautilus Platform is the company's flagship offering. It is a high-throughput proteomic analysis system designed to detect and quantify millions of proteins with unprecedented sensitivity and scale. The platform aims to accelerate drug discovery, disease diagnostics, and fundamental biological research by providing deeper insights into cellular processes and disease mechanisms. Competitors in the broader proteomics market include companies offering mass spectrometry-based proteomics solutions, antibody-based assays (ELISA, Western Blot), and other protein analysis tools. Specific direct competitors developing similar ultra-deep proteome analysis platforms are still emerging.
- Market Share Data: As the Nautilus Platform is in its early stages of commercialization and adoption, specific market share data is not yet established. The company is focused on building its customer base and demonstrating the platform's capabilities.
- Product Name: Nautilus Platform
Market Dynamics
Industry Overview
Nautilus Biotechnology Inc. operates within the rapidly growing life sciences and biotechnology tools market, specifically focusing on the proteomics segment. The demand for advanced proteomic analysis solutions is driven by the increasing understanding of the role of proteins in health and disease, the advancement of personalized medicine, and the need for more efficient drug discovery and development processes. The industry is characterized by continuous innovation and a drive for higher sensitivity, throughput, and data richness.
Positioning
Nautilus Biotechnology Inc. positions itself as a disruptive innovator in proteomics, offering a platform that aims to overcome the limitations of current technologies in terms of depth and scale of protein analysis. Its competitive advantage lies in its proprietary technology, which promises to enable scientists to uncover novel biological insights and accelerate research and development pipelines. The company seeks to become a leader in enabling ultra-deep proteome analysis for a wide range of applications.
Total Addressable Market (TAM)
The total addressable market for proteomics technologies is substantial and growing, driven by applications in drug discovery, diagnostics, and academic research. Analysts estimate the global proteomics market to be in the tens of billions of dollars and projected to grow significantly in the coming years. Nautilus Biotechnology Inc. is positioned to capture a significant portion of this market by offering a uniquely powerful and comprehensive proteomic analysis solution that addresses unmet needs.
Upturn SWOT Analysis
Strengths
- Proprietary technology for ultra-deep proteome analysis
- Potential for significant disruption in proteomics
- Experienced management team
- Focus on a high-growth market segment
Weaknesses
- Relatively new technology with limited commercial track record
- Need for significant capital investment for scaling
- Reliance on adoption by the scientific community
- Potential for high cost of platform adoption
Opportunities
- Growing demand for deep proteomic insights in drug discovery and diagnostics
- Partnerships with pharmaceutical and biotech companies
- Expansion into new application areas (e.g., agriculture, food science)
- Advancements in AI and data analytics for proteomics interpretation
Threats
- Competition from established life science tool providers
- Rapid technological advancements by competitors
- Challenges in regulatory approval for diagnostic applications
- Economic downturns impacting R&D budgets of potential customers
- Potential for intellectual property challenges
Competitors and Market Share
Key Competitors
- Thermo Fisher Scientific (TMO)
- Illumina (ILMN)
- Agilent Technologies (A)
- Seer Inc. (SEER)
Competitive Landscape
Nautilus Biotechnology Inc. faces a competitive landscape with established players offering a range of life science tools. Its advantage lies in its novel technology that promises deeper proteomic analysis. However, it must compete with the extensive product portfolios, established customer relationships, and significant R&D budgets of larger companies. Emerging competitors like Seer Inc. are also developing innovative proteomics solutions, making it a dynamic market.
Growth Trajectory and Initiatives
Historical Growth: Historically, Nautilus Biotechnology Inc.'s growth has been characterized by significant investment in R&D and platform development, alongside efforts to secure funding through equity offerings. The company has progressed from an early-stage research entity to a company on the cusp of commercializing its core technology.
Future Projections: Future growth projections for Nautilus Biotechnology Inc. are heavily dependent on the successful adoption and commercialization of the Nautilus Platform. Analysts' expectations would typically focus on revenue growth post-commercial launch, the expansion of its customer base, and the development of new applications for its technology. Specific revenue and earnings per share (EPS) projections would be available from financial research firms.
Recent Initiatives: Recent initiatives likely include scaling up manufacturing capabilities for the Nautilus Platform, engaging with key opinion leaders and potential customers, securing strategic partnerships, and continuing to refine the platform's capabilities based on early feedback and further research.
Summary
Nautilus Biotechnology Inc. is a promising company with disruptive proteomic analysis technology, positioning it for significant growth in a high-demand market. Its strengths lie in its proprietary platform and experienced team, while its main weaknesses involve the early stage of commercialization and high capital requirements. The company has substantial opportunities in drug discovery and diagnostics, but must navigate threats from established competitors and rapid technological evolution. Continued successful execution of its commercialization strategy and strategic partnerships will be critical for its success.
Similar Stocks
Sources and Disclaimers
Data Sources:
- Company's SEC filings (10-K, 10-Q)
- Company investor relations website
- Financial news and analysis platforms (e.g., Yahoo Finance, Bloomberg, Seeking Alpha)
- Industry research reports
Disclaimers:
This JSON output is generated based on publicly available information and may not be exhaustive or reflect the most up-to-date data. It is intended for informational purposes only and should not be considered investment advice. Investors should conduct their own due diligence and consult with a qualified financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Nautilus Biotechnology Inc
Exchange NASDAQ | Headquaters Seattle, WA, United States | ||
IPO Launch date 2021-06-10 | Co-Founder, CEO, President, Secretary & Director Mr. Sujal M. Patel | ||
Sector Healthcare | Industry Biotechnology | Full time employees 124 | Website https://www.nautilus.bio |
Full time employees 124 | Website https://www.nautilus.bio | ||
Nautilus Biotechnology, Inc., a development stage life sciences company, engages in creating a platform technology for quantifying and unlocking the complexity of the proteome. The company develops Nautilus Platform, a proteomics platform that includes end-to-end solution comprising instruments, consumables, and software analysis. It also offers proteome analysis system, a high-resolution optical imaging system with integrated fluidics and liquid handling sub-system to deposit protein libraries onto a flow cell and to process labeled multi-affinity reagent probe binding and imaging cycles rapidly to decode and quantify the proteins present in biological samples. In addition, the company offers reagent kits, which include sample preparation, flow cells, multi-affinity probe reagents, and instrument buffers system to perform multi-cycle analysis runs. Nautilus Biotechnology, Inc. was founded in 2016 and is headquartered in Seattle, Washington.

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